|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000186891 |
Summary for TNFRSF18 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000186891 | Gene symbol | TNFRSF18 |
| Gene name | TNF receptor superfamily member 18 | |
| HGNC | 11914 | |
| Entrez ID | 8784 | |
| Gene type | protein_coding | |
| Synonyms | TNFRSF18|AITR|GITR|CD357 | |
| UniProtAcc | Q9Y5U5 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for TNFRSF18 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TNFRSF18 | 1.57e+02 | 2.62e+00 | 4.02e-01 | 6.52e+00 | 6.92e-11 | 9.49e-10 | THCA |
| TNFRSF18 | 3.06e+02 | 2.34e+00 | 5.44e-01 | 4.30e+00 | 1.72e-05 | 9.56e-05 | BLCA |
| TNFRSF18 | 6.25e+02 | 3.03e+00 | 5.88e-01 | 5.15e+00 | 2.62e-07 | 7.88e-06 | ESCA |
| TNFRSF18 | 9.63e+01 | 2.27e+00 | 6.39e-01 | 3.55e+00 | 3.82e-04 | 1.45e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TNFRSF18 | 5.34e+02 | 2.89e+00 | 1.52e-01 | 1.90e+01 | 1.18e-80 | 2.80e-79 | BRCA |
Top |
Sex-biased somatic mutation for TNFRSF18 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for TNFRSF18 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg16046810 | chr1:1205284 | CGI:chr1:1206290-1206770 | promoter,gene body | 7.85e-01 | 8.92e-01 | -4.03e+00 | 5.64e-05 | 5.75e-04 | -1.07e-01 |
| LUSC | cg07119157 | chr1:1207552 | CGI:chr1:1206290-1206770 | promoter | 5.38e-01 | 6.68e-01 | -3.08e+00 | 2.10e-03 | 4.33e-03 | -1.29e-01 |
| COAD | cg07119157 | chr1:1207552 | CGI:chr1:1206290-1206770 | promoter | 4.23e-01 | 5.33e-01 | -3.29e+00 | 1.00e-03 | 2.25e-03 | -1.10e-01 |
| BLCA | cg00086243 | chr1:1207025 | CGI:chr1:1206290-1206770 | promoter | 1.87e-01 | 3.52e-01 | -4.74e+00 | 2.17e-06 | 6.20e-05 | -1.65e-01 |
| LIHC | cg16046810 | chr1:1205284 | CGI:chr1:1206290-1206770 | promoter,gene body | 6.10e-01 | 8.32e-01 | -5.33e+00 | 9.67e-08 | 5.12e-07 | -2.21e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg19237691 | chr1:1206237 | CGI:chr1:1206290-1206770 | promoter,gene body | 1.99e-01 | 3.21e-01 | -8.19e+00 | 2.68e-16 | 1.08e-15 | -1.22e-01 |
| BRCA | cg14886269 | chr1:1206547 | CGI:chr1:1206290-1206770 | promoter,exon,CDS,gene body | 1.83e-01 | 3.01e-01 | -9.28e+00 | 1.75e-20 | 9.87e-20 | -1.18e-01 |
| HNSC | cg10583942 | chr1:1207512 | CGI:chr1:1206290-1206770 | promoter | 4.66e-01 | 5.89e-01 | -2.61e+00 | 8.98e-03 | 1.76e-02 | -1.23e-01 |
Top |
Exon skipping events with PSI in TCGA for TNFRSF18 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for TNFRSF18 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for TNFRSF18 |
| TFs related to TNFRSF18. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | ZNF141 | TNFRSF18 | 3.67e+00 | 1.38e-02 | 4.79e+00 | 9.80e-01 | Female-biased |
| BRCA | ZNF28 | TNFRSF18 | 3.63e+00 | 1.07e-02 | 4.82e+00 | 9.84e-01 | Female-biased |
| TNFRSF18 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for TNFRSF18 |
| RBPs related to ES in TNFRSF18. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TNFRSF18 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs12084545 | chr1:3162385:T:A | - | 0.101764809343718 | 0.0466031265919786 | STAD | Female-baised eQTL |
| rs1997636 | chr1:3166130:C:T | - | 0.101764809343718 | 0.0466031265919786 | STAD | Female-baised eQTL |
| rs12080488 | chr1:3166730:C:T | - | 0.101764809343718 | 0.0466031265919786 | STAD | Female-baised eQTL |
| rs59663420 | chr1:3169225:T:C | - | 0.101764809343718 | 0.0466031265919786 | STAD | Female-baised eQTL |
| rs6691196 | chr1:7334758:C:G | - | 0.124323531105377 | 0.00175788942092116 | BLCA | Female-baised eQTL |
| rs6577439 | chr1:7336907:A:C | - | 0.0910532177137498 | 0.0227604093943949 | BLCA | Female-baised eQTL |
| rs1572138 | chr1:8904780:C:T | - | 0.093434796933311 | 0.0387596803228755 | BLCA | Female-baised eQTL |
| rs111917811 | chr1:6427917:G:A | - | 0.112953819574461 | 0.0462471420157953 | BLCA | Female-baised eQTL |
| rs937486 | chr1:5576281:G:C | - | 0.0762965587706312 | 0.0434973103442102 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17031661 | chr1:7863516:T:C | - | 0.0527589059529668 | 0.0223723300863872 | LIHC | Male-baised eQTL |
| rs7521730 | chr1:3203566:C:T | - | 0.0524421898988883 | 0.0328485187435038 | KIRC | Male-baised eQTL |
| rs10492941 | chr1:3210573:C:A | - | 0.0539741775701084 | 0.0355611250668858 | KIRC | Male-baised eQTL |
| rs7413013 | chr1:3995220:G:C | - | -0.0354805048427757 | 0.0371953629727811 | KIRC | Male-baised eQTL |
| rs60425253 | chr1:3210500:C:G | - | 0.0529868147395505 | 0.0394057735216412 | KIRC | Male-baised eQTL |
| rs12070338 | chr1:1258333:C:G | - | 0.0971254955655048 | 0.0429600926772675 | BLCA | Male-baised eQTL |
| rs12072310 | chr1:1258343:A:C | - | 0.0971254955655048 | 0.0429600926772675 | BLCA | Male-baised eQTL |
| rs12135176 | chr1:4268002:G:A | - | 0.0558187342598191 | 0.0068697266775302 | COAD | Male-baised eQTL |
| rs78188739 | chr1:4264930:T:C | - | 0.0538799694697934 | 0.0113021007975289 | COAD | Male-baised eQTL |
| rs7540505 | chr1:4241452:T:C | - | 0.0510177007912575 | 0.0186496710573356 | COAD | Male-baised eQTL |
| rs16838501 | chr1:4268892:G:A | - | 0.0491473318890504 | 0.0252182460451764 | COAD | Male-baised eQTL |
| rs76704243 | chr1:4259344:G:A | - | 0.0488920054413098 | 0.0275114020614185 | COAD | Male-baised eQTL |
| rs983915 | chr1:4275306:C:T | - | 0.0523857328655941 | 0.0316091839090769 | COAD | Male-baised eQTL |
| rs17407901 | chr1:4281457:C:T | - | 0.0469788350073301 | 0.0401652949082255 | COAD | Male-baised eQTL |
| rs17408082 | chr1:4283675:C:A | - | 0.0468906763676926 | 0.0410825602629021 | COAD | Male-baised eQTL |
| rs115540351 | chr1:4286153:G:A | - | 0.0468906763676926 | 0.0410825602629021 | COAD | Male-baised eQTL |
| rs113496894 | chr1:4287888:G:T | - | 0.0468906763676926 | 0.0410825602629021 | COAD | Male-baised eQTL |
| rs78129923 | chr1:4288145:G:A | - | 0.0467574548991559 | 0.042362194247684 | COAD | Male-baised eQTL |
| rs7511825 | chr1:4289620:C:T | - | 0.0467464648101591 | 0.0424509819042503 | COAD | Male-baised eQTL |
| rs111757731 | chr1:4289700:G:A | - | 0.0467464648101591 | 0.0424509819042503 | COAD | Male-baised eQTL |
| rs17407762 | chr1:4270141:G:A | - | 0.0477831031172185 | 0.0460271267979396 | COAD | Male-baised eQTL |
| rs57149515 | chr1:4268153:G:A | - | 0.0445041564312247 | 0.0496140273317707 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of TNFRSF18 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000186891 | TNFRSF18 | C0023281 | Leishmaniasis | 1 | CTD_human |
