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lncRNA: ENSG00000215386

Summary for MIR99AHG

Gene summary

Gene information	Ensembl ID	ENSG00000215386
	Gene symbol	MIR99AHG
	Gene name	mir-99a-let-7c cluster host gene
	HGNC	1274
	Entrez ID	388815
	Gene type	lincRNA
	Synonyms	MIR99AHG\|21q21.1
	UniProtAcc

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Structure and expression level for MIR99AHG

AS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.

Differentially expressed gene analysis between cancer and normal samples.

Ensembl ID	Base mean	log2FC(AD/control)	lfcSE	Stat	P-value	Adjc.p-value	DEG direction	Cancer type
ENSG00000215386	4.102308e+02	-1.023896e+00	2.516693e-01	-4.068420e+00	4.730000e-05	1.419510e-04	DOWN	KICH

Correlation between lncRNAs and cancer stages.

LncRNA Ensembl ID	Correlation	P-value	Cancer Type	Adjc.p-value
ENSG00000215386	-5.368784e-01	5.838261e-08	KICH	2.425587e-07
ENSG00000215386	-3.451640e-01	1.360156e-09	KIRP	1.432854e-08

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lncRNA-Protein interaction for MIR99AHG

lncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID	LncRNA ENST ID	LncRNA Name	Protein Ensembl ID	Protein Name	CatRAPID Score	Lncpro Score	UniPortID	Gene Subtype	Public source
ENSG00000215386	ENST00000619222	MIR99AHG	ENSG00000123636	BAZ2B	62.94	97.1428	Q9UIF8	TF,Epi	NA
ENSG00000215386	ENST00000418813	MIR99AHG	ENSG00000123636	BAZ2B	116.82	95.2211	Q9UIF8	TF,Epi	NA
ENSG00000215386	ENST00000602892	MIR99AHG	ENSG00000123636	BAZ2B	115.3	93.7721	Q9UIF8	TF,Epi	NA
ENSG00000215386	ENST00000441820	MIR99AHG	ENSG00000123636	BAZ2B	92.65	91.0089	Q9UIF8	TF,Epi	NA
ENSG00000215386	ENST00000419952	MIR99AHG	ENSG00000123636	BAZ2B	92.24	91.5223	Q9UIF8	TF,Epi	NA
ENSG00000215386	ENST00000400178	MIR99AHG	ENSG00000123636	BAZ2B	88.85	92.0612	Q9UIF8	TF,Epi	NA
ENSG00000215386	ENST00000602323	MIR99AHG	ENSG00000123636	BAZ2B	74.86	95.8823	Q9UIF8	TF,Epi	NA

lncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID	LncRNA ENST ID	LncRNA Name	Protein Ensembl ID	Protein Name	CatRAPID Score	Lncpro Score	UniPortID	Gene Subtype	Public source
ENSG00000215386	ENST00000602892	MIR99AHG	ENSG00000123636	BAZ2B	115.3	94.0785	Q9UIF8	TF,Epi	NA
ENSG00000215386	ENST00000441820	MIR99AHG	ENSG00000123636	BAZ2B	92.65	92.6353	Q9UIF8	TF,Epi	NA
ENSG00000215386	ENST00000602892	MIR99AHG	ENSG00000185630	PBX1	8.07	91.3626	P40424	TF	NA
ENSG00000215386	ENST00000602892	MIR99AHG	ENSG00000134138	MEIS2	5.81	91.757	O14770	TF	NA
ENSG00000215386	ENST00000418813	MIR99AHG	ENSG00000123636	BAZ2B	116.82	94.6569	Q9UIF8	TF,Epi	NA
ENSG00000215386	ENST00000619222	MIR99AHG	ENSG00000123636	BAZ2B	62.94	97.1023	Q9UIF8	TF,Epi	NA
ENSG00000215386	ENST00000619222	MIR99AHG	ENSG00000256223	ZNF10	14.36	93.0154	P21506	TF	NA
ENSG00000215386	ENST00000418813	MIR99AHG	ENSG00000134138	MEIS2	5.33	91.2112	O14770	TF	NA
ENSG00000215386	ENST00000419952	MIR99AHG	ENSG00000123636	BAZ2B	92.24	90.0094	Q9UIF8	TF,Epi	NA
ENSG00000215386	ENST00000400178	MIR99AHG	ENSG00000123636	BAZ2B	88.85	92.2521	Q9UIF8	TF,Epi	NA
ENSG00000215386	ENST00000602323	MIR99AHG	ENSG00000123636	BAZ2B	74.86	95.9106	Q9UIF8	TF,Epi	NA

lncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).

LncRNA Ensembl ID	LncRNA ENST ID	LncRNA Name	Protein Ensembl ID	Protein Name	CatRAPID Score	Lncpro Score	UniPortID	Gene Subtype	Public source
ENSG00000215386	ENST00000602323	MIR99AHG	ENSG00000163728	TTC14	54.09	91.1965	Q96N46	RBP	NA
ENSG00000215386	ENST00000418813	MIR99AHG	ENSG00000163728	TTC14	82.38	92.4815	Q96N46	RBP	NA

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lncRNA-DNA interaction for MIR99AHG

lncRNA targets the enhancer region and positively regulates the gene expression.

Only predicted by TDF

BAZ2B,NFIA,MEIS2,ZNF10,TTC14

Exist in public source

lncRNA targets the promoter region and positively regulates the gene expression.

lncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for MIR99AHG

lncRNA targets the 3'UTR region and negatively regulates the mRNA.

lncRNA targets the skipped exon region.

-lncRNA and exonskipping events are positively correlated.

LncRNA Ensembl ID

LncRNA ENST ID

Exon ID

Skipped Exon

ndG

Gene name with skipped exon

TransID with skipped exon

ORF mutation

-lncRNA and exonskipping events are negatively correlated.

LncRNA Ensembl ID

LncRNA ENST ID

Exon ID

Skipped Exon

ndG

Gene name with skipped exon

TransID with skipped exon

LOF

lncRNA targets by miRNA.

LncRNA Ensembl ID

miRNA ID

LncRNA ENST ID

Binding site in lncRNA

Score

Energy

Align Len

Public source

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Variants for MIR99AHG

RNA A-to-I editing events in lncRNA.

LncRNAediting ID	LncRNA Ensembl ID	Chromosome	Editing Position	Strand	Gene Type	Gene Name	Transcript ID	Transcript Type	Transcript Name
LncEditing_371183	ENSG00000215386.9	chr21	16527894	+	lincRNA	MIR99AHG	ENST00000619222.3	lincRNA	MIR99AHG-001
LncEditing_373426	ENSG00000215386.9	chr21	16607509	+	lincRNA	MIR99AHG	ENST00000619222.3	lincRNA	MIR99AHG-001

Edited-associated DElncRNAs in cancer.

LncRNA Ensembl ID	LncRNA Index	Cancer Type	Chr_Postion_Strand	AVE1	AVE2	log2FC	W-value	P-value	Adjc.p-value	Change
ENSG00000215386	LncEditing_373426	GBM	chr21_16607509_+	4.796385e+00	2.901161e+00	1.378707e+00	4.481211e+00	7.422058e-06	1.250926e-05	UP
ENSG00000215386	LncEditing_373426	LGG	chr21_16607509_+	5.018600e+00	3.375316e+00	1.747450e+00	9.573549e+00	1.032980e-21	3.440018e-21	UP
ENSG00000215386	LncEditing_371183	OV	chr21_16527894_+	2.435162e+00	1.292728e+00	1.094572e+00	4.534595e+00	5.771424e-06	7.166542e-06	UP

Correlation between RNA A-to-I editing events's frequecy and lncRNA expression.

LncRNA Ensembl ID

LncRNA Index

Correlation

P-value

Adjc.p-value

Cis-expression quantitative trait loci(cis-eQTL) of lncRNA.

LncRNA Ensembl ID

LncRNA Name

SNP info

Number of Positive corelated Cancer

Positive corelated Cancer

Number of Negative corelated Cancer

Negative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncRNA regulates differentially expressed genes by function as enhancer.

LncRNA Ensembl ID

PC Gene ID

PC Gene Name

Positive correlated cancers

Cancer with PC gene up-regulation

Cancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

LncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).

lncRNA ID

TF ID

TF Name

PCgene ID

PCgene Name

Number of Cancer

Canaer Types

LncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).

lncRNA ID

TF ID

TF Name

PCgene ID

PCgene Name

Number of Cancer

Canaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

LncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.

LncRNA Ensembl ID

RBP ID

RBP Gene Name

Exon Skipping ID

Skipped Exon

EX Gene Name

EX Affected TransID

ORF_anno

Cancer Type

LncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.

LncRNA Ensembl ID

RBP ID

RBP Gene Name

Exon Skipping ID

Skipped Exon

EX Gene Name

EX Affected TransID

ORF_anno

Cancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.

LncRNA Ensembl ID

LncRNA ENST ID

PC Gene Name

PC Gene ID

PC ENST ID

nDG

Cancer with PC gene up-regulation

Cancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncRNA regulates mRNA by competing the miRNA binding site with mRNA.

LncRNA Ensembl ID

lncRNA-miRNA-mRNA

Cancer Types

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lncRNA coding potential

ORFfinder result for the gencode.v22.lncRNA.transcript.fa.

lncRNA Ensembl ID	lncRNA ENST ID	length(AA)	start at transcript	end at transcript
ENSG00000215386.9	ENST00000602580.4	71	524	309
ENSG00000215386.9	ENST00000619222.3	91	65	340
ENSG00000215386.9	ENST00000602935.4	91	65	340
ENSG00000215386.9	ENST00000400178.5	106	28	348
ENSG00000215386.9	ENST00000456342.4	91	38	313
ENSG00000215386.9	ENST00000428669.5	119	603	244
ENSG00000215386.9	ENST00000419952.4	86	338	78
ENSG00000215386.9	ENST00000445461.5	125	433	56
ENSG00000215386.9	ENST00000602505.4	179	579	40
ENSG00000215386.9	ENST00000602339.4	53	150	311
ENSG00000215386.9	ENST00000602892.4	53	221	382
ENSG00000215386.9	ENST00000418813.5	63	262	453
ENSG00000215386.9	ENST00000435697.1	77	569	336
ENSG00000215386.9	ENST00000453910.4	63	158	349
ENSG00000215386.9	ENST00000602620.1	63	72	263
ENSG00000215386.9	ENST00000441820.4	73	326	105
ENSG00000215386.9	ENST00000602280.4	45	325	188
ENSG00000215386.9	ENST00000602323.1	77	474	241

	lncRNA summary
	lncRNA structure and expression level
	lncRNA-Protein interaction
	lncRNA-DNA interaction
	lncRNA-RNA interaction
	Variants in lncRNA
	lncRNAs regulate the target genes through functioning as enhancers
	lncRNAs regulate the target genes through recruiting transcript factors
	lncRNAs regulate the alternative splicing events through interacting with splicing factor
	lncRNAs regulate mRNA through targeting the 3'-UTR region
	lncRNAs regulate mRNA by competing with miRNA
	lncRNA coding potential