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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000246985

Summary for SOCS2-AS1

check button Gene summary

Gene informationEnsembl ID

ENSG00000246985

Gene symbol

SOCS2-AS1

Gene nameSOCS2 antisense RNA 1
HGNC

27054

Entrez ID

144481

Gene typeprocessed_transcript
Synonyms12q22|SOCS2-AS1
UniProtAcc

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Structure and expression level for SOCS2-AS1

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002469854.195419e+022.225018e+006.514356e-013.415561e+006.365070e-042.534873e-03UPGBM

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value

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lncRNA-Protein interaction for SOCS2-AS1

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for SOCS2-AS1

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
SOCS2
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for SOCS2-AS1

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for SOCS2-AS1

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name
LncEditing_255590ENSG00000246985.6chr1293542554-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255592ENSG00000246985.6chr1293542555-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255598ENSG00000246985.6chr1293542565-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255618ENSG00000246985.6chr1293542624-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255650ENSG00000246985.6chr1293542759-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255656ENSG00000246985.6chr1293542773-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255658ENSG00000246985.6chr1293542776-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255668ENSG00000246985.6chr1293542928-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255670ENSG00000246985.6chr1293542929-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255672ENSG00000246985.6chr1293542932-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255680ENSG00000246985.6chr1293542958-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255688ENSG00000246985.6chr1293542985-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255726ENSG00000246985.6chr1293543060-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255728ENSG00000246985.6chr1293543064-processed_transcriptSOCS2-AS1ENST00000500986.4antisenseSOCS2-AS1-002
LncEditing_255944ENSG00000246985.6chr1293565298-processed_transcriptSOCS2-AS1ENST00000547845.4retained_intronSOCS2-AS1-003

check buttonEdited-associated DElncRNAs in cancer.
Differentially expressed gene
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange
ENSG00000246985LncEditing_255592GBMchr12_93542555_-4.643882e+002.054933e+008.501665e-017.068105e+001.570638e-121.166740e-11UP
ENSG00000246985LncEditing_255598GBMchr12_93542565_-4.426791e+001.927089e+008.334456e-017.387267e+001.498771e-131.638521e-12UP
ENSG00000246985LncEditing_255618GBMchr12_93542624_-3.660229e+002.309331e+001.504984e+005.281189e+001.283479e-072.903777e-07UP
ENSG00000246985LncEditing_255650GBMchr12_93542759_-2.893393e+002.604595e+006.591823e+002.533154e+001.130414e-021.222600e-02UP
ENSG00000246985LncEditing_255658GBMchr12_93542776_-3.984462e+002.038219e+001.034045e+006.413895e+001.418475e-106.136609e-10UP
ENSG00000246985LncEditing_255668GBMchr12_93542928_-2.960123e+002.549619e+004.643047e+004.215911e+002.487719e-053.841091e-05UP
ENSG00000246985LncEditing_255680GBMchr12_93542958_-3.862581e+002.499999e+001.593276e+004.019261e+005.838088e-058.374137e-05UP
ENSG00000246985LncEditing_255728GBMchr12_93543064_-3.020039e+002.582722e+004.431152e+003.040509e+002.361784e-032.785253e-03UP
ENSG00000246985LncEditing_255590PCPGchr12_93542554_-2.277706e+001.624000e+002.049058e+004.067403e+004.753992e-057.501428e-05UP
ENSG00000246985LncEditing_255592PCPGchr12_93542555_-2.456614e+001.303854e+001.094226e+007.645691e+002.078269e-143.060724e-13UP
ENSG00000246985LncEditing_255598PCPGchr12_93542565_-2.681866e+001.492291e+001.182440e+005.672585e+001.406589e-084.618936e-08UP
ENSG00000246985LncEditing_255650PCPGchr12_93542759_-2.225228e+001.526108e+001.837911e+004.780979e+001.744434e-063.686065e-06UP
ENSG00000246985LncEditing_255656PCPGchr12_93542773_-2.352382e+001.317416e+001.195583e+007.000470e+002.551061e-122.339275e-11UP
ENSG00000246985LncEditing_255658PCPGchr12_93542776_-2.393965e+001.347235e+001.205690e+007.119678e+001.081795e-121.072964e-11UP
ENSG00000246985LncEditing_255668PCPGchr12_93542928_-2.452129e+001.443137e+001.307487e+006.183442e+006.271888e-102.959357e-09UP
ENSG00000246985LncEditing_255670PCPGchr12_93542929_-2.250310e+001.037075e+008.947717e-019.619951e+006.586236e-226.745987e-20UP
ENSG00000246985LncEditing_255672PCPGchr12_93542932_-2.557069e+001.311836e+001.038525e+007.906110e+002.655569e-154.302021e-14UP
ENSG00000246985LncEditing_255688PCPGchr12_93542985_-2.049269e+009.314233e-018.790432e-018.561801e+001.111182e-173.176672e-16UP
ENSG00000246985LncEditing_255726PCPGchr12_93543060_-2.150034e+009.571761e-018.565288e-019.414531e+004.752004e-212.886842e-19UP
ENSG00000246985LncEditing_255650THYMchr12_93542759_-2.702615e+001.823720e+001.762203e+001.994463e+004.610151e-024.631009e-02UP
ENSG00000246985LncEditing_255656THYMchr12_93542773_-3.250650e+001.420100e+008.370051e-015.172210e+002.313409e-077.787999e-07UP
ENSG00000246985LncEditing_255668THYMchr12_93542928_-3.247104e+001.748652e+001.119933e+003.756765e+001.721243e-042.835604e-04UP
ENSG00000246985LncEditing_255656PRADchr12_93542773_-7.953758e+007.273051e+007.747372e+001.998497e+004.566281e-024.597397e-02UP
ENSG00000246985LncEditing_255658PRADchr12_93542776_-6.469305e+007.829369e+00-3.632594e+00-2.347937e+001.887772e-021.971154e-02DOWN
ENSG00000246985LncEditing_255672PRADchr12_93542932_-8.374485e+006.411438e+002.595026e+005.528036e+003.238354e-085.158671e-08UP
ENSG00000246985LncEditing_255688PRADchr12_93542985_-7.742643e+003.582167e+008.992857e-015.202626e+001.964925e-072.881565e-07UP
ENSG00000246985LncEditing_255726PRADchr12_93543060_-7.707689e+003.839010e+009.944665e-014.665342e+003.081041e-064.215035e-06UP

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value
ENSG00000246985LncEditing_255658-4.618792e-014.650045e-024.796889e-02
ENSG00000246985LncEditing_255598-4.945636e-012.946834e-037.954140e-03
ENSG00000246985LncEditing_255650-3.402350e-011.675651e-022.249504e-02
ENSG00000246985LncEditing_255656-3.066622e-019.821303e-031.512065e-02
ENSG00000246985LncEditing_255668-5.841072e-011.052808e-051.719587e-04
ENSG00000246985LncEditing_255592-6.376557e-011.505133e-048.676649e-04
ENSG00000246985LncEditing_255656-3.242110e-013.620042e-023.774087e-02
ENSG00000246985LncEditing_255658-5.867491e-011.628765e-033.990474e-03
ENSG00000246985LncEditing_255672-5.588614e-012.654364e-041.154994e-03
ENSG00000246985LncEditing_255688-4.255071e-012.162649e-041.009236e-03
ENSG00000246985LncEditing_255656-3.288471e-015.382547e-074.395564e-06
ENSG00000246985LncEditing_255672-3.391342e-012.119245e-094.329314e-08
ENSG00000246985LncEditing_255688-4.057979e-011.270587e-022.274508e-02
ENSG00000246985LncEditing_255944-6.647929e-016.852628e-031.628903e-02

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation
ENSG00000246985ENSG00000120833SOCS2CHOL,GBM,LAML,PCPG,PRAD,SARC,THYMGBM

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000246985.6ENST00000499137.59252327
ENSG00000246985.6ENST00000500986.4967761066
ENSG00000246985.6ENST00000547845.4123646275
ENSG00000246985.6ENST00000551626.18535093