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lncRNA: ENSG00000237883

Summary for DGUOK-AS1

Gene summary

Gene information	Ensembl ID	ENSG00000237883
	Gene symbol	DGUOK-AS1
	Gene name	DGUOK antisense RNA 1
	HGNC	43441
	Entrez ID	100874048
	Gene type	antisense
	Synonyms	02p13.1\|DGUOK-AS1
	UniProtAcc

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Structure and expression level for DGUOK-AS1

AS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.

Differentially expressed gene analysis between cancer and normal samples.

Ensembl ID	Base mean	log2FC(AD/control)	lfcSE	Stat	P-value	Adjc.p-value	DEG direction	Cancer type
ENSG00000237883	4.845154e+01	1.907441e+00	3.774743e-01	5.053168e+00	4.350000e-07	3.060000e-06	UP	CHOL
ENSG00000237883	1.204156e+02	1.060847e+00	1.269761e-01	8.354699e+00	6.560000e-17	7.210000e-16	UP	THCA
ENSG00000237883	2.166825e+02	3.129558e+00	6.066240e-01	5.158974e+00	2.480000e-07	7.550000e-06	UP	CESC
ENSG00000237883	7.198491e+01	1.170512e+00	1.899021e-01	6.163761e+00	7.100000e-10	4.410000e-09	UP	UCEC
ENSG00000237883	1.734359e+02	1.951692e+00	1.442944e-01	1.352577e+01	1.100000e-41	1.950000e-40	UP	LUSC

Correlation between lncRNAs and cancer stages.

LncRNA Ensembl ID	Correlation	P-value	Cancer Type	Adjc.p-value
ENSG00000237883	6.787642e-01	2.980474e-07	CHOL	9.283625e-06

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lncRNA-Protein interaction for DGUOK-AS1

lncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID

LncRNA ENST ID

LncRNA Name

Protein Ensembl ID

Protein Name

CatRAPID Score

Lncpro Score

UniPortID

Gene Subtype

Public source

lncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID

LncRNA ENST ID

LncRNA Name

Protein Ensembl ID

Protein Name

CatRAPID Score

Lncpro Score

UniPortID

Gene Subtype

Public source

lncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID

LncRNA ENST ID

LncRNA Name

Protein Ensembl ID

Protein Name

CatRAPID Score

Lncpro Score

UniPortID

Gene Subtype

Public source

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lncRNA-DNA interaction for DGUOK-AS1

lncRNA targets the enhancer region and positively regulates the gene expression.

lncRNA targets the promoter region and positively regulates the gene expression.

lncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for DGUOK-AS1

lncRNA targets the 3'UTR region and negatively regulates the mRNA.

Only predicted by lncTar

HSPG2,TNS3,MAP4,VGLL4,A2M,KIF2A,PTPN11,QKI,NDST1,ARHGAP31,FOXN3

Exist in public source

lncRNA targets the skipped exon region.

-lncRNA and exonskipping events are positively correlated.

lncRNA and exonskipping events positive correlated

LncRNA Ensembl ID	LncRNA ENST ID	Exon ID	Skipped Exon	dG	ndG	Gene name with skipped exon	TransID with skipped exon	ORF mutation
ENSG00000237883	ENST00000413452	exon_skip_132443	chr16:2077597-2077726	-11.94	-0.1095	TSC2	ENST00000219476	In-frame
ENSG00000237883	ENST00000413452	exon_skip_499771	chr9:128592982-128593042	-11.06	-0.2836	SPTAN1	ENST00000372731	In-frame
ENSG00000237883	ENST00000413452	exon_skip_5133	chr1:43602070-43602097	-5.84	-0.6489	PTPRF	ENST00000359947	In-frame
ENSG00000237883	ENST00000413452	exon_skip_302276	chr19:10808568-10808580	-3.45	-1.7250	DNM2	ENST00000355667	In-frame

-lncRNA and exonskipping events are negatively correlated.

lncRNA and exonskipping events negative correlated

LncRNA Ensembl ID	LncRNA ENST ID	Exon ID	Skipped Exon	dG	ndG	Gene name with skipped exon	TransID with skipped exon	LOF
ENSG00000237883	ENST00000413452	exon_skip_33516	chr1:156938417-156938513	-13.60	-0.2615	ARHGEF11	ENST00000361409	In-frame
ENSG00000237883	ENST00000413452	exon_skip_43507	chr10:84499874-84499959	-17.15	-0.2722	CCSER2	ENST00000224756	Frame-shift
ENSG00000237883	ENST00000413452	exon_skip_368285	chr22:29329711-29329720	-2.68	-0.4467	AP1B1	ENST00000357586,ENST00000405198	In-frame
ENSG00000237883	ENST00000439192	exon_skip_380242	chr3:186784961-186785101	-12.60	-0.1260	EIF4A2	ENST00000323963	Frame-shift
ENSG00000237883	ENST00000413452	exon_skip_382458	chr3:38131595-38131638	-11.33	-0.2698	ACAA1	ENST00000333167	Frame-shift
ENSG00000237883	ENST00000413452	exon_skip_353395	chr20:62130218-62130296	-10.97	-0.1959	LSM14B	ENST00000279068	In-frame
ENSG00000237883	ENST00000413452	exon_skip_470226	chr7:103307595-103307708	-13.02	-0.2325	PMPCB	ENST00000249269	Frame-shift
ENSG00000237883	ENST00000413452	exon_skip_357772	chr20:47659398-47659452	-6.83	-0.1588	SULF2	ENST00000359930,ENST00000484875	In-frame

lncRNA targets by miRNA.

LncRNA Ensembl ID

miRNA ID

LncRNA ENST ID

Binding site in lncRNA

Score

Energy

Align Len

Public source

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Variants for DGUOK-AS1

RNA A-to-I editing events in lncRNA.

LncRNAediting ID

LncRNA Ensembl ID

Chromosome

Editing Position

Strand

Gene Type

Gene Name

Transcript ID

Transcript Type

Transcript Name

Edited-associated DElncRNAs in cancer.

LncRNA Ensembl ID

LncRNA Index

Cancer Type

Chr_Postion_Strand

AVE1

AVE2

log2FC

W-value

P-value

Adjc.p-value

Change

Correlation between RNA A-to-I editing events's frequecy and lncRNA expression.

LncRNA Ensembl ID

LncRNA Index

Correlation

P-value

Adjc.p-value

Cis-expression quantitative trait loci(cis-eQTL) of lncRNA.

LncRNA Ensembl ID

LncRNA Name

SNP info

Number of Positive corelated Cancer

Positive corelated Cancer

Number of Negative corelated Cancer

Negative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncRNA regulates differentially expressed genes by function as enhancer.

LncRNA Ensembl ID

PC Gene ID

PC Gene Name

Positive correlated cancers

Cancer with PC gene up-regulation

Cancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

LncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).

lncRNA ID

TF ID

TF Name

PCgene ID

PCgene Name

Number of Cancer

Canaer Types

LncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).

lncRNA ID

TF ID

TF Name

PCgene ID

PCgene Name

Number of Cancer

Canaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

LncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.

LncRNA Ensembl ID

RBP ID

RBP Gene Name

Exon Skipping ID

Skipped Exon

EX Gene Name

EX Affected TransID

ORF_anno

Cancer Type

LncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.

LncRNA Ensembl ID

RBP ID

RBP Gene Name

Exon Skipping ID

Skipped Exon

EX Gene Name

EX Affected TransID

ORF_anno

Cancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.

LncRNA Ensembl ID	LncRNA ENST ID	PC Gene Name	PC Gene ID	PC ENST ID	dG	nDG	Cancer with PC gene up-regulation	Cancer with PC gene Down-regulation
ENSG00000237883	ENST00000453103	A2M	ENSG00000175899	ENST00000318602	-0.1298	108	-	CHOL,CESC,UCEC,LUSC
ENSG00000237883	ENST00000453103	A2M	ENSG00000175899	ENST00000546069	-0.1088	1	-	CHOL,CESC,UCEC,LUSC
ENSG00000237883	ENST00000453103	TNS3	ENSG00000136205	ENST00000442536	-0.2700	115	-	THCA,LUSC
ENSG00000237883	ENST00000453103	TNS3	ENSG00000136205	ENST00000458317	-0.5223	163	-	THCA,LUSC
ENSG00000237883	ENST00000439192	A2M	ENSG00000175899	ENST00000318602	-0.1298	100	-	CHOL,CESC,UCEC,LUSC
ENSG00000237883	ENST00000439192	TNS3	ENSG00000136205	ENST00000442536	-0.2700	107	-	THCA,LUSC
ENSG00000237883	ENST00000439192	TNS3	ENSG00000136205	ENST00000458317	-0.5223	155	-	THCA,LUSC
ENSG00000237883	ENST00000413452	A2M	ENSG00000175899	ENST00000318602	-0.1298	28	-	CHOL,CESC,UCEC,LUSC
ENSG00000237883	ENST00000413452	A2M	ENSG00000175899	ENST00000539638	-0.1090	1	-	CHOL,CESC,UCEC,LUSC
ENSG00000237883	ENST00000413452	ARHGAP31	ENSG00000031081	ENST00000264245	-0.1093	1	-	CESC,UCEC,LUSC
ENSG00000237883	ENST00000413452	TNS3	ENSG00000136205	ENST00000442536	-0.2700	35	-	THCA,LUSC
ENSG00000237883	ENST00000413452	TNS3	ENSG00000136205	ENST00000458317	-0.5223	83	-	THCA,LUSC

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lncRNAs regulate mRNA by competing with miRNA

lncRNA regulates mRNA by competing the miRNA binding site with mRNA.

LncRNA Ensembl ID

lncRNA-miRNA-mRNA

Cancer Types

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lncRNA coding potential

ORFfinder result for the gencode.v22.lncRNA.transcript.fa.

lncRNA Ensembl ID	lncRNA ENST ID	length(AA)	start at transcript	end at transcript
ENSG00000237883.1	ENST00000453103.1	58	205	381
ENSG00000237883.1	ENST00000439192.1	102	306	1
ENSG00000237883.1	ENST00000413452.1	147	442	2

	lncRNA summary
	lncRNA structure and expression level
	lncRNA-Protein interaction
	lncRNA-DNA interaction
	lncRNA-RNA interaction
	Variants in lncRNA
	lncRNAs regulate the target genes through functioning as enhancers
	lncRNAs regulate the target genes through recruiting transcript factors
	lncRNAs regulate the alternative splicing events through interacting with splicing factor
	lncRNAs regulate mRNA through targeting the 3'-UTR region
	lncRNAs regulate mRNA by competing with miRNA
	lncRNA coding potential