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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000248508

Summary for SRP14-DT

check button Gene summary

Gene informationEnsembl ID

ENSG00000248508

Gene symbol

SRP14-DT

Gene nameSRP14 divergent transcript
HGNC

48619

Entrez ID

100131089

Gene typelincRNA
Synonyms15q15.1|SRP14-AS1|SRP14-DT
UniProtAcc

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Structure and expression level for SRP14-DT

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value
ENSG00000248508-3.595232e-015.396775e-04KICH7.823383e-04
ENSG00000248508-3.596148e-012.422824e-10KIRP3.218143e-09
ENSG00000248508-3.200378e-016.032377e-15THCA9.048565e-14

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lncRNA-Protein interaction for SRP14-DT

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
Epi result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000116560SFPQ31.6892.3285P23246RBP,EpiNA
ENSG00000248508ENST00000504245SRP14-AS1ENSG00000083544TDRD336.2590.4738Q9H7E2RBP,EpiNA

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
TF result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000167967E4F160.1891.9361Q66K89TFNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000130254SAFB258.5493.7347Q14151TF,RBPENCODE
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000105127AKAP852.5394.0393O43823TFNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000099326MZF148.1592.6799P28698TFNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000070476ZXDC42.5291.8712Q2QGD7TFNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000196670ZFP6236.2493.0932Q8NB50TFNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000126804ZBTB134.7892.0903Q9Y2K1TFNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000198040ZNF8431.1191.2467P51523TFNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000168795ZBTB525.6492.7306O15062TFNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000166432ZMAT123.0492.7459Q5H9K5TFNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000186272ZNF1722.9591.6884P17021TFNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000167766ZNF838.8292.2965P51522TFChIP-seq
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000185670ZBTB34.3690.1123Q9H5J0TFNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000154957ZNF183.8390.749P17022TFNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000112511PHF13.3390.1939O43189TF,EpiNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000143390RFX52.8394.0077P48382TFChIP-seq
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000275111ZNF22.7692.2092Q9BSG1TFNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000175395ZNF251.6692.1709P17030TFNA
ENSG00000248508ENST00000504245SRP14-AS1ENSG00000130254SAFB287.3691.337Q14151TF,RBPENCODE
ENSG00000248508ENST00000504245SRP14-AS1ENSG00000196378ZNF3410.4790.5482Q8IZ26TFNA

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
RBP result
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source
ENSG00000248508ENST00000504245SRP14-AS1ENSG00000130254SAFB287.3691.3356Q14151TF,RBPENCODE
ENSG00000248508ENST00000504245SRP14-AS1ENSG00000004534RBM684.890.4232P78332RBPHigh-throughput data
ENSG00000248508ENST00000504245SRP14-AS1ENSG00000137776SLTM73.6193.9228Q9NWH9RBPENCODE
ENSG00000248508ENST00000504245SRP14-AS1ENSG00000106344RBM2873.3891.6222Q9NW13RBPNA
ENSG00000248508ENST00000504245SRP14-AS1ENSG00000198000NOL871.9892.5401Q76FK4RBPNA
ENSG00000248508ENST00000504245SRP14-AS1ENSG00000133226SRRM142.3693.6199Q8IYB3RBPNA
ENSG00000248508ENST00000504245SRP14-AS1ENSG00000083544TDRD336.2590.3682Q9H7E2RBP,EpiNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000163510CWC2260.7494.9391Q9HCG8RBPNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000130254SAFB258.5493.3762Q14151TF,RBPENCODE
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000004534RBM657.5594.3053P78332RBPHigh-throughput data
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000064607SUGP256.4891.5553Q8IX01RBPNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000163728TTC1454.4592.013Q96N46RBPNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000003756RBM554.2192.0383P52756RBPNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000198000NOL852.6292.6725Q76FK4RBPNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000106344RBM2850.8493.0948Q9NW13RBPNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000137776SLTM49.8293.798Q9NWH9RBPENCODE
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000176102CSTF339.191.7832Q12996RBPNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000135870RC3H135.4994.0104Q5TC82RBPNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000116560SFPQ31.6892.9534P23246RBP,EpiNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000133226SRRM124.2494.68Q8IYB3RBPNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000184863RBM3317.5990.3103Q96EV2RBPNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000121390PSPC111.0592.5513Q8WXF1RBPNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000174720LARP75.891.8475Q4G0J3RBPNA
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000149532CPSF74.5890.1267Q8N684RBPPAR-CLIP
ENSG00000248508ENST00000559012SRP14-AS1ENSG00000172795DCP22.9691.1422Q8IU60RBPNA

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lncRNA-DNA interaction for SRP14-DT

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for SRP14-DT

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
lncRNA and exonskipping events positive correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation
ENSG00000248508ENST00000559012exon_skip_13601chr1:164820071-164820184-12.77-0.1359PBX1ENST00000420696Frame-shift
ENSG00000248508ENST00000559012exon_skip_82144chr12:50087362-50087485-15.40-0.1510SMARCD1ENST00000394963In-frame
ENSG00000248508ENST00000559012exon_skip_482144chr8:22539468-22539498-8.81-0.5506PPP3CCENST00000240139In-frame
ENSG00000248508ENST00000559012exon_skip_424741chr4:83458345-83458429-8.56-0.1173MRPS18CENST00000295491In-frame
ENSG00000248508ENST00000559012exon_skip_27065chr1:52906518-52906611-12.76-0.2163ECHDC2ENST00000371522In-frame

-lncRNA and exonskipping events are negatively correlated.
lncRNA and exonskipping events negative correlated
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF
ENSG00000248508ENST00000559012exon_skip_111863chr14:23565815-23565892-15.03-0.2783AP1G2ENST00000308724,ENST00000397120Frame-shift
ENSG00000248508ENST00000559012exon_skip_343146chr2:127057472-127057601-17.62-0.1546BIN1ENST00000316724In-frame
ENSG00000248508ENST00000559012exon_skip_494079chr8:144099080-144099205-20.57-0.1922SHARPINENST00000398712Frame-shift

check buttonlncRNA targets by miRNA.
lncRNA targets by miRNA
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source
ENSG00000248508hsa-mir-222ENST00000504245chr15:40041009-40041121244.00-96.13113NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40041428-40041546242.00-103.78117NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40039871-40039985220.00-102.13116NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40040809-40040929216.00-100.66118NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40040493-40040611215.00-106.48114NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40040370-40040484213.00-97.28117NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40040131-40040245206.00-98.03115NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40039712-40039815196.00-95.48109NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40039565-40039667183.00-90.89100NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40039312-40039417181.00-102.40107NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40040248-40040352181.00-95.39111NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40039993-40040094171.00-83.92109NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40039416-40039527169.00-89.66110NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40040618-40040726163.00-105.88109NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40041168-40041284157.00-99.42118NA
ENSG00000248508hsa-mir-222ENST00000504245chr15:40041302-40041411156.00-103.46114NA
ENSG00000248508hsa-mir-222ENST00000560341chr15:40039773-40039875232.00-97.01100NA
ENSG00000248508hsa-mir-222ENST00000560341chr15:40039579-40039710192.00-99.97126NA
ENSG00000248508hsa-mir-222ENST00000560341chr15:40039350-40039459179.00-97.52111NA
ENSG00000248508hsa-mir-222ENST00000560341chr15:40039477-40039588150.00-87.12115NA
ENSG00000248508hsa-mir-222ENST00000559012chr15:40064915-40065029220.00-102.13116NA
ENSG00000248508hsa-mir-222ENST00000559012chr15:40064431-40064562204.00-90.89122NA
ENSG00000248508hsa-mir-222ENST00000559012chr15:40064756-40064859196.00-95.48109NA
ENSG00000248508hsa-mir-222ENST00000559012chr15:40064609-40064711183.00-90.89100NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40040592-40040711223.00-109.90119NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40040479-40040591216.00-101.70114NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40040251-40040357194.00-92.6988NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40040951-40041056190.00-93.82111NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40039945-40040054187.00-86.24109NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40040733-40040848183.00-87.46116NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40039491-40039608177.00-84.79116NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40039708-40039823176.00-94.70110NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40041363-40041468173.00-106.74108NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40039312-40039391158.00-91.2485NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40040350-40040458155.00-85.12112NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40041226-40041342155.00-89.26115NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40040064-40040182149.00-77.55116NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40039831-40039948145.00-89.60114NA
ENSG00000248508hsa-mir-766ENST00000504245chr15:40041088-40041201143.00-90.84119NA
ENSG00000248508hsa-mir-766ENST00000560341chr15:40039576-40039698184.00-94.52114NA
ENSG00000248508hsa-mir-766ENST00000560341chr15:40039715-40039835183.00-95.47120NA
ENSG00000248508hsa-mir-766ENST00000560341chr15:40039423-40039542166.00-87.40120NA
ENSG00000248508hsa-mir-766ENST00000559012chr15:40064479-40064584196.00-82.34109NA
ENSG00000248508hsa-mir-766ENST00000559012chr15:40064388-40064468178.00-74.1472NA
ENSG00000248508hsa-mir-766ENST00000559012chr15:40064752-40064867176.00-94.70110NA
ENSG00000248508hsa-mir-766ENST00000559012chr15:40064614-40064730171.00-90.75116NA
ENSG00000248508hsa-mir-766ENST00000559012chr15:40064923-40065049154.00-108.94126NA

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Variants for SRP14-DT

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types
ENSG00000248508SRP14-DT,hsa-mir-222,MARCHF8KICH,TGCT,THCA,LGG,GBM
ENSG00000248508SRP14-DT,hsa-mir-222,ZBTB5KICH,THCA,LGG,GBM,KIRP
ENSG00000248508SRP14-DT,hsa-mir-222,XPNPEP3TGCT,THCA,LGG,GBM,KIRP
ENSG00000248508SRP14-DT,hsa-mir-222,DHTKD1KICH,TGCT,THCA,LGG,GBM
ENSG00000248508SRP14-DT,hsa-mir-222,SHLD2KICH,THCA,LGG,GBM,KIRP

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000248508.5ENST00000504245.416037973315
ENSG00000248508.5ENST00000560341.21276901073
ENSG00000248508.5ENST00000559012.178240476