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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000236017

Summary for ASMTL-AS1

check button Gene summary

Gene informationEnsembl ID

ENSG00000236017

Gene symbol

ASMTL-AS1

Gene nameASMTL antisense RNA 1
HGNC

25811

Entrez ID
Gene typeantisense
SynonymsASMTL-AS1|Xp22.33 and Yp11.32
UniProtAcc

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Structure and expression level for ASMTL-AS1

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002360172.276497e+022.678130e+002.039820e-011.312925e+012.240000e-393.500000e-38UPKIRC
ENSG000002360172.337763e+021.528611e+003.031302e-015.042753e+004.590000e-071.850000e-06UPKICH
ENSG000002360172.468790e+021.335800e+003.057202e-014.369355e+001.250000e-058.420000e-05UPBLCA
ENSG000002360172.759857e+022.031186e+005.609850e-013.620748e+002.937520e-042.950833e-03UPCESC
ENSG000002360172.564103e+021.597527e+001.887225e-018.464955e+002.560000e-174.580000e-16UPPRAD
ENSG000002360171.756791e+021.256520e+001.983076e-016.336217e+002.350000e-101.120000e-09UPLUAD
ENSG000002360179.894033e+011.336234e+001.880514e-017.105685e+001.200000e-128.690000e-12UPCOAD
ENSG000002360171.587227e+021.571053e+001.659925e-019.464602e+002.950000e-216.400000e-20UPLIHC
ENSG000002360171.063187e+021.839577e+003.640199e-015.053505e+004.340000e-075.990000e-06UPREAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002360174.326759e-012.992849e-03CHOL4.237350e-03
ENSG000002360173.564506e-012.728730e-05TGCT4.120383e-03

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lncRNA-Protein interaction for ASMTL-AS1

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000236017ENST00000602357ASMTL-AS1ENSG00000204371EHMT238.7293.183Q96KQ7EpiNA
ENSG00000236017ENST00000602357ASMTL-AS1ENSG00000104885DOT1L24.8290.133Q8TEK3TF,EpiNA
ENSG00000236017ENST00000602357ASMTL-AS1ENSG00000154832CXXC120.9291.8106Q9P0U4TF,EpiNA
ENSG00000236017ENST00000602357ASMTL-AS1ENSG00000108799EZH123.6691.4751Q92800EpiNA
ENSG00000236017ENST00000420411ASMTL-AS1ENSG00000171456ASXL18.1890.5448Q8IXJ9EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000236017ENST00000602357ASMTL-AS1ENSG00000167967E4F132.6490.8172Q66K89TFNA
ENSG00000236017ENST00000602357ASMTL-AS1ENSG00000104885DOT1L24.8290.7821Q8TEK3TF,EpiNA
ENSG00000236017ENST00000602357ASMTL-AS1ENSG00000154832CXXC120.9291.5918Q9P0U4TF,EpiNA
ENSG00000236017ENST00000602357ASMTL-AS1ENSG00000147789ZNF717.7391.5583P17097TFNA
ENSG00000236017ENST00000602357ASMTL-AS1ENSG00000197857ZNF449.1391.7191P15621TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000236017ENST00000602357ASMTL-AS1ENSG00000004534RBM631.590.872P78332RBPNA
ENSG00000236017ENST00000602357ASMTL-AS1ENSG00000106344RBM2827.8791.2082Q9NW13RBPNA
ENSG00000236017ENST00000602357ASMTL-AS1ENSG00000133226SRRM112.6293.7357Q8IYB3RBPNA
ENSG00000236017ENST00000602357ASMTL-AS1ENSG00000167978SRRM28.7596.3341Q9UQ35RBPNA

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lncRNA-DNA interaction for ASMTL-AS1

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for ASMTL-AS1

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
CNOT1,MRPL44,DIABLO,SLC35E1,VPS26C,PNPO,SLC30A6,GET3,UHRF1BP1L,SNX12,CHP1,TBC1D5,AIDA,RTL6,ACTR3,GNL3L,TPM3,TOX4,RHOA,PLEKHB2,GORASP2,DNAJC14,CAP1,CLTC,ATRN,KCTD10,SDHC,MRPL19,DHX8,HSPA8,PAK2,SEC24D,STRAP,PRMT5,STK24,CCNI,RTCB,ASXL2,PSME3,AP2B1,G3BP2,MAPK1,SUMO3,SMAD1,ACBD3,PRKAR2A,RAB5C,SSR1,NIPA2,ACVR1,KBTBD4,MFSD1,APP,CHTF8,DCTN1,PCMT1,SF3A1,ABHD5,SERINC3,ACTR2,DCAF7,PEX19,PIGS,VAMP7,GGCX,ERC1,FASTKD2,SEC23B,MED1,EIF3L,EIF4G2,ILF2,SMG8,SETD7,CYFIP1,MIEF1,ZNF28,TMED2,ARL2BP,TEX2,VAMP3,ITFG1,SRRD,ARPC2,TMBIM6,CPSF2,HAUS2,ATXN10,PSMD1,TMED10,NDUFS1,WSB2,PGM2
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000236017ENST00000602357exon_skip_1234chr1:11658532-11658628-15.38-0.2078FBXO44ENST00000251547,ENST00000376770In-frame
ENSG00000236017ENST00000602357exon_skip_470077chr7:102397619-102397698-14.56-0.2051PRKRIP1ENST00000397912,ENST00000496391Frame-shift

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000236017ENST00000602357exon_skip_114365chr14:74290026-74290118-13.61-0.2001ABCD4ENST00000356924Frame-shift
ENSG00000236017ENST00000602357exon_skip_327433chr2:86125794-86125880-6.51-0.1302PTCD3ENST00000254630Frame-shift
ENSG00000236017ENST00000602357exon_skip_370518chr22:50247691-50247776-13.60-0.1619HDAC10ENST00000216271Frame-shift
ENSG00000236017ENST00000602357exon_skip_377198chr3:123130479-123130616-23.38-0.1916PDIA5ENST00000316218Frame-shift
ENSG00000236017ENST00000602357exon_skip_382458chr3:38131595-38131638-8.56-0.2518ACAA1ENST00000333167Frame-shift
ENSG00000236017ENST00000602357exon_skip_41813chr10:68337857-68337996-13.87-0.1401HNRNPH3ENST00000265866Frame-shift
ENSG00000236017ENST00000602357exon_skip_52701chr10:97468965-97469104-13.81-0.1291MMS19ENST00000370782,ENST00000438925Frame-shift
ENSG00000236017ENST00000602357exon_skip_77641chr11:117207066-117207160-12.54-0.2366PCSK7ENST00000320934Frame-shift
ENSG00000236017ENST00000602357exon_skip_110959chr14:20372732-20372857-19.50-0.1681TEP1ENST00000262715Frame-shift
ENSG00000236017ENST00000602357exon_skip_138351chr16:70469151-70469323-17.87-0.1077FUKENST00000288078Frame-shift
ENSG00000236017ENST00000602357exon_skip_139933chr16:90035632-90035687-7.60-0.2621GAS8ENST00000268699Frame-shift
ENSG00000236017ENST00000602357exon_skip_153380chr17:45137018-45137139-17.49-0.1666ACBD4ENST00000376955Frame-shift
ENSG00000236017ENST00000602357exon_skip_309204chr19:49181348-49181461-21.38-0.1926TRPM4ENST00000252826Frame-shift
ENSG00000236017ENST00000602357exon_skip_340759chr2:85552415-85552567-16.56-0.1335GGCXENST00000233838Frame-shift
ENSG00000236017ENST00000602357exon_skip_374551chr3:50100531-50100605-9.41-0.1384RBM5ENST00000347869Frame-shift
ENSG00000236017ENST00000602357exon_skip_380242chr3:186784961-186785101-11.34-0.1400EIF4A2ENST00000323963Frame-shift
ENSG00000236017ENST00000602357exon_skip_387016chr3:121788283-121788432-15.80-0.1170IQCB1ENST00000310864Frame-shift
ENSG00000236017ENST00000602357exon_skip_509943chrX:47175018-47175092-10.59-0.1736RBM10ENST00000377604Frame-shift
ENSG00000236017ENST00000602357exon_skip_4796chr1:41007448-41007545-11.67-0.2202CTPS1ENST00000372616,ENST00000372621Frame-shift
ENSG00000236017ENST00000602357exon_skip_9446chr1:147270931-147271005-7.80-0.1182CHD1LENST00000369258Frame-shift
ENSG00000236017ENST00000602357exon_skip_23423chr1:26294204-26294331-17.91-0.3198UBXN11ENST00000374221,ENST00000374222Frame-shift
ENSG00000236017ENST00000420411exon_skip_38175chr1:234398381-234398553-16.28-0.1030TARBP1ENST00000040877Frame-shift
ENSG00000236017ENST00000602357exon_skip_53559chr10:101793912-101793998-11.75-0.1433OGAENST00000361464Frame-shift
ENSG00000236017ENST00000419737exon_skip_59071chr11:47234756-47234934-19.81-0.1834DDB2ENST00000256996Frame-shift
ENSG00000236017ENST00000602357exon_skip_66482chr11:126274926-126275021-11.89-0.1367FOXRED1ENST00000263578Frame-shift
ENSG00000236017ENST00000602357exon_skip_87733chr12:120571190-120571291-14.79-0.1804RNF10ENST00000325954Frame-shift
ENSG00000236017ENST00000602357exon_skip_92074chr12:50142052-50142110-6.54-0.1189CERS5ENST00000317551Frame-shift
ENSG00000236017ENST00000602357exon_skip_95407chr12:95040475-95040597-13.09-0.1271NR2C1ENST00000333003Frame-shift
ENSG00000236017ENST00000602357exon_skip_111863chr14:23565815-23565892-20.04-0.2904AP1G2ENST00000308724,ENST00000397120Frame-shift
ENSG00000236017ENST00000602357exon_skip_111870chr14:23566561-23566686-14.41-0.1501AP1G2ENST00000397120Frame-shift
ENSG00000236017ENST00000602357exon_skip_127618chr15:58890280-58890461-19.34-0.1209SLTMENST00000380516Frame-shift
ENSG00000236017ENST00000602357exon_skip_133217chr16:8635038-8635079-9.13-0.3804METTL22ENST00000381920Frame-shift
ENSG00000236017ENST00000602357exon_skip_290158chr17:42953723-42953778-10.53-0.2065AARSD1ENST00000427569Frame-shift
ENSG00000236017ENST00000425740exon_skip_296625chr18:42057882-42058051-17.63-0.1168PIK3C3ENST00000262039Frame-shift
ENSG00000236017ENST00000602357exon_skip_300663chr19:1425877-1425960-10.66-0.1441DAZAP1ENST00000233078Frame-shift
ENSG00000236017ENST00000419737exon_skip_302168chr19:10680345-10680443-9.97-0.1262ILF3ENST00000590261Frame-shift
ENSG00000236017ENST00000602357exon_skip_326885chr2:74490024-74490127-23.37-0.2626TTC31ENST00000233623Frame-shift
ENSG00000236017ENST00000602357exon_skip_335558chr2:240596680-240596942-30.33-0.1223CAPN10ENST00000391984Frame-shift
ENSG00000236017ENST00000602357exon_skip_353131chr20:58669290-58669453-23.73-0.1474STX16ENST00000371141Frame-shift
ENSG00000236017ENST00000602357exon_skip_370525chr22:50250426-50250523-16.11-0.1751HDAC10ENST00000216271Frame-shift
ENSG00000236017ENST00000602357exon_skip_374497chr3:49999439-49999513-9.56-0.1386RBM6ENST00000266022Frame-shift
ENSG00000236017ENST00000602357exon_skip_384420chr3:49812647-49812738-16.07-0.2034UBA7ENST00000333486Frame-shift
ENSG00000236017ENST00000602357exon_skip_436035chr5:79656957-79657001-5.96-0.2591TENT2ENST00000296783,ENST00000428308,ENST00000453514Frame-shift
ENSG00000236017ENST00000602357exon_skip_438188chr5:141638954-141639021-11.88-0.1773RELL2ENST00000297164,ENST00000444782Frame-shift
ENSG00000236017ENST00000602357exon_skip_442657chr5:74730259-74730398-10.62-0.1221GFM2ENST00000296805,ENST00000509430Frame-shift
ENSG00000236017ENST00000602357exon_skip_444499chr5:138164086-138164133-7.04-0.2071BRD8ENST00000254900Frame-shift
ENSG00000236017ENST00000602357exon_skip_445390chr5:150403120-150403312-23.39-0.1462CD74ENST00000009530In-frame
ENSG00000236017ENST00000602357exon_skip_446758chr5:178212972-178213103-13.41-0.1064PHYKPLENST00000308158Frame-shift
ENSG00000236017ENST00000602357exon_skip_446770chr5:178215275-178215430-19.00-0.1293PHYKPLENST00000308158Frame-shift
ENSG00000236017ENST00000602357exon_skip_466137chr7:48103296-48103411-17.36-0.1736UPP1ENST00000331803,ENST00000395564Frame-shift
ENSG00000236017ENST00000602357exon_skip_470226chr7:103307595-103307708-11.71-0.1464PMPCBENST00000249269Frame-shift
ENSG00000236017ENST00000602357exon_skip_511212chrX:71555189-71555385-17.92-0.1203OGTENST00000373719Frame-shift
ENSG00000236017ENST00000602357exon_skip_357254chr20:44622587-44622652-10.97-0.1741ADAENST00000372874Frame-shift
ENSG00000236017ENST00000602357exon_skip_129597chr15:75363998-75364188-22.36-0.1944MAN2C1ENST00000267978Frame-shift
ENSG00000236017ENST00000602357exon_skip_5818chr1:45568484-45568684-23.48-0.1256AKR1A1ENST00000351829,ENST00000372070Frame-shift

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for ASMTL-AS1

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA-RBP complex negative regulation
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type
ENSG00000236017ENSG00000004534RBM6exon_skip_114365ENSG00000119688:chr14:74290026-74290118ABCD4ENST00000356924Frame-shiftUVM,SKCM,READ,OV,PCPG,THCA
ENSG00000236017ENSG00000004534RBM6exon_skip_370518ENSG00000100429:chr22:50247691-50247776HDAC10ENST00000216271Frame-shiftSARC,STAD,UVM,SKCM,READ,PRAD,PAAD,THCA
ENSG00000236017ENSG00000004534RBM6exon_skip_377198ENSG00000065485:chr3:123130479-123130616PDIA5ENST00000316218Frame-shiftUVM,SKCM,READ,OV,PCPG
ENSG00000236017ENSG00000004534RBM6exon_skip_382458ENSG00000060971:chr3:38131595-38131638ACAA1ENST00000333167Frame-shiftSARC,STAD,UVM,SKCM,READ,OV,PRAD,PCPG,PAAD,THCA
ENSG00000236017ENSG00000004534RBM6exon_skip_41813ENSG00000096746:chr10:68337857-68337996HNRNPH3ENST00000265866Frame-shiftSTAD,UVM,SKCM,PCPG,PAAD,THCA
ENSG00000236017ENSG00000004534RBM6exon_skip_53559ENSG00000198408:chr10:101793912-101793998OGAENST00000361464Frame-shiftUVM,READ,PCPG,PAAD,THCA
ENSG00000236017ENSG00000004534RBM6exon_skip_95407ENSG00000120798:chr12:95040475-95040597NR2C1ENST00000333003Frame-shiftUVM,SKCM,PCPG,PAAD,THCA
ENSG00000236017ENSG00000004534RBM6exon_skip_127618ENSG00000137776:chr15:58890280-58890461SLTMENST00000380516Frame-shiftUVM,SKCM,OV,PAAD,THCA
ENSG00000236017ENSG00000004534RBM6exon_skip_290158ENSG00000266967:chr17:42953723-42953778AARSD1ENST00000427569Frame-shiftSKCM,READ,PRAD,PAAD,THCA
ENSG00000236017ENSG00000004534RBM6exon_skip_470226ENSG00000105819:chr7:103307595-103307708PMPCBENST00000249269Frame-shiftUVM,SKCM,LIHC,PRAD,PCPG,PAAD,THCA

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation
ENSG00000236017ENST00000443929ABHD5ENSG00000011198ENST00000413300-0.1883427-COAD
ENSG00000236017ENST00000425740ABHD5ENSG00000011198ENST00000413300-0.2259608-COAD
ENSG00000236017ENST00000420411ABHD5ENSG00000011198ENST00000413300-0.2259376-COAD
ENSG00000236017ENST00000419737ABHD5ENSG00000011198ENST00000413300-0.2259195-COAD
ENSG00000236017ENST00000602357ABHD5ENSG00000011198ENST00000413300-0.225996-COAD

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000236017.6ENST00000443929.411620367
ENSG00000236017.6ENST00000425740.51223650
ENSG00000236017.6ENST00000420411.5223829158
ENSG00000236017.6ENST00000419737.517553580
ENSG00000236017.6ENST00000602357.417431552