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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000267107

Summary for PCAT19

check button Gene summary

Gene informationEnsembl ID

ENSG00000267107

Gene symbol

PCAT19

Gene nameprostate cancer associated transcript 19
HGNC

49593

Entrez ID

100505495

Gene typelincRNA
SynonymsPCAT19|19q13.2
UniProtAcc

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Structure and expression level for PCAT19

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002671072.349680e+02-1.261017e+001.717421e-01-7.342508e+002.100000e-131.770000e-12DOWNKICH
ENSG000002671073.522365e+02-1.013545e+002.946325e-01-3.440031e+005.816470e-041.560999e-03DOWNUCEC
ENSG000002671072.950489e+02-2.995559e+001.670657e-01-1.793043e+016.830000e-723.400000e-70DOWNLUSC
ENSG000002671073.139624e+02-1.689210e+009.370995e-02-1.802595e+011.220000e-725.100000e-71DOWNBRCA
ENSG000002671073.300563e+02-2.418871e+001.425389e-01-1.696990e+011.370000e-641.480000e-62DOWNLUAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG00000267107-6.167062e-011.236849e-10KICH1.689662e-09
ENSG00000267107-3.497510e-012.648298e-18LUAD7.878687e-17

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lncRNA-Protein interaction for PCAT19

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000267107ENST00000594315PCAT19ENSG00000169554ZEB241.9394.5604O60315TFNA
ENSG00000267107ENST00000594315PCAT19ENSG00000121068TBX238.2792.4708Q13207TFNA
ENSG00000267107ENST00000594315PCAT19ENSG00000148516ZEB134.3693.47P37275TFNA
ENSG00000267107ENST00000594315PCAT19ENSG00000177374HIC131.6392.6313Q14526TFNA
ENSG00000267107ENST00000594315PCAT19ENSG00000136630HLX6.9592.8966Q14774TFNA
ENSG00000267107ENST00000595837PCAT19ENSG00000136630HLX6.8692.7227Q14774TFNA
ENSG00000267107ENST00000597702PCAT19ENSG00000169554ZEB241.8594.6876O60315TFNA
ENSG00000267107ENST00000597702PCAT19ENSG00000121068TBX237.3292.9911Q13207TFNA
ENSG00000267107ENST00000597702PCAT19ENSG00000148516ZEB136.9692.4744P37275TFNA
ENSG00000267107ENST00000597702PCAT19ENSG00000177374HIC135.0692.0121Q14526TFNA
ENSG00000267107ENST00000588495PCAT19ENSG00000136630HLX13.0894.8494Q14774TFNA
ENSG00000267107ENST00000597702PCAT19ENSG00000125740FOSB9.9591.9689P53539TFNA
ENSG00000267107ENST00000597702PCAT19ENSG00000136630HLX7.3992.4493Q14774TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for PCAT19

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
ZNF22,KLF9,JDP2,HLX,KLF6,HIC1,KLF2,TBX2,ETS1,RBMS3,ZEB2,MEOX2,MEF2C,BCL6B,FLI1,SOX7,HEYL,QKI,ERG
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.
Only predicted by TDF
ZNF22,RBMS3,JUND,MSX1
Exist in public source
NA

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for PCAT19

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
GRHL2
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000267107ENST00000595063exon_skip_21628chr1:9756480-9756510-4.93-0.7043CLSTN1ENST00000377298In-frame
ENSG00000267107ENST00000595063exon_skip_43507chr10:84499874-84499959-11.89-0.1802CCSER2ENST00000224756Frame-shift
ENSG00000267107ENST00000595063exon_skip_287874chr17:29085603-29085648-6.73-0.4807MYO18AENST00000527372In-frame
ENSG00000267107ENST00000595063exon_skip_436488chr5:96726793-96726859-7.60-0.1490CASTENST00000341926,ENST00000395813In-frame

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000267107ENST00000595063exon_skip_48713chr10:34336198-34336243-4.74-0.2633PARD3ENST00000374789In-frame
ENSG00000267107ENST00000595063exon_skip_325891chr2:62987930-62988038-9.53-0.1121EHBP1ENST00000263991In-frame
ENSG00000267107ENST00000595063exon_skip_434332chr5:34813573-34813660-8.60-0.1229RAI14ENST00000265109,ENST00000428746,ENST00000503673In-frame
ENSG00000267107ENST00000598215exon_skip_435063chr5:66075023-66075230-15.58-0.1146ERBINENST00000284037In-frame
ENSG00000267107ENST00000595063exon_skip_499771chr9:128592982-128593042-8.38-0.2394SPTAN1ENST00000372731In-frame
ENSG00000267107ENST00000595063exon_skip_44998chr10:110132304-110132400-8.65-0.1765ADD3ENST00000356080In-frame
ENSG00000267107ENST00000595063exon_skip_384879chr3:52554723-52554879-18.28-0.1385PBRM1ENST00000296302In-frame
ENSG00000267107ENST00000599801exon_skip_430601chr4:82842139-82842481-23.22-0.1037SEC31AENST00000355196,ENST00000395310,ENST00000448323In-frame
ENSG00000267107ENST00000595063exon_skip_456460chr6:17771113-17771218-14.14-0.1554KIF13AENST00000259711In-frame

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for PCAT19

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types
ENSG00000267107ENSG00000148516ZEB1ENSG00000144642RBMS35BRCA,KIRC,LUSC,PAAD,STAD

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000267107.5ENST00000588495.46984293
ENSG00000267107.5ENST00000599801.410235951
ENSG00000267107.5ENST00000595837.156159329
ENSG00000267107.5ENST00000594315.1648851079
ENSG00000267107.5ENST00000597702.111810366
ENSG00000267107.5ENST00000598215.1799248
ENSG00000267107.5ENST00000595063.1687213