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Gene: ENSG00000161692 |
Summary for DBF4B |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000161692 | Gene symbol | DBF4B |
| Gene name | DBF4 zinc finger B | |
| HGNC | 17883 | |
| Entrez ID | 80174 | |
| Gene type | protein_coding | |
| Synonyms | DBF4B|FLJ13087|DRF1|ASKL1|chifb|ZDBF1B | |
| UniProtAcc | Q8NFT6 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for DBF4B |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| DBF4B | 4.81e+02 | 1.31e+00 | 1.24e-01 | 1.06e+01 | 2.64e-26 | 1.09e-24 | HNSC |
| DBF4B | 7.22e+02 | 1.06e+00 | 1.42e-01 | 7.44e+00 | 9.70e-14 | 2.74e-12 | STAD |
| DBF4B | 1.25e+03 | 1.18e+00 | 2.61e-01 | 4.53e+00 | 5.97e-06 | 1.04e-04 | ESCA |
| DBF4B | 2.93e+02 | 1.74e+00 | 3.35e-01 | 5.20e+00 | 1.98e-07 | 1.66e-06 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| DBF4B | 3.54e+02 | 1.42e+00 | 2.22e-01 | 6.39e+00 | 1.69e-10 | 4.31e-09 | READ |
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Sex-biased somatic mutation for DBF4B |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for DBF4B |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| HNSC | cg14578363 | chr17:44707710 | CGI:chr17:44708532-44708910 | promoter | 7.30e-01 | 8.56e-01 | -3.40e+00 | 6.86e-04 | 1.32e-03 | -1.25e-01 |
| LUSC | cg14578363 | chr17:44707710 | CGI:chr17:44708532-44708910 | promoter | 7.59e-01 | 9.11e-01 | -3.74e+00 | 1.84e-04 | 9.29e-04 | -1.52e-01 |
| LUSC | cg22697517 | chr17:44708010 | CGI:chr17:44708532-44708910 | promoter | 2.89e-01 | 4.91e-01 | -4.26e+00 | 2.06e-05 | 5.26e-04 | -2.02e-01 |
| COAD | cg22697517 | chr17:44708010 | CGI:chr17:44708532-44708910 | promoter | 2.88e-01 | 4.11e-01 | -4.32e+00 | 1.59e-05 | 8.33e-05 | -1.23e-01 |
| BLCA | cg14578363 | chr17:44707710 | CGI:chr17:44708532-44708910 | promoter | 7.09e-01 | 9.02e-01 | -3.94e+00 | 8.04e-05 | 3.43e-04 | -1.93e-01 |
| CHOL | cg22697517 | chr17:44708010 | CGI:chr17:44708532-44708910 | promoter | 2.93e-01 | 5.19e-01 | -3.10e+00 | 1.96e-03 | 1.07e-02 | -2.27e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRP | cg22697517 | chr17:44708010 | CGI:chr17:44708532-44708910 | promoter | 4.20e-01 | 5.47e-01 | -2.66e+00 | 7.83e-03 | 1.43e-02 | -1.26e-01 |
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Exon skipping events with PSI in TCGA for DBF4B |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for DBF4B |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for DBF4B |
| TFs related to DBF4B. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | PLAGL2 | DBF4B | 2.87e+00 | 5.75e-03 | 3.93e+00 | 9.80e-01 | Female-biased |
| ESCA | PRDM6 | DBF4B | 3.88e+00 | 9.84e-01 | 2.71e+00 | 7.39e-04 | Male-biased |
| ESCA | ZNF182 | DBF4B | 4.25e+00 | 9.91e-01 | 3.04e+00 | 6.16e-04 | Male-biased |
| ESCA | ZNF22 | DBF4B | 4.25e+00 | 9.92e-01 | 2.92e+00 | 3.13e-04 | Male-biased |
| ESCA | ZNF225 | DBF4B | 4.08e+00 | 9.89e-01 | 2.84e+00 | 5.10e-04 | Male-biased |
| ESCA | ZNF235 | DBF4B | 3.99e+00 | 9.87e-01 | 2.79e+00 | 5.92e-04 | Male-biased |
| ESCA | ZNF287 | DBF4B | 4.04e+00 | 9.88e-01 | 2.88e+00 | 8.28e-04 | Male-biased |
| ESCA | ZNF487 | DBF4B | 4.17e+00 | 9.90e-01 | 2.98e+00 | 6.64e-04 | Male-biased |
| ESCA | ZNF879 | DBF4B | 3.93e+00 | 9.86e-01 | 2.56e+00 | 2.28e-04 | Male-biased |
| ESCA | ZNF98 | DBF4B | 4.07e+00 | 9.88e-01 | 3.03e+00 | 1.56e-03 | Male-biased |
| MESO | BACH1 | DBF4B | 2.92e+00 | 3.87e-03 | 4.47e+00 | 9.89e-01 | Female-biased |
| MESO | BATF | DBF4B | 3.02e+00 | 4.36e-03 | 4.54e+00 | 9.89e-01 | Female-biased |
| MESO | FOXJ2 | DBF4B | 2.12e+00 | 8.56e-04 | 4.07e+00 | 9.86e-01 | Female-biased |
| MESO | FOXJ3 | DBF4B | 2.40e+00 | 1.22e-03 | 4.27e+00 | 9.89e-01 | Female-biased |
| MESO | FOXK2 | DBF4B | 2.84e+00 | 6.95e-03 | 4.22e+00 | 9.82e-01 | Female-biased |
| MESO | FOXP2 | DBF4B | 2.46e+00 | 2.10e-03 | 4.17e+00 | 9.86e-01 | Female-biased |
| MESO | NFE2L2 | DBF4B | 2.71e+00 | 6.43e-03 | 4.11e+00 | 9.81e-01 | Female-biased |
| MESO | NR4A2 | DBF4B | 3.35e+00 | 1.10e-02 | 4.59e+00 | 9.83e-01 | Female-biased |
| MESO | POU3F4 | DBF4B | 4.20e+00 | 1.12e-02 | 5.45e+00 | 9.87e-01 | Female-biased |
| MESO | POU6F1 | DBF4B | 3.63e+00 | 9.01e-03 | 4.95e+00 | 9.87e-01 | Female-biased |
| MESO | STAT2 | DBF4B | 1.80e+00 | 1.29e-04 | 4.21e+00 | 9.89e-01 | Female-biased |
| MESO | STAT5B | DBF4B | 2.59e+00 | 2.11e-03 | 4.31e+00 | 9.88e-01 | Female-biased |
| MESO | TCF4 | DBF4B | 2.85e+00 | 7.92e-03 | 4.18e+00 | 9.80e-01 | Female-biased |
| MESO | TCF7L2 | DBF4B | 2.90e+00 | 7.86e-03 | 4.24e+00 | 9.81e-01 | Female-biased |
| MESO | ZKSCAN2 | DBF4B | 2.68e+00 | 8.88e-04 | 4.63e+00 | 9.93e-01 | Female-biased |
| MESO | ZNF85 | DBF4B | 2.57e+00 | 1.11e-03 | 4.47e+00 | 9.92e-01 | Female-biased |
| MESO | ZNF879 | DBF4B | 1.99e+00 | 1.91e-04 | 4.30e+00 | 9.91e-01 | Female-biased |
| PAAD | ZNF692 | DBF4B | 2.97e+00 | 3.74e-03 | 3.96e+00 | 9.82e-01 | Female-biased |
| DBF4B related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for DBF4B |
| RBPs related to ES in DBF4B. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DBF4B related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs9897116 | chr17:45145941:A:G | - | 0.171674653846792 | 0.000980343013837196 | LUSC | Female-baised eQTL |
| rs901753 | chr17:45151124:C:T | - | 0.171077769059789 | 0.00104607593805146 | LUSC | Female-baised eQTL |
| rs17544278 | chr17:44631414:T:C | - | 0.156128275323922 | 0.00181194527832607 | LUSC | Female-baised eQTL |
| rs78763692 | chr17:44939826:T:G | - | 0.161960081571917 | 0.00533266472583556 | LUSC | Female-baised eQTL |
| rs17682536 | chr17:44723046:C:T | gene | 0.138731984655668 | 0.00812574034584372 | LUSC | Female-baised eQTL |
| rs76096668 | chr17:44891769:G:A | - | 0.147503427390995 | 0.0100512894335701 | LUSC | Female-baised eQTL |
| rs59542675 | chr17:45175776:G:A | - | 0.146105247583289 | 0.0150718134317069 | LUSC | Female-baised eQTL |
| rs77390070 | chr17:42401653:G:A | - | -0.153000561714954 | 0.0385995622007583 | STAD | Female-baised eQTL |
| rs3760379 | chr17:44916487:A:G | - | -0.0694361477270103 | 0.0182043517348407 | LUAD | Female-baised eQTL |
| rs8081716 | chr17:53444472:T:C | - | 0.15478609700998 | 0.0118287692156342 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs757592 | chr17:44770490:C:A | - | 0.0708164964544097 | 0.00325669810811499 | LGG | Male-baised eQTL |
| rs11650453 | chr17:51887492:T:G | - | 0.121996550147463 | 0.00482597419884493 | LGG | Male-baised eQTL |
| rs8077830 | chr17:51888905:A:G | - | 0.121996550147463 | 0.00482597419884493 | LGG | Male-baised eQTL |
| rs8071064 | chr17:51893177:C:T | - | 0.121996550147463 | 0.00482597419884493 | LGG | Male-baised eQTL |
| rs73348433 | chr17:51897710:C:T | - | 0.121996550147463 | 0.00482597419884493 | LGG | Male-baised eQTL |
| rs1392935 | chr17:51861769:G:A | - | 0.100557622103133 | 0.024227882827874 | LGG | Male-baised eQTL |
| rs7219219 | chr17:51871817:T:A | - | 0.100557622103133 | 0.024227882827874 | LGG | Male-baised eQTL |
| rs11079830 | chr17:48605268:G:A | - | -0.0531661422971696 | 0.0299210583405191 | LGG | Male-baised eQTL |
| rs3744477 | chr17:44750305:G:A | gene | 0.0591971769197172 | 0.0479854766592125 | LGG | Male-baised eQTL |
| rs62063221 | chr17:51862817:A:G | - | 0.0959307624680932 | 0.0496486470818816 | LGG | Male-baised eQTL |
| rs62063226 | chr17:51866988:T:G | - | 0.0959307624680932 | 0.0496486470818816 | LGG | Male-baised eQTL |
| rs8071052 | chr17:51870949:T:G | - | 0.0959307624680932 | 0.0496486470818816 | LGG | Male-baised eQTL |
| rs9900575 | chr17:41151423:T:C | - | 0.0633952118718635 | 0.0497879722182839 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of DBF4B |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
