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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000179406

Summary for LINC00174

check button Gene summary

Gene informationEnsembl ID

ENSG00000179406

Gene symbol

LINC00174

Gene namelong intergenic non-protein coding RNA 174
HGNC

27788

Entrez ID

285908

Gene typelincRNA
Synonyms07q11.21|LINC00174
UniProtAcc

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Structure and expression level for LINC00174

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000001794065.477236e+021.504266e+001.295844e-011.160839e+013.740000e-314.020000e-30UPKIRC
ENSG000001794065.755918e+021.831149e+001.819359e-011.006480e+017.900000e-242.410000e-22UPHNSC
ENSG000001794067.867951e+021.324798e+002.004974e-016.607561e+003.910000e-113.310000e-10UPKIRP
ENSG000001794063.062835e+02-1.549047e+003.937496e-01-3.934092e+008.350000e-051.561710e-03DOWNPCPG
ENSG000001794066.004494e+021.053011e+001.491232e-017.061347e+001.650000e-126.870000e-12UPLUSC
ENSG000001794062.042654e+021.002442e+001.477092e-016.786588e+001.150000e-117.540000e-11UPCOAD
ENSG000001794062.481601e+021.601614e+002.748543e-015.827140e+005.640000e-091.240000e-07UPREAD

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG000001794064.883066e-016.664717e-04CHOL1.245561e-03

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lncRNA-Protein interaction for LINC00174

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000179406ENST00000416572LINC00174ENSG00000272333KMT2B40.0794.0135Q9UMN6TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000104885DOT1L66.4696.4455Q8TEK3TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000263001GTF2I60.0396.6561P78347TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000101126ADNP46.2695.5028Q9H2P0TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000010803SCMH146.0792.1703Q96GD3TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000112511PHF141.6292.7931O43189TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000143033MTF235.9395.1219Q9Y483TF,EpiNA
ENSG00000179406ENST00000416572LINC00174ENSG00000076108BAZ2A57.1290.1713Q9UIF9TF,RBP,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000198919DZIP371.7796.6148Q86Y13RBP,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000277258PCGF268.5891.6288P35227TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000155363MOV1056.1895.9726Q9HCE1RBP,EpiCLIP,iCLIP,PAR-CLIP,High-throughput data;GSE70061

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000179406ENST00000416572LINC00174ENSG00000118058KMT2A72.3195.4131Q03164TF,EpiNA
ENSG00000179406ENST00000416572LINC00174ENSG00000124782RREB165.5192.8335Q92766TFNA
ENSG00000179406ENST00000416572LINC00174ENSG00000196867ZFP2860.6991.8588Q8NHY6TFNA
ENSG00000179406ENST00000416572LINC00174ENSG00000187605TET358.9792.7617O43151TF,EpiNA
ENSG00000179406ENST00000416572LINC00174ENSG00000076108BAZ2A57.1293.8195Q9UIF9TF,RBP,EpiNA
ENSG00000179406ENST00000416572LINC00174ENSG00000171634BPTF53.9794.3701Q12830TF,EpiNA
ENSG00000179406ENST00000416572LINC00174ENSG00000159140SON50.9792.856P18583TF,RBPNA
ENSG00000179406ENST00000416572LINC00174ENSG00000272333KMT2B40.0795.1034Q9UMN6TF,EpiNA
ENSG00000179406ENST00000416572LINC00174ENSG00000126705AHDC124.6591.7403Q5TGY3TFNA
ENSG00000179406ENST00000416572LINC00174ENSG00000185670ZBTB37.6791.3811Q9H5J0TFNA
ENSG00000179406ENST00000421767LINC00174ENSG00000236287ZBED579.1493.4451Q49AG3TFNA
ENSG00000179406ENST00000421767LINC00174ENSG00000168152THAP968.7894.5213Q9H5L6TFNA
ENSG00000179406ENST00000421767LINC00174ENSG00000277258PCGF268.5893.0489P35227TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000147862NFIB68.290.6833O00712TFNA
ENSG00000179406ENST00000421767LINC00174ENSG00000104885DOT1L66.4696.6521Q8TEK3TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000263001GTF2I60.0396.7791P78347TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000170581STAT257.7495.5256P52630TFChIP-seq
ENSG00000179406ENST00000421767LINC00174ENSG00000197857ZNF4457.2592.3098P15621TFNA
ENSG00000179406ENST00000421767LINC00174ENSG00000186272ZNF1749.7891.6193P17021TFNA
ENSG00000179406ENST00000421767LINC00174ENSG00000158711ELK447.1790.2632P28324TFNA
ENSG00000179406ENST00000421767LINC00174ENSG00000140993TIGD746.6695.4924Q6NT04TFNA
ENSG00000179406ENST00000421767LINC00174ENSG00000101126ADNP46.2695.6568Q9H2P0TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000010803SCMH146.0793.0084Q96GD3TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000102878HSF445.9592.7792Q9ULV5TFNA
ENSG00000179406ENST00000421767LINC00174ENSG00000112511PHF141.6293.1809O43189TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000221944TIGD139.5195.1697Q96MW7TFNA
ENSG00000179406ENST00000421767LINC00174ENSG00000143033MTF235.9395.1082Q9Y483TF,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000196378ZNF3434.0794.4205Q8IZ26TFNA
ENSG00000179406ENST00000421767LINC00174ENSG00000126456IRF329.1493.5562Q14653TFNA
ENSG00000179406ENST00000421767LINC00174ENSG00000128604IRF527.8494.2542Q13568TFNA
ENSG00000179406ENST00000421767LINC00174ENSG00000205250E2F414.7190.7076Q16254TFChIP-seq

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000179406ENST00000421767LINC00174ENSG00000162927PUS1082.3493.4627Q3MIT2RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000079134THOC177.8395.6713Q96FV9RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000082898XPO173.5991.6947O14980RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000278619MRM171.9990.866Q6IN84RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000198919DZIP371.7796.7972Q86Y13RBP,EpiNA
ENSG00000179406ENST00000421767LINC00174ENSG00000156304SCAF467.1596.2376O95104RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000122965RBM1963.1695.5047Q9Y4C8RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000160917CPSF462.0992.109O95639RBPPAR-CLIP
ENSG00000179406ENST00000421767LINC00174ENSG00000126070AGO359.7894.9872Q9H9G7RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000162408NOL959.6494.5054Q5SY16RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000155363MOV1056.1896.2372Q9HCE1RBP,EpiCLIP,iCLIP,PAR-CLIP,High-throughput data;GSE70061
ENSG00000179406ENST00000421767LINC00174ENSG00000129566TEP154.9997.3401Q99973RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000139746RBM2654.2693.3498Q5T8P6RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000136271DDX5649.8994.8969Q9NY93RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000117569PTBP249.1691.6862Q9UKA9RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000135870RC3H148.1795.2225Q5TC82RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000071894CPSF143.4395.7374Q10570RBPPAR-CLIP
ENSG00000179406ENST00000421767LINC00174ENSG00000241058NSUN637.293.058Q8TEA1RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000111364DDX5533.7394.746Q8NHQ9RBPNA
ENSG00000179406ENST00000421767LINC00174ENSG00000179151EDC331.3494.6789Q96F86RBPNA
ENSG00000179406ENST00000416572LINC00174ENSG00000198000NOL863.5390.0081Q76FK4RBPNA
ENSG00000179406ENST00000416572LINC00174ENSG00000106344RBM2861.1890.3595Q9NW13RBPNA
ENSG00000179406ENST00000416572LINC00174ENSG00000076108BAZ2A57.1293.5278Q9UIF9TF,RBP,EpiNA
ENSG00000179406ENST00000416572LINC00174ENSG00000159140SON50.9793.0341P18583TF,RBPNA
ENSG00000179406ENST00000416572LINC00174ENSG00000135870RC3H143.091.3881Q5TC82RBPNA
ENSG00000179406ENST00000416572LINC00174ENSG00000156304SCAF436.894.1376O95104RBPNA
ENSG00000179406ENST00000416572LINC00174ENSG00000129351ILF332.9692.9987Q12906RBPENCODE,eCLIP
ENSG00000179406ENST00000416572LINC00174ENSG00000111605CPSF610.3490.276Q16630RBPeCLIP,PAR-CLIP
ENSG00000179406ENST00000416572LINC00174ENSG00000149532CPSF73.7890.8929Q8N684RBPHigh-throughput data,PAR-CLIP

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lncRNA-DNA interaction for LINC00174

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for LINC00174

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000179406ENST00000416366exon_skip_470077chr7:102397619-102397698-16.26-1.0163PRKRIP1ENST00000397912,ENST00000496391Frame-shift

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000179406ENST00000416366exon_skip_38175chr1:234398381-234398553-19.55-0.1470TARBP1ENST00000040877Frame-shift
ENSG00000179406ENST00000416366exon_skip_66482chr11:126274926-126275021-18.00-0.2022FOXRED1ENST00000263578Frame-shift
ENSG00000179406ENST00000416366exon_skip_111863chr14:23565815-23565892-17.99-0.2464AP1G2ENST00000308724,ENST00000397120Frame-shift
ENSG00000179406ENST00000416366exon_skip_382458chr3:38131595-38131638-9.86-0.2595ACAA1ENST00000333167Frame-shift
ENSG00000179406ENST00000416366exon_skip_41813chr10:68337857-68337996-17.45-0.1419HNRNPH3ENST00000265866Frame-shift
ENSG00000179406ENST00000416366exon_skip_95407chr12:95040475-95040597-15.88-0.1393NR2C1ENST00000333003Frame-shift
ENSG00000179406ENST00000416366exon_skip_133217chr16:8635038-8635079-10.24-0.2844METTL22ENST00000381920Frame-shift
ENSG00000179406ENST00000416366exon_skip_309204chr19:49181348-49181461-24.70-0.2573TRPM4ENST00000252826Frame-shift
ENSG00000179406ENST00000416366exon_skip_370518chr22:50247691-50247776-18.25-0.3259HDAC10ENST00000216271Frame-shift
ENSG00000179406ENST00000416366exon_skip_380242chr3:186784961-186785101-14.74-0.1391EIF4A2ENST00000323963Frame-shift
ENSG00000179406ENST00000438894exon_skip_387016chr3:121788283-121788432-11.92-0.1310IQCB1ENST00000310864Frame-shift
ENSG00000179406ENST00000416366exon_skip_436035chr5:79656957-79657001-13.59-0.4384TENT2ENST00000296783,ENST00000428308,ENST00000453514Frame-shift
ENSG00000179406ENST00000416366exon_skip_442657chr5:74730259-74730398-19.10-0.1661GFM2ENST00000296805,ENST00000509430Frame-shift
ENSG00000179406ENST00000416366exon_skip_4796chr1:41007448-41007545-15.69-0.2615CTPS1ENST00000372616,ENST00000372621Frame-shift
ENSG00000179406ENST00000416366exon_skip_7523chr1:78660553-78660654-14.53-0.1772IFI44ENST00000370747Frame-shift
ENSG00000179406ENST00000416366exon_skip_9446chr1:147270931-147271005-13.21-0.3002CHD1LENST00000369258Frame-shift
ENSG00000179406ENST00000416366exon_skip_41841chr10:68756272-68756483-27.16-0.1509CCAR1ENST00000265872Frame-shift
ENSG00000179406ENST00000416366exon_skip_53559chr10:101793912-101793998-12.79-0.1523OGAENST00000361464Frame-shift
ENSG00000179406ENST00000416366exon_skip_74009chr11:64773429-64773505-15.81-0.2875SF1ENST00000377390Frame-shift
ENSG00000179406ENST00000416366exon_skip_114365chr14:74290026-74290118-16.51-0.1795ABCD4ENST00000356924Frame-shift
ENSG00000179406ENST00000416366exon_skip_114376chr14:74293153-74293248-16.91-0.3020ABCD4ENST00000356924Frame-shift
ENSG00000179406ENST00000416366exon_skip_139422chr16:89114338-89114487-24.31-0.1814ACSF3ENST00000317447,ENST00000406948Frame-shift
ENSG00000179406ENST00000416366exon_skip_290158chr17:42953723-42953778-11.77-0.2402AARSD1ENST00000427569Frame-shift
ENSG00000179406ENST00000416366exon_skip_300663chr19:1425877-1425960-9.60-0.1263DAZAP1ENST00000233078Frame-shift
ENSG00000179406ENST00000416366exon_skip_302168chr19:10680345-10680443-12.83-0.1584ILF3ENST00000590261Frame-shift
ENSG00000179406ENST00000416366exon_skip_326885chr2:74490024-74490127-20.82-0.2479TTC31ENST00000233623Frame-shift
ENSG00000179406ENST00000416366exon_skip_327433chr2:86125794-86125880-5.88-0.1307PTCD3ENST00000254630Frame-shift
ENSG00000179406ENST00000416366exon_skip_327748chr2:95410863-95411026-21.88-0.1439FAHD2AENST00000233379,ENST00000447036Frame-shift
ENSG00000179406ENST00000416366exon_skip_353131chr20:58669290-58669453-29.57-0.1945STX16ENST00000371141Frame-shift
ENSG00000179406ENST00000416366exon_skip_370525chr22:50250426-50250523-19.10-0.1969HDAC10ENST00000216271Frame-shift
ENSG00000179406ENST00000416366exon_skip_446770chr5:178215275-178215430-20.84-0.1437PHYKPLENST00000308158Frame-shift
ENSG00000179406ENST00000416366exon_skip_470226chr7:103307595-103307708-16.16-0.1816PMPCBENST00000249269Frame-shift
ENSG00000179406ENST00000416366exon_skip_499390chr9:127808557-127808705-29.84-0.2508FPGSENST00000373247Frame-shift
ENSG00000179406ENST00000416366exon_skip_511212chrX:71555189-71555385-23.37-0.1224OGTENST00000373719Frame-shift
ENSG00000179406ENST00000416366exon_skip_59071chr11:47234756-47234934-20.74-0.1620DDB2ENST00000256996Frame-shift
ENSG00000179406ENST00000416366exon_skip_377198chr3:123130479-123130616-20.90-0.1850PDIA5ENST00000316218Frame-shift
ENSG00000179406ENST00000416366exon_skip_489575chr8:47782161-47782254-13.88-0.1542PRKDCENST00000314191In-frame
ENSG00000179406ENST00000416366exon_skip_131398chr15:101286213-101286293-10.91-0.2480SNRPA1ENST00000254193Frame-shift

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for LINC00174

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA-RBP complex negative regulation
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type
ENSG00000179406ENSG00000241058NSUN6exon_skip_382458ENSG00000060971:chr3:38131595-38131638ACAA1ENST00000333167Frame-shiftSARC,UVM,SKCM,OV,MESO,PCPG,PAAD,THCA
ENSG00000179406ENSG00000139746RBM26exon_skip_382458ENSG00000060971:chr3:38131595-38131638ACAA1ENST00000333167Frame-shiftSARC,STAD,UVM,PAAD,THCA
ENSG00000179406ENSG00000079134THOC1exon_skip_382458ENSG00000060971:chr3:38131595-38131638ACAA1ENST00000333167Frame-shiftSTAD,UVM,SKCM,OV,PRAD,UCS,PCPG,PAAD,THCA
ENSG00000179406ENSG00000079134THOC1exon_skip_370518ENSG00000100429:chr22:50247691-50247776HDAC10ENST00000216271Frame-shiftUVM,SKCM,PRAD,PCPG,PAAD
ENSG00000179406ENSG00000079134THOC1exon_skip_442657ENSG00000164347:chr5:74730259-74730398GFM2ENST00000296805,ENST00000509430Frame-shiftUVM,SKCM,UCS,PCPG,PAAD,THCA
ENSG00000179406ENSG00000079134THOC1exon_skip_470226ENSG00000105819:chr7:103307595-103307708PMPCBENST00000249269Frame-shiftUVM,SKCM,PRAD,UCS,PCPG,PAAD,THCA

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000179406.6ENST00000421767.15686256
ENSG00000179406.6ENST00000416572.123730763789
ENSG00000179406.6ENST00000438894.162197385
ENSG00000179406.6ENST00000416366.1762232