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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000233901

Summary for LINC01503

check button Gene summary

Gene informationEnsembl ID

ENSG00000233901

Gene symbol

LINC01503

Gene namelong intergenic non-protein coding RNA 1503
HGNC

51184

Entrez ID

100506119

Gene typelincRNA
SynonymsLINC01503|09q34.11
UniProtAcc

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Structure and expression level for LINC01503

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002339011.329316e+021.004817e+001.219003e-018.242940e+001.680000e-161.780000e-15UPTHCA
ENSG000002339014.012948e+02-1.295389e+001.590620e-01-8.143928e+003.830000e-161.830000e-15DOWNKIRC
ENSG000002339014.299512e+02-2.411878e+002.764274e-01-8.725177e+002.660000e-183.690000e-17DOWNKICH
ENSG000002339013.736643e+02-1.314149e+002.580166e-01-5.093274e+003.520000e-071.650000e-06DOWNKIRP
ENSG000002339012.887231e+021.524583e+002.635845e-015.784039e+007.290000e-094.030000e-08UPUCEC
ENSG000002339015.200709e+021.834843e+004.204899e-014.363584e+001.280000e-052.379700e-04UPESCA
ENSG000002339011.888727e+02-1.107691e+001.552502e-01-7.134878e+009.690000e-139.600000e-12DOWNPRAD
ENSG000002339018.230424e+021.960867e+001.455625e-011.347097e+012.320000e-414.040000e-40UPLUSC

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002339015.259697e-012.067074e-04CHOL5.189281e-04
ENSG00000233901-5.952458e-017.648478e-10KICH6.558163e-09
ENSG00000233901-3.840212e-011.072834e-11KIRP1.927946e-10
ENSG00000233901-3.486073e-013.447773e-17PRAD4.377986e-16

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lncRNA-Protein interaction for LINC01503

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000233901ENST00000423122LINC01503ENSG00000106624AEBP116.5390.4476Q8IUX7TFNA
ENSG00000233901ENST00000423122LINC01503ENSG00000125817CENPB7.3390.9917P07199TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for LINC01503

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for LINC01503

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
BPTF,NCOA2,CHERP,TMF1,LARP4,GLYR1,DDX46,CPSF7,AKAP1,NR2C2,ZNF91,SF3A1,DDX6,AQR,RREB1
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000233901ENST00000423122exon_skip_96112chr12:109945259-109945349-16.17-0.2651GIT2ENST00000355312In-frame
ENSG00000233901ENST00000423122exon_skip_75223chr11:72012400-72012442-5.72-0.1682NUMA1ENST00000393695In-frame
ENSG00000233901ENST00000423122exon_skip_382356chr3:37091466-37091538-6.97-0.2178LRRFIP2ENST00000336686In-frame

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000233901ENST00000423122exon_skip_85538chr12:71894324-71894375-9.52-0.2322TBC1D15ENST00000550746In-frame
ENSG00000233901ENST00000423122exon_skip_120396chr14:105150990-105151104-13.73-0.1271JAG2ENST00000331782In-frame
ENSG00000233901ENST00000423122exon_skip_153096chr17:44074968-44075087-11.65-0.1975G6PC3ENST00000269097Frame-shift
ENSG00000233901ENST00000423122exon_skip_305632chr19:35262545-35262692-15.91-0.1283LSRENST00000361790In-frame
ENSG00000233901ENST00000423122exon_skip_455363chr6:161098277-161098427-22.50-0.2163MAP3K4ENST00000392142In-frame

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for LINC01503

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name
LncEditing_221235ENSG00000233901.4chr9129344510+lincRNALINC01503ENST00000444125.1lincRNALINC01503-003
LncEditing_221241ENSG00000233901.4chr9129344522+lincRNALINC01503ENST00000444125.1lincRNALINC01503-003
LncEditing_221259ENSG00000233901.4chr9129344549+lincRNALINC01503ENST00000444125.1lincRNALINC01503-003
LncEditing_221262ENSG00000233901.4chr9129344550+lincRNALINC01503ENST00000444125.1lincRNALINC01503-003
LncEditing_221457ENSG00000233901.4chr9129347250+lincRNALINC01503ENST00000444125.1lincRNALINC01503-003
LncEditing_221466ENSG00000233901.4chr9129347276+lincRNALINC01503ENST00000444125.1lincRNALINC01503-003
LncEditing_221469ENSG00000233901.4chr9129347284+lincRNALINC01503ENST00000444125.1lincRNALINC01503-003

check buttonEdited-associated DElncRNAs in cancer.
Differentially expressed gene
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange
ENSG00000233901LncEditing_221457DLBCchr9_129347250_+3.003800e+001.435510e+009.387687e-012.611165e+009.023439e-031.384000e-02UP
ENSG00000233901LncEditing_221469GBMchr9_129347284_+7.352844e+004.852035e+001.667466e+004.148151e+003.351718e-055.030686e-05UP
ENSG00000233901LncEditing_221457LGGchr9_129347250_+2.741332e+001.830210e+001.715654e+007.069959e+001.549799e-122.655724e-12UP
ENSG00000233901LncEditing_221457PCPGchr9_129347250_+2.655698e+001.906553e+002.091506e+004.041070e+005.320789e-058.314801e-05UP
ENSG00000233901LncEditing_221235OVchr9_129344510_+3.046071e+011.439677e+019.248943e-015.821916e+005.817677e-098.937935e-09UP
ENSG00000233901LncEditing_221241OVchr9_129344522_+3.111867e+011.412328e+018.774201e-015.921116e+003.197648e-095.026046e-09UP
ENSG00000233901LncEditing_221262OVchr9_129344550_+2.995067e+011.300872e+018.311797e-017.282109e+003.286423e-137.573599e-13UP
ENSG00000233901LncEditing_221466OVchr9_129347276_+9.129971e+001.713390e+01-1.101113e+00-3.544705e+003.930533e-044.370164e-04DOWN
ENSG00000233901LncEditing_221469OVchr9_129347284_+1.074566e+011.770562e+01-1.388016e+00-2.880639e+003.968701e-034.187287e-03DOWN
ENSG00000233901LncEditing_221259ESCAchr9_129344549_+8.549247e+003.633569e+008.101034e-015.091952e+003.543963e-076.098643e-07UP
ENSG00000233901LncEditing_221262ESCAchr9_129344550_+7.413812e+003.465537e+009.114636e-015.532170e+003.162925e-086.356175e-08UP
ENSG00000233901LncEditing_221469ESCAchr9_129347284_+5.507748e+004.340629e+002.910715e+002.659076e+007.835527e-038.340917e-03UP

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value
ENSG00000233901LncEditing_221466-3.665726e-016.939437e-039.006099e-03
ENSG00000233901LncEditing_221469-4.143706e-014.019701e-052.205504e-04
ENSG00000233901LncEditing_221469-4.680302e-012.108455e-023.043454e-02
ENSG00000233901LncEditing_221457-5.496093e-013.718902e-061.301616e-05

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000233901.4ENST00000436710.41454351
ENSG00000233901.4ENST00000444125.1112564899
ENSG00000233901.4ENST00000423122.1133381782