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lncRNA: ENSG00000225889

Summary for AC074289.1

Gene summary

Gene information	Ensembl ID	ENSG00000225889
	Gene symbol	AC074289.1
	Gene name
	HGNC
	Entrez ID
	Gene type	antisense
	Synonyms
	UniProtAcc

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Structure and expression level for AC074289.1

AS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.

Differentially expressed gene analysis between cancer and normal samples.

Ensembl ID	Base mean	log2FC(AD/control)	lfcSE	Stat	P-value	Adjc.p-value	DEG direction	Cancer type
ENSG00000225889	2.563718e+02	1.574311e+00	1.446396e-01	1.088437e+01	1.370000e-27	1.240000e-26	UP	KIRC
ENSG00000225889	2.511026e+02	1.457371e+00	2.059024e-01	7.077973e+00	1.460000e-12	6.120000e-12	UP	LUSC

Correlation between lncRNAs and cancer stages.

LncRNA Ensembl ID

Correlation

P-value

Cancer Type

Adjc.p-value

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lncRNA-Protein interaction for AC074289.1

lncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID	LncRNA ENST ID	LncRNA Name	Protein Ensembl ID	Protein Name	CatRAPID Score	Lncpro Score	UniPortID	Gene Subtype	Public source
ENSG00000225889	ENST00000438115	AC074289.1	ENSG00000078487	ZCWPW1	49.41	91.0396	Q9H0M4	Epi	NA
ENSG00000225889	ENST00000451350	AC074289.1	ENSG00000154832	CXXC1	61.46	95.0368	Q9P0U4	TF,Epi	NA
ENSG00000225889	ENST00000451350	AC074289.1	ENSG00000078487	ZCWPW1	51.64	91.0231	Q9H0M4	Epi	NA

lncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID	LncRNA ENST ID	LncRNA Name	Protein Ensembl ID	Protein Name	CatRAPID Score	Lncpro Score	UniPortID	Gene Subtype	Public source
ENSG00000225889	ENST00000438115	AC074289.1	ENSG00000167967	E4F1	95.57	91.4723	Q66K89	TF	NA
ENSG00000225889	ENST00000438115	AC074289.1	ENSG00000167766	ZNF83	9.03	90.2052	P51522	TF	NA
ENSG00000225889	ENST00000438115	AC074289.1	ENSG00000065029	ZNF76	5.78	90.2557	P36508	TF	NA
ENSG00000225889	ENST00000451350	AC074289.1	ENSG00000167967	E4F1	95.26	93.707	Q66K89	TF	NA
ENSG00000225889	ENST00000451350	AC074289.1	ENSG00000154832	CXXC1	61.46	94.9869	Q9P0U4	TF,Epi	NA
ENSG00000225889	ENST00000449678	AC074289.1	ENSG00000167967	E4F1	44.56	92.3414	Q66K89	TF	NA
ENSG00000225889	ENST00000451350	AC074289.1	ENSG00000065029	ZNF76	16.02	94.5218	P36508	TF	NA
ENSG00000225889	ENST00000451350	AC074289.1	ENSG00000167766	ZNF83	11.9	92.8063	P51522	TF	NA
ENSG00000225889	ENST00000451350	AC074289.1	ENSG00000154957	ZNF18	6.69	92.3253	P17022	TF	NA
ENSG00000225889	ENST00000451350	AC074289.1	ENSG00000250571	GLI4	5.54	91.9814	P10075	TF	NA

lncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID	LncRNA ENST ID	LncRNA Name	Protein Ensembl ID	Protein Name	CatRAPID Score	Lncpro Score	UniPortID	Gene Subtype	Public source
ENSG00000225889	ENST00000451350	AC074289.1	ENSG00000163728	TTC14	83.88	95.1109	Q96N46	RBP	NA
ENSG00000225889	ENST00000451350	AC074289.1	ENSG00000105705	SUGP1	32.33	92.3107	Q8IWZ8	RBP	NA
ENSG00000225889	ENST00000451350	AC074289.1	ENSG00000161547	SRSF2	3.46	92.8505	Q01130	RBP	NA
ENSG00000225889	ENST00000438115	AC074289.1	ENSG00000163728	TTC14	87.99	91.6873	Q96N46	RBP	NA

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lncRNA-DNA interaction for AC074289.1

lncRNA targets the enhancer region and positively regulates the gene expression.

Only predicted by TDF

AGAP6,ZBTB8OS,GLI4,TRMU,ZMYND15,RNF166,DGKA,PPOX,KAT8,PIGL,MUTYH,ZCWPW1,ULK3,KLHDC4,TMEM259,CCNL2,CENATAC,CLK3,PHKG2,NARF,ARHGAP4,TMEM175,CENPT,CYTH1,TTC14,ZGLP1,OSBPL7,TAZ,SUGP1,SPG7,STX10,KAT2A,PIDD1,METAP1D,PLA2G6,TAF1C,LCAT,POLG2,CHKB,OSGEP,EXD3,USF1,CLK1,CXXC1,ERMARD,MRNIP,ELMOD3,PCED1A,NRBP2,MTRF1,HDAC10,ARGLU1,ANKS3,NOXA1,YJEFN3,WSB1,AUP1,ORMDL1,KRI1,RSRP1,HSPBAP1,AGER,GPS2,NOL12,CLEC2D,CLASRP,SRSF2,TRPT1,LTB4R,TSEN54,ZNF83,GOLGA8B,HEMK1,STRADA,OGFR,ZNF18,PAN2,GOLGA8A,BRAT1,CYP2R1,PAM16,NEIL1,GIGYF1,FAM193B,TMCO6,SLC25A28,NAT9,UBA7,LIPT1,CZIB,RASSF4,MYL5,LUC7L,HEXD,DPH7,SCNN1D,TRA2A,WDR27,UBXN11,EME2,POLM,NR2C1,AMY2B,ACAP3,WBP1,CCDC57,TEPSIN,SIRT7

Exist in public source

lncRNA targets the promoter region and positively regulates the gene expression.

lncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for AC074289.1

lncRNA targets the 3'UTR region and negatively regulates the mRNA.

lncRNA targets the skipped exon region.

-lncRNA and exonskipping events are positively correlated.

LncRNA Ensembl ID

LncRNA ENST ID

Exon ID

Skipped Exon

ndG

Gene name with skipped exon

TransID with skipped exon

ORF mutation

-lncRNA and exonskipping events are negatively correlated.

LncRNA Ensembl ID

LncRNA ENST ID

Exon ID

Skipped Exon

ndG

Gene name with skipped exon

TransID with skipped exon

LOF

lncRNA targets by miRNA.

LncRNA Ensembl ID

miRNA ID

LncRNA ENST ID

Binding site in lncRNA

Score

Energy

Align Len

Public source

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Variants for AC074289.1

RNA A-to-I editing events in lncRNA.

LncRNAediting ID

LncRNA Ensembl ID

Chromosome

Editing Position

Strand

Gene Type

Gene Name

Transcript ID

Transcript Type

Transcript Name

Edited-associated DElncRNAs in cancer.

LncRNA Ensembl ID

LncRNA Index

Cancer Type

Chr_Postion_Strand

AVE1

AVE2

log2FC

W-value

P-value

Adjc.p-value

Change

Correlation between RNA A-to-I editing events's frequecy and lncRNA expression.

LncRNA Ensembl ID

LncRNA Index

Correlation

P-value

Adjc.p-value

Cis-expression quantitative trait loci(cis-eQTL) of lncRNA.

LncRNA Ensembl ID

LncRNA Name

SNP info

Number of Positive corelated Cancer

Positive corelated Cancer

Number of Negative corelated Cancer

Negative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncRNA regulates differentially expressed genes by function as enhancer.

LncRNA Ensembl ID	PC Gene ID	PC Gene Name	Positive correlated cancers	Cancer with PC gene up-regulation	Cancer with PC gene down-regulation
ENSG00000225889	ENSG00000069493	CLEC2D	DLBC,GBM,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000089820	ARHGAP4	DLBC,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000100429	HDAC10	DLBC,GBM,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000104859	CLASRP	DLBC,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000108773	KAT2A	DLBC,KIRC,KIRP,LGG,LUSC,TGCT	KIRC,LUSC
ENSG00000225889	ENSG00000158062	UBXN11	DLBC,KIRC,KIRP,LAML,TGCT	KIRC
ENSG00000225889	ENSG00000177595	PIDD1	DLBC,GBM,KIRC,KIRP,LGG	KIRC
ENSG00000225889	ENSG00000197774	EME2	DLBC,GBM,KIRC,KIRP,LGG,THYM	KIRC
ENSG00000225889	ENSG00000213398	LCAT	DLBC,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000213903	LTB4R	DLBC,KIRC,KIRP,LAML,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000215375	MYL5	DLBC,GBM,KIRC,KIRP,LGG	KIRC
ENSG00000225889	ENSG00000250067	YJEFN3	DLBC,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000273899	NOL12	DLBC,GBM,KIRC,KIRP,LGG,LUSC,TGCT	KIRC,LUSC
ENSG00000225889	ENSG00000013441	CLK1	GBM,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000100288	CHKB	GBM,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000100416	TRMU	GBM,KIRC,KIRP,LGG,LUSC	LUSC
ENSG00000225889	ENSG00000102125	TAZ	GBM,KIRC,KIRP,LGG,LUSC	KIRC
ENSG00000225889	ENSG00000107551	RASSF4	GBM,KIRC,KIRP,LAML,TGCT	KIRC
ENSG00000225889	ENSG00000109046	WSB1	GBM,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000117616	RSRP1	GBM,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000132522	GPS2	GBM,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000141497	ZMYND15	GBM,KIRC,KIRP,LGG,THYM	KIRC
ENSG00000225889	ENSG00000158717	RNF166	GBM,KIRC,KIRP,LAML,LGG	KIRC
ENSG00000225889	ENSG00000161010	MRNIP	GBM,KIRC,KIRP,LGG,THYM	KIRC
ENSG00000225889	ENSG00000162572	SCNN1D	GBM,KIRC,KIRP,LGG,TGCT,THYM	KIRC
ENSG00000225889	ENSG00000184465	WDR27	GBM,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000185189	NRBP2	GBM,KIRC,KIRP,LAML,LGG	KIRC
ENSG00000225889	ENSG00000186166	CENATAC	GBM,KIRC,KIRP,LGG,LUSC,TGCT	KIRC
ENSG00000225889	ENSG00000204149	AGAP6	GBM,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000204305	AGER	GBM,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000217930	PAM16	GBM,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000221978	CCNL2	GBM,KIRC,KIRP,LGG,TGCT	KIRC
ENSG00000225889	ENSG00000240038	AMY2B	GBM,KIRC,KIRP,LGG,THYM	KIRC
ENSG00000225889	ENSG00000256525	POLG2	GBM,KIRC,KIRP,LGG,LUSC	KIRC
ENSG00000225889	ENSG00000060491	OGFR	KIRC,KIRP,LAML,LGG,THYM	KIRC
ENSG00000225889	ENSG00000065357	DGKA	KIRC,KIRP,LGG,LUSC,TGCT	KIRC,LUSC
ENSG00000225889	ENSG00000129347	KRI1	KIRC,KIRP,LGG,LUSC,TGCT	LUSC
ENSG00000225889	ENSG00000175265	GOLGA8A	KIRC,KIRP,LGG,LUSC,TGCT	KIRC,LUSC
ENSG00000225889	ENSG00000215252	GOLGA8B	KIRC,KIRP,LGG,LUSC,TGCT	KIRC

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lncRNAs regulate the target genes through recruiting transcript factors

LncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).

lncRNA ID

TF ID

TF Name

PCgene ID

PCgene Name

Number of Cancer

Canaer Types

LncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).

lncRNA ID

TF ID

TF Name

PCgene ID

PCgene Name

Number of Cancer

Canaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

LncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.

LncRNA Ensembl ID

RBP ID

RBP Gene Name

Exon Skipping ID

Skipped Exon

EX Gene Name

EX Affected TransID

ORF_anno

Cancer Type

LncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.

LncRNA Ensembl ID

RBP ID

RBP Gene Name

Exon Skipping ID

Skipped Exon

EX Gene Name

EX Affected TransID

ORF_anno

Cancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.

LncRNA Ensembl ID

LncRNA ENST ID

PC Gene Name

PC Gene ID

PC ENST ID

nDG

Cancer with PC gene up-regulation

Cancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncRNA regulates mRNA by competing the miRNA binding site with mRNA.

LncRNA Ensembl ID

lncRNA-miRNA-mRNA

Cancer Types

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lncRNA coding potential

ORFfinder result for the gencode.v22.lncRNA.transcript.fa.

lncRNA Ensembl ID	lncRNA ENST ID	length(AA)	start at transcript	end at transcript
ENSG00000225889.6	ENST00000438115.5	62	541	353
ENSG00000225889.6	ENST00000413030.5	56	531	361
ENSG00000225889.6	ENST00000426365.4	93	280	2
ENSG00000225889.6	ENST00000449678.4	54	275	439
ENSG00000225889.6	ENST00000436950.4	74	263	39
ENSG00000225889.6	ENST00000451350.1	83	14	265

	lncRNA summary
	lncRNA structure and expression level
	lncRNA-Protein interaction
	lncRNA-DNA interaction
	lncRNA-RNA interaction
	Variants in lncRNA
	lncRNAs regulate the target genes through functioning as enhancers
	lncRNAs regulate the target genes through recruiting transcript factors
	lncRNAs regulate the alternative splicing events through interacting with splicing factor
	lncRNAs regulate mRNA through targeting the 3'-UTR region
	lncRNAs regulate mRNA by competing with miRNA
	lncRNA coding potential