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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000224397

Summary for PELATON

check button Gene summary

Gene informationEnsembl ID

ENSG00000224397

Gene symbol

PELATON

Gene nameplaque enriched lncRNA in atherosclerotic and inflammatory bowel macrophage regulation
HGNC

50328

Entrez ID

100506115

Gene typelincRNA
SynonymsLINC01272|20q13.13|PELATON
UniProtAcc

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Structure and expression level for PELATON

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002243971.393328e+023.472081e+007.090755e-014.896632e+009.750000e-078.010000e-06UPGBM
ENSG000002243971.728570e+021.166542e+001.859436e-016.273636e+003.530000e-102.000000e-09UPTHCA
ENSG000002243971.991717e+022.585420e+001.531381e-011.688293e+016.010000e-642.370000e-62UPKIRC
ENSG000002243973.225876e+023.583266e+003.093120e-011.158463e+014.930000e-313.520000e-29UPKIRP
ENSG000002243978.674916e+012.216989e+002.107571e-011.051917e+017.050000e-261.790000e-24UPUCEC
ENSG000002243972.282524e+021.719483e+003.260847e-015.273116e+001.340000e-075.120000e-06UPESCA
ENSG000002243976.063314e+02-3.079016e+001.664768e-01-1.849516e+012.260000e-761.270000e-74DOWNLUSC
ENSG000002243977.285576e+02-2.490950e+001.532970e-01-1.624917e+012.260000e-591.910000e-57DOWNLUAD
ENSG000002243971.331066e+021.315682e+001.629706e-018.073129e+006.850000e-166.670000e-15UPCOAD
ENSG000002243973.287584e+021.853342e+002.122278e-018.732795e+002.480000e-181.290000e-16UPSTAD
ENSG000002243971.356312e+021.806284e+003.261069e-015.538931e+003.040000e-085.600000e-07UPREAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002243973.362137e-012.147348e-05ESCA1.216831e-03
ENSG000002243973.653052e-011.244897e-20KIRC1.098438e-19
ENSG000002243973.253057e-016.181547e-16UCEC7.806541e-15

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lncRNA-Protein interaction for PELATON

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000224397ENST00000425497LINC01272ENSG00000106624AEBP125.0592.7609Q8IUX7TFNA
ENSG00000224397ENST00000425497LINC01272ENSG00000136630HLX20.9690.9821Q14774TFNA
ENSG00000224397ENST00000421019LINC01272ENSG00000136630HLX11.1290.3879Q14774TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for PELATON

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
ELF4,RNH1,JDP2,FOXP3,HLX,TLR8,EGR2,ETV7,ETS1,RUNX1,GLMP,MAFB,CREM,IRF1,VDR,SPI1
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for PELATON

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
CHTOP,NONO,SOX12,PUM2,CSTF3,DDX17,ILF3,CPSF6,RBMX,SFPQ,PATZ1
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000224397ENST00000421019exon_skip_368285chr22:29329711-29329720-2.82-0.5640AP1B1ENST00000357586,ENST00000405198In-frame

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000224397ENST00000421019exon_skip_482403chr8:27445793-27445919-15.39-0.1729PTK2BENST00000346049,ENST00000397501In-frame

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for PELATON

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000224397.4ENST00000425497.4139254673
ENSG00000224397.4ENST00000445003.4137471884
ENSG00000224397.4ENST00000622604.3113169510
ENSG00000224397.4ENST00000422459.1137269682
ENSG00000224397.4ENST00000421019.1137277690