|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000171786 |
Summary for NHLH1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000171786 | Gene symbol | NHLH1 |
| Gene name | nescient helix-loop-helix 1 | |
| HGNC | 7817 | |
| Entrez ID | 4807 | |
| Gene type | protein_coding | |
| Synonyms | NHLH1|NSCL|NSCL1|bHLHa35 | |
| UniProtAcc | Q02575 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for NHLH1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for NHLH1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for NHLH1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg00006397 | chr1:160366909 | CGI:chr1:160343138-160343548 | promoter | 4.32e-01 | 3.14e-01 | 2.17e+00 | 2.96e-02 | 4.08e-02 | 1.18e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg00006397 | chr1:160366909 | CGI:chr1:160343138-160343548 | promoter | 3.93e-01 | 5.07e-01 | -4.36e+00 | 1.29e-05 | 4.70e-05 | -1.14e-01 |
| HNSC | cg12529228 | chr1:160367204 | CGI:chr1:160343138-160343548 | UTR,promoter,exon,gene body | 7.69e-01 | 8.77e-01 | -3.58e+00 | 3.42e-04 | 7.31e-04 | -1.08e-01 |
| LUSC | cg13992678 | chr1:160366800 | CGI:chr1:160343138-160343548 | promoter | 4.00e-01 | 5.30e-01 | -3.21e+00 | 1.34e-03 | 3.17e-03 | -1.30e-01 |
| LUSC | cg00006397 | chr1:160366909 | CGI:chr1:160343138-160343548 | promoter | 3.89e-01 | 5.63e-01 | -3.62e+00 | 2.98e-04 | 1.21e-03 | -1.74e-01 |
| LUSC | cg12529228 | chr1:160367204 | CGI:chr1:160343138-160343548 | UTR,promoter,exon,gene body | 7.09e-01 | 8.75e-01 | -3.43e+00 | 5.95e-04 | 1.85e-03 | -1.66e-01 |
| LUSC | cg00955867 | chr1:160367248 | CGI:chr1:160343138-160343548 | UTR,promoter,exon,gene body | 7.27e-01 | 8.53e-01 | -2.74e+00 | 6.12e-03 | 9.50e-03 | -1.26e-01 |
| BLCA | cg12529228 | chr1:160367204 | CGI:chr1:160343138-160343548 | UTR,promoter,exon,gene body | 6.97e-01 | 8.32e-01 | -2.92e+00 | 3.51e-03 | 6.14e-03 | -1.35e-01 |
| KIRP | cg18023842 | chr1:160366685 | CGI:chr1:160343138-160343548 | promoter | 9.16e-01 | 8.15e-01 | 6.13e+00 | 8.99e-10 | 5.01e-08 | 1.01e-01 |
| KIRP | cg13992678 | chr1:160366800 | CGI:chr1:160343138-160343548 | promoter | 6.68e-01 | 5.51e-01 | 3.84e+00 | 1.23e-04 | 3.09e-04 | 1.17e-01 |
| KIRP | cg00006397 | chr1:160366909 | CGI:chr1:160343138-160343548 | promoter | 7.75e-01 | 6.57e-01 | 4.40e+00 | 1.08e-05 | 3.97e-05 | 1.18e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg08247612 | chr1:160366696 | CGI:chr1:160343138-160343548 | promoter | 8.45e-01 | 7.35e-01 | 1.19e+01 | 1.22e-32 | 2.50e-31 | 1.10e-01 |
| COAD | cg13992678 | chr1:160366800 | CGI:chr1:160343138-160343548 | promoter | 3.48e-01 | 4.58e-01 | -2.95e+00 | 3.16e-03 | 6.80e-03 | -1.10e-01 |
Top |
Exon skipping events with PSI in TCGA for NHLH1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for NHLH1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for NHLH1 |
| TFs related to NHLH1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | POU4F1 | NHLH1 | 3.41e+00 | 1.03e-02 | 4.20e+00 | 9.82e-01 | Female-biased |
| UVM | POU4F1 | NHLH1 | 3.95e+00 | 8.70e-03 | 5.34e+00 | 9.87e-01 | Female-biased |
| UVM | POU4F2 | NHLH1 | 3.82e+00 | 9.03e-03 | 5.18e+00 | 9.86e-01 | Female-biased |
| NHLH1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
 |
Top |
Sex-biased RBP-ES network for NHLH1 |
| RBPs related to ES in NHLH1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| NHLH1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000171786 | LINC02869,hsa-mir-665,NHLH1 | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000171786 | PRECSIT,hsa-mir-665,NHLH1 | Male-specific ceRNA | TCGA-KIRP |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7519821 | chr1:161402818:T:C | - | 0.307401084732283 | 0.000165829045321473 | GBM | Female-baised eQTL |
| rs72714981 | chr1:161337265:G:C | - | 0.30715684463533 | 0.000180579907582877 | GBM | Female-baised eQTL |
| rs78556724 | chr1:161337461:A:G | - | 0.30715684463533 | 0.000180579907582877 | GBM | Female-baised eQTL |
| rs11585941 | chr1:161342866:A:G | - | 0.30715684463533 | 0.000180579907582877 | GBM | Female-baised eQTL |
| rs16832849 | chr1:161352027:A:G | - | 0.30715684463533 | 0.000180579907582877 | GBM | Female-baised eQTL |
| rs11577663 | chr1:161358237:G:A | - | 0.30715684463533 | 0.000180579907582877 | GBM | Female-baised eQTL |
| rs72714985 | chr1:161358259:C:A | - | 0.30715684463533 | 0.000180579907582877 | GBM | Female-baised eQTL |
| rs11584714 | chr1:161368971:C:G | - | 0.30715684463533 | 0.000180579907582877 | GBM | Female-baised eQTL |
| rs6427589 | chr1:161378139:T:C | - | 0.30715684463533 | 0.000180579907582877 | GBM | Female-baised eQTL |
| rs16832913 | chr1:161385190:G:A | - | 0.30715684463533 | 0.000180579907582877 | GBM | Female-baised eQTL |
| rs16832945 | chr1:161399656:C:T | - | 0.30715684463533 | 0.000180579907582877 | GBM | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs1925661 | chr1:152673803:C:T | - | 0.216695627297907 | 0.00197485151724344 | GBM | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of NHLH1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
