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Gene: ENSG00000145014 |
Summary for TMEM44 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000145014 | Gene symbol | TMEM44 |
| Gene name | transmembrane protein 44 | |
| HGNC | 25120 | |
| Entrez ID | 93109 | |
| Gene type | protein_coding | |
| Synonyms | TMEM44|DKFZp686O18124 | |
| UniProtAcc | Q2T9K0 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for TMEM44 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| TMEM44 | 9.13e+02 | 1.12e+00 | 1.29e-01 | 8.73e+00 | 2.49e-18 | 1.11e-16 | THCA |
| TMEM44 | 1.11e+03 | 1.41e+00 | 1.74e-01 | 8.12e+00 | 4.71e-16 | 6.13e-15 | HNSC |
| TMEM44 | 1.55e+03 | 1.04e+00 | 1.70e-01 | 6.10e+00 | 1.09e-09 | 2.72e-09 | LUSC |
| TMEM44 | 1.05e+03 | 1.48e+00 | 2.58e-01 | 5.74e+00 | 9.64e-09 | 1.24e-07 | BLCA |
| TMEM44 | 9.33e+02 | 1.09e+00 | 1.47e-01 | 7.42e+00 | 1.19e-13 | 3.29e-12 | STAD |
| TMEM44 | 7.51e+02 | 1.72e+00 | 3.96e-01 | 4.33e+00 | 1.52e-05 | 8.15e-05 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for TMEM44 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for TMEM44 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg03862437 | chr3:194632703 | CGI:chr3:194633032-194633761 | promoter,gene body | 5.85e-01 | 7.27e-01 | -2.20e+00 | 2.75e-02 | 3.95e-02 | -1.43e-01 |
| KIRC | cg03862437 | chr3:194632703 | CGI:chr3:194633032-194633761 | promoter,gene body | 6.95e-01 | 5.89e-01 | 4.27e+00 | 1.93e-05 | 1.28e-04 | 1.05e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg03862437 | chr3:194632703 | CGI:chr3:194633032-194633761 | promoter,gene body | 5.89e-01 | 8.34e-01 | -5.03e+00 | 4.84e-07 | 1.94e-06 | -2.45e-01 |
| LUAD | cg03862437 | chr3:194632703 | CGI:chr3:194633032-194633761 | promoter,gene body | 5.04e-01 | 6.74e-01 | -3.66e+00 | 2.52e-04 | 6.09e-04 | -1.70e-01 |
| LUSC | cg03862437 | chr3:194632703 | CGI:chr3:194633032-194633761 | promoter,gene body | 3.18e-01 | 6.36e-01 | -4.17e+00 | 3.00e-05 | 5.26e-04 | -3.17e-01 |
| COAD | cg03862437 | chr3:194632703 | CGI:chr3:194633032-194633761 | promoter,gene body | 2.89e-01 | 3.93e-01 | -2.56e+00 | 1.03e-02 | 1.47e-02 | -1.03e-01 |
| KIRP | cg27033479 | chr3:194632825 | CGI:chr3:194633032-194633761 | promoter,gene body | 7.77e-02 | 1.88e-01 | -5.89e+00 | 3.84e-09 | 8.25e-08 | -1.10e-01 |
| CHOL | cg03862437 | chr3:194632703 | CGI:chr3:194633032-194633761 | promoter,gene body | 5.69e-01 | 9.03e-01 | -2.43e+00 | 1.50e-02 | 2.65e-02 | -3.34e-01 |
| CHOL | cg27033479 | chr3:194632825 | CGI:chr3:194633032-194633761 | promoter,gene body | 1.11e-01 | 3.69e-01 | -3.17e+00 | 1.52e-03 | 1.07e-02 | -2.58e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for TMEM44 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for TMEM44 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
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| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| ESCA | TMEM44-010 | chr3_194620809_- | 5.82e-01 | 7.06e-01 | -2.06e+00 | 3.96e-02 | 4.99e-02 | -1.24e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for TMEM44 |
| TFs related to TMEM44. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| TMEM44 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for TMEM44 |
| RBPs related to ES in TMEM44. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| LUSC | HNRNPH2 | exon_skip_391001 | 8.38e+00 | 9.83e-01 | 8.01e+00 | 9.62e-03 | Male-biased |
| LUSC | SAMD4A | exon_skip_391021 | 6.80e+00 | 3.63e-03 | 7.25e+00 | 9.85e-01 | Female-biased |
| COAD | SAMD4A | exon_skip_391021 | 7.61e+00 | 9.90e-01 | 6.40e+00 | 1.77e-05 | Male-biased |
| LUAD | HNRNPH2 | exon_skip_391001 | 8.32e+00 | 9.88e-01 | 7.93e+00 | 5.01e-03 | Male-biased |
| KIRP | HNRNPH2 | exon_skip_390999 | 8.59e+00 | 9.91e-01 | 8.14e+00 | 2.79e-03 | Male-biased |
| BRCA | HNRNPH2 | exon_skip_390999 | 7.81e+00 | 1.18e-02 | 8.41e+00 | 9.81e-01 | Female-biased |
| ESCA | HNRNPH2 | exon_skip_391001 | 7.64e+00 | 1.96e-03 | 8.29e+00 | 9.91e-01 | Female-biased |
| ESCA | SAMD4A | exon_skip_391021 | 6.36e+00 | 3.33e-03 | 6.94e+00 | 9.83e-01 | Female-biased |
| THCA | HNRNPH2 | exon_skip_391004 | 8.01e+00 | 6.98e-03 | 8.33e+00 | 9.86e-01 | Female-biased |
| SKCM | HNRNPH2 | exon_skip_391001 | 8.02e+00 | 4.31e-03 | 8.46e+00 | 9.89e-01 | Female-biased |
| HNSC | SAMD4A | exon_skip_391021 | 7.34e+00 | 9.88e-01 | 6.70e+00 | 7.39e-04 | Male-biased |
| TMEM44 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000145014 | AC011476.2,hsa-mir-455,TMEM44 | Male-specific ceRNA | TCGA-STAD |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs112686151 | chr3:197921222:G:A | - | 0.145200460019269 | 0.0110884193574567 | STAD | Female-baised eQTL |
| rs112460661 | chr3:197928018:G:C | - | 0.132890029282798 | 0.0318574506793902 | STAD | Female-baised eQTL |
| rs76482311 | chr3:197918488:A:C | - | 0.132399706013095 | 0.0332555123445866 | STAD | Female-baised eQTL |
| rs79913146 | chr3:197919508:T:C | - | 0.132399706013095 | 0.0332555123445866 | STAD | Female-baised eQTL |
| rs17500920 | chr3:190307104:T:A | - | 0.0559016131396997 | 0.0352804289097596 | LUAD | Female-baised eQTL |
| rs56937307 | chr3:194907370:G:A | - | 0.120537760474943 | 0.0387038747993517 | COAD | Female-baised eQTL |
| rs56938299 | chr3:194907379:A:G | - | 0.120537760474943 | 0.0387038747993517 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs17489503 | chr3:189338943:T:C | - | 0.190632803999019 | 0.0268455027597651 | PCPG | Male-baised eQTL |
| rs7617882 | chr3:189302105:A:T | - | 0.205753871909941 | 0.043651174391144 | PCPG | Male-baised eQTL |
| rs7640560 | chr3:189302522:G:A | - | 0.205753871909941 | 0.043651174391144 | PCPG | Male-baised eQTL |
| rs71308916 | chr3:188159669:G:A | - | 0.0757349789641645 | 0.000840814079206661 | LIHC | Male-baised eQTL |
| rs11929015 | chr3:191800684:A:G | - | 0.0485835068957833 | 0.017680889533414 | LIHC | Male-baised eQTL |
| rs7636009 | chr3:191802365:A:G | - | 0.0499872155784297 | 0.0255264044352165 | LIHC | Male-baised eQTL |
| rs1499841 | chr3:191953889:T:A | - | 0.0465934540952468 | 0.0192547155275302 | LUSC | Male-baised eQTL |
| rs1499840 | chr3:191954181:C:T | - | 0.0462760752159285 | 0.0213637184268476 | LUSC | Male-baised eQTL |
| rs1717656 | chr3:187175708:G:A | - | 0.132089572920962 | 0.00199882099414007 | LUAD | Male-baised eQTL |
| rs368266562 | chr3:187178798:C:T | - | 0.115457223980199 | 0.00855905241645597 | LUAD | Male-baised eQTL |
| rs12491229 | chr3:187183211:A:G | - | 0.115457223980199 | 0.00855905241645597 | LUAD | Male-baised eQTL |
| rs2016011 | chr3:187188691:C:T | - | 0.115457223980199 | 0.00855905241645597 | LUAD | Male-baised eQTL |
| rs185949544 | chr3:187175728:T:A | - | 0.105441326991926 | 0.0145010166161102 | LUAD | Male-baised eQTL |
| rs138293636 | chr3:187179630:G:A | - | 0.111661355827023 | 0.0231340433533096 | LUAD | Male-baised eQTL |
| rs144466240 | chr3:187180299:C:A | - | 0.111661355827023 | 0.0231340433533096 | LUAD | Male-baised eQTL |
| rs9866953 | chr3:187180990:G:C | - | 0.111661355827023 | 0.0231340433533096 | LUAD | Male-baised eQTL |
| rs1271569 | chr3:189471526:G:A | - | -0.0890187876418291 | 0.0265027857388144 | COAD | Male-baised eQTL |
| rs1255941 | chr3:189471120:C:T | - | -0.0797066339431027 | 0.0304659169534698 | COAD | Male-baised eQTL |
| rs1255940 | chr3:189473781:A:C | - | -0.0797066339431027 | 0.0304659169534698 | COAD | Male-baised eQTL |
| rs2290328 | chr3:189494967:A:G | - | -0.105105018113863 | 0.0311933778573502 | COAD | Male-baised eQTL |
| rs2290327 | chr3:189495018:A:G | - | -0.105105018113863 | 0.0311933778573502 | COAD | Male-baised eQTL |
| rs1255943 | chr3:189470185:A:G | - | -0.079797716158413 | 0.0347230857497933 | COAD | Male-baised eQTL |
| rs185465 | chr3:189467968:G:T | - | -0.0877883930741407 | 0.0356818074472398 | COAD | Male-baised eQTL |
| rs41517648 | chr3:189497492:C:A | - | -0.105150181109 | 0.0397004121107452 | COAD | Male-baised eQTL |
| rs2067571 | chr3:189448364:T:C | - | 0.0709084550192583 | 0.0463672180717108 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of TMEM44 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
