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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000255337

Summary for TMEM123-DT

check button Gene summary

Gene informationEnsembl ID

ENSG00000255337

Gene symbol

TMEM123-DT

Gene nameTMEM123 divergent transcript
HGNC

55502

Entrez ID

101928424

Gene typeantisense
SynonymsRP11-315O6.1|11q22.2|TMEM123-DT
UniProtAcc

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Structure and expression level for TMEM123-DT

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002553376.720140e+01-1.162822e+001.278475e-01-9.095383e+009.430000e-201.310000e-18DOWNTHCA
ENSG000002553375.727809e+011.126811e+001.177483e-019.569659e+001.070000e-217.100000e-21UPKIRC
ENSG000002553375.720670e+011.115274e+002.367717e-014.710335e+002.470000e-061.010000e-05UPKIRP
ENSG000002553374.794757e+011.207181e+001.747626e-016.907546e+004.930000e-123.870000e-11UPLIHC

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002553374.011633e-016.312011e-03CHOL7.829501e-03
ENSG00000255337-3.072950e-017.646556e-14THCA8.327414e-13

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lncRNA-Protein interaction for TMEM123-DT

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for TMEM123-DT

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
TRIR,MRPL52,BLOC1S1,SCNM1,C11orf1,ARL16,TCEA2,ZBTB8OS,ZSWIM9,GLI4,EMG1,TMEM234,NMRAL1,SH2B1,IRF3,CIRBP,STK11,SNRNP25,C1orf159,DDX56,PET100,FAM98C,MZF1,CHTF18,WDR83OS,C7orf50,PPOX,CDPF1,RRNAD1,KAT8,SNF8,BCS1L,ACD,MKS1,RP11-523H20.5,C1orf35,XAB2,TRAPPC12,MUTYH,BCL7C,MRPL28,ZCWPW1,LIN37,SNRPA,SMUG1,HDAC11,MSANTD2,IFT27,RECQL5,GFER,HIRIP3,PHKG2,NARF,PMF1,NUBP2,LRRC75B,RFXANK,ACBD6,LAMTOR2,RAB13,NT5C3B,CENPT,COQ4,COPS9,DRC3,ZMAT5,SUGP1,SPG7,STX10,ARMC5,C19orf44,IQCD,LSM4,ACBD4,LRRC23,DNAJB2,ECHDC2,PLA2G6,TAF1C,COX19,CWC15,ENDOV,AAAS,PSENEN,METTL17,PPIE,BAD,NELFE,CBY1,WDR83,METTL23,EXD3,USF1,CXXC1,RABL2A,NASP,DHPS,PCED1A,BABAM1,ACYP1,NDUFB7,MVB12A,LMF1,CFAP298,HEXIM2,DDX49,INO80E,THOC6,ANKS3,ATRAID,YJU2,RASSF7,ZBED8,DENND6B,PEX11G,CCHCR1,PRMT7,ZFYVE19,FAM228B,TMEM160,COX4I1,SGF29,NEK8,TIGD1,DDX51,ESS2,NDUFC1,THAP3,PSMB3,TSEN54,PSPN,ODF3B,ATG4B,HEMK1,LMNTD2,CCDC191,SPATA33,MCRIP2,PCSK4,TMA7,PFDN5,CCS,PELP1,C19orf25,SETD4,FAM234A,HMGN3,MYG1,DUSP28,NAT9,POP5,BOLA1,CZIB,RPS19BP1,YPEL3,SAP30BP,NTHL1,ARHGAP33,MYL5,METTL26,RPA3,C14orf93,CCDC24,UBXN11,CCDC12,CEP131,TOMM7,HINFP,S100A13,CERS5,GPS1,NCAPH2,SIRT6,COPRS,HSPB11,TRIOBP,CCDC57,ENKD1,FKBP2,IQCC
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.
Only predicted by TDF
C14orf93,HEMK1,MZF1,C19orf25,OCEL1,TRIOBP,C19orf44,DHPS,INO80E,DMAP1,FKBPL,BABAM1,TSEN54,YPEL3,NENF,RRNAD1,SETD4,NT5C,TMA7,FAM98C,TMEM160,THAP3,PPOX,NMRAL1,CIRBP,ZCWPW1,HIRIP3
Exist in public source
NA

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for TMEM123-DT

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
CNOT1,RNF4,RNF123,NIPA2,CLTC,DNAJC14,BECN1,PSMD1,SCYL2,ATP11B,KIAA0100,PNPO,EDEM1,EIF4G2,SLC36A1,VAMP7,WDR44,SEC23A
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for TMEM123-DT

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation
ENSG00000255337ENSG00000004777ARHGAP33CHOL,KIRC,KIRP,LIHC,THCAKIRC,LIHC
ENSG00000255337ENSG00000064490RFXANKCHOL,DLBC,KIRP,LIHC,PRADLIHC
ENSG00000255337ENSG00000115257PCSK4CHOL,KIRC,KIRP,LGG,THCAKIRP
ENSG00000255337ENSG00000124074ENKD1CHOL,KIRC,KIRP,LGG,PRAD,THCA,THYMKIRP
ENSG00000255337ENSG00000127586CHTF18CHOL,KIRC,KIRP,LIHC,PRADKIRC,KIRP,LIHC
ENSG00000255337ENSG00000130731METTL26CHOL,DLBC,KIRP,LIHC,PRADKIRP
ENSG00000255337ENSG00000143793C1orf35CHOL,DLBC,KIRC,KIRP,LIHC,PRADLIHC
ENSG00000255337ENSG00000158062UBXN11CHOL,KIRC,KIRP,LGG,PRAD,THCAKIRC,KIRP
ENSG00000255337ENSG00000163156SCNM1CHOL,KIRC,KIRP,LIHC,PRADLIHC
ENSG00000255337ENSG00000167930FAM234ACHOL,DLBC,KIRP,PRAD,THYMKIRP
ENSG00000255337ENSG00000168096ANKS3CHOL,KIRC,KIRP,LIHC,PRAD,THCA,THYMKIRP,LIHC
ENSG00000255337ENSG00000169592INO80ECHOL,DLBC,KIRC,KIRP,PRAD,THCAKIRC
ENSG00000255337ENSG00000177989ODF3BCHOL,KIRC,KIRP,LGG,PRAD,THYMKIRC,KIRP
ENSG00000255337ENSG00000178026LRRC75BCHOL,KIRC,KIRP,PRAD,THCA,THYMKIRC,KIRP
ENSG00000255337ENSG00000185522LMNTD2CHOL,DLBC,KIRC,KIRP,LIHC,THCAKIRC,KIRP
ENSG00000255337ENSG00000204536CCHCR1CHOL,DLBC,KIRC,KIRP,LIHCLIHC
ENSG00000255337ENSG00000215375MYL5CHOL,DLBC,KIRC,KIRP,LGG,PRAD,THCAKIRC,KIRP
ENSG00000255337ENSG00000221886ZBED8CHOL,KIRC,LIHC,OV,THCALIHC
ENSG00000255337ENSG00000230124ACBD6CHOL,DLBC,KIRC,LIHC,PRADLIHC
ENSG00000255337ENSG00000267796LIN37CHOL,KIRC,KIRP,LIHC,PRAD,THCAKIRC
ENSG00000255337ENSG00000277791PSMB3CHOL,DLBC,KIRP,LIHC,PRADKIRP
ENSG00000255337ENSG00000010626LRRC23DLBC,KIRC,KIRP,LGG,PRAD,THCAKIRP
ENSG00000255337ENSG00000182173TSEN54DLBC,KIRC,KIRP,LIHC,PRADLIHC
ENSG00000255337ENSG00000109065NAT9KIRC,KIRP,LIHC,PRAD,THCA,THYMLIHC

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000255337.1ENST00000528717.188233499