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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000224189

Summary for HAGLR

check button Gene summary

Gene informationEnsembl ID

ENSG00000224189

Gene symbol

HAGLR

Gene nameHOXD antisense growth-associated long non-coding RNA
HGNC

43755

Entrez ID

401022

Gene typeantisense
SynonymsHAGLR|02q31.1
UniProtAcc

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Structure and expression level for HAGLR

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002241893.987170e+023.259092e+002.406768e-011.354136e+018.910000e-425.480000e-40UPTHCA
ENSG000002241893.256245e+022.213368e+002.202768e-011.004812e+019.360000e-242.840000e-22UPHNSC
ENSG000002241898.144734e+02-1.276320e+002.932125e-01-4.352883e+001.340000e-054.830000e-05DOWNKIRP
ENSG000002241895.660543e+022.008953e+004.780898e-014.202042e+002.650000e-054.319380e-04UPESCA
ENSG000002241891.142602e+033.010035e+004.842691e-016.215626e+005.110000e-103.930000e-08UPPCPG
ENSG000002241891.062290e+03-1.602817e+001.746361e-01-9.178040e+004.390000e-202.860000e-19DOWNLUSC
ENSG000002241894.545062e+02-2.112783e+002.292307e-01-9.216841e+003.060000e-204.170000e-19DOWNCOAD
ENSG000002241892.649043e+026.251591e+003.571605e-011.750359e+011.350000e-686.720000e-66UPLIHC
ENSG000002241893.015973e+02-2.633889e+004.884115e-01-5.392767e+006.940000e-081.160000e-06DOWNREAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG00000224189-4.188900e-014.398534e-05KICH8.168706e-05
ENSG00000224189-4.081849e-018.173792e-26KIRC1.671912e-24
ENSG000002241893.613778e-018.752442e-14LIHC7.590008e-13
ENSG000002241893.024573e-011.942689e-13THCA1.795858e-12

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lncRNA-Protein interaction for HAGLR

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000224189ENST00000417086HAGLRENSG00000114982KANSL384.491.3038Q9P2N6EpiNA
ENSG00000224189ENST00000425005HAGLRENSG00000183337BCOR40.2794.3442Q6W2J9EpiNA
ENSG00000224189ENST00000436126HAGLRENSG00000197879MYO1C79.8791.4302O00159EpiNA
ENSG00000224189ENST00000436126HAGLRENSG00000084676NCOA173.5392.8453Q15788TF,EpiPredict
ENSG00000224189ENST00000417086HAGLRENSG00000197879MYO1C67.292.4258O00159EpiNA
ENSG00000224189ENST00000436126HAGLRENSG00000137337MDC160.5294.4437Q14676EpiNA
ENSG00000224189ENST00000425005HAGLRENSG00000084676NCOA139.9291.659Q15788TF,EpiPredict
ENSG00000224189ENST00000425005HAGLRENSG00000137337MDC133.4694.1262Q14676EpiNA
ENSG00000224189ENST00000549329HAGLRENSG00000197879MYO1C64.2790.0604O00159EpiNA
ENSG00000224189ENST00000549329HAGLRENSG00000137337MDC148.4291.2389Q14676EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000224189ENST00000436126HAGLRENSG00000084676NCOA173.5392.8713Q15788TF,EpiPredict
ENSG00000224189ENST00000416928HAGLRENSG00000184481FOXO465.7192.101P98177TFNA
ENSG00000224189ENST00000425005HAGLRENSG00000084676NCOA139.9290.7296Q15788TF,EpiPredict

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000224189ENST00000436126HAGLRENSG00000163510CWC2293.592.7707Q9HCG8RBPNA
ENSG00000224189ENST00000436126HAGLRENSG00000129566TEP182.5794.5356Q99973RBPNA
ENSG00000224189ENST00000417086HAGLRENSG00000163510CWC2282.2491.6423Q9HCG8RBPNA
ENSG00000224189ENST00000417086HAGLRENSG00000129566TEP172.6993.0594Q99973RBPNA

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lncRNA-DNA interaction for HAGLR

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.
Only predicted by TDF
COL4A5,PCYOX1,MGAT4A,PREPL,COL4A4,MTMR10,PAQR5,CDC42BPA,PKP4,MDC1,CYS1,FAM168B,STAM2,PAPSS1,UVRAG,RAB11FIP5,CLASP1,ADCY9,RNF144A,IL6R,TESK2,LARP6,CWC22,KANSL3,ATP2B1,LANCL1,SEMA4C,CYTH1,VAMP2,SLC41A1,MPC1,GALNT7,BCOR,POGZ,LRRFIP1,MTURN,ARHGAP19,MTUS1,ASAP3,WDSUB1,FNBP1,LPAR1,PPM1B,SEMA3G,BLZF1,IGSF3,TSN,HDHD2,PATZ1,SESTD1,ATP8A1,IWS1,LCOR,ARVCF,MBP,STRN,PTPN21,TTC21B,KIF1C,MYO1C,TMCC3,ZADH2,TRAK2,CBX7,MAP4K3,ITPKB,COL4A3,INPP1,SLC46A3,RAP1GAP,GGT6,GLTP,CLMN,SECISBP2L,HADHB,SMIM14,USP12,TMPRSS2,GRB14,JUP,SNX1,NCKAP1,LIPH,SLCO2A1,UBXN2A,TAPT1,RMND5A,CYBRD1,FMO5,EMCN,LGR4,CRMP1,NIPAL3,SP3,FARP2,STARD8,GNG7,SNX30,PLPP3,TMEM131,SORT1,ARHGEF37,TEP1,TMEM59,FGFR2,TDRKH,PAIP2B,CNNM2,ATF2
Exist in public source
NA

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for HAGLR

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
TBRG4
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for HAGLR

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation
ENSG00000224189ENSG00000070759TESK2ACC,COAD,GBM,KIRP,LGG,READCOAD,READ
ENSG00000224189ENSG00000070778PTPN21ACC,COAD,KIRC,LUSC,READCOAD,LUSC,READ
ENSG00000224189ENSG00000071073MGAT4AACC,COAD,KICH,READ,UCSCOAD,READ
ENSG00000224189ENSG00000071967CYBRD1ACC,KIRP,LUSC,READ,UVMKIRP,LUSC,READ
ENSG00000224189ENSG00000088280ASAP3ACC,COAD,READ,TGCT,UCSCOAD,READ
ENSG00000224189ENSG00000109586GALNT7ACC,COAD,LGG,READ,THCATHCAREAD
ENSG00000224189ENSG00000115290GRB14ACC,GBM,KICH,KIRC,KIRPKIRP
ENSG00000224189ENSG00000116005PCYOX1ACC,KICH,KIRC,KIRP,LUSC,TGCTKIRP,LUSC
ENSG00000224189ENSG00000129250KIF1CACC,COAD,GBM,LGG,LUSC,READ,TGCT,UVMLUSC
ENSG00000224189ENSG00000129422MTUS1ACC,COAD,KIRP,LGG,READKIRP,READ
ENSG00000224189ENSG00000130052STARD8ACC,KICH,KIRP,LUSC,TGCTKIRP,LUSC
ENSG00000224189ENSG00000139508SLC46A3ACC,COAD,KICH,LUSC,READCOAD,LUSC
ENSG00000224189ENSG00000143061IGSF3ACC,COAD,KICH,KIRC,UVMCOAD
ENSG00000224189ENSG00000143772ITPKBACC,HNSC,KICH,KIRC,KIRP,READKIRP,READ
ENSG00000224189ENSG00000152484USP12ACC,KICH,KIRP,LUSC,TGCT,UCSLUSC
ENSG00000224189ENSG00000162407PLPP3ACC,COAD,KICH,LUSC,READCOAD,LUSC,READ
ENSG00000224189ENSG00000163898LIPHACC,COAD,KIRC,READ,THCATHCACOAD,READ
ENSG00000224189ENSG00000166912MTMR10ACC,KICH,KIRC,LGG,READ,TGCTREAD
ENSG00000224189ENSG00000174640SLCO2A1ACC,COAD,KIRP,PRAD,READCOAD,READ
ENSG00000224189ENSG00000187231SESTD1ACC,HNSC,KICH,LUSC,PCPG,TGCT,UVMPCPGLUSC
ENSG00000224189ENSG00000197879MYO1CACC,COAD,KICH,LUSC,READLUSC
ENSG00000224189ENSG00000198121LPAR1ACC,COAD,KICH,LGG,READCOAD,READ
ENSG00000224189ENSG00000205213LGR4ACC,COAD,KICH,KIRC,KIRP,READCOAD,READ
ENSG00000224189ENSG00000116209TMEM59BLCA,COAD,KICH,KIRC,KIRP,LGG,READCOAD,READ
ENSG00000224189ENSG00000057704TMCC3COAD,GBM,LGG,PCPG,READPCPGCOAD,READ
ENSG00000224189ENSG00000060762MPC1COAD,KICH,KIRC,KIRP,READ,UVMCOAD,READ
ENSG00000224189ENSG00000066468FGFR2COAD,GBM,KICH,KIRC,LGG,LIHC,READCOAD,READ
ENSG00000224189ENSG00000070961ATP2B1COAD,HNSC,LIHC,READ,TGCTCOAD,READ
ENSG00000224189ENSG00000075568TMEM131COAD,KICH,KIRP,READ,TGCTCOAD
ENSG00000224189ENSG00000100307CBX7COAD,KIRP,LUSC,READ,TGCTCOAD,KIRP,LUSC,READ
ENSG00000224189ENSG00000124406ATP8A1COAD,GBM,LUSC,PCPG,PRAD,TGCT,UVMCOAD,LUSC
ENSG00000224189ENSG00000131781FMO5COAD,KIRC,LUAD,LUSC,READCOAD,LUSC,READ
ENSG00000224189ENSG00000137819PAQR5COAD,KICH,KIRC,KIRP,LUSC,READCOAD,KIRP,LUSC,READ
ENSG00000224189ENSG00000138029HADHBCOAD,KICH,KIRC,READ,TGCTCOAD
ENSG00000224189ENSG00000139433GLTPCOAD,GBM,LGG,LIHC,READCOAD,READ
ENSG00000224189ENSG00000148842CNNM2COAD,KICH,KIRC,KIRP,READCOAD,KIRP,READ
ENSG00000224189ENSG00000160712IL6RCOAD,LUAD,LUSC,OV,READ,TGCTCOAD,LUSC,READ
ENSG00000224189ENSG00000162104ADCY9COAD,KICH,LUAD,LUSC,READCOAD,LUSC,READ
ENSG00000224189ENSG00000163683SMIM14COAD,KICH,KIRC,KIRP,READCOAD,READ
ENSG00000224189ENSG00000165959CLMNCOAD,GBM,KIRC,KIRP,LGG,READ,TGCTCOAD,KIRP,READ
ENSG00000224189ENSG00000167741GGT6COAD,KICH,KIRC,KIRP,READCOAD,KIRP,READ
ENSG00000224189ENSG00000169762TAPT1COAD,GBM,KIRC,LUAD,LUSC,READLUSC
ENSG00000224189ENSG00000183111ARHGEF37COAD,GBM,LGG,READ,UVMCOAD,READ
ENSG00000224189ENSG00000184012TMPRSS2COAD,KIRC,KIRP,LUAD,LUSC,READCOAD,KIRP,LUSC,READ
ENSG00000224189ENSG00000220205VAMP2COAD,KICH,KIRC,READ,SARCCOAD,READ
ENSG00000224189ENSG00000099889ARVCFESCA,GBM,PCPG,SARC,TGCT,UVMPCPG
ENSG00000224189ENSG00000072832CRMP1GBM,KICH,PCPG,STAD,THCAPCPG
ENSG00000224189ENSG00000138593SECISBP2LGBM,LGG,LUSC,READ,TGCTLUSC,READ
ENSG00000224189ENSG00000138801PAPSS1GBM,KIRC,KIRP,LGG,LIHC,PCPGPCPG
ENSG00000224189ENSG00000144283PKP4GBM,KICH,KIRC,LGG,PCPG,UVMPCPG
ENSG00000224189ENSG00000151692RNF144AGBM,KIRC,KIRP,LGG,LIHC,READLIHCREAD
ENSG00000224189ENSG00000180354MTURNGBM,KIRC,KIRP,LGG,TGCTKIRP
ENSG00000224189ENSG00000187239FNBP1GBM,LGG,LIHC,READ,TGCTREAD
ENSG00000224189ENSG00000188153COL4A5GBM,KICH,KIRC,KIRP,LGGKIRP
ENSG00000224189ENSG00000081052COL4A4KICH,KIRC,KIRP,LUAD,LUSCKIRP,LUSC
ENSG00000224189ENSG00000124831LRRFIP1KICH,KIRC,KIRP,LUSC,READLUSC
ENSG00000224189ENSG00000134243SORT1KICH,KIRC,KIRP,LGG,LUSCLUSC
ENSG00000224189ENSG00000169031COL4A3KICH,KIRC,KIRP,LUAD,LUSCKIRP,LUSC
ENSG00000224189ENSG00000176533GNG7KICH,KIRC,KIRP,LUAD,LUSCKIRP,LUSC
ENSG00000224189ENSG00000205795CYS1KICH,KIRC,KIRP,LUSC,READLUSC,READ
ENSG00000224189ENSG00000076864RAP1GAPKIRC,KIRP,LUAD,LUSC,UCSKIRP,LUSC
ENSG00000224189ENSG00000164035EMCNKIRC,KIRP,LUSC,READ,UVMKIRP,LUSC,READ

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation
ENSG00000224189ENST00000416928TBRG4ENSG00000136270ENST00000258770-0.1318117LUSC,READ-
ENSG00000224189ENST00000416928TBRG4ENSG00000136270ENST00000361278-0.1318117LUSC,READ-
ENSG00000224189ENST00000416928TBRG4ENSG00000136270ENST00000395655-0.1318117LUSC,READ-
ENSG00000224189ENST00000416928TBRG4ENSG00000136270ENST00000494076-0.1318117LUSC,READ-
ENSG00000224189ENST00000436126TBRG4ENSG00000136270ENST00000258770-0.1672106LUSC,READ-
ENSG00000224189ENST00000436126TBRG4ENSG00000136270ENST00000361278-0.1672106LUSC,READ-
ENSG00000224189ENST00000436126TBRG4ENSG00000136270ENST00000395655-0.1672106LUSC,READ-
ENSG00000224189ENST00000436126TBRG4ENSG00000136270ENST00000494076-0.1672106LUSC,READ-
ENSG00000224189ENST00000447538TBRG4ENSG00000136270ENST00000258770-0.17101LUSC,READ-
ENSG00000224189ENST00000447538TBRG4ENSG00000136270ENST00000361278-0.17101LUSC,READ-
ENSG00000224189ENST00000447538TBRG4ENSG00000136270ENST00000395655-0.17101LUSC,READ-
ENSG00000224189ENST00000447538TBRG4ENSG00000136270ENST00000494076-0.17101LUSC,READ-
ENSG00000224189ENST00000546798TBRG4ENSG00000136270ENST00000258770-0.19171LUSC,READ-
ENSG00000224189ENST00000546798TBRG4ENSG00000136270ENST00000361278-0.19171LUSC,READ-
ENSG00000224189ENST00000546798TBRG4ENSG00000136270ENST00000395655-0.19171LUSC,READ-
ENSG00000224189ENST00000546798TBRG4ENSG00000136270ENST00000494076-0.19171LUSC,READ-
ENSG00000224189ENST00000413969TBRG4ENSG00000136270ENST00000258770-0.12031LUSC,READ-
ENSG00000224189ENST00000413969TBRG4ENSG00000136270ENST00000361278-0.12031LUSC,READ-
ENSG00000224189ENST00000413969TBRG4ENSG00000136270ENST00000395655-0.12031LUSC,READ-
ENSG00000224189ENST00000413969TBRG4ENSG00000136270ENST00000494076-0.12031LUSC,READ-
ENSG00000224189ENST00000552156TBRG4ENSG00000136270ENST00000258770-0.121315LUSC,READ-
ENSG00000224189ENST00000552156TBRG4ENSG00000136270ENST00000361278-0.121315LUSC,READ-
ENSG00000224189ENST00000552156TBRG4ENSG00000136270ENST00000395655-0.121315LUSC,READ-
ENSG00000224189ENST00000552156TBRG4ENSG00000136270ENST00000494076-0.121315LUSC,READ-
ENSG00000224189ENST00000456876TBRG4ENSG00000136270ENST00000258770-0.148256LUSC,READ-
ENSG00000224189ENST00000456876TBRG4ENSG00000136270ENST00000361278-0.148256LUSC,READ-
ENSG00000224189ENST00000456876TBRG4ENSG00000136270ENST00000395655-0.148256LUSC,READ-
ENSG00000224189ENST00000456876TBRG4ENSG00000136270ENST00000494076-0.148257LUSC,READ-
ENSG00000224189ENST00000425005TBRG4ENSG00000136270ENST00000258770-0.120170LUSC,READ-
ENSG00000224189ENST00000425005TBRG4ENSG00000136270ENST00000361278-0.120170LUSC,READ-
ENSG00000224189ENST00000425005TBRG4ENSG00000136270ENST00000395655-0.120170LUSC,READ-
ENSG00000224189ENST00000425005TBRG4ENSG00000136270ENST00000494076-0.120170LUSC,READ-
ENSG00000224189ENST00000452365TBRG4ENSG00000136270ENST00000258770-0.1053152LUSC,READ-
ENSG00000224189ENST00000452365TBRG4ENSG00000136270ENST00000361278-0.1053152LUSC,READ-
ENSG00000224189ENST00000452365TBRG4ENSG00000136270ENST00000395655-0.1053152LUSC,READ-
ENSG00000224189ENST00000452365TBRG4ENSG00000136270ENST00000494076-0.1053152LUSC,READ-

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000224189.5ENST00000416928.511726379
ENSG00000224189.5ENST00000417086.419234612
ENSG00000224189.5ENST00000547207.169887678
ENSG00000224189.5ENST00000436126.456277447
ENSG00000224189.5ENST00000447538.556478648
ENSG00000224189.5ENST00000549329.456285455
ENSG00000224189.5ENST00000546798.45639209
ENSG00000224189.5ENST00000413969.456314484
ENSG00000224189.5ENST00000552156.4652199
ENSG00000224189.5ENST00000456876.15692262
ENSG00000224189.5ENST00000425005.413240438
ENSG00000224189.5ENST00000452365.17311232