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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000229980

Summary for TOB1-AS1

check button Gene summary

Gene informationEnsembl ID

ENSG00000229980

Gene symbol

TOB1-AS1

Gene nameTOB1 antisense RNA 1
HGNC

44340

Entrez ID

400604

Gene typeprocessed_transcript
SynonymsTOB1-AS1|17q21.33
UniProtAcc

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Structure and expression level for TOB1-AS1

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value

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lncRNA-Protein interaction for TOB1-AS1

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000229980ENST00000523470TOB1-AS1ENSG00000167967E4F141.1590.157Q66K89TFNA
ENSG00000229980ENST00000523470TOB1-AS1ENSG00000154832CXXC128.1390.0518Q9P0U4TF,EpiNA
ENSG00000229980ENST00000416263TOB1-AS1ENSG00000167967E4F151.6790.0434Q66K89TFNA
ENSG00000229980ENST00000416263TOB1-AS1ENSG00000065029ZNF7624.090.8629P36508TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000229980ENST00000416263TOB1-AS1ENSG00000004534RBM648.9692.7381P78332RBPNA
ENSG00000229980ENST00000416263TOB1-AS1ENSG00000150316CWC1516.4791.1447Q9P013RBPNA
ENSG00000229980ENST00000523470TOB1-AS1ENSG00000004534RBM639.4391.655P78332RBPNA

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lncRNA-DNA interaction for TOB1-AS1

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
NDUFB10,MRPL52,IDH3G,BLOC1S1,FAAP100,C11orf1,DUT,NDUFS6,ARL16,PYM1,TCEA2,NUDT16L1,GLI4,CFDP1,TRMU,PRPSAP2,C15orf61,MCRS1,CTBP1,MRPS26,SH2B1,CIRBP,SNRNP25,PET100,IMP3,NICN1,CHCHD5,IP6K2,PPOX,DYNC2I2,CDPF1,COQ5,KAT8,SNF8,ZSWIM7,PPP2R3B,SLC25A11,HINT2,NPRL3,ACD,C1orf35,XAB2,MTIF3,TIMM17B,CDK5RAP1,B3GAT3,MARCHF9,BUD23,BANF1,MRPL28,DCAF8,ZCWPW1,NPRL2,KLHDC4,EIPR1,HPF1,LIN37,STK16,CENATAC,CLK3,SMUG1,VPS9D1,IFT27,TRAPPC2L,GFER,HIRIP3,NARF,PHKG2,PMF1,SURF1,ZC3HC1,TMEM175,NUBP2,MIEN1,SWSAP1,COA3,LSM5,RFXANK,SGSM3,PPIH,CENPT,MRPL24,COG4,DUS2,GKAP1,DHRS12,ZMAT5,MRM1,MICOS13,TAZ,SUGP1,SPG7,STX10,NAA80,ANAPC7,KAT2A,UBL7,ARMC5,ACBD4,NAA38,USE1,CYB5D2,RCCD1,PLA2G6,RNPS1,ERAL1,TBL3,UQCRC1,UQCC2,RPL36AL,CWC15,COX17,POLG2,ATP5MJ,ENDOV,MST1,AAAS,SSU72,DPY30,LAS1L,UBL5,PPIE,FAM50A,NELFE,ELP6,WDR83,METTL23,USF1,CXXC1,C17orf75,ALKBH7,GABPB1,ERMARD,DHPS,RPAIN,STX8,PCED1A,BABAM1,ACYP1,TUSC2,GEMIN6,ING4,PIH1D1,ELP5,PGP,CTU2,MRPS15,HDAC10,HEXIM2,DDX49,SCRN2,PPP1R3F,INO80E,ANKS3,NOXA1,PEX16,C3orf62,SMDT1,YJU2,PQBP1,PIGQ,LENG1,TMEM186,TEDC1,TADA2A,NDUFA2,BORCS6,C12orf76,PRMT7,ZFYVE19,COX4I1,ATP5PD,SGF29,TIGD1,C12orf73,ECSIT,FUZ,COA8,ESS2,DYRK4,THAP3,GEMIN2,VPS28,TRPT1,MOB2,TSEN54,PSPN,ATG4B,SERP2,HEMK1,COASY,STMN3,MRPL57,ARFRP1,CD2BP2,DCUN1D2,CIAO2B,MCRIP2,TSSK6,ALKBH4,PTOV1,IFI27L1,PCSK4,TMA7,PAM16,CCS,MRPL27,NDUFAF5,MYL6B,TPRKB,MYG1,ABHD10,PSMC5,NEDD8,NDUFB1,DUSP28,NAT9,POP5,BOLA1,ACOT8,TSR3,ABHD14A,YPEL3,PROCA1,THAP8,NUDCD2,LUC7L,SAP30BP,BCDIN3D,COA5,RPA3,HEXD,UCKL1,SDHAF2,FKBP3,EEFSEC,SCAND1,IDH3B,ATP5MC2,C14orf93,DPH7,PSME3IP1,ANAPC11,PDCD6,DGCR6L,UBXN11,CCDC12,CEP131,PTRHD1,EAPP,DDX41,HINFP,XPA,RSAD1,FASTK,ATPAF2,SIRT6,MCRIP1,RALY,CCDC51,SPAG7,PCYT2,SIRT7,MVD,FAM3A,ATP5IF1,IMMP1L
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.
Only predicted by TDF
DCAF8,SGSM3,DPH7,C14orf93,TBL3,GLI4,THOP1,COG4,DHPS,HDAC10,C19orf73,ECSIT,EID2B,SWSAP1,OXLD1,DUS1L,FASTK,RNF113A,MRPL52,STK16,COX7C,TRMU,PQBP1,NARF,TADA3,HEMK1,ARL16,E4F1,KLHDC4,NICN1,PSMB6,AIP,DYRK4,TIGD1,PDCD6,ING4,GPANK1,FKBPL,CEP131,YPEL3,USF1,PIH1D1,COX6A1,PRPF3,ALKBH4,MCRS1,GFER,NDUFB1,TIMM17B,THAP3,ZCWPW1,VPS28,DCUN1D2,TUSC2,MRPL24,ACD,HINT2,OCEL1,C3orf62,SLC25A14,BANF1,QTRT1,C17orf75,BLOC1S1,C14orf2,CFDP1,TSEN54,MARCH9,TBKBP1,APOPT1,NT5M,ZSWIM7,EAPP,TMEM256,PCSK4,CCDC130,SDHAF4,IFI27L1,C12orf10,PPIE,ATPIF1,PROCA1,IDH3B,FAM195B,C12orf73,BABAM1,POP5,SLC25A11,SGF29,ARIH2OS,RBM6,ERMARD,CIRBP,TAZ,KCTD2,COQ5
Exist in public source
NA

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for TOB1-AS1

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
OSMR,IQGAP1,FNDC3B,ITGAV,SSH1,ACTN4,ECE1,KPNA6,STAT3,TGOLN2,CAP1,ZYG11B,MFSD14A,CYFIP1,TUBB6,SNX6,MYH9
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for TOB1-AS1

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types
ENSG00000229980ENSG00000167967E4F1ENSG00000204237OXLD15KICH,KIRP,LGG,PRAD,THCA
ENSG00000229980ENSG00000167967E4F1ENSG00000126768TIMM17B5KICH,KIRP,LGG,PRAD,THCA

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000229980.4ENST00000416263.31374111
ENSG00000229980.4ENST00000523470.1172816298
ENSG00000229980.4ENST00000514358.194264545
ENSG00000229980.4ENST00000519432.1103523212