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Center for Computational Systems Medicine
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lncRNA summary

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lncRNA structure and expression level

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lncRNA-Protein interaction

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lncRNA-DNA interaction

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lncRNA-RNA interaction

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Variants in lncRNA

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lncRNAs regulate the target genes through functioning as enhancers

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lncRNAs regulate the target genes through recruiting transcript factors

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lncRNAs regulate the alternative splicing events through interacting with splicing factor

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lncRNAs regulate mRNA through targeting the 3'-UTR region

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lncRNAs regulate mRNA by competing with miRNA

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lncRNA coding potential

lncRNA: ENSG00000187621

Summary for TCL6

check button Gene summary

Gene informationEnsembl ID

ENSG00000187621

Gene symbol

TCL6

Gene nameT cell leukemia/lymphoma 6
HGNC

13463

Entrez ID
Gene typeprocessed_transcript
SynonymsTCL6|14q32.13
UniProtAcc

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Structure and expression level for TCL6

check buttonAS events and RNA A-to-I editing events of lncRNA in TCGA based on Genvode V22 structure.
UCSC result

check buttonDifferentially expressed gene analysis between cancer and normal samples.
DEG result
Ensembl IDBase meanlog2FC(AD/control)lfcSEStatP-valueAdjc.p-valueDEG direction Cancer type
ENSG000001876211.098753e+031.415925e+004.135074e-013.424182e+006.166540e-041.544369e-03UPKICH

check buttonCorrelation between lncRNAs and cancer stages.
LncRNA Ensembl IDCorrelationP-valueCancer TypeAdjc.p-value

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lncRNA-Protein interaction for TCL6

lncrna_protein
check buttonlncRNA-epigenetic factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-transcript factor interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

check buttonlncRNA-RNA binding protein interaction (#cancer types with positive correlation >= 5).
LncRNA Ensembl IDLncRNA ENST IDLncRNA NameProtein Ensembl IDProtein NameCatRAPID ScoreLncpro ScoreUniPortIDGene SubtypePublic source

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lncRNA-DNA interaction for TCL6

lncrna_DNA
check buttonlncRNA targets the enhancer region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and positively regulates the gene expression.

check buttonlncRNA targets the promoter region and negatively regulates the gene expression.

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lncRNA-RNA interaction for TCL6

lncrna_RNA
check buttonlncRNA targets the 3'UTR region and negatively regulates the mRNA.

check buttonlncRNA targets the skipped exon region.
-lncRNA and exonskipping events are positively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonORF mutation

-lncRNA and exonskipping events are negatively correlated.
LncRNA Ensembl IDLncRNA ENST IDExon IDSkipped ExondGndGGene name with skipped exonTransID with skipped exonLOF

check buttonlncRNA targets by miRNA.
LncRNA Ensembl IDmiRNA IDLncRNA ENST IDBinding site in lncRNAScoreEnergyAlign LenPublic source

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Variants for TCL6

check buttonRNA A-to-I editing events in lncRNA.
LncRNAediting IDLncRNA Ensembl IDChromosomeEditing PositionStrandGene TypeGene NameTranscript IDTranscript TypeTranscript Name

check buttonEdited-associated DElncRNAs in cancer.
LncRNA Ensembl IDLncRNA IndexCancer TypeChr_Postion_StrandAVE1AVE2log2FCW-valueP-valueAdjc.p-valueChange

check buttonCorrelation between RNA A-to-I editing events's frequecy and lncRNA expression.
LncRNA Ensembl IDLncRNA IndexCorrelationP-valueAdjc.p-value

check buttonCis-expression quantitative trait loci(cis-eQTL) of lncRNA.
LncRNA Ensembl IDLncRNA NameSNP infoNumber of Positive corelated CancerPositive corelated CancerNumber of Negative corelated CancerNegative corelated Cancer
ENSG00000187621TCL6rs2369034:96086843:G:A01PRAD
ENSG00000187621TCL6rs2369035:96086844:A:G01PRAD
ENSG00000187621TCL6rs2369033:96086814:G:A01PRAD
ENSG00000187621TCL6rs2369036:96086855:T:C01PRAD
ENSG00000187621TCL6rs2369037:96086857:T:G01PRAD
ENSG00000187621TCL6rs12892622:96087940:A:T01THCA
ENSG00000187621TCL6rs8022523:96088172:A:G:+1THCA0
ENSG00000187621TCL6rs12893464:96087650:T:C01THCA
ENSG00000187621TCL6rs12892573:96087862:A:C01THCA
ENSG00000187621TCL6rs12892323:96087496:G:A01THCA
ENSG00000187621TCL6rs12892341:96087534:G:C01THCA
ENSG00000187621TCL6rs12892699:96087749:G:A01THCA
ENSG00000187621TCL6rs12892700:96087750:G:A01THCA
ENSG00000187621TCL6rs8021788:96088050:A:G01THCA
ENSG00000187621TCL6rs8021926:96088095:A:G01THCA
ENSG00000187621TCL6rs12892547:96087774:C:T01THCA
ENSG00000187621TCL6rs8022532:96088202:C:T:-01THCA
ENSG00000187621TCL6rs4905354:96088310:C:T01THCA
ENSG00000187621TCL6rs8003231:96088237:T:C01THCA
ENSG00000187621TCL6rs4905355:96088316:G:A01THCA
ENSG00000187621TCL6rs4905356:96088377:C:T01THCA
ENSG00000187621TCL6rs61206716:96088603:A:ACT01THCA

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lncRNAs regulate the target genes through functioning as enhancers

lncrna_enhancer
check buttonlncRNA regulates differentially expressed genes by function as enhancer.
LncRNA Ensembl IDPC Gene IDPC Gene NamePositive correlated cancersCancer with PC gene up-regulationCancer with PC gene down-regulation

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lncRNAs regulate the target genes through recruiting transcript factors

lncrna_TF
check buttonLncRNA-TF complex positively regulates the gene expression by target promoter region (#cancer types with positive correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

check buttonLncRNA-TF complex negatively regulates the gene expression by target promoter region (#cancer types with negative correlation >= 5).
lncRNA IDTF IDTF NamePCgene IDPCgene NameNumber of CancerCanaer Types

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lncRNAs regulate the alternative splicing event through interacting with splicing factor

lncrna_AS
check buttonLncRNA-RBP complex positively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

check buttonLncRNA-RBP complex negatively regulates the exon skippping events by target skipped eoxon region.
LncRNA Ensembl IDRBP IDRBP Gene NameExon Skipping IDSkipped ExonEX Gene NameEX Affected TransIDORF_annoCancer Type

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lncRNAs regulate mRNA through targeting the 3'-UTR region

lncrna_mRNA
check buttonlncRNA regulates differential expressed mRNA by directly targeting 3' UTR region.
LncRNA Ensembl IDLncRNA ENST IDPC Gene NamePC Gene IDPC ENST IDdGnDGCancer with PC gene up-regulationCancer with PC gene Down-regulation

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lncRNAs regulate mRNA by competing with miRNA

lncrna_miRNA
check buttonlncRNA regulates mRNA by competing the miRNA binding site with mRNA.
LncRNA Ensembl IDlncRNA-miRNA-mRNACancer Types

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lncRNA coding potential

check buttonORFfinder result for the gencode.v22.lncRNA.transcript.fa.
lncRNA Ensembl IDlncRNA ENST IDlength(AA)start at transcriptend at transcript
ENSG00000187621.13ENST00000357168.5125126503
ENSG00000187621.13ENST00000460130.413413191723
ENSG00000187621.13ENST00000483087.461728910
ENSG00000187621.13ENST00000459662.416314691960
ENSG00000187621.13ENST00000610999.121511181765
ENSG00000187621.13ENST00000467865.414117672192
ENSG00000187621.13ENST00000352367.911121832518
ENSG00000187621.13ENST00000497248.414117672192
ENSG00000187621.13ENST00000486671.114117672192
ENSG00000187621.13ENST00000465501.4141161586
ENSG00000187621.13ENST00000619182.3122675307
ENSG00000187621.13ENST00000495696.1122544176