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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000223749

Summary for MIR503HG

check button Gene summary

Gene informationEnsembl ID

ENSG00000223749

Gene symbol

MIR503HG

Gene nameMIR503 host gene
HGNC

28258

Entrez ID
Gene typelincRNA
SynonymsXq26.3|MIR503HG
UniProtAcc

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Structure and expression level for MIR503HG

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000002237491.074656e+02-1.226976e+003.139384e-01-3.908332e+009.290000e-052.874600e-04DOWNKIRP
ENSG000002237499.008203e+01-3.525961e+003.260216e-01-1.081511e+012.920000e-278.070000e-26DOWNUCEC
ENSG000002237498.540616e+011.760594e+001.951166e-019.023290e+001.830000e-191.780000e-18UPLUAD
ENSG000002237496.324334e+013.893337e+005.098663e-017.635996e+002.240000e-141.520000e-12UPREAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000002237494.273526e-011.060413e-04ACC1.957685e-03
ENSG00000223749-4.923007e-019.576619e-07KICH2.708335e-06
ENSG00000223749-3.719239e-011.073624e-20UCEC6.481740e-19

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lncRNA-Protein interaction for MIR503HG

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000223749ENST00000441492MIR503HGENSG00000104885DOT1L70.8594.792Q8TEK3TF,EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000223749ENST00000445415MIR503HGENSG00000136630HLX7.1491.0712Q14774TFNA
ENSG00000223749ENST00000441492MIR503HGENSG00000167967E4F192.3695.2052Q66K89TFNA
ENSG00000223749ENST00000441492MIR503HGENSG00000074047GLI274.1896.7247P10070TFChIP-seq,catRAPID
ENSG00000223749ENST00000441492MIR503HGENSG00000104885DOT1L70.8594.7238Q8TEK3TF,EpiNA
ENSG00000223749ENST00000441492MIR503HGENSG00000136630HLX13.0292.2289Q14774TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000223749ENST00000441492MIR503HGENSG00000105705SUGP129.893.176Q8IWZ8RBPNA
ENSG00000223749ENST00000441492MIR503HGENSG00000089280FUS14.2192.9376P35637RBPHigh-throughput data combine LncPro prediction
ENSG00000223749ENST00000441492MIR503HGENSG00000149532CPSF75.993.753Q8N684RBPHigh-throughput data combine LncPro prediction,PAR-CLIP
ENSG00000223749ENST00000440570MIR503HGENSG00000124193SRSF618.6391.2337Q13247RBPNA

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lncRNA-DNA interaction for MIR503HG

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for MIR503HG

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000223749ENST00000441492exon_skip_302276chr19:10808568-10808580-5.45-0.9083DNM2ENST00000355667In-frame
ENSG00000223749ENST00000441492exon_skip_11029chr1:154989559-154989707-18.18-0.1317FLAD1ENST00000292180Frame-shift
ENSG00000223749ENST00000441492exon_skip_423795chr4:55888887-55888932-7.22-0.2329EXOC1ENST00000346134,ENST00000381295In-frame

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for MIR503HG

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000223749.6ENST00000440570.497255548
ENSG00000223749.6ENST00000414769.1772300
ENSG00000223749.6ENST00000445415.177628395
ENSG00000223749.6ENST00000457876.47525252
ENSG00000223749.6ENST00000441492.1117581228