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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000250742

Summary for LINC02381

check button Gene summary

Gene informationEnsembl ID

ENSG00000250742

Gene symbol

LINC02381

Gene namelong intergenic non-protein coding RNA 2381
HGNC

53304

Entrez ID

400043

Gene typelincRNA
SynonymsLINC02381|12q13.13|RP11-834C11.4
UniProtAcc

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Structure and expression level for LINC02381

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002507426.653957e+022.709390e+004.197644e-016.454549e+001.090000e-102.150000e-09UPGBM
ENSG000002507421.528955e+021.384464e+004.528745e-013.057059e+002.235200e-037.027204e-03UPCHOL
ENSG000002507427.434115e+02-2.242741e+001.289961e-01-1.738611e+011.050000e-674.740000e-66DOWNKIRC
ENSG000002507421.766684e+03-1.183621e+003.792260e-01-3.121149e+001.801470e-034.154610e-03DOWNKICH
ENSG000002507429.186825e+02-1.612561e+001.947307e-01-8.280977e+001.220000e-162.050000e-15DOWNKIRP
ENSG000002507428.105477e+02-2.796772e+004.701028e-01-5.949276e+002.690000e-091.720000e-07DOWNESCA
ENSG000002507422.862815e+021.195012e+002.031704e-015.881822e+004.060000e-091.700000e-08UPLUAD
ENSG000002507421.136537e+021.143363e+002.788366e-014.100476e+004.120000e-051.226710e-04UPLIHC

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002507426.057877e-011.036354e-05CHOL7.203087e-05
ENSG00000250742-5.445841e-013.451609e-08KICH1.537015e-07
ENSG00000250742-3.141427e-012.160822e-15KIRC9.394878e-15
ENSG00000250742-3.538544e-014.870219e-10KIRP5.614536e-09

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lncRNA-Protein interaction for LINC02381

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000250742ENST00000508564RP11-834C11.4ENSG00000163132MSX134.490.6897P28360TFNA
ENSG00000250742ENST00000508564RP11-834C11.4ENSG00000169740ZNF3226.4790.8805P17041TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for LINC02381

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
MECOM,CXXC5,GATA6,FOXA3,UNC50,MYRF,TGIF2,RBM47,ZNF69,HNF1B
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for LINC02381

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000250742ENST00000508564exon_skip_75398chr11:72692752-72692785-13.68-0.6840ARAP1ENST00000393605In-frame

check buttonlncRNA targets by miRNA.
lncRNA targets by miRNA
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source
ENSG00000250742hsa-mir-193bENST00000508564chr12:54127090-54127158177.00-74.3378NA
ENSG00000250742hsa-mir-193bENST00000508564chr12:54126357-54126441167.00-86.4882NA
ENSG00000250742hsa-mir-193bENST00000508564chr12:54126184-54126263164.00-78.0382NA
ENSG00000250742hsa-mir-193bENST00000508564chr12:54127218-54127304164.00-80.7587NA
ENSG00000250742hsa-mir-193bENST00000508564chr12:54126516-54126604162.00-76.1688NA
ENSG00000250742hsa-mir-193bENST00000508564chr12:54127357-54127440158.00-66.7169NA
ENSG00000250742hsa-mir-193bENST00000508564chr12:54126758-54126834155.00-78.8080NA
ENSG00000250742hsa-mir-193bENST00000508564chr12:54126099-54126179153.00-93.9174NA
ENSG00000250742hsa-mir-193bENST00000508564chr12:54126901-54126981141.00-79.0979NA

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Variants for LINC02381

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000250742.1ENST00000508564.16758261