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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000237125

Summary for HAND2-AS1

check button Gene summary

Gene informationEnsembl ID

ENSG00000237125

Gene symbol

HAND2-AS1

Gene nameHAND2 antisense RNA 1
HGNC

48872

Entrez ID

79804

Gene typeantisense
SynonymsHAND2-AS1|04q34.1
UniProtAcc

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Structure and expression level for HAND2-AS1

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002371251.879678e+044.903972e+005.316354e-019.224314e+002.850000e-201.010000e-17UPPCPG
ENSG000002371258.835526e+02-2.859678e+004.699267e-01-6.085370e+001.160000e-091.350000e-08DOWNSTAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value

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lncRNA-Protein interaction for HAND2-AS1

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for HAND2-AS1

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for HAND2-AS1

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for HAND2-AS1

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name
LncEditing_145335ENSG00000237125.7chr4173583200+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145391ENSG00000237125.7chr4173583262+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145516ENSG00000237125.7chr4173584076+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145528ENSG00000237125.7chr4173584081+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145540ENSG00000237125.7chr4173584084+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145564ENSG00000237125.7chr4173584104+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145570ENSG00000237125.7chr4173584107+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145576ENSG00000237125.7chr4173584117+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145618ENSG00000237125.7chr4173584179+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145636ENSG00000237125.7chr4173584198+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145650ENSG00000237125.7chr4173585237+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145658ENSG00000237125.7chr4173585283+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145674ENSG00000237125.7chr4173585299+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145678ENSG00000237125.7chr4173585306+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145682ENSG00000237125.7chr4173585313+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145694ENSG00000237125.7chr4173585330+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145702ENSG00000237125.7chr4173585352+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145722ENSG00000237125.7chr4173585395+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145742ENSG00000237125.7chr4173585415+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145746ENSG00000237125.7chr4173585435+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145758ENSG00000237125.7chr4173585450+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145778ENSG00000237125.7chr4173585617+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145782ENSG00000237125.7chr4173585627+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145794ENSG00000237125.7chr4173585655+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145798ENSG00000237125.7chr4173585656+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145822ENSG00000237125.7chr4173585705+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145849ENSG00000237125.7chr4173587193+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025
LncEditing_145852ENSG00000237125.7chr4173587197+antisenseHAND2-AS1ENST00000515376.4antisenseHAND2-AS1-025

check buttonEdited-associated DElncRNAs in cancer.
Differentially expressed gene
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange
ENSG00000237125LncEditing_145335PCPGchr4_173583200_+4.633927e+013.489912e+012.444720e+003.900997e+009.579744e-051.423778e-04UP
ENSG00000237125LncEditing_145391PCPGchr4_173583262_+4.841345e+013.729471e+012.656487e+003.184626e+001.449410e-031.793710e-03UP
ENSG00000237125LncEditing_145516PCPGchr4_173584076_+4.450450e+013.224587e+012.151293e+004.277738e+001.888024e-053.208320e-05UP
ENSG00000237125LncEditing_145528PCPGchr4_173584081_+4.616117e+013.835988e+013.744175e+002.790895e+005.256251e-036.111335e-03UP
ENSG00000237125LncEditing_145540PCPGchr4_173584084_+4.536889e+013.246355e+012.070897e+004.359079e+001.306109e-052.291584e-05UP
ENSG00000237125LncEditing_145564PCPGchr4_173584104_+4.504744e+012.813858e+011.472981e+005.584043e+002.349910e-087.274243e-08UP
ENSG00000237125LncEditing_145570PCPGchr4_173584107_+4.524562e+012.829224e+011.476294e+005.204650e+001.943630e-075.024491e-07UP
ENSG00000237125LncEditing_145576PCPGchr4_173584117_+4.403095e+012.953805e+011.736282e+004.260965e+002.035461e-053.434841e-05UP
ENSG00000237125LncEditing_145618PCPGchr4_173584179_+4.345651e+013.769432e+014.872698e+002.579206e+009.902784e-031.096299e-02UP
ENSG00000237125LncEditing_145636PCPGchr4_173584198_+4.264638e+012.633296e+011.437704e+003.837709e+001.241875e-041.764770e-04UP
ENSG00000237125LncEditing_145650PCPGchr4_173585237_+4.365299e+013.083330e+011.993656e+004.537737e+005.686124e-061.050744e-05UP
ENSG00000237125LncEditing_145658PCPGchr4_173585283_+4.431317e+012.659694e+011.357819e+005.190571e+002.096498e-075.390996e-07UP
ENSG00000237125LncEditing_145674PCPGchr4_173585299_+4.641696e+013.834096e+013.626271e+002.252479e+002.429204e-022.555397e-02UP
ENSG00000237125LncEditing_145678PCPGchr4_173585306_+4.629407e+013.578657e+012.692448e+003.825942e+001.302730e-041.835150e-04UP
ENSG00000237125LncEditing_145682PCPGchr4_173585313_+4.659748e+013.107344e+011.710659e+005.502446e+003.745569e-081.103240e-07UP
ENSG00000237125LncEditing_145694PCPGchr4_173585330_+4.992111e+013.853225e+012.676777e+002.306328e+002.109233e-022.233305e-02UP
ENSG00000237125LncEditing_145702PCPGchr4_173585352_+4.244897e+013.840426e+016.922179e+002.391989e+001.675734e-021.801785e-02UP
ENSG00000237125LncEditing_145722PCPGchr4_173585395_+4.385380e+013.292262e+012.417661e+003.977454e+006.965718e-051.064572e-04UP
ENSG00000237125LncEditing_145742PCPGchr4_173585415_+4.264110e+013.701383e+014.897631e+002.756183e+005.848018e-036.750919e-03UP
ENSG00000237125LncEditing_145746PCPGchr4_173585435_+4.474146e+013.140534e+011.958470e+004.476162e+007.599688e-061.378152e-05UP
ENSG00000237125LncEditing_145758PCPGchr4_173585450_+4.430300e+013.898875e+015.424569e+001.971953e+004.861498e-024.871522e-02UP
ENSG00000237125LncEditing_145778PCPGchr4_173585617_+4.268748e+012.610547e+011.409521e+003.907486e+009.326162e-051.390342e-04UP
ENSG00000237125LncEditing_145782PCPGchr4_173585627_+4.182725e+013.452072e+013.610365e+002.615012e+008.922426e-039.968503e-03UP
ENSG00000237125LncEditing_145794PCPGchr4_173585655_+4.293178e+012.537993e+011.318638e+004.199717e+002.672486e-054.417783e-05UP
ENSG00000237125LncEditing_145798PCPGchr4_173585656_+4.385915e+012.599830e+011.325451e+004.754600e+001.988400e-064.129755e-06UP
ENSG00000237125LncEditing_145822PCPGchr4_173585705_+4.299269e+012.673800e+011.459429e+004.118356e+003.815853e-056.140743e-05UP
ENSG00000237125LncEditing_145849PCPGchr4_173587193_+4.262103e+013.072272e+012.117480e+003.082577e+002.052167e-032.462600e-03UP
ENSG00000237125LncEditing_145852PCPGchr4_173587197_+4.203472e+012.971896e+011.999210e+002.810443e+004.947328e-035.765951e-03UP

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value
ENSG00000237125LncEditing_145335-3.312367e-012.085857e-036.594000e-03
ENSG00000237125LncEditing_145674-4.016235e-019.248697e-031.501141e-02
ENSG00000237125LncEditing_145758-5.822289e-018.107663e-059.489949e-04
ENSG00000237125LncEditing_145778-3.528223e-012.758929e-022.864417e-02
ENSG00000237125LncEditing_145822-3.520047e-014.454156e-024.479536e-02

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000237125.7ENST00000512099.481377132
ENSG00000237125.7ENST00000515310.4108413739
ENSG00000237125.7ENST00000514673.475368592
ENSG00000237125.7ENST00000507062.4134297701
ENSG00000237125.7ENST00000512929.41479761419
ENSG00000237125.7ENST00000502334.492556278
ENSG00000237125.7ENST00000507636.4134377781
ENSG00000237125.7ENST00000510221.455111278
ENSG00000237125.7ENST00000509640.4935286
ENSG00000237125.7ENST00000512246.488618352
ENSG00000237125.7ENST00000507322.488342608
ENSG00000237125.7ENST00000502941.488785519
ENSG00000237125.7ENST00000510339.4725223
ENSG00000237125.7ENST00000515350.49630262736
ENSG00000237125.7ENST00000507571.49628912601
ENSG00000237125.7ENST00000508534.49628142524
ENSG00000237125.7ENST00000505621.49627622472
ENSG00000237125.7ENST00000502896.488711445
ENSG00000237125.7ENST00000503198.414719812424
ENSG00000237125.7ENST00000616485.314715882031
ENSG00000237125.7ENST00000511196.414715852028
ENSG00000237125.7ENST00000515376.4613188
ENSG00000237125.7ENST00000505032.468287493
ENSG00000237125.7ENST00000515741.4611186
ENSG00000237125.7ENST00000511728.482373621
ENSG00000237125.7ENST00000509866.462373561
ENSG00000237125.7ENST00000512943.462206394
ENSG00000237125.7ENST00000503474.451502347
ENSG00000237125.7ENST00000515345.47511861413
ENSG00000237125.7ENST00000503309.482245493
ENSG00000237125.7ENST00000512209.557127300
ENSG00000237125.7ENST00000504740.474234458
ENSG00000237125.7ENST00000508887.491502777
ENSG00000237125.7ENST00000505817.1108316642
ENSG00000237125.7ENST00000514431.484202453
ENSG00000237125.7ENST00000510268.191484759
ENSG00000237125.7ENST00000504429.164507313