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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000188242

Summary for PP7080

check button Gene summary

Gene informationEnsembl ID

ENSG00000188242

Gene symbol

PP7080

Gene name
HGNC
Entrez ID

25845

Gene typeantisense
Synonyms
UniProtAcc

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Structure and expression level for PP7080

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000001882422.165982e+03-2.439976e+001.414538e-01-1.724928e+011.130000e-664.930000e-65DOWNKIRC
ENSG000001882423.486538e+03-2.861393e+001.782760e-01-1.605036e+015.680000e-581.100000e-55DOWNKICH
ENSG000001882421.605956e+03-3.242771e+001.695204e-01-1.912909e+011.450000e-813.630000e-78DOWNKIRP
ENSG000001882424.695890e+03-1.817381e+004.509117e-01-4.030460e+005.570000e-057.922490e-04DOWNESCA
ENSG000001882421.080463e+031.559877e+001.140252e-011.368011e+011.330000e-422.450000e-41UPLUSC
ENSG000001882426.916817e+021.003403e+009.738220e-021.030376e+016.780000e-259.690000e-24UPLUAD
ENSG000001882421.932959e+03-3.284652e+001.976273e-01-1.662044e+014.960000e-628.790000e-60DOWNCOAD
ENSG000001882424.584193e+021.204926e+001.600919e-017.526467e+005.210000e-145.170000e-13UPLIHC

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000001882425.182298e-012.658929e-04CHOL6.126465e-04
ENSG00000188242-4.704633e-013.283835e-06KICH8.044896e-06
ENSG00000188242-3.410665e-014.998748e-18KIRC2.959785e-17
ENSG00000188242-3.084923e-017.419305e-08KIRP5.151359e-07
ENSG000001882424.124251e-017.377970e-18LIHC2.155144e-16

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lncRNA-Protein interaction for PP7080

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000188242ENST00000510604PP7080ENSG00000147130ZMYM344.2394.2483Q14202EpiPredict
ENSG00000188242ENST00000510604PP7080ENSG00000183337BCOR43.6692.091Q6W2J9EpiChIP-seq
ENSG00000188242ENST00000510604PP7080ENSG00000154832CXXC133.0790.7387Q9P0U4TF,EpiNA
ENSG00000188242ENST00000510604PP7080ENSG00000157212PAXIP140.192.2786Q6ZW49EpiNA
ENSG00000188242ENST00000510604PP7080ENSG00000141582CBX416.2992.0773O00257EpiNA
ENSG00000188242ENST00000510604PP7080ENSG00000149929HIRIP312.9791.2354Q9BW71EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000188242ENST00000510604PP7080ENSG00000174282ZBTB466.5491.6862Q9P1Z0TFNA
ENSG00000188242ENST00000510714PP7080ENSG00000236287ZBED536.6490.1955Q49AG3TFNA
ENSG00000188242ENST00000510604PP7080ENSG00000154832CXXC133.0790.7264Q9P0U4TF,EpiNA
ENSG00000188242ENST00000510604PP7080ENSG00000236287ZBED531.4892.0564Q49AG3TFNA
ENSG00000188242ENST00000510604PP7080ENSG00000147789ZNF728.4890.7728P17097TFNA
ENSG00000188242ENST00000510604PP7080ENSG00000105708ZNF1414.7290.639P17017TFNA
ENSG00000188242ENST00000510604PP7080ENSG00000196378ZNF348.2491.4291Q8IZ26TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000188242ENST00000510604PP7080ENSG00000106344RBM2845.5292.1846Q9NW13RBPNA

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lncRNA-DNA interaction for PP7080

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for PP7080

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.
Only predicted by lncTar
FCGR2A
Exist in public source
NA

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000188242ENST00000502511exon_skip_60345chr11:63903985-63904147-25.76-0.1853MARK2ENST00000402010In-frame

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000188242ENST00000502511exon_skip_436498chr5:96729152-96729209-5.80-0.1055CASTENST00000341926,ENST00000395813In-frame

check buttonlncRNA targets by miRNA.
lncRNA targets by miRNA
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source
ENSG00000188242hsa-mir-21ENST00000510714chr5:466161-466240160.00-82.5271NA
ENSG00000188242hsa-mir-21ENST00000510714chr5:466380-466449160.00-70.6672NA
ENSG00000188242hsa-mir-21ENST00000510714chr5:466287-466364157.00-58.3270NA
ENSG00000188242hsa-mir-21ENST00000510714chr5:466456-466528147.00-78.0371NA
ENSG00000188242hsa-mir-21ENST00000342584chr5:471755-471822162.00-60.0067NA
ENSG00000188242hsa-mir-21ENST00000342584chr5:470769-470848160.00-82.5271NA
ENSG00000188242hsa-mir-21ENST00000342584chr5:471503-471575160.00-67.9668NA
ENSG00000188242hsa-mir-21ENST00000342584chr5:471294-471372159.00-85.8678NA
ENSG00000188242hsa-mir-21ENST00000342584chr5:471032-471105158.00-58.5172NA
ENSG00000188242hsa-mir-21ENST00000342584chr5:471612-471692158.00-62.3179NA
ENSG00000188242hsa-mir-21ENST00000342584chr5:471866-471938157.00-73.9470NA
ENSG00000188242hsa-mir-21ENST00000342584chr5:472287-472360153.00-64.9067NA
ENSG00000188242hsa-mir-21ENST00000342584chr5:471214-471285152.00-55.3471NA
ENSG00000188242hsa-mir-21ENST00000342584chr5:470882-470955147.00-68.6274NA
ENSG00000188242hsa-mir-21ENST00000510604chr5:471368-471447160.00-82.5271NA
ENSG00000188242hsa-mir-21ENST00000510604chr5:471960-472032160.00-67.9668NA
ENSG00000188242hsa-mir-21ENST00000510604chr5:471751-471829159.00-85.8678NA
ENSG00000188242hsa-mir-21ENST00000510604chr5:471671-471742152.00-55.3471NA
ENSG00000188242hsa-mir-21ENST00000510604chr5:471494-471562151.00-60.9867NA
ENSG00000188242hsa-mir-21ENST00000510604chr5:472032-472106145.00-66.7872NA
ENSG00000188242hsa-mir-21ENST00000502511chr5:472297-472368168.00-71.7870NA
ENSG00000188242hsa-mir-21ENST00000502511chr5:472211-472283157.00-80.7568NA
ENSG00000188242hsa-mir-21ENST00000502511chr5:472124-472196151.00-76.6572NA
ENSG00000188242hsa-mir-21ENST00000502511chr5:472585-472657140.00-71.2765NA

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Variants for PP7080

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation
ENSG00000188242ENST00000510714FCGR2AENSG00000143226ENST00000536731-0.16286KIRC,KIRP,ESCALUSC
ENSG00000188242ENST00000342584FCGR2AENSG00000143226ENST00000536731-0.2281738KIRC,KIRP,ESCALUSC
ENSG00000188242ENST00000510604FCGR2AENSG00000143226ENST00000536731-0.2281458KIRC,KIRP,ESCALUSC
ENSG00000188242ENST00000502511FCGR2AENSG00000143226ENST00000536731-0.172412KIRC,KIRP,ESCALUSC

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000188242.4ENST00000510714.120078680
ENSG00000188242.4ENST00000342584.396578288
ENSG00000188242.4ENST00000510604.11821253705
ENSG00000188242.4ENST00000502511.1129814425