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Gene: ENSG00000151465 |
Summary for CDC123 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000151465 | Gene symbol | CDC123 |
| Gene name | cell division cycle 123 | |
| HGNC | 16827 | |
| Entrez ID | 8872 | |
| Gene type | protein_coding | |
| Synonyms | CDC123|D123 | |
| UniProtAcc | O75794 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for CDC123 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
Top |
Sex-biased somatic mutation for CDC123 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for CDC123 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for CDC123 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for CDC123 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for CDC123 |
| TFs related to CDC123. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BLCA | KLF7 | CDC123 | 4.13e+00 | 9.87e-01 | 2.60e+00 | 8.23e-04 | Male-biased |
| BLCA | SP1 | CDC123 | 3.98e+00 | 9.80e-01 | 2.82e+00 | 2.73e-03 | Male-biased |
| BLCA | ZNF180 | CDC123 | 4.04e+00 | 9.82e-01 | 2.91e+00 | 3.09e-03 | Male-biased |
| BLCA | ZNF441 | CDC123 | 4.14e+00 | 9.86e-01 | 2.86e+00 | 1.89e-03 | Male-biased |
| CHOL | ZNF200 | CDC123 | 2.97e+00 | 4.75e-03 | 4.08e+00 | 9.84e-01 | Female-biased |
| ESCA | ZNF121 | CDC123 | 4.15e+00 | 9.85e-01 | 3.31e+00 | 5.04e-03 | Male-biased |
| ESCA | ZNF181 | CDC123 | 4.08e+00 | 9.81e-01 | 3.32e+00 | 7.81e-03 | Male-biased |
| ESCA | ZNF33A | CDC123 | 4.15e+00 | 9.81e-01 | 3.42e+00 | 9.32e-03 | Male-biased |
| ESCA | ZNF443 | CDC123 | 4.14e+00 | 9.85e-01 | 3.33e+00 | 5.76e-03 | Male-biased |
| ESCA | ZNF496 | CDC123 | 4.11e+00 | 9.85e-01 | 3.28e+00 | 5.17e-03 | Male-biased |
| ESCA | ZNF571 | CDC123 | 4.11e+00 | 9.84e-01 | 3.28e+00 | 5.29e-03 | Male-biased |
| LGG | ZNF235 | CDC123 | 4.00e+00 | 9.82e-01 | 2.40e+00 | 3.63e-05 | Male-biased |
| LGG | ZNF496 | CDC123 | 4.02e+00 | 9.82e-01 | 3.08e+00 | 8.45e-04 | Male-biased |
| MESO | ZNF418 | CDC123 | 1.92e+00 | 2.16e-04 | 4.21e+00 | 9.89e-01 | Female-biased |
| CDC123 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for CDC123 |
| RBPs related to ES in CDC123. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| UVM | PCBP2 | exon_skip_39686 | 8.47e+00 | 9.93e-01 | 7.83e+00 | 2.22e-04 | Male-biased |
| THYM | SNRPA | exon_skip_39684 | 8.98e+00 | 9.82e-01 | 8.69e+00 | 1.32e-02 | Male-biased |
| LIHC | SNRPA | exon_skip_39684 | 8.61e+00 | 1.06e-02 | 8.99e+00 | 9.85e-01 | Female-biased |
| DLBC | RBMS1 | exon_skip_39685 | 1.42e+01 | 3.36e-04 | 1.49e+01 | 1.00e+00 | Female-biased |
| BRCA | PCBP2 | exon_skip_39686 | 8.70e+00 | 9.87e-01 | 8.08e+00 | 7.45e-03 | Male-biased |
| BRCA | RBMS1 | exon_skip_39685 | 1.42e+01 | 9.83e-01 | 1.37e+01 | 1.70e-02 | Male-biased |
| PCPG | SNRPA | exon_skip_39684 | 8.97e+00 | 9.93e-01 | 8.53e+00 | 2.52e-03 | Male-biased |
| MESO | SNRPA | exon_skip_39684 | 8.57e+00 | 5.83e-03 | 8.96e+00 | 9.89e-01 | Female-biased |
| LGG | SNRPA | exon_skip_39684 | 8.56e+00 | 7.68e-03 | 8.92e+00 | 9.88e-01 | Female-biased |
| GBM | RBMS1 | exon_skip_39685 | 1.39e+01 | 9.90e-01 | 1.35e+01 | 9.42e-03 | Male-biased |
| GBM | SNRPA | exon_skip_39684 | 9.00e+00 | 9.93e-01 | 8.54e+00 | 2.78e-03 | Male-biased |
| CDC123 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs74391212 | chr10:6120777:G:A | - | 0.338224736837274 | 0.00539108279511744 | KIRP | Female-baised eQTL |
| rs58361051 | chr10:6121643:G:A | - | 0.314654219463578 | 0.00785340637281618 | KIRP | Female-baised eQTL |
| rs7076208 | chr10:3815624:G:A | - | 0.233109762365024 | 0.0113367781071648 | KIRP | Female-baised eQTL |
| rs11257429 | chr10:11924017:T:C | - | -0.128918339343005 | 0.0218162132276892 | LIHC | Female-baised eQTL |
| rs10752211 | chr10:10869359:T:C | - | 0.140493873571893 | 0.0477606868532987 | LIHC | Female-baised eQTL |
| rs9333114 | chr10:15660993:C:A | - | 0.14119538068577 | 0.0270257043447963 | STAD | Female-baised eQTL |
| rs10903814 | chr10:2578990:C:A | - | 0.102513567637698 | 0.0450051819089087 | STAD | Female-baised eQTL |
| rs113078785 | chr10:7567363:G:A | - | 0.0838872194682839 | 0.045576688860802 | KIRC | Female-baised eQTL |
| rs4749992 | chr10:10817650:C:G | - | -0.0557476957886201 | 0.0173263708276344 | LUAD | Female-baised eQTL |
| rs7079799 | chr10:14064315:T:C | - | 0.0626976210309262 | 0.0254998246989397 | LUAD | Female-baised eQTL |
| rs7901640 | chr10:18368024:G:A | - | 0.0819264943680868 | 0.0202147063331405 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17145614 | chr10:9252520:A:G | - | 0.0935607582951121 | 2.32305015066208e-05 | KIRP | Male-baised eQTL |
| rs57259010 | chr10:2409116:T:G | - | 0.0854220142367555 | 0.000111663027414812 | KIRP | Male-baised eQTL |
| rs73592759 | chr10:4366239:A:G | - | 0.0897914680630353 | 0.000122478152290581 | KIRP | Male-baised eQTL |
| rs2791415 | chr10:6918079:C:T | - | -0.0804376557617777 | 0.000588789532143001 | KIRP | Male-baised eQTL |
| rs2804125 | chr10:6918551:A:G | - | -0.0804376557617777 | 0.000588789532143001 | KIRP | Male-baised eQTL |
| rs2804116 | chr10:6915325:C:T | - | -0.0802910927108337 | 0.000622134070940008 | KIRP | Male-baised eQTL |
| rs6602701 | chr10:14074118:T:A | - | 0.0842905497827462 | 0.00159082532202308 | KIRP | Male-baised eQTL |
| rs861155 | chr10:2400849:A:C | - | 0.077830132144557 | 0.00248094218870889 | KIRP | Male-baised eQTL |
| rs2765667 | chr10:2401159:T:C | - | 0.077830132144557 | 0.00248094218870889 | KIRP | Male-baised eQTL |
| rs826486 | chr10:2402090:C:T | - | 0.077830132144557 | 0.00248094218870889 | KIRP | Male-baised eQTL |
| rs826487 | chr10:2402401:C:T | - | 0.077830132144557 | 0.00248094218870889 | KIRP | Male-baised eQTL |
| rs826488 | chr10:2402981:C:T | - | 0.077830132144557 | 0.00248094218870889 | KIRP | Male-baised eQTL |
| rs2765696 | chr10:2404336:C:G | - | 0.077830132144557 | 0.00248094218870889 | KIRP | Male-baised eQTL |
| rs2638451 | chr10:2404549:C:A | - | 0.077830132144557 | 0.00248094218870889 | KIRP | Male-baised eQTL |
| rs2638450 | chr10:2404808:C:T | - | 0.077830132144557 | 0.00248094218870889 | KIRP | Male-baised eQTL |
| rs2765695 | chr10:2404967:C:T | - | 0.077830132144557 | 0.00248094218870889 | KIRP | Male-baised eQTL |
| rs2765694 | chr10:2404985:C:T | - | 0.077830132144557 | 0.00248094218870889 | KIRP | Male-baised eQTL |
| rs1018008 | chr10:2406460:G:T | - | 0.077830132144557 | 0.00248094218870889 | KIRP | Male-baised eQTL |
| rs3864831 | chr10:19456896:G:A | - | 0.0732169540462553 | 0.00470208806571324 | KIRP | Male-baised eQTL |
| rs113899947 | chr10:19456900:G:A | - | 0.0732169540462553 | 0.00470208806571324 | KIRP | Male-baised eQTL |
| rs11256171 | chr10:9378360:T:C | - | 0.0721328354318531 | 0.00629319711422859 | KIRP | Male-baised eQTL |
| rs11251967 | chr10:3615183:A:G | - | 0.079238889180105 | 0.00736659495051462 | KIRP | Male-baised eQTL |
| rs4880986 | chr10:2243616:C:G | - | -0.0580749230778462 | 0.00982944110877169 | KIRP | Male-baised eQTL |
| rs17132705 | chr10:4357022:G:A | - | 0.0719832017633893 | 0.0102870475210298 | KIRP | Male-baised eQTL |
| rs56058543 | chr10:4357851:A:G | - | 0.0719832017633893 | 0.0102870475210298 | KIRP | Male-baised eQTL |
| rs11012340 | chr10:20789493:G:A | - | 0.0708547289448076 | 0.0212444441281607 | KIRP | Male-baised eQTL |
| rs10794877 | chr10:2226053:T:C | - | -0.0558703964654356 | 0.0224131621888434 | KIRP | Male-baised eQTL |
| rs56091793 | chr10:2226425:C:T | - | -0.0558703964654356 | 0.0224131621888434 | KIRP | Male-baised eQTL |
| rs2765691 | chr10:2406965:C:A | - | 0.0642799393093977 | 0.0243245202422196 | KIRP | Male-baised eQTL |
| rs10794882 | chr10:2229402:C:A | - | -0.0626257982321866 | 0.024838946813792 | KIRP | Male-baised eQTL |
| rs11012443 | chr10:20978913:T:C | - | 0.0584739332383289 | 0.0260520971287058 | KIRP | Male-baised eQTL |
| rs2765690 | chr10:2407065:G:A | - | 0.0613261224137105 | 0.0280886976387967 | KIRP | Male-baised eQTL |
| rs17146734 | chr10:9922010:A:G | - | 0.0653802861354993 | 0.029560471451807 | KIRP | Male-baised eQTL |
| rs826498 | chr10:2411595:C:A | - | 0.063473253417049 | 0.0354906250636876 | KIRP | Male-baised eQTL |
| rs10905882 | chr10:11021073:T:C | - | -0.0593803298068393 | 0.0424037057067424 | KIRP | Male-baised eQTL |
| rs1291864 | chr10:11037203:T:C | - | -0.069325859452609 | 0.0160038979817152 | LGG | Male-baised eQTL |
| rs11255071 | chr10:7282296:C:T | - | 0.0288099753353039 | 0.0396123081183105 | KIRC | Male-baised eQTL |
| rs57028795 | chr10:12580500:G:T | - | 0.0546599976238172 | 0.0444129879562912 | KIRC | Male-baised eQTL |
| rs6601916 | chr10:5138083:G:A | - | -0.0320055609970367 | 0.0383555694185231 | BLCA | Male-baised eQTL |
| rs10906246 | chr10:12887615:G:A | - | -0.0616146886830914 | 0.0249132675664922 | LUAD | Male-baised eQTL |
| rs1888666 | chr10:12891952:A:T | - | -0.061237542752868 | 0.028454731353819 | LUAD | Male-baised eQTL |
| rs1888665 | chr10:12891926:C:A | - | -0.0608878198936553 | 0.0313608815490844 | LUAD | Male-baised eQTL |
| rs4391734 | chr10:2653374:C:T | - | 0.077358061448699 | 0.0112900361365551 | COAD | Male-baised eQTL |
| rs11256579 | chr10:10370080:C:T | - | -0.0704338459032439 | 0.0413299940828057 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of CDC123 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
