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Gene: ENSG00000188306 |
Summary for LRRIQ4 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000188306 | Gene symbol | LRRIQ4 |
| Gene name | leucine rich repeats and IQ motif containing 4 | |
| HGNC | 34298 | |
| Entrez ID | 344657 | |
| Gene type | protein_coding | |
| Synonyms | LRRIQ4|LRRC64 | |
| UniProtAcc | A6NIV6 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for LRRIQ4 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for LRRIQ4 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for LRRIQ4 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUAD | cg23081534 | chr3:169822291 | CGI:chr3:169812087-169812647 | promoter,exon,CDS,gene body | 7.89e-01 | 9.59e-01 | -2.75e+00 | 5.91e-03 | 8.61e-03 | -1.70e-01 |
| HNSC | cg18155853 | chr3:169822716 | CGI:chr3:169812087-169812647 | promoter,exon,CDS,gene body | 7.27e-01 | 9.83e-01 | -5.27e+00 | 1.33e-07 | 1.20e-06 | -2.55e-01 |
| LUSC | cg23081534 | chr3:169822291 | CGI:chr3:169812087-169812647 | promoter,exon,CDS,gene body | 7.27e-01 | 9.69e-01 | -3.16e+00 | 1.57e-03 | 3.54e-03 | -2.42e-01 |
| LUSC | cg18155853 | chr3:169822716 | CGI:chr3:169812087-169812647 | promoter,exon,CDS,gene body | 6.49e-01 | 9.88e-01 | -4.32e+00 | 1.57e-05 | 5.26e-04 | -3.39e-01 |
| LUSC | cg13262467 | chr3:169821102 | CGI:chr3:169812087-169812647 | promoter | 6.23e-01 | 8.11e-01 | -3.15e+00 | 1.63e-03 | 3.62e-03 | -1.88e-01 |
| LUSC | cg13793580 | chr3:169822509 | CGI:chr3:169812087-169812647 | promoter,exon,CDS,gene body | 5.28e-01 | 8.82e-01 | -4.28e+00 | 1.90e-05 | 5.26e-04 | -3.54e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg18155853 | chr3:169822716 | CGI:chr3:169812087-169812647 | promoter,exon,CDS,gene body | 8.54e-01 | 9.83e-01 | -6.96e+00 | 3.38e-12 | 9.97e-12 | -1.29e-01 |
| BRCA | cg13793580 | chr3:169822509 | CGI:chr3:169812087-169812647 | promoter,exon,CDS,gene body | 7.41e-01 | 9.11e-01 | -9.79e+00 | 1.29e-22 | 8.75e-22 | -1.70e-01 |
| LIHC | cg18155853 | chr3:169822716 | CGI:chr3:169812087-169812647 | promoter,exon,CDS,gene body | 8.84e-01 | 9.85e-01 | -3.18e+00 | 1.47e-03 | 3.05e-03 | -1.01e-01 |
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Exon skipping events with PSI in TCGA for LRRIQ4 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for LRRIQ4 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for LRRIQ4 |
| TFs related to LRRIQ4. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | KLF1 | LRRIQ4 | 3.87e+00 | 9.82e-01 | 2.80e+00 | 2.98e-03 | Male-biased |
| ACC | KLF15 | LRRIQ4 | 4.14e+00 | 9.83e-01 | 3.29e+00 | 7.75e-03 | Male-biased |
| ACC | MAZ | LRRIQ4 | 4.15e+00 | 9.84e-01 | 3.26e+00 | 6.57e-03 | Male-biased |
| ACC | SP1 | LRRIQ4 | 3.98e+00 | 9.87e-01 | 2.66e+00 | 1.03e-03 | Male-biased |
| ACC | WT1 | LRRIQ4 | 3.95e+00 | 9.81e-01 | 3.04e+00 | 5.96e-03 | Male-biased |
| ACC | ZBTB17 | LRRIQ4 | 4.35e+00 | 9.80e-01 | 3.61e+00 | 1.30e-02 | Male-biased |
| ACC | ZNF33A | LRRIQ4 | 4.48e+00 | 9.85e-01 | 3.68e+00 | 9.70e-03 | Male-biased |
| ACC | ZNF341 | LRRIQ4 | 4.30e+00 | 9.86e-01 | 3.40e+00 | 6.62e-03 | Male-biased |
| ACC | ZNF467 | LRRIQ4 | 4.41e+00 | 9.84e-01 | 3.61e+00 | 9.90e-03 | Male-biased |
| ACC | ZNF519 | LRRIQ4 | 4.36e+00 | 9.92e-01 | 3.14e+00 | 1.73e-03 | Male-biased |
| ACC | ZNF571 | LRRIQ4 | 4.39e+00 | 9.92e-01 | 3.19e+00 | 1.86e-03 | Male-biased |
| ACC | ZNF770 | LRRIQ4 | 4.41e+00 | 9.91e-01 | 3.36e+00 | 3.48e-03 | Male-biased |
| BRCA | ZNF418 | LRRIQ4 | 3.81e+00 | 9.67e-03 | 5.04e+00 | 9.86e-01 | Female-biased |
| DLBC | FOXC2 | LRRIQ4 | 3.62e+00 | 1.02e-02 | 4.51e+00 | 9.83e-01 | Female-biased |
| DLBC | IRF1 | LRRIQ4 | 4.31e+00 | 1.03e-02 | 5.20e+00 | 9.88e-01 | Female-biased |
| DLBC | IRF2 | LRRIQ4 | 4.37e+00 | 1.38e-02 | 5.18e+00 | 9.84e-01 | Female-biased |
| DLBC | ZNF418 | LRRIQ4 | 3.86e+00 | 1.10e-03 | 5.40e+00 | 9.97e-01 | Female-biased |
| DLBC | ZNF567 | LRRIQ4 | 3.74e+00 | 9.29e-03 | 4.65e+00 | 9.86e-01 | Female-biased |
| DLBC | ZNF879 | LRRIQ4 | 3.77e+00 | 2.03e-03 | 5.12e+00 | 9.95e-01 | Female-biased |
| MESO | ZNF182 | LRRIQ4 | 4.35e+00 | 9.90e-01 | 2.68e+00 | 2.01e-03 | Male-biased |
| MESO | ZNF22 | LRRIQ4 | 4.36e+00 | 9.90e-01 | 2.72e+00 | 2.20e-03 | Male-biased |
| MESO | ZNF235 | LRRIQ4 | 4.49e+00 | 9.91e-01 | 2.85e+00 | 2.26e-03 | Male-biased |
| MESO | ZNF287 | LRRIQ4 | 4.39e+00 | 9.89e-01 | 2.84e+00 | 3.15e-03 | Male-biased |
| MESO | ZNF384 | LRRIQ4 | 4.03e+00 | 9.84e-01 | 2.41e+00 | 2.40e-03 | Male-biased |
| MESO | ZNF487 | LRRIQ4 | 4.23e+00 | 9.87e-01 | 2.66e+00 | 2.81e-03 | Male-biased |
| MESO | ZNF492 | LRRIQ4 | 4.02e+00 | 9.81e-01 | 2.59e+00 | 4.49e-03 | Male-biased |
| MESO | ZNF613 | LRRIQ4 | 4.20e+00 | 9.87e-01 | 2.60e+00 | 2.59e-03 | Male-biased |
| MESO | ZNF98 | LRRIQ4 | 4.18e+00 | 9.86e-01 | 2.62e+00 | 2.98e-03 | Male-biased |
| PCPG | FOXC2 | LRRIQ4 | 3.63e+00 | 1.20e-02 | 4.39e+00 | 9.81e-01 | Female-biased |
| PCPG | ZBTB17 | LRRIQ4 | 4.50e+00 | 9.84e-01 | 3.65e+00 | 8.27e-03 | Male-biased |
| PCPG | ZNF181 | LRRIQ4 | 5.08e+00 | 9.84e-01 | 4.33e+00 | 1.31e-02 | Male-biased |
| PCPG | ZNF33A | LRRIQ4 | 5.02e+00 | 9.84e-01 | 4.27e+00 | 1.32e-02 | Male-biased |
| PCPG | ZNF418 | LRRIQ4 | 3.97e+00 | 9.92e-04 | 5.29e+00 | 9.97e-01 | Female-biased |
| PCPG | ZNF519 | LRRIQ4 | 4.56e+00 | 9.80e-01 | 3.82e+00 | 1.33e-02 | Male-biased |
| PCPG | ZNF770 | LRRIQ4 | 4.82e+00 | 9.89e-01 | 3.92e+00 | 6.60e-03 | Male-biased |
| PCPG | ZNF774 | LRRIQ4 | 4.54e+00 | 9.85e-01 | 3.68e+00 | 7.96e-03 | Male-biased |
| PCPG | ZNF879 | LRRIQ4 | 4.33e+00 | 1.35e-02 | 5.07e+00 | 9.84e-01 | Female-biased |
| UVM | FOXC2 | LRRIQ4 | 4.65e+00 | 9.86e-01 | 2.43e+00 | 1.28e-03 | Male-biased |
| UVM | IRF1 | LRRIQ4 | 5.27e+00 | 9.93e-01 | 3.32e+00 | 2.56e-03 | Male-biased |
| UVM | IRF2 | LRRIQ4 | 5.19e+00 | 9.86e-01 | 3.74e+00 | 7.80e-03 | Male-biased |
| UVM | IRF4 | LRRIQ4 | 5.75e+00 | 9.80e-01 | 4.71e+00 | 1.75e-02 | Male-biased |
| UVM | IRF7 | LRRIQ4 | 6.25e+00 | 9.91e-01 | 4.81e+00 | 8.23e-03 | Male-biased |
| UVM | IRF9 | LRRIQ4 | 5.53e+00 | 9.87e-01 | 4.17e+00 | 9.45e-03 | Male-biased |
| UVM | PATZ1 | LRRIQ4 | 1.61e+00 | 3.04e-04 | 4.36e+00 | 9.82e-01 | Female-biased |
| UVM | ZNF182 | LRRIQ4 | 4.84e+00 | 9.88e-01 | 2.78e+00 | 1.98e-03 | Male-biased |
| UVM | ZNF22 | LRRIQ4 | 4.87e+00 | 9.89e-01 | 2.73e+00 | 1.60e-03 | Male-biased |
| UVM | ZNF235 | LRRIQ4 | 4.86e+00 | 9.89e-01 | 2.67e+00 | 1.41e-03 | Male-biased |
| UVM | ZNF287 | LRRIQ4 | 4.71e+00 | 9.86e-01 | 2.72e+00 | 2.27e-03 | Male-biased |
| UVM | ZNF384 | LRRIQ4 | 4.62e+00 | 9.85e-01 | 2.49e+00 | 1.61e-03 | Male-biased |
| UVM | ZNF418 | LRRIQ4 | 5.68e+00 | 9.98e-01 | 1.68e+00 | 1.22e-05 | Male-biased |
| UVM | ZNF429 | LRRIQ4 | 2.88e+00 | 4.85e-03 | 4.52e+00 | 9.81e-01 | Female-biased |
| UVM | ZNF487 | LRRIQ4 | 4.73e+00 | 9.87e-01 | 2.68e+00 | 1.98e-03 | Male-biased |
| UVM | ZNF492 | LRRIQ4 | 4.57e+00 | 9.82e-01 | 2.78e+00 | 3.62e-03 | Male-biased |
| UVM | ZNF567 | LRRIQ4 | 4.60e+00 | 9.82e-01 | 2.85e+00 | 3.93e-03 | Male-biased |
| UVM | ZNF613 | LRRIQ4 | 4.75e+00 | 9.87e-01 | 2.66e+00 | 1.78e-03 | Male-biased |
| UVM | ZNF879 | LRRIQ4 | 5.32e+00 | 9.96e-01 | 2.26e+00 | 1.20e-04 | Male-biased |
| UVM | ZNF98 | LRRIQ4 | 4.70e+00 | 9.86e-01 | 2.79e+00 | 2.70e-03 | Male-biased |
| LRRIQ4 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for LRRIQ4 |
| RBPs related to ES in LRRIQ4. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LRRIQ4 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of LRRIQ4 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
