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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000237512

Summary for UNC5B-AS1

check button Gene summary

Gene informationEnsembl ID

ENSG00000237512

Gene symbol

UNC5B-AS1

Gene nameUNC5B antisense RNA 1
HGNC

45096

Entrez ID

728978

Gene typeantisense
SynonymsUNC5B-AS1|10q22.1
UniProtAcc

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Structure and expression level for UNC5B-AS1

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002375126.780560e+015.075721e+002.512293e-012.020354e+019.110000e-914.830000e-88UPTHCA
ENSG000002375127.265638e+013.705352e+003.769865e-019.828873e+008.460000e-231.790000e-21UPKICH
ENSG000002375124.581089e+011.153685e+003.052686e-013.779244e+001.573050e-044.698710e-04UPUCEC
ENSG000002375127.901578e+015.966777e+001.119428e+005.330202e+009.810000e-084.520000e-06UPPCPG
ENSG000002375125.083972e+012.045191e+002.368399e-018.635332e+005.860000e-183.390000e-17UPLUSC
ENSG000002375128.176370e+01-1.704669e+003.489989e-01-4.884454e+001.040000e-066.830000e-06DOWNSTAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002375125.115432e-013.005700e-07KICH9.888141e-07
ENSG000002375123.141910e-011.964069e-14THCA2.559729e-13

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lncRNA-Protein interaction for UNC5B-AS1

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for UNC5B-AS1

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
SLIRP,PRDX5,SEM1,NDUFS8,CRB3,TAX1BP3,CENPB,MFSD10,GFER,ADAP1,PPP1R16A,GATD1,NUDT14,FAM83H,FAM71E1,TMEM223,AGPAT2,SLC25A10,DCXR,ITPA,C8orf82,THYN1,REEP4,THOC6,PEX16,FBXL6,SERF2,ARFRP1,S100A11,PHLDA3,TMEM238,ATP5F1D,APRT,BAIAP2,CYHR1,TRIOBP
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.
Only predicted by TDF
THOC6,NT5C,SLC25A10,SHFM1,HCFC1R1,TRIOBP
Exist in public source
NA

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for UNC5B-AS1

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
SMAD5,HBP1,PIKFYVE,PHF3,RO60,ZEB1,TMEM263,MDC1,KLHL28,ARID1B,ACADM,FOXJ3,DHX40,FAM114A2,MED23,ARNT,FBXO11,APPBP2,AZI2,MFSD14A,SYNJ1
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000237512ENST00000447119exon_skip_90104chr12:10709907-10710114-33.43-0.1932YBX3ENST00000228251In-frame

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for UNC5B-AS1

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation
ENSG00000237512ENSG00000127922SEM1ESCA,KICH,PAAD,THCA,THYMKICH
ENSG00000237512ENSG00000163191S100A11ESCA,PAAD,TGCT,THCA,THYMTHCA
ENSG00000237512ENSG00000105963ADAP1KICH,PAAD,THCA,THYM,UCSKICH
ENSG00000237512ENSG00000110717NDUFS8KICH,PAAD,TGCT,THCA,THYMKICH
ENSG00000237512ENSG00000142530FAM71E1KICH,TGCT,THCA,THYM,UCSKICH
ENSG00000237512ENSG00000168569TMEM223KICH,PAAD,TGCT,THCA,THYMKICH
ENSG00000237512ENSG00000177225GATD1KICH,PAAD,THCA,THYM,UCSKICH
ENSG00000237512ENSG00000182325FBXL6KICH,PAAD,THCA,THYM,UCSKICH
ENSG00000237512ENSG00000187954CYHR1KICH,PAAD,THCA,THYM,UCSKICH
ENSG00000237512ENSG00000198931APRTKICH,PAAD,TGCT,THCA,THYMKICH
ENSG00000237512ENSG00000174307PHLDA3OV,PAAD,THCA,THYM,UCSTHCA
ENSG00000237512ENSG00000213977TAX1BP3STAD,TGCT,THCA,THYM,UCSTHCA

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation
ENSG00000237512ENST00000449737DHX40ENSG00000108406ENST00000577596-0.10941-KICH
ENSG00000237512ENST00000449737DHX40ENSG00000108406ENST00000425628-0.1863108-KICH
ENSG00000237512ENST00000449737ACADMENSG00000117054ENST00000420607-0.211394-KICH,PCPG
ENSG00000237512ENST00000449737ACADMENSG00000117054ENST00000528016-0.13061-KICH,PCPG
ENSG00000237512ENST00000447119DHX40ENSG00000108406ENST00000425628-0.190071-KICH
ENSG00000237512ENST00000447119ACADMENSG00000117054ENST00000420607-0.2113269-KICH,PCPG
ENSG00000237512ENST00000447119ACADMENSG00000117054ENST00000528016-0.1192176-KICH,PCPG

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000237512.5ENST00000449737.471350135
ENSG00000237512.5ENST00000447119.2115125469