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Gene: ENSG00000148824 |
Summary for MTG1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000148824 | Gene symbol | MTG1 |
| Gene name | mitochondrial ribosome associated GTPase 1 | |
| HGNC | 32159 | |
| Entrez ID | 92170 | |
| Gene type | protein_coding | |
| Synonyms | MTG1| | |
| UniProtAcc | Q9BT17 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for MTG1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MTG1 | 5.06e+02 | 1.81e+00 | 2.47e-01 | 7.32e+00 | 2.55e-13 | 1.02e-11 | BLCA |
| Differentially expressed gene analysis between tumor female and normal female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MTG1 | 3.23e+02 | 1.12e+00 | 1.39e-01 | 8.07e+00 | 6.87e-16 | 5.71e-15 | LUAD |
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Sex-biased somatic mutation for MTG1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for MTG1 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for MTG1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for MTG1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for MTG1 |
| TFs related to MTG1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | ZNF235 | MTG1 | 4.35e+00 | 9.88e-01 | 2.61e+00 | 2.20e-03 | Male-biased |
| BRCA | ZNF287 | MTG1 | 4.17e+00 | 9.84e-01 | 2.50e+00 | 2.64e-03 | Male-biased |
| MESO | EMX1 | MTG1 | 3.01e+00 | 9.52e-03 | 4.28e+00 | 9.80e-01 | Female-biased |
| MESO | EMX2 | MTG1 | 2.71e+00 | 6.33e-03 | 4.11e+00 | 9.81e-01 | Female-biased |
| MESO | ZNF418 | MTG1 | 4.67e-01 | 4.73e-06 | 3.78e+00 | 9.80e-01 | Female-biased |
| MTG1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for MTG1 |
| RBPs related to ES in MTG1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MTG1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs2265907 | chr10:133405340:G:T | gene | -0.0642004529746099 | 0.0135037372321346 | THCA | Female-baised eQTL |
| rs12252576 | chr10:133413740:T:C | gene | 0.0635826214475713 | 0.0157307444363772 | THCA | Female-baised eQTL |
| rs11101742 | chr10:133410868:G:C | gene | 0.0608949169237173 | 0.0167839684615616 | THCA | Female-baised eQTL |
| rs11816147 | chr10:133414949:T:C | gene | 0.0611908047634572 | 0.0275196729360925 | THCA | Female-baised eQTL |
| rs6413432 | chr10:133535040:T:A | - | 0.187425836519202 | 0.0368903170084916 | BLCA | Female-baised eQTL |
| rs2864987 | chr10:133535075:A:G | - | 0.187425836519202 | 0.0368903170084916 | BLCA | Female-baised eQTL |
| rs2864986 | chr10:133535169:C:A | - | 0.187425836519202 | 0.0368903170084916 | BLCA | Female-baised eQTL |
| rs2864984 | chr10:133535453:C:A | - | 0.187425836519202 | 0.0368903170084916 | BLCA | Female-baised eQTL |
| rs11593514 | chr10:131819008:C:T | - | 0.0958957292083351 | 0.000851815995716683 | LUAD | Female-baised eQTL |
| rs11595115 | chr10:131794285:G:A | - | 0.105452475121383 | 0.00139182569631081 | LUAD | Female-baised eQTL |
| rs11244603 | chr10:124376453:C:T | - | 0.0853055509852331 | 0.0178456664345727 | LUAD | Female-baised eQTL |
| rs72831404 | chr10:129216218:A:G | - | 0.0454591858290072 | 0.0230532084840142 | LUAD | Female-baised eQTL |
| rs9887979 | chr10:129214838:G:A | - | 0.0463762477049631 | 0.0254315948323728 | LUAD | Female-baised eQTL |
| rs11244602 | chr10:124376387:G:A | - | 0.0823108551282573 | 0.0311524032006383 | LUAD | Female-baised eQTL |
| rs1078389 | chr10:129212508:G:C | - | 0.0441936751955487 | 0.0408490885881263 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs978472 | chr10:126614697:A:G | - | 0.177912355582576 | 0.0482648818780567 | THCA | Male-baised eQTL |
| rs10741177 | chr10:128884838:C:T | - | -0.150233558872787 | 0.0493618208495218 | LGG | Male-baised eQTL |
| rs1924687 | chr10:128886429:A:T | - | -0.150233558872787 | 0.0493618208495218 | LGG | Male-baised eQTL |
| rs942528 | chr10:128877253:G:T | - | -0.0381624406980194 | 0.0412141068221492 | KIRC | Male-baised eQTL |
| rs2944512 | chr10:131273592:A:G | - | -0.0823581146331921 | 0.0436827226660907 | KIRC | Male-baised eQTL |
| rs942529 | chr10:128877300:G:A | - | -0.0379539896526275 | 0.0471802632614604 | KIRC | Male-baised eQTL |
| rs7083430 | chr10:129632616:G:A | - | 0.0702828766794329 | 0.0123622142261006 | BLCA | Male-baised eQTL |
| rs4751456 | chr10:127566896:A:G | - | -0.0415657854645346 | 0.0169844348414208 | COAD | Male-baised eQTL |
| rs1547321 | chr10:127568294:A:G | - | -0.0408198154710765 | 0.0245179813052186 | COAD | Male-baised eQTL |
| rs1547322 | chr10:127568404:T:C | - | -0.0408198154710765 | 0.0245179813052186 | COAD | Male-baised eQTL |
| rs2489391 | chr10:127149631:T:C | - | -0.0555017017400427 | 0.0263629345255886 | COAD | Male-baised eQTL |
| rs10830135 | chr10:127567703:G:A | - | -0.0404911610251456 | 0.026595504690912 | COAD | Male-baised eQTL |
| rs4750707 | chr10:128513177:T:C | - | -0.0716314286895369 | 0.0285640067965057 | COAD | Male-baised eQTL |
| rs2265177 | chr10:133469269:T:G | - | -0.0535270088922687 | 0.0296734061115465 | COAD | Male-baised eQTL |
| rs2492653 | chr10:133469470:A:G | - | -0.0535270088922687 | 0.0296734061115465 | COAD | Male-baised eQTL |
| rs951077 | chr10:127143806:G:T | - | -0.054449964729758 | 0.0307556699199858 | COAD | Male-baised eQTL |
| rs1770390 | chr10:127144753:T:C | - | -0.054449964729758 | 0.0307556699199858 | COAD | Male-baised eQTL |
| rs10510133 | chr10:123587475:G:T | - | -0.0497043663431883 | 0.0317322129953834 | COAD | Male-baised eQTL |
| rs73375155 | chr10:125034023:C:A | - | 0.0865626102037929 | 0.0346252329266221 | COAD | Male-baised eQTL |
| rs705163 | chr10:123492738:G:T | - | -0.0455711028541992 | 0.0349403756903193 | COAD | Male-baised eQTL |
| rs705164 | chr10:123493531:G:A | - | -0.0452091435996006 | 0.0375024759043063 | COAD | Male-baised eQTL |
| rs705165 | chr10:123496579:G:T | - | -0.0452091435996006 | 0.0375024759043063 | COAD | Male-baised eQTL |
| rs59096071 | chr10:132923854:G:A | - | 0.0883015796717179 | 0.0381056678719514 | COAD | Male-baised eQTL |
| rs10764784 | chr10:128518735:T:A | - | -0.0528343393456209 | 0.0405761217366107 | COAD | Male-baised eQTL |
| rs7096203 | chr10:133511001:A:C | - | 0.0441724174255624 | 0.0458663702243522 | COAD | Male-baised eQTL |
| rs7096321 | chr10:133511032:A:G | - | 0.0441724174255624 | 0.0458663702243522 | COAD | Male-baised eQTL |
| rs73388744 | chr10:129633732:T:G | - | 0.0790448653432485 | 0.0470607709236726 | COAD | Male-baised eQTL |
| rs705162 | chr10:123492159:G:A | - | -0.0435314176901425 | 0.0473751016932955 | COAD | Male-baised eQTL |
| rs7083073 | chr10:133509452:T:A | - | 0.0439464370555065 | 0.0489080699941089 | COAD | Male-baised eQTL |
| rs7092634 | chr10:133509473:G:A | - | 0.0439464370555065 | 0.0489080699941089 | COAD | Male-baised eQTL |
| rs6537609 | chr10:133509580:A:G | - | 0.0439415474911524 | 0.0493089649882597 | COAD | Male-baised eQTL |
| rs7911139 | chr10:133510021:T:C | - | 0.0439415474911524 | 0.0493089649882597 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of MTG1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
