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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000253948

Summary for VPS13B-DT

check button Gene summary

Gene informationEnsembl ID

ENSG00000253948

Gene symbol

VPS13B-DT

Gene nameVPS13B divergent transcript
HGNC

54375

Entrez ID

105375666

Gene typelincRNA
SynonymsRP11-410L14.2|VPS13B-DT|08q22.2
UniProtAcc

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Structure and expression level for VPS13B-DT

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002539484.021162e+011.038785e+001.754719e-015.919950e+003.220000e-091.760000e-08UPLIHC

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002539484.757984e-019.552337e-04CHOL1.636154e-03
ENSG00000253948-3.130357e-014.651235e-08KIRP3.343417e-07

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lncRNA-Protein interaction for VPS13B-DT

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for VPS13B-DT

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for VPS13B-DT

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
ELF1,RREB1,BACH1
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000253948ENST00000521696exon_skip_111863chr14:23565815-23565892-14.80-0.2902AP1G2ENST00000308724,ENST00000397120Frame-shift
ENSG00000253948ENST00000521696exon_skip_114365chr14:74290026-74290118-14.23-0.2223ABCD4ENST00000356924Frame-shift
ENSG00000253948ENST00000521696exon_skip_370518chr22:50247691-50247776-12.92-0.1656HDAC10ENST00000216271Frame-shift
ENSG00000253948ENST00000521696exon_skip_384420chr3:49812647-49812738-13.38-0.1715UBA7ENST00000333486Frame-shift
ENSG00000253948ENST00000521696exon_skip_6419chr1:51756319-51756358-8.09-0.5056OSBPL9ENST00000428468In-frame
ENSG00000253948ENST00000521696exon_skip_132355chr16:1786756-1786955-26.00-0.2407NUBP2ENST00000262302Frame-shift
ENSG00000253948ENST00000521696exon_skip_324294chr2:27774423-27774530-10.78-0.1268MRPL33ENST00000296102Frame-shift
ENSG00000253948ENST00000521696exon_skip_481821chr8:22067084-22067159-17.50-0.2536DMTNENST00000265800,ENST00000358242,ENST00000432128,ENST00000523266In-frame
ENSG00000253948ENST00000521696exon_skip_16568chr1:201989382-201989531-16.26-0.1153RNPEPENST00000295640Frame-shift
ENSG00000253948ENST00000521696exon_skip_319223chr19:43526200-43526349-19.05-0.2140ETHE1ENST00000292147Frame-shift
ENSG00000253948ENST00000521696exon_skip_326885chr2:74490024-74490127-22.25-0.3007TTC31ENST00000233623Frame-shift
ENSG00000253948ENST00000521696exon_skip_333962chr2:219247112-219247246-19.33-0.1498STK16ENST00000396738,ENST00000409638Frame-shift
ENSG00000253948ENST00000521696exon_skip_335558chr2:240596680-240596942-25.41-0.1187CAPN10ENST00000391984Frame-shift
ENSG00000253948ENST00000521696exon_skip_374375chr3:49675182-49675309-22.75-0.2106APEHENST00000296456Frame-shift
ENSG00000253948ENST00000521696exon_skip_382458chr3:38131595-38131638-7.90-0.2394ACAA1ENST00000333167Frame-shift
ENSG00000253948ENST00000521696exon_skip_442657chr5:74730259-74730398-11.98-0.1964GFM2ENST00000296805,ENST00000509430Frame-shift
ENSG00000253948ENST00000521696exon_skip_446758chr5:178212972-178213103-14.45-0.1246PHYKPLENST00000308158Frame-shift
ENSG00000253948ENST00000521696exon_skip_462144chr6:125298713-125298816-16.26-0.1730HDDC2ENST00000398153Frame-shift
ENSG00000253948ENST00000521696exon_skip_494079chr8:144099080-144099205-28.38-0.2489SHARPINENST00000398712Frame-shift
ENSG00000253948ENST00000521696exon_skip_501752chr9:136992924-136992974-10.61-0.2947PAXXENST00000371620Frame-shift
ENSG00000253948ENST00000521696exon_skip_123601chr15:74897010-74897219-20.67-0.1406MPIENST00000352410Frame-shift
ENSG00000253948ENST00000521696exon_skip_140232chr16:634888-634956-11.77-0.1962METTL26ENST00000301686Frame-shift
ENSG00000253948ENST00000521696exon_skip_67297chr11:614173-614399-23.94-0.1234IRF7ENST00000397574,ENST00000525445Frame-shift

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for VPS13B-DT

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000253948.1ENST00000521696.18640300