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Gene: ENSG00000186815 |
Summary for TPCN1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000186815 | Gene symbol | TPCN1 |
| Gene name | two pore segment channel 1 | |
| HGNC | 18182 | |
| Entrez ID | 53373 | |
| Gene type | protein_coding | |
| Synonyms | TPCN1|KIAA1169|FLJ20612|TPC1 | |
| UniProtAcc | Q9ULQ1 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for TPCN1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TPCN1 | 2.33e+03 | -1.07e+00 | 1.06e-01 | -1.01e+01 | 4.72e-24 | 2.87e-23 | LUSC |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for TPCN1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for TPCN1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| LUSC | cg19052193 | chr12:113222636 | CGI:chr12:113221233-113221852 | promoter,gene body | 4.24e-01 | 2.68e-01 | 2.63e+00 | 8.58e-03 | 1.23e-02 | 1.56e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg19052193 | chr12:113222636 | CGI:chr12:113221233-113221852 | promoter,gene body | 2.22e-01 | 3.48e-01 | -8.78e+00 | 1.61e-18 | 7.70e-18 | -1.27e-01 |
Top |
Exon skipping events with PSI in TCGA for TPCN1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for TPCN1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| KIRC | TPCN1-005 | chr12_113281759_+ | 3.18e-01 | 4.27e-01 | -2.08e+00 | 3.80e-02 | 4.91e-02 | -1.09e-01 |
| LUAD | TPCN1-016 | chr12_113256572_+ | 2.23e-01 | 3.34e-01 | -2.74e+00 | 6.17e-03 | 2.32e-02 | -1.12e-01 |
| LUAD | TPCN1-005 | chr12_113283935_+ | 3.13e-01 | 4.41e-01 | -2.26e+00 | 2.40e-02 | 4.03e-02 | -1.28e-01 |
| LUAD | TPCN1-005 | chr12_113283936_+ | 4.51e-01 | 6.44e-01 | -3.32e+00 | 9.04e-04 | 1.86e-02 | -1.93e-01 |
| COAD | TPCN1-005 | chr12_113281759_+ | 3.27e-01 | 5.26e-01 | -3.06e+00 | 2.22e-03 | 1.45e-02 | -1.99e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for TPCN1 |
| TFs related to TPCN1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TPCN1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for TPCN1 |
| RBPs related to ES in TPCN1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LUSC | ZC3H10 | exon_skip_87373 | 9.87e+00 | 9.96e-01 | 9.29e+00 | 1.64e-03 | Male-biased |
| LUAD | BRUNOL6 | exon_skip_87375 | 8.67e+00 | 1.42e-02 | 8.97e+00 | 9.81e-01 | Female-biased |
| LUAD | ZC3H10 | exon_skip_87373 | 9.26e+00 | 1.54e-02 | 9.55e+00 | 9.82e-01 | Female-biased |
| READ | ZC3H10 | exon_skip_87373 | 9.57e+00 | 9.95e-01 | 9.12e+00 | 2.66e-03 | Male-biased |
| MESO | BRUNOL6 | exon_skip_87375 | 8.41e+00 | 4.57e-03 | 8.83e+00 | 9.90e-01 | Female-biased |
| LGG | BRUNOL6 | exon_skip_87375 | 8.80e+00 | 9.81e-01 | 8.50e+00 | 1.42e-02 | Male-biased |
| GBM | ZC3H10 | exon_skip_87373 | 9.51e+00 | 9.92e-01 | 9.11e+00 | 5.18e-03 | Male-biased |
| KIRC | ZC3H10 | exon_skip_87373 | 9.51e+00 | 9.84e-01 | 9.23e+00 | 1.37e-02 | Male-biased |
| SKCM | BRUNOL6 | exon_skip_87375 | 8.62e+00 | 4.89e-03 | 9.05e+00 | 9.91e-01 | Female-biased |
| HNSC | BRUNOL6 | exon_skip_87375 | 8.90e+00 | 9.85e-01 | 8.56e+00 | 1.01e-02 | Male-biased |
| HNSC | ZC3H10 | exon_skip_87373 | 9.08e+00 | 5.63e-03 | 9.47e+00 | 9.92e-01 | Female-biased |
| TPCN1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs56190986 | chr12:118408458:C:T | - | 0.130573878364957 | 0.0412607067487924 | HNSC | Female-baised eQTL |
| rs2393419 | chr12:118578602:C:T | - | 0.119095911853019 | 0.0175518015969804 | SARC | Female-baised eQTL |
| rs117969759 | chr12:117972739:G:A | - | 0.185996522108906 | 0.00946417433789723 | BLCA | Female-baised eQTL |
| rs12229276 | chr12:103810993:T:G | - | 0.0890866504473932 | 0.0304488138902732 | BLCA | Female-baised eQTL |
| rs10861105 | chr12:103796221:C:T | - | 0.0888208035752227 | 0.0427920415531626 | BLCA | Female-baised eQTL |
| rs11111788 | chr12:103796375:G:A | - | 0.0888208035752227 | 0.0427920415531626 | BLCA | Female-baised eQTL |
| rs73192053 | chr12:103797077:A:G | - | 0.0888208035752227 | 0.0427920415531626 | BLCA | Female-baised eQTL |
| rs11111789 | chr12:103797762:G:C | - | 0.0888208035752227 | 0.0427920415531626 | BLCA | Female-baised eQTL |
| rs4964806 | chr12:103798982:C:T | - | 0.0888208035752227 | 0.0427920415531626 | BLCA | Female-baised eQTL |
| rs4964794 | chr12:103800640:T:C | - | 0.0888208035752227 | 0.0427920415531626 | BLCA | Female-baised eQTL |
| rs11111792 | chr12:103801079:C:G | - | 0.0888208035752227 | 0.0427920415531626 | BLCA | Female-baised eQTL |
| rs4964812 | chr12:103795837:A:G | - | 0.0885452989882632 | 0.0428651292448259 | BLCA | Female-baised eQTL |
| rs4767727 | chr12:118831709:G:A | - | -0.143752601782103 | 0.0462907447455021 | BLCA | Female-baised eQTL |
| rs1866295 | chr12:103793168:G:T | - | 0.0876240419365904 | 0.0486153643322578 | BLCA | Female-baised eQTL |
| rs11111785 | chr12:103795278:A:G | - | 0.0876240419365904 | 0.0486153643322578 | BLCA | Female-baised eQTL |
| rs11111786 | chr12:103795279:T:C | - | 0.0876240419365904 | 0.0486153643322578 | BLCA | Female-baised eQTL |
| rs12298267 | chr12:119987251:A:G | - | 0.0581355842957557 | 0.0320793181142252 | LUAD | Female-baised eQTL |
| rs2730441 | chr12:118877265:G:A | - | -0.0763456821057155 | 0.0295776783822805 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs4964154 | chr12:105663215:A:G | - | 0.107935417547557 | 0.0183895000414119 | SARC | Male-baised eQTL |
| rs2484593 | chr12:114850944:T:A | - | 0.116905683156693 | 0.026147978163236 | SARC | Male-baised eQTL |
| rs4612912 | chr12:116753654:G:A | - | -0.106878082228237 | 0.0481388686437204 | SARC | Male-baised eQTL |
| rs4767447 | chr12:116756981:A:T | - | -0.106878082228237 | 0.0481388686437204 | SARC | Male-baised eQTL |
| rs4767448 | chr12:116759756:A:G | - | -0.106878082228237 | 0.0481388686437204 | SARC | Male-baised eQTL |
| rs7980144 | chr12:116760044:A:G | - | -0.10668690115813 | 0.0494831987032659 | SARC | Male-baised eQTL |
| rs12819773 | chr12:117423566:C:G | - | 0.111490891604978 | 0.0454301387548768 | LGG | Male-baised eQTL |
| rs1140886 | chr12:121243733:C:T | - | -0.0602387995814107 | 0.0144287111863473 | KIRC | Male-baised eQTL |
| rs61937978 | chr12:119045802:C:A | - | 0.0440248783873082 | 0.00267163655152244 | BLCA | Male-baised eQTL |
| rs116476235 | chr12:119050834:T:C | - | 0.0438316928140265 | 0.00292667039622662 | BLCA | Male-baised eQTL |
| rs61937980 | chr12:119052442:T:C | - | 0.0434068244944982 | 0.0032917640767595 | BLCA | Male-baised eQTL |
| rs76891460 | chr12:119111598:C:T | - | 0.0524352066807442 | 0.00862080727642371 | BLCA | Male-baised eQTL |
| rs143422405 | chr12:119107910:G:A | - | 0.0520782643918938 | 0.00958751002158401 | BLCA | Male-baised eQTL |
| rs145893264 | chr12:119075602:T:A | - | 0.0377609732512098 | 0.0102200113535203 | BLCA | Male-baised eQTL |
| rs12582329 | chr12:119117695:C:T | - | 0.045147629658699 | 0.0431224687546752 | BLCA | Male-baised eQTL |
| rs59154725 | chr12:119118718:G:A | - | 0.0445277011969057 | 0.0492831737639063 | BLCA | Male-baised eQTL |
| rs1568162 | chr12:117646734:T:C | - | 0.0581731642700838 | 0.0275596656194095 | LUAD | Male-baised eQTL |
| rs2188398 | chr12:110834683:T:A | - | -0.0524656076959506 | 0.0375950356774846 | LUAD | Male-baised eQTL |
| rs1858886 | chr12:110822752:G:A | - | -0.0532687764290201 | 0.0417387120397528 | LUAD | Male-baised eQTL |
| rs10492332 | chr12:114136921:G:A | - | -0.0753225380986455 | 0.0369069947155553 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs12816345 | chr12:114052248:C:T | Distant downstream | -0.0773511596890631 | 0.0227004196659906 | HNSC | Female-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs12367200 | chr12:114055174:G:T | Distant downstream | -0.0773511596890631 | 0.0227004196659906 | HNSC | Female-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs4578435 | chr12:113524480:A:G | Distant downstream | 0.054751584324064 | 0.0490747403112898 | COAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs10774710 | chr12:113692637:G:A | Distant downstream | -0.0328918083003422 | 0.00106784110988775 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs7952886 | chr12:113302166:T:G | Distant downstream | -0.0553173788770579 | 0.00339383946827873 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs73203045 | chr12:113693605:T:C | Distant downstream | -0.0402689489734496 | 0.00534653449609381 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs11831237 | chr12:113691551:G:A | Distant downstream | -0.038575211265091 | 0.0098358023624105 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs897539 | chr12:113693226:G:A | Distant downstream | -0.027995800432334 | 0.0103208061885106 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs10850196 | chr12:113691316:T:C | Distant downstream | -0.0280777135618346 | 0.0109183336417588 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs7310146 | chr12:113693816:G:A | Distant downstream | -0.027817542725648 | 0.0120721573825229 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs6489917 | chr12:113693613:A:G | Distant downstream | -0.0278177320830272 | 0.0120761479262815 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs10774709 | chr12:113692336:G:A | Distant downstream | -0.0276033974348462 | 0.0120769329578756 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs7313928 | chr12:113694421:G:C | Distant downstream | -0.0280261886681098 | 0.0124375644982062 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs7302589 | chr12:113691978:C:T | Distant downstream | -0.0271514871428117 | 0.0157324569484104 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs7302590 | chr12:113691983:C:T | Distant downstream | -0.0271514871428117 | 0.0157324569484104 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs7302726 | chr12:113692098:C:T | Distant downstream | -0.0271401235539915 | 0.0158281411400881 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs7132903 | chr12:113691876:A:C | Distant downstream | -0.0271272478827525 | 0.0159204671134596 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs7314879 | chr12:113694471:C:G | Distant downstream | -0.0271972818511413 | 0.0176467257853295 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs7295636 | chr12:113723443:A:G | Distant downstream | -0.0434610833026412 | 0.039341645465551 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs11066679 | chr12:113685597:G:C | Distant downstream | -0.0288400337504902 | 0.0422436108956873 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs73203035 | chr12:113684550:A:T | Distant downstream | -0.0286953798558763 | 0.0427597397130489 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs11833881 | chr12:113684991:A:G | Distant downstream | -0.0286953798558763 | 0.0427597397130489 | LUAD | Male-baised sQTL |
| exon_skip_87385 | chr12:113284717:113284771 | In-frame | rs11834352 | chr12:113684878:T:C | Distant downstream | -0.0282408994469975 | 0.043099851914542 | LUAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of TPCN1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000186815 | TPCN1 | C0028960 | Oligospermia | 1 | CTD_human |
