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Center for Computational Systems Medicine
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Gene summary

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Gene structure and Gene expression level

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Sex-biased somatic mutation

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DNA methylation with beta values in gene

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Exon skipping events with PSI in TCGA

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RNA A-to-I editing events in TCGA

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Sex-biased TF-Gene network of gene

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Sex-biased RBP-ES network of gene

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Sex-biased CeRNA regulation of gene

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Sex-biased eQTL regulation of gene

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Sex-biased eQTM regulation of gene

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Sex-biased sQTL regulation of gene

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Sex-biased sQTM regulation of gene

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Related disease information of gene

Gene: ENSG00000142867

Summary for BCL10

check button Gene summary

Gene informationEnsembl ID

ENSG00000142867

Gene symbol

BCL10

Gene nameBCL10 immune signaling adaptor
HGNC

989

Entrez ID

8915

Gene typeprotein_coding
SynonymsBCL10|CARMEN|CIPER|mE10|c-E10|CLAP
UniProtAcc

O95999


check buttonDrugs associated with this gene(DrugBank).
Gene IDGene SymbolDrug IDDrug NameDrug Type

check buttonCancer therapeutic drugs associated with this gene(NCI).
Gene IDGene NameDrug IDDrug NameDrug TypeCancer

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Structure and expression level for BCL10

check buttonAS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure.
∗For more information on exon skipping events please check the ExonskipDB database.
∗For more information on exon skipping events please check the CAeditome database.
UCSC result

check buttonLandscape of gene expressions across multiple cancer types.
gene expression analysis

check buttonDifferentially expressed gene analysis between tumor male and tumor female samples.
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type

check buttonDifferentially expressed gene analysis between tumor male and normal male samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
BCL101.37e+03-1.13e+001.99e-01-5.67e+001.44e-081.78e-07BLCA

check buttonDifferentially expressed gene analysis between tumor female and normal female samples.
DEG result
Coding NameBase Meanlog2FoldChangelfcSEStatP valueP.adjust ValueCancer Type
BCL101.29e+03-1.26e+002.33e-01-5.41e+006.38e-087.82e-07READ

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Sex-biased somatic mutation for BCL10

∗For more information on exon skipping events please check the ExonskipDB database.
Gene IDCancer TypeHugo SymbolMaleFemalepvalorci.upci.lowadjPval

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DNA methylation with beta values for BCL10

check buttonLandscape of DNA methylation across multiple cancer types.
methylation heatmap

check buttonDifferentially expressed CpG sites between male tumor and female tumor patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg05475904chr1:85277694CGI:chr1:85276182-85276852promoter8.54e-016.37e-013.04e+002.34e-031.47e-022.16e-01
BRCAcg16377367chr1:85277814CGI:chr1:85276182-85276852promoter6.43e-013.86e-013.31e+009.22e-048.99e-032.57e-01

check buttonDifferentially expressed CpG sites between male tumor and male normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
COADcg17322118chr1:85278049CGI:chr1:85276182-85276852promoter8.46e-019.46e-01-4.82e+001.41e-061.48e-05-1.00e-01
BLCAcg05475904chr1:85277694CGI:chr1:85276182-85276852promoter8.58e-019.63e-01-2.26e+002.39e-022.81e-02-1.05e-01
LIHCcg17322118chr1:85278049CGI:chr1:85276182-85276852promoter7.32e-018.62e-01-2.80e+005.14e-036.76e-03-1.30e-01

check buttonDifferentially expressed CpG sites between female tumor and female normal patients.
Cancer TypeCpG SitePositionCpG IslandPosition to Geneave1ave2wilcoxon.wwilcoxon.ppadjdBeta
BRCAcg05475904chr1:85277694CGI:chr1:85276182-85276852promoter8.54e-019.64e-01-8.08e+006.41e-162.51e-15-1.10e-01
BRCAcg16377367chr1:85277814CGI:chr1:85276182-85276852promoter6.43e-019.11e-01-1.05e+019.76e-268.90e-25-2.68e-01
BRCAcg17322118chr1:85278049CGI:chr1:85276182-85276852promoter6.50e-018.99e-01-9.58e+009.92e-226.23e-21-2.50e-01

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Exon skipping events with PSI in TCGA for BCL10

∗Please access ExonSkipDB for exon skipping annotation.
check buttonDifferentially expressed exon skipping events between male tumor and female tumor patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between male tumor and male normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

check buttonDifferentially expressed exon skipping events between female tumor and female normal patients.
Cancer TypeExon Skippingave.female_Tave.female_Nwilcoxon.wwilcoxon.ppadjdPSI

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RNA A-to-I editing events in TCGA for BCL10

∗Please access CAeditome for RNA editing annotation.
check buttonDifferentially expressed RNA editing events between male tumor and female tumor patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between male tumor and male normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonDifferentially expressed RNA editing events between female tumor and female normal patients.
Cancer TypeTranscriptEditingave.male_Tave.female_Twilcoxon.wwilcoxon.pp_adjdFre

check buttonProtein coding RNA editing(s).
Editing PositionVariant TypeGene SymbolTranscript IDNTchangeAAchange

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Sex-biased TF-Gene network for BCL10

check buttonTFs related to BCL10.
∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
TF Gene
Cancer TypeTFTarget GeneMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType
ACCZNF235BCL103.80e+009.83e-012.28e+004.54e-04Male-biased
ACCZNF287BCL103.87e+009.85e-012.35e+004.56e-04Male-biased
ACCZNF418BCL103.83e+009.84e-011.51e+001.15e-05Male-biased
READFOXR2BCL103.34e+005.88e-034.30e+009.84e-01Female-biased
READZNF418BCL103.67e+002.24e-034.90e+009.94e-01Female-biased
READZNF79BCL103.44e+003.55e-034.54e+009.90e-01Female-biased
THYMZNF418BCL103.43e+001.76e-034.55e+009.91e-01Female-biased
THYMZNF79BCL103.18e+002.82e-034.17e+009.84e-01Female-biased

check buttonBCL10 related gene.
∗Only the gene encode TF might with this result.
∗For more information please check Sex-biased TF-Coding gene network.

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Sex-biased RBP-ES network for BCL10

check buttonRBPs related to ES in BCL10.
∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98.
∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98.
Cancer TypeRBPTarget ESMale Edge ScoreMale Edge ThresholdFemale Edge ScoreFemale Edge ThresholdType

check buttonBCL10 related ES.
∗Only the gene encode RBP might with this result.
∗For more information please check Sex-biased RBP-ES network in cancer.

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Sex-biased CeRNA regulation of gene

check buttonSex-biased CeRNA regulation of gene.
Gene IDceRNA(lncRNA-miRNA-mRNA)GroupCancer Type
ENSG00000142867AC078883.1,hsa-mir-340,BCL10Male-specific ceRNATCGA-BLCA

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Sex-biased eQTL regulation of gene

check buttonSex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
eQTLDescription

check buttonMale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs4658282chr1:91944605:A:G--0.1931289066391180.0087543411424334HNSCFemale-baised eQTL
rs6656817chr1:91946003:T:C--0.1931289066391180.0087543411424334HNSCFemale-baised eQTL
rs6702511chr1:91946032:A:G--0.1931289066391180.0087543411424334HNSCFemale-baised eQTL
rs61779157chr1:91985461:C:T-0.2114089847938060.0144833514191845HNSCFemale-baised eQTL
rs12569167chr1:91986652:T:A-0.2098261179291030.0164034996835628HNSCFemale-baised eQTL
rs12040031chr1:91961859:T:A-0.2189671084041390.0166730751662227HNSCFemale-baised eQTL
rs6604070chr1:91963468:C:G-0.2189671084041390.0166730751662227HNSCFemale-baised eQTL
rs76525820chr1:91964987:G:A-0.2189671084041390.0166730751662227HNSCFemale-baised eQTL
rs7541712chr1:91968038:C:T-0.2189671084041390.0166730751662227HNSCFemale-baised eQTL
rs1156281chr1:91977138:A:C-0.2189671084041390.0166730751662227HNSCFemale-baised eQTL
rs12045408chr1:91978642:A:G-0.2189479579054120.0264639739691271HNSCFemale-baised eQTL
rs61779156chr1:91983727:C:T-0.2189479579054120.0264639739691271HNSCFemale-baised eQTL
rs2799522chr1:91841419:C:G-0.1225378850344940.0237335160295521LGGFemale-baised eQTL
rs3103333chr1:91836023:G:A-0.122839574060760.026091576723742LGGFemale-baised eQTL
rs1983170chr1:91520925:G:A-0.107044479745510.0429670325174028BLCAFemale-baised eQTL
rs13447527chr1:91517916:C:T-0.1059943998247530.0448234783739955BLCAFemale-baised eQTL
rs530803chr1:91506817:T:G--0.1070935082626370.0448252264728843BLCAFemale-baised eQTL
rs578155chr1:91510984:G:A--0.1070935082626370.0448252264728843BLCAFemale-baised eQTL
rs483532chr1:91514890:A:G--0.1062524919778580.0480352340865452BLCAFemale-baised eQTL
rs2044265chr1:88498831:T:G-0.06012026674339550.0158765067730705LUADFemale-baised eQTL
rs72942437chr1:84832266:T:C--0.0720452123660210.033576227651725LUADFemale-baised eQTL
rs12130014chr1:84832131:G:C-0.05176406721658980.0447591604443674LUADFemale-baised eQTL
rs1032185chr1:76158142:C:T-0.05154151535514790.049399956942398LUADFemale-baised eQTL

check buttonFemale-specific eQTL regulation.
SNP IDSNP InfoPosition to GeneEffect ScoreFDRCancer TypeBiased Type
rs10493767chr1:85483339:T:A-0.1094189338009480.00202083452406618LGGMale-baised eQTL
rs17127799chr1:85484375:T:C-0.1094189338009480.00202083452406618LGGMale-baised eQTL
rs4847369chr1:92793404:A:G--0.09627079345411360.0291161766465069LGGMale-baised eQTL
rs4847218chr1:92793405:T:A--0.09627079345411360.0291161766465069LGGMale-baised eQTL
rs1977224chr1:92802592:G:A--0.09538849372750060.0313277187746494LGGMale-baised eQTL
rs61771337chr1:76144595:G:A-0.09048888757454240.0392788681954709LGGMale-baised eQTL
rs7536227chr1:92796833:C:T--0.09216319604380140.0433131911652012LGGMale-baised eQTL
rs149923993chr1:92796836:C:T--0.09216319604380140.0433131911652012LGGMale-baised eQTL
rs7536228chr1:92796839:C:T--0.09216319604380140.0433131911652012LGGMale-baised eQTL
rs11164818chr1:92800257:T:C--0.0912775964424690.0484074990443866LGGMale-baised eQTL
rs12029026chr1:92801281:T:C--0.0912775964424690.0484074990443866LGGMale-baised eQTL
rs6604024chr1:92790780:A:C--0.08877200114700220.0494959965666727LGGMale-baised eQTL
rs11164812chr1:92791817:A:G--0.08877200114700220.0494959965666727LGGMale-baised eQTL
rs11164813chr1:92792120:A:G--0.08877200114700220.0494959965666727LGGMale-baised eQTL
rs4847370chr1:92793636:C:T--0.08877200114700220.0494959965666727LGGMale-baised eQTL
rs684347chr1:88626496:C:T-0.1285941813187080.0451882871241748LUADMale-baised eQTL
rs556966chr1:88627115:A:G-0.1285941813187080.0451882871241748LUADMale-baised eQTL
rs9660834chr1:85932983:T:C-0.1059946900279150.00485696974708821COADMale-baised eQTL
rs1768388chr1:81132679:A:G-0.06469640097337070.00620142725051073COADMale-baised eQTL
rs12098203chr1:81367926:A:G-0.103221019961450.00724087305316692COADMale-baised eQTL
rs1752220chr1:81131218:G:A-0.06448611262787440.00807142906584252COADMale-baised eQTL
rs17130580chr1:88698914:C:T-0.1341846432038870.00930148021527184COADMale-baised eQTL
rs11163260chr1:81362746:G:A-0.09972841153003360.0109863909231649COADMale-baised eQTL
rs12120918chr1:85914741:C:T-0.09164306798223440.0131429748647718COADMale-baised eQTL
rs12136958chr1:85915967:G:A-0.09164306798223440.0131429748647718COADMale-baised eQTL
rs56301284chr1:85941335:C:G-0.09090547862053410.014601362151436COADMale-baised eQTL
rs17131660chr1:84395075:A:G-0.1043576046332840.017596363205561COADMale-baised eQTL
rs404716chr1:91163098:G:A--0.06486394988650.0197160959887481COADMale-baised eQTL
rs17404261chr1:85968695:T:C-0.08729016972827590.0200062352116392COADMale-baised eQTL
rs2125723chr1:89566286:C:T-0.05259919932919450.0264009556497894COADMale-baised eQTL
rs12723903chr1:89571491:C:T-0.05259919932919450.0264009556497894COADMale-baised eQTL
rs12118443chr1:89573029:G:A-0.05259919932919450.0264009556497894COADMale-baised eQTL
rs12118464chr1:89573161:G:A-0.05259919932919450.0264009556497894COADMale-baised eQTL
rs12733491chr1:89573474:G:A-0.05259919932919450.0264009556497894COADMale-baised eQTL
rs10922667chr1:89573968:T:A-0.05259919932919450.0264009556497894COADMale-baised eQTL
rs12739453chr1:89574728:G:A-0.05259919932919450.0264009556497894COADMale-baised eQTL
rs12760395chr1:89574802:A:G-0.05259919932919450.0264009556497894COADMale-baised eQTL
rs1459637chr1:89575199:A:G-0.05259919932919450.0264009556497894COADMale-baised eQTL
rs61798917chr1:89040410:G:A--0.0590855048461620.0267114834384516COADMale-baised eQTL
rs1752219chr1:81132221:C:T-0.05775483660666480.0269206787196765COADMale-baised eQTL
rs12410381chr1:89571135:T:C-0.05176882666402860.0298352790112883COADMale-baised eQTL
rs10922666chr1:89571143:G:C-0.05176882666402860.0298352790112883COADMale-baised eQTL
rs12411255chr1:89571188:G:A-0.05176882666402860.0298352790112883COADMale-baised eQTL
rs12410923chr1:89570227:G:A-0.05178671001127550.0305456330170013COADMale-baised eQTL
rs10922665chr1:89570949:G:C-0.05178671001127550.0305456330170013COADMale-baised eQTL
rs10518591chr1:78908894:C:T-0.07300153713558810.0360837585408048COADMale-baised eQTL
rs312395chr1:84509277:T:C-0.07333271375794720.0371900790000874COADMale-baised eQTL
rs17419571chr1:81338592:G:A-0.08733446391680160.0431037780736957COADMale-baised eQTL
rs1752211chr1:81126272:T:A-0.05469306873772310.0435605264154618COADMale-baised eQTL
rs12732722chr1:75642203:C:G--0.05593075508354060.0455738851896961COADMale-baised eQTL
rs10922668chr1:89577677:A:G-0.0505415082325360.0475482293300516COADMale-baised eQTL
rs10922669chr1:89577681:A:G-0.0505415082325360.0475482293300516COADMale-baised eQTL
rs138847036chr1:75825305:A:G-0.07330028185040280.0477718187865926COADMale-baised eQTL
rs4847319chr1:94630033:C:G--0.0553054864246370.0487733740689426COADMale-baised eQTL
rs12125301chr1:89042818:G:A--0.0561988138872570.0490420341037928COADMale-baised eQTL
rs12122780chr1:89043233:T:C--0.0561988138872570.0490420341037928COADMale-baised eQTL
rs1074541chr1:89043816:A:G--0.0561988138872570.0490420341037928COADMale-baised eQTL
rs7541867chr1:89047854:G:A--0.0561988138872570.0490420341037928COADMale-baised eQTL
rs17106655chr1:81535601:G:A-0.08030418833089550.0490427638666812COADMale-baised eQTL

check buttonOpposite sex-biased eQTL regulation.
SNP IDSNP InfoPosition to GeneMale EffectMale FDRFemale EffectFemale FDRSex-biased Gene in CancerCancer Type

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Sex-biased eQTM regulation of gene

check buttonSex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table).
eQTMDescription

check buttonMale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonFemale-specific eQTM regulation.
CpG SiteCpG PostionPosition to GeneEffect ScoreFDRCor.rCor.PvalueCancer Type

check buttonOpposite sex-biased eQTM regulation.
CpG SiteCpG PostionCpG IslandPosition to GeneMale EffectMale FDRFemale EffectFemale FDRMale CorMale P-valueFemale CorFemale P-valueSex-biased Coding GeneCancer Type

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Sex-biased sQTL regulation of gene

check buttonSex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTLDescription

check buttonMale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonFemale-specific sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESEffect ScoreFDRCancer TypeBiased Type

check buttonOpposite sex-biased sQTL regulation.
ES IDSkipped ExonORF AnnoSNP IDSNP InfoSNP Position to ESMale EffectMale FDRFemale EffectFemale FDRCancer Type

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Sex-biased sQTM regulation of gene

check buttonSex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table).
sQTMDescription

check buttonMale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonFemale-specific sQTM regulation.
EX IDSkipped ExonCPG SiteCPG PositionPosition to EX EventsEffect ScoreFDRCor.rCor.PvalueORF_annoCancer Type

check buttonOpposite sex-biased sQTM regulation.
EX IDEX InfoSkipped ExonCPG SiteCPG PositionCPG IslandPosition to EX EventsMale EffectMale FDRFemale EffectFemale FDRMale CorrelationMale P-valueFemale CorrelationFemale P-valueORF_annoCancer Type

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Related disease information of BCL10

check buttonDiseases associated with this gene (DisGeNET).
Gene IDGene SymbolDisease IDDisease NameNumber of PMIDSource
ENSG00000142867BCL10C0024302Reticulosarcoma1CTD_human
ENSG00000142867BCL10C0024304Lymphoma, Mixed-Cell1CTD_human
ENSG00000142867BCL10C0024305Lymphoma, Non-Hodgkin1CTD_human
ENSG00000142867BCL10C0024306Lymphoma, Undifferentiated1CTD_human
ENSG00000142867BCL10C0079740High Grade Lymphoma (neoplasm)1CTD_human
ENSG00000142867BCL10C0079741Lymphoma, Intermediate-Grade1CTD_human
ENSG00000142867BCL10C0079747Low Grade Lymphoma (neoplasm)1CTD_human
ENSG00000142867BCL10C0079757Diffuse Mixed-Cell Lymphoma1CTD_human
ENSG00000142867BCL10C0079770Lymphoma, Small Noncleaved-Cell1CTD_human
ENSG00000142867BCL10C0242647Mucosa-Associated Lymphoid Tissue Lymphoma1CTD_human
ENSG00000142867BCL10C0345967Malignant mesothelioma1CTD_human
ENSG00000142867BCL10C1336708Testicular Germ Cell Tumor1CTD_human
ENSG00000142867BCL10C3714542Lymphoma, Diffuse1CTD_human
ENSG00000142867BCL10C4015195IMMUNODEFICIENCY 371CTD_human
ENSG00000142867BCL10C4721532Lymphoma, Non-Hodgkin, Familial1CTD_human