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Gene: ENSG00000174236 |
Summary for REP15 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000174236 | Gene symbol | REP15 |
| Gene name | RAB15 effector protein | |
| HGNC | 33748 | |
| Entrez ID | 387849 | |
| Gene type | protein_coding | |
| Synonyms | REP15|RAB15EP | |
| UniProtAcc | Q6BDI9 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for REP15 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| REP15 | 6.69e+01 | -2.53e+00 | 7.74e-01 | -3.27e+00 | 1.08e-03 | 3.71e-03 | READ |
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Sex-biased somatic mutation for REP15 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for REP15 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg16706260 | chr12:27696437 | CGI:chr12:27710700-27711148 | promoter | 4.68e-01 | 2.41e-01 | 2.20e+00 | 2.78e-02 | 3.97e-02 | 2.28e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| ESCA | cg07809176 | chr12:27696519 | CGI:chr12:27710700-27711148 | promoter | 7.30e-01 | 4.86e-01 | 1.99e+00 | 4.71e-02 | 4.87e-02 | 2.44e-01 |
| CHOL | cg07809176 | chr12:27696519 | CGI:chr12:27710700-27711148 | promoter | 8.02e-01 | 6.72e-01 | 2.21e+00 | 2.70e-02 | 3.50e-02 | 1.30e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg16706260 | chr12:27696437 | CGI:chr12:27710700-27711148 | promoter | 4.68e-01 | 7.80e-01 | -1.00e+01 | 1.29e-23 | 9.62e-23 | -3.12e-01 |
| BRCA | cg07809176 | chr12:27696519 | CGI:chr12:27710700-27711148 | promoter | 6.13e-01 | 8.77e-01 | -8.55e+00 | 1.21e-17 | 5.40e-17 | -2.65e-01 |
| HNSC | cg16706260 | chr12:27696437 | CGI:chr12:27710700-27711148 | promoter | 7.13e-01 | 5.17e-01 | 2.58e+00 | 9.91e-03 | 1.85e-02 | 1.96e-01 |
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Exon skipping events with PSI in TCGA for REP15 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for REP15 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for REP15 |
| TFs related to REP15. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | E2F6 | REP15 | 4.82e+00 | 9.90e-01 | 3.94e+00 | 7.21e-03 | Male-biased |
| ACC | OSR2 | REP15 | 4.67e+00 | 9.81e-01 | 3.97e+00 | 1.54e-02 | Male-biased |
| ACC | ZBTB17 | REP15 | 4.89e+00 | 9.95e-01 | 3.74e+00 | 2.29e-03 | Male-biased |
| ACC | ZNF519 | REP15 | 5.40e+00 | 9.98e-01 | 3.88e+00 | 5.13e-04 | Male-biased |
| ACC | ZNF571 | REP15 | 5.32e+00 | 9.98e-01 | 3.90e+00 | 7.72e-04 | Male-biased |
| ACC | ZNF770 | REP15 | 5.16e+00 | 9.95e-01 | 4.08e+00 | 3.11e-03 | Male-biased |
| GBM | ZNF235 | REP15 | 4.72e+00 | 1.59e-02 | 5.62e+00 | 9.83e-01 | Female-biased |
| PAAD | ZNF121 | REP15 | 4.76e+00 | 9.82e-01 | 3.99e+00 | 1.39e-02 | Male-biased |
| PCPG | E2F6 | REP15 | 4.58e+00 | 9.86e-01 | 3.70e+00 | 7.26e-03 | Male-biased |
| PCPG | FOXC2 | REP15 | 3.04e+00 | 4.12e-03 | 4.04e+00 | 9.83e-01 | Female-biased |
| PCPG | FOXE1 | REP15 | 3.84e+00 | 1.25e-02 | 4.59e+00 | 9.82e-01 | Female-biased |
| PCPG | PRDM6 | REP15 | 3.20e+00 | 3.85e-03 | 4.21e+00 | 9.86e-01 | Female-biased |
| PCPG | ZNF182 | REP15 | 3.48e+00 | 8.98e-03 | 4.30e+00 | 9.82e-01 | Female-biased |
| PCPG | ZNF225 | REP15 | 3.25e+00 | 2.77e-03 | 4.34e+00 | 9.89e-01 | Female-biased |
| PCPG | ZNF235 | REP15 | 3.50e+00 | 2.96e-03 | 4.57e+00 | 9.92e-01 | Female-biased |
| PCPG | ZNF287 | REP15 | 3.38e+00 | 2.95e-03 | 4.45e+00 | 9.90e-01 | Female-biased |
| PCPG | ZNF487 | REP15 | 3.48e+00 | 5.35e-03 | 4.42e+00 | 9.88e-01 | Female-biased |
| PCPG | ZNF716 | REP15 | 3.92e+00 | 1.44e-02 | 4.64e+00 | 9.81e-01 | Female-biased |
| PCPG | ZNF768 | REP15 | 4.87e+00 | 9.81e-01 | 4.15e+00 | 1.45e-02 | Male-biased |
| SKCM | PRDM6 | REP15 | 4.88e+00 | 1.67e-02 | 5.69e+00 | 9.81e-01 | Female-biased |
| SKCM | ZNF182 | REP15 | 4.90e+00 | 1.37e-02 | 5.78e+00 | 9.84e-01 | Female-biased |
| SKCM | ZNF225 | REP15 | 5.04e+00 | 1.16e-02 | 5.97e+00 | 9.87e-01 | Female-biased |
| SKCM | ZNF287 | REP15 | 5.07e+00 | 1.82e-02 | 5.87e+00 | 9.80e-01 | Female-biased |
| SKCM | ZNF487 | REP15 | 5.03e+00 | 1.82e-02 | 5.82e+00 | 9.80e-01 | Female-biased |
| SKCM | ZNF98 | REP15 | 4.89e+00 | 1.66e-02 | 5.71e+00 | 9.81e-01 | Female-biased |
| UVM | ZNF235 | REP15 | 6.03e+00 | 9.81e-01 | 4.98e+00 | 1.71e-02 | Male-biased |
| REP15 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for REP15 |
| RBPs related to ES in REP15. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| REP15 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs74069643 | chr12:27978670:A:T | - | 0.0720875421288742 | 0.00829460161748308 | COAD | Female-baised eQTL |
| rs60617108 | chr12:27979242:T:A | - | 0.0696605772566908 | 0.0120304149867218 | COAD | Female-baised eQTL |
| rs58047304 | chr12:27979439:A:C | - | 0.0696605772566908 | 0.0120304149867218 | COAD | Female-baised eQTL |
| rs60524788 | chr12:27980400:T:C | - | 0.0696605772566908 | 0.0120304149867218 | COAD | Female-baised eQTL |
| rs60845637 | chr12:27980673:A:G | - | 0.0696605772566908 | 0.0120304149867218 | COAD | Female-baised eQTL |
| rs73094070 | chr12:27980940:A:C | - | 0.0696605772566908 | 0.0120304149867218 | COAD | Female-baised eQTL |
| rs58929084 | chr12:27982597:A:T | - | 0.0696605772566908 | 0.0120304149867218 | COAD | Female-baised eQTL |
| rs60769223 | chr12:27982995:T:C | - | 0.0696605772566908 | 0.0120304149867218 | COAD | Female-baised eQTL |
| rs55875912 | chr12:27983500:T:A | - | 0.0696605772566908 | 0.0120304149867218 | COAD | Female-baised eQTL |
| rs61542435 | chr12:27983667:A:G | - | 0.0696605772566908 | 0.0120304149867218 | COAD | Female-baised eQTL |
| rs708147 | chr12:33586606:C:A | - | 0.0449779452173133 | 0.0121260339646917 | COAD | Female-baised eQTL |
| rs708150 | chr12:33588722:C:A | - | 0.0449779452173133 | 0.0121260339646917 | COAD | Female-baised eQTL |
| rs708151 | chr12:33590914:C:A | - | 0.0449779452173133 | 0.0121260339646917 | COAD | Female-baised eQTL |
| rs1873014 | chr12:33592084:A:G | - | 0.0449779452173133 | 0.0121260339646917 | COAD | Female-baised eQTL |
| rs1024851 | chr12:22159697:G:A | - | 0.0408258097758236 | 0.0156542037080587 | COAD | Female-baised eQTL |
| rs12297891 | chr12:31740676:C:G | - | 0.0814741496190015 | 0.0157194343074511 | COAD | Female-baised eQTL |
| rs9706019 | chr12:34530453:C:T | - | -0.049076624247911 | 0.0164948401968165 | COAD | Female-baised eQTL |
| rs7976974 | chr12:22160482:C:T | - | 0.0405712036474107 | 0.0173924513653623 | COAD | Female-baised eQTL |
| rs7973355 | chr12:27999510:G:C | - | 0.0671960853387134 | 0.0176064205696 | COAD | Female-baised eQTL |
| rs7138238 | chr12:19661250:C:T | - | 0.0517983809949758 | 0.0214898226859234 | COAD | Female-baised eQTL |
| rs7305441 | chr12:27993519:C:T | - | 0.056896038162561 | 0.0321329339266564 | COAD | Female-baised eQTL |
| rs66496633 | chr12:27990739:A:C | - | 0.0567844766066114 | 0.0328888975068961 | COAD | Female-baised eQTL |
| rs57198280 | chr12:19662604:C:T | - | 0.0511366486669751 | 0.035687367338244 | COAD | Female-baised eQTL |
| rs815039 | chr12:33571830:G:T | - | 0.0382627269860793 | 0.0359087501889137 | COAD | Female-baised eQTL |
| rs708138 | chr12:33580378:A:G | - | 0.0398776977742322 | 0.0425191663256062 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs11609146 | chr12:28702882:G:A | - | 0.0658834936873308 | 0.017929604196379 | COAD | Male-baised eQTL |
| rs75555245 | chr12:28818369:C:T | - | 0.0702634292027079 | 0.0261568624054715 | COAD | Male-baised eQTL |
| rs59631457 | chr12:26196771:A:G | - | 0.0389965906233669 | 0.0365144864186473 | COAD | Male-baised eQTL |
| rs58292015 | chr12:26197191:G:A | - | 0.0389965906233669 | 0.0365144864186473 | COAD | Male-baised eQTL |
| rs2343870 | chr12:26201566:G:C | - | 0.0389965906233669 | 0.0365144864186473 | COAD | Male-baised eQTL |
| rs74482118 | chr12:26202828:A:G | - | 0.0389965906233669 | 0.0365144864186473 | COAD | Male-baised eQTL |
| rs75859481 | chr12:26204528:T:G | - | 0.0389965906233669 | 0.0365144864186473 | COAD | Male-baised eQTL |
| rs7954597 | chr12:29961412:C:T | - | 0.0452180675045322 | 0.0369871078830146 | COAD | Male-baised eQTL |
| rs74721570 | chr12:26199842:C:T | - | 0.0389152173620558 | 0.0374215549695325 | COAD | Male-baised eQTL |
| rs11047236 | chr12:24053180:C:G | - | 0.0549047640074901 | 0.0404790439027418 | COAD | Male-baised eQTL |
| rs11047237 | chr12:24053392:A:T | - | 0.0549047640074901 | 0.0404790439027418 | COAD | Male-baised eQTL |
| rs73072468 | chr12:26278534:A:C | - | 0.04862998960509 | 0.0409247399569116 | COAD | Male-baised eQTL |
| rs73072470 | chr12:26278821:G:A | - | 0.04862998960509 | 0.0409247399569116 | COAD | Male-baised eQTL |
| rs73072474 | chr12:26280405:C:T | - | 0.0485887592931557 | 0.0413343029918167 | COAD | Male-baised eQTL |
| rs17467456 | chr12:26280167:G:A | - | 0.048524593029027 | 0.0419088028801716 | COAD | Male-baised eQTL |
| rs35065 | chr12:30996728:T:C | - | 0.0463861702711032 | 0.0421153508347859 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of REP15 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
