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lncRNA: ENSG00000234608

Summary for MAPKAPK5-AS1

Gene summary

Gene information	Ensembl ID	ENSG00000234608
	Gene symbol	MAPKAPK5-AS1
	Gene name	MAPKAPK5 antisense RNA 1
	HGNC	24091
	Entrez ID	51275
	Gene type	lincRNA
	Synonyms	MAPKAPK5-AS1\|12q24.12
	UniProtAcc	Q8N8E1

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Structure and expression level for MAPKAPK5-AS1

AS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.

Differentially expressed gene analysis between cancer and normal samples.

Ensembl ID

Base mean

log2FC(AD/control)

lfcSE

Stat

P-value

Adjc.p-value

DEG direction

Cancer type

Correlation between lncRNAs and cancer stages.

LncRNA Ensembl ID	Correlation	P-value	Cancer Type	Adjc.p-value
ENSG00000234608	4.601112e-01	1.472325e-03	CHOL	2.340691e-03
ENSG00000234608	4.414544e-01	1.117399e-08	ESCA	3.799156e-06
ENSG00000234608	3.177496e-01	1.127022e-12	HNSC	1.145901e-10
ENSG00000234608	4.621099e-01	1.486323e-22	LIHC	8.249094e-20

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lncRNA-Protein interaction for MAPKAPK5-AS1

lncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID	LncRNA ENST ID	LncRNA Name	Protein Ensembl ID	Protein Name	CatRAPID Score	Lncpro Score	UniPortID	Gene Subtype	Public source
ENSG00000234608	ENST00000443596	MAPKAPK5-AS1	ENSG00000083544	TDRD3	20.65	91.0699	Q9H7E2	RBP,Epi	ChIP-seq
ENSG00000234608	ENST00000442119	MAPKAPK5-AS1	ENSG00000116560	SFPQ	23.0	91.0854	P23246	RBP,Epi	NA

lncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID	LncRNA ENST ID	LncRNA Name	Protein Ensembl ID	Protein Name	CatRAPID Score	Lncpro Score	UniPortID	Gene Subtype	Public source
ENSG00000234608	ENST00000443596	MAPKAPK5-AS1	ENSG00000025156	HSF2	9.78	92.665	Q03933	TF	NA
ENSG00000234608	ENST00000443596	MAPKAPK5-AS1	ENSG00000102878	HSF4	5.87	90.7155	Q9ULV5	TF	NA
ENSG00000234608	ENST00000443596	MAPKAPK5-AS1	ENSG00000120798	NR2C1	4.46	91.6347	P13056	TF	NA
ENSG00000234608	ENST00000443596	MAPKAPK5-AS1	ENSG00000138073	PREB	3.03	90.6841	Q9HCU5	TF	NA
ENSG00000234608	ENST00000590479	MAPKAPK5-AS1	ENSG00000147789	ZNF7	27.85	90.4122	P17097	TF	NA
ENSG00000234608	ENST00000590479	MAPKAPK5-AS1	ENSG00000180035	ZNF48	8.68	91.0801	Q96MX3	TF	NA

lncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID	LncRNA ENST ID	LncRNA Name	Protein Ensembl ID	Protein Name	CatRAPID Score	Lncpro Score	UniPortID	Gene Subtype	Public source
ENSG00000234608	ENST00000590479	MAPKAPK5-AS1	ENSG00000111641	NOP2	52.46	92.0977	P46087	RBP	NA
ENSG00000234608	ENST00000590479	MAPKAPK5-AS1	ENSG00000004534	RBM6	49.61	94.2179	P78332	RBP	NA
ENSG00000234608	ENST00000590479	MAPKAPK5-AS1	ENSG00000107625	DDX50	31.54	90.6973	Q9BQ39	RBP,Epi	NA
ENSG00000234608	ENST00000590479	MAPKAPK5-AS1	ENSG00000116560	SFPQ	27.0	92.605	P23246	RBP,Epi	NA
ENSG00000234608	ENST00000590479	MAPKAPK5-AS1	ENSG00000129351	ILF3	23.69	91.7614	Q12906	RBP	ENCODE,eCLIP
ENSG00000234608	ENST00000590479	MAPKAPK5-AS1	ENSG00000105705	SUGP1	18.0	90.0403	Q8IWZ8	RBP	NA
ENSG00000234608	ENST00000443596	MAPKAPK5-AS1	ENSG00000013573	DDX11	57.96	92.7503	Q96FC9	RBP	NA
ENSG00000234608	ENST00000443596	MAPKAPK5-AS1	ENSG00000079134	THOC1	39.64	91.2165	Q96FV9	RBP	NA
ENSG00000234608	ENST00000443596	MAPKAPK5-AS1	ENSG00000132153	DHX30	33.82	92.8003	Q7L2E3	RBP	ENCODE
ENSG00000234608	ENST00000443596	MAPKAPK5-AS1	ENSG00000083544	TDRD3	20.65	91.8937	Q9H7E2	RBP,Epi	ChIP-seq
ENSG00000234608	ENST00000442119	MAPKAPK5-AS1	ENSG00000004534	RBM6	42.16	90.8491	P78332	RBP	NA
ENSG00000234608	ENST00000442119	MAPKAPK5-AS1	ENSG00000176102	CSTF3	28.28	90.3749	Q12996	RBP	NA
ENSG00000234608	ENST00000442119	MAPKAPK5-AS1	ENSG00000116560	SFPQ	23.0	90.8335	P23246	RBP,Epi	NA

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lncRNA-DNA interaction for MAPKAPK5-AS1

lncRNA targets the enhancer region and positively regulates the gene expression.

lncRNA targets the promoter region and positively regulates the gene expression.

lncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for MAPKAPK5-AS1

lncRNA targets the 3'UTR region and negatively regulates the mRNA.

Only predicted by lncTar

ZEB2,SMAD1,PBX1,CPEB4,RXRA,ZHX3,RUNX1,NFIC,AGFG1,GTF2I,SYNJ1,BAZ2A,ARNT,PRDM2,KLF7,RREB1,KLF13,ZEB1

Exist in public source

lncRNA targets the skipped exon region.

-lncRNA and exonskipping events are positively correlated.

lncRNA and exonskipping events positive correlated

LncRNA Ensembl ID	LncRNA ENST ID	Exon ID	Skipped Exon	dG	ndG	Gene name with skipped exon	TransID with skipped exon	ORF mutation
ENSG00000234608	ENST00000609983	exon_skip_17679	chr1:211312719-211312961	-19.18	-0.1054	RCOR3	ENST00000367005	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_430633	chr4:82861630-82861708	-9.42	-0.2298	SEC31A	ENST00000355196,ENST00000395310,ENST00000448323	In-frame
ENSG00000234608	ENST00000609228	exon_skip_44998	chr10:110132304-110132400	-10.29	-0.1429	ADD3	ENST00000356080	In-frame

-lncRNA and exonskipping events are negatively correlated.

lncRNA and exonskipping events negative correlated

LncRNA Ensembl ID	LncRNA ENST ID	Exon ID	Skipped Exon	dG	ndG	Gene name with skipped exon	TransID with skipped exon	LOF
ENSG00000234608	ENST00000609983	exon_skip_319223	chr19:43526200-43526349	-17.89	-0.1209	ETHE1	ENST00000292147	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_363747	chr22:23877720-23877869	-18.44	-0.2004	SLC2A11	ENST00000345044	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_52891	chr10:98429790-98429889	-13.18	-0.1515	HPS1	ENST00000325103,ENST00000361490	In-frame
ENSG00000234608	ENST00000609983	exon_skip_140339	chr16:635611-635774	-20.28	-0.1389	METTL26	ENST00000301686	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_301267	chr19:6746028-6746196	-14.80	-0.1184	TRIP10	ENST00000313244	In-frame
ENSG00000234608	ENST00000609983	exon_skip_382458	chr3:38131595-38131638	-9.51	-0.2570	ACAA1	ENST00000333167	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_11029	chr1:154989559-154989707	-16.76	-0.2361	FLAD1	ENST00000292180	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_41813	chr10:68337857-68337996	-16.47	-0.1471	HNRNPH3	ENST00000265866	Frame-shift
ENSG00000234608	ENST00000456429	exon_skip_41841	chr10:68756272-68756483	-27.76	-0.1534	CCAR1	ENST00000265872	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_62623	chr11:69079833-69079883	-9.92	-0.2024	TPCN2	ENST00000294309	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_66482	chr11:126274926-126275021	-10.74	-0.1279	FOXRED1	ENST00000263578	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_66800	chr11:130123611-130123779	-18.53	-0.1227	APLP2	ENST00000263574	In-frame
ENSG00000234608	ENST00000609983	exon_skip_87733	chr12:120571190-120571291	-9.31	-0.2909	RNF10	ENST00000325954	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_114365	chr14:74290026-74290118	-11.74	-0.1925	ABCD4	ENST00000356924	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_114376	chr14:74293153-74293248	-14.30	-0.1765	ABCD4	ENST00000356924	Frame-shift
ENSG00000234608	ENST00000456429	exon_skip_152672	chr17:42540949-42541206	-32.08	-0.1248	NAGLU	ENST00000225927	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_290158	chr17:42953723-42953778	-9.44	-0.8582	AARSD1	ENST00000427569	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_370518	chr22:50247691-50247776	-10.89	-0.2593	HDAC10	ENST00000216271	Frame-shift
ENSG00000234608	ENST00000456429	exon_skip_380242	chr3:186784961-186785101	-17.80	-0.1271	EIF4A2	ENST00000323963	Frame-shift
ENSG00000234608	ENST00000456429	exon_skip_438307	chr5:141974803-141974955	-16.24	-0.1279	RNF14	ENST00000347642,ENST00000356143,ENST00000394519,ENST00000394520	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_442657	chr5:74730259-74730398	-12.58	-0.1015	GFM2	ENST00000296805,ENST00000509430	Frame-shift
ENSG00000234608	ENST00000443596	exon_skip_466113	chr7:48099669-48099787	-9.81	-0.1211	UPP1	ENST00000331803,ENST00000395564	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_470226	chr7:103307595-103307708	-10.58	-0.1150	PMPCB	ENST00000249269	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_13857	chr1:168038370-168038488	-8.90	-0.4684	DCAF6	ENST00000312263	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_108095	chr14:73955450-73955509	-10.14	-0.2253	COQ6	ENST00000334571	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_374581	chr3:50110378-50110463	-10.26	-0.1350	RBM5	ENST00000347869	Frame-shift
ENSG00000234608	ENST00000609228	exon_skip_16568	chr1:201989382-201989531	-14.02	-0.1275	RNPEP	ENST00000295640	Frame-shift
ENSG00000234608	ENST00000456429	exon_skip_5818	chr1:45568484-45568684	-31.19	-0.1668	AKR1A1	ENST00000351829,ENST00000372070	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_67681	chr11:893426-893519	-15.47	-0.1934	CHID1	ENST00000323578,ENST00000436108,ENST00000449825	In-frame
ENSG00000234608	ENST00000609983	exon_skip_153767	chr17:48057031-48057121	-12.91	-0.1956	NFE2L1	ENST00000362042	In-frame
ENSG00000234608	ENST00000609983	exon_skip_315468	chr19:12677107-12677211	-15.35	-0.1599	DHPS	ENST00000210060	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_361485	chr21:29008239-29008307	-8.52	-0.1331	RWDD2B	ENST00000493196	Frame-shift
ENSG00000234608	ENST00000609983	exon_skip_445390	chr5:150403120-150403312	-18.92	-0.1034	CD74	ENST00000009530	In-frame
ENSG00000234608	ENST00000609228	exon_skip_97655	chr12:120579773-120579923	-16.46	-0.1193	POP5	ENST00000357500	In-frame
ENSG00000234608	ENST00000609983	exon_skip_78771	chr11:134248808-134248959	-17.25	-0.1358	THYN1	ENST00000341541,ENST00000392594,ENST00000392595	Frame-shift

lncRNA targets by miRNA.

LncRNA Ensembl ID

miRNA ID

LncRNA ENST ID

Binding site in lncRNA

Score

Energy

Align Len

Public source

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Variants for MAPKAPK5-AS1

RNA A-to-I editing events in lncRNA.

LncRNAediting ID	LncRNA Ensembl ID	Chromosome	Editing Position	Strand	Gene Type	Gene Name	Transcript ID	Transcript Type	Transcript Name
LncEditing_257137	ENSG00000234608.6	chr12	111840388	-	lincRNA	MAPKAPK5-AS1	ENST00000609983.1	lincRNA	MAPKAPK5-AS1-011

Edited-associated DElncRNAs in cancer.

LncRNA Ensembl ID	LncRNA Index	Cancer Type	Chr_Postion_Strand	AVE1	AVE2	log2FC	W-value	P-value	Adjc.p-value	Change
ENSG00000234608	LncEditing_257137	UCEC	chr12_111840388_-	8.713370e+00	8.192935e+00	1.125485e+01	2.047302e+00	4.062844e-02	4.062844e-02	UP
ENSG00000234608	LncEditing_257137	OV	chr12_111840388_-	6.221919e+00	7.256382e+00	-4.506721e+00	-2.378583e+00	1.737933e-02	1.776575e-02	DOWN

Correlation between RNA A-to-I editing events's frequecy and lncRNA expression.

LncRNA Ensembl ID

LncRNA Index

Correlation

P-value

Adjc.p-value

Cis-expression quantitative trait loci(cis-eQTL) of lncRNA.

LncRNA Ensembl ID

LncRNA Name

SNP info

Number of Positive corelated Cancer

Positive corelated Cancer

Number of Negative corelated Cancer

Negative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncRNA regulates differentially expressed genes by function as enhancer.

LncRNA Ensembl ID

PC Gene ID

PC Gene Name

Positive correlated cancers

Cancer with PC gene up-regulation

Cancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

LncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).

lncRNA ID

TF ID

TF Name

PCgene ID

PCgene Name

Number of Cancer

Canaer Types

LncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).

lncRNA ID

TF ID

TF Name

PCgene ID

PCgene Name

Number of Cancer

Canaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

LncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.

LncRNA Ensembl ID

RBP ID

RBP Gene Name

Exon Skipping ID

Skipped Exon

EX Gene Name

EX Affected TransID

ORF_anno

Cancer Type

LncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.

LncRNA Ensembl ID	RBP ID	RBP Gene Name	Exon Skipping ID	Skipped Exon	EX Gene Name	EX Affected TransID	ORF_anno	Cancer Type
ENSG00000234608	ENSG00000004534	RBM6	exon_skip_382458	ENSG00000060971:chr3:38131595-38131638	ACAA1	ENST00000333167	Frame-shift	UVM,SKCM,THYM,PAAD,THCA
ENSG00000234608	ENSG00000079134	THOC1	exon_skip_382458	ENSG00000060971:chr3:38131595-38131638	ACAA1	ENST00000333167	Frame-shift	STAD,UVM,SKCM,PAAD,THCA
ENSG00000234608	ENSG00000004534	RBM6	exon_skip_470226	ENSG00000105819:chr7:103307595-103307708	PMPCB	ENST00000249269	Frame-shift	UVM,SKCM,THYM,PAAD,THCA

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.

LncRNA Ensembl ID

LncRNA ENST ID

PC Gene Name

PC Gene ID

PC ENST ID

nDG

Cancer with PC gene up-regulation

Cancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncRNA regulates mRNA by competing the miRNA binding site with mRNA.

LncRNA Ensembl ID

lncRNA-miRNA-mRNA

Cancer Types

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lncRNA coding potential

ORFfinder result for the gencode.v22.lncRNA.transcript.fa.

lncRNA Ensembl ID	lncRNA ENST ID	length(AA)	start at transcript	end at transcript
ENSG00000234608.6	ENST00000428207.3	76	302	72
ENSG00000234608.6	ENST00000443596.1	169	565	1074
ENSG00000234608.6	ENST00000456429.4	110	578	910
ENSG00000234608.6	ENST00000442119.4	169	565	1074
ENSG00000234608.6	ENST00000590479.4	62	332	520
ENSG00000234608.6	ENST00000609228.1	62	280	468
ENSG00000234608.6	ENST00000609983.1	89	520	251

	lncRNA summary
	lncRNA structure and expression level
	lncRNA-Protein interaction
	lncRNA-DNA interaction
	lncRNA-RNA interaction
	Variants in lncRNA
	lncRNAs regulate the target genes through functioning as enhancers
	lncRNAs regulate the target genes through recruiting transcript factors
	lncRNAs regulate the alternative splicing events through interacting with splicing factor
	lncRNAs regulate mRNA through targeting the 3'-UTR region
	lncRNAs regulate mRNA by competing with miRNA
	lncRNA coding potential