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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000225783

Summary for MIAT

check button Gene summary

Gene informationEnsembl ID

ENSG00000225783

Gene symbol

MIAT

Gene namemyocardial infarction associated transcript
HGNC

33425

Entrez ID

440823

Gene typelincRNA
SynonymsMIAT|22q12.1
UniProtAcc

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Structure and expression level for MIAT

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002257831.587329e+03-2.897284e+006.556937e-01-4.418655e+009.930000e-066.370000e-05DOWNGBM
ENSG000002257836.937073e+023.406024e+008.887348e-013.832441e+001.268780e-041.476866e-03UPCESC
ENSG000002257831.103554e+044.679753e+007.147372e-016.547516e+005.850000e-115.410000e-09UPPCPG
ENSG000002257832.020427e+032.276367e+002.577938e-018.830185e+001.050000e-186.320000e-18UPLUSC
ENSG000002257839.873363e+021.759510e+002.274241e-017.736693e+001.020000e-147.020000e-14UPLUAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value

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lncRNA-Protein interaction for MIAT

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000225783ENST00000616213MIATENSG00000141258SGSM2116.5191.7681O43147TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000225783ENST00000419237MIATENSG00000163728TTC1440.5190.123Q96N46RBPNA

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lncRNA-DNA interaction for MIAT

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
SGSM2,TTC14,SUGP2
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for MIAT

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for MIAT

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer
ENSG00000225783MIATrs16982564:27054179:G:A1LGG0
ENSG00000225783MIATrs34730265:27048046:C:T1LGG0
ENSG00000225783MIATrs35778551:27054989:G:A1LGG0
ENSG00000225783MIATrs11912702:27056763:C:G1LGG0
ENSG00000225783MIATrs2331290:27058525:A:G:-01LGG
ENSG00000225783MIATrs2331291:27058821:A:G:-01LGG
ENSG00000225783MIATrs34144672:27073550:T:C1LGG0
ENSG00000225783MIATrs35870418:27065794:C:T1LGG0
ENSG00000225783MIATrs34403716:27064576:G:A1LGG0
ENSG00000225783MIATrs35955962:27065224:G:A1LGG0
ENSG00000225783MIATrs34311659:27065477:A:T1LGG0
ENSG00000225783MIATrs62224896:27062296:G:A1LGG0
ENSG00000225783MIATrs151107782:27057937:CAT:C1LGG0
ENSG00000225783MIATrs11913458:27045740:G:A1LGG0
ENSG00000225783MIATrs5752374:27050962:T:C1LGG0
ENSG00000225783MIATrs11913541:27045504:A:C:+01LGG
ENSG00000225783MIATrs739311:27051338:C:G:-1LGG0

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000225783.5ENST00000421867.4102492184
ENSG00000225783.5ENST00000418918.4112646308
ENSG00000225783.5ENST00000440347.410441096
ENSG00000225783.5ENST00000450203.498114410
ENSG00000225783.5ENST00000430483.463389577
ENSG00000225783.5ENST00000439738.488122388
ENSG00000225783.5ENST00000422403.49592379
ENSG00000225783.5ENST00000436238.49562349
ENSG00000225783.5ENST00000425476.473371592
ENSG00000225783.5ENST00000455640.4712172
ENSG00000225783.5ENST00000451141.18638298
ENSG00000225783.5ENST00000452429.47612242
ENSG00000225783.5ENST00000413665.49534321
ENSG00000225783.5ENST00000616469.39932627
ENSG00000225783.5ENST00000620145.316462105716
ENSG00000225783.5ENST00000616213.316462105716
ENSG00000225783.5ENST00000613780.316460845590
ENSG00000225783.5ENST00000458302.416462845790
ENSG00000225783.5ENST00000419237.11124342
ENSG00000225783.5ENST00000449717.173255476
ENSG00000225783.5ENST00000453023.176221451