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Gene: ENSG00000142867 |
Summary for BCL10 |
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Gene information | Ensembl ID | ENSG00000142867 | Gene symbol | BCL10 |
Gene name | BCL10 immune signaling adaptor | |
HGNC | 989 | |
Entrez ID | 8915 | |
Gene type | protein_coding | |
Synonyms | BCL10|CARMEN|CIPER|mE10|c-E10|CLAP | |
UniProtAcc | O95999 |
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Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
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Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for BCL10 |
![]() ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
BCL10 | 1.37e+03 | -1.13e+00 | 1.99e-01 | -5.67e+00 | 1.44e-08 | 1.78e-07 | BLCA |
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Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
BCL10 | 1.29e+03 | -1.26e+00 | 2.33e-01 | -5.41e+00 | 6.38e-08 | 7.82e-07 | READ |
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Sex-biased somatic mutation for BCL10 |
∗For more information on exon skipping events please check the ExonskipDB database. |
Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for BCL10 |
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Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
BRCA | cg05475904 | chr1:85277694 | CGI:chr1:85276182-85276852 | promoter | 8.54e-01 | 6.37e-01 | 3.04e+00 | 2.34e-03 | 1.47e-02 | 2.16e-01 |
BRCA | cg16377367 | chr1:85277814 | CGI:chr1:85276182-85276852 | promoter | 6.43e-01 | 3.86e-01 | 3.31e+00 | 9.22e-04 | 8.99e-03 | 2.57e-01 |
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Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
COAD | cg17322118 | chr1:85278049 | CGI:chr1:85276182-85276852 | promoter | 8.46e-01 | 9.46e-01 | -4.82e+00 | 1.41e-06 | 1.48e-05 | -1.00e-01 |
BLCA | cg05475904 | chr1:85277694 | CGI:chr1:85276182-85276852 | promoter | 8.58e-01 | 9.63e-01 | -2.26e+00 | 2.39e-02 | 2.81e-02 | -1.05e-01 |
LIHC | cg17322118 | chr1:85278049 | CGI:chr1:85276182-85276852 | promoter | 7.32e-01 | 8.62e-01 | -2.80e+00 | 5.14e-03 | 6.76e-03 | -1.30e-01 |
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Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
BRCA | cg05475904 | chr1:85277694 | CGI:chr1:85276182-85276852 | promoter | 8.54e-01 | 9.64e-01 | -8.08e+00 | 6.41e-16 | 2.51e-15 | -1.10e-01 |
BRCA | cg16377367 | chr1:85277814 | CGI:chr1:85276182-85276852 | promoter | 6.43e-01 | 9.11e-01 | -1.05e+01 | 9.76e-26 | 8.90e-25 | -2.68e-01 |
BRCA | cg17322118 | chr1:85278049 | CGI:chr1:85276182-85276852 | promoter | 6.50e-01 | 8.99e-01 | -9.58e+00 | 9.92e-22 | 6.23e-21 | -2.50e-01 |
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Exon skipping events with PSI in TCGA for BCL10 |
∗Please access ExonSkipDB for exon skipping annotation. |
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Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for BCL10 |
∗Please access CAeditome for RNA editing annotation. |
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Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
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Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
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Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
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Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for BCL10 |
![]() ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
ACC | ZNF235 | BCL10 | 3.80e+00 | 9.83e-01 | 2.28e+00 | 4.54e-04 | Male-biased |
ACC | ZNF287 | BCL10 | 3.87e+00 | 9.85e-01 | 2.35e+00 | 4.56e-04 | Male-biased |
ACC | ZNF418 | BCL10 | 3.83e+00 | 9.84e-01 | 1.51e+00 | 1.15e-05 | Male-biased |
READ | FOXR2 | BCL10 | 3.34e+00 | 5.88e-03 | 4.30e+00 | 9.84e-01 | Female-biased |
READ | ZNF418 | BCL10 | 3.67e+00 | 2.24e-03 | 4.90e+00 | 9.94e-01 | Female-biased |
READ | ZNF79 | BCL10 | 3.44e+00 | 3.55e-03 | 4.54e+00 | 9.90e-01 | Female-biased |
THYM | ZNF418 | BCL10 | 3.43e+00 | 1.76e-03 | 4.55e+00 | 9.91e-01 | Female-biased |
THYM | ZNF79 | BCL10 | 3.18e+00 | 2.82e-03 | 4.17e+00 | 9.84e-01 | Female-biased |
![]() ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for BCL10 |
![]() ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
![]() ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
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Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
ENSG00000142867 | AC078883.1,hsa-mir-340,BCL10 | Male-specific ceRNA | TCGA-BLCA |
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Sex-biased eQTL regulation of gene |
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eQTL | Description |
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SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
rs4658282 | chr1:91944605:A:G | - | -0.193128906639118 | 0.0087543411424334 | HNSC | Female-baised eQTL |
rs6656817 | chr1:91946003:T:C | - | -0.193128906639118 | 0.0087543411424334 | HNSC | Female-baised eQTL |
rs6702511 | chr1:91946032:A:G | - | -0.193128906639118 | 0.0087543411424334 | HNSC | Female-baised eQTL |
rs61779157 | chr1:91985461:C:T | - | 0.211408984793806 | 0.0144833514191845 | HNSC | Female-baised eQTL |
rs12569167 | chr1:91986652:T:A | - | 0.209826117929103 | 0.0164034996835628 | HNSC | Female-baised eQTL |
rs12040031 | chr1:91961859:T:A | - | 0.218967108404139 | 0.0166730751662227 | HNSC | Female-baised eQTL |
rs6604070 | chr1:91963468:C:G | - | 0.218967108404139 | 0.0166730751662227 | HNSC | Female-baised eQTL |
rs76525820 | chr1:91964987:G:A | - | 0.218967108404139 | 0.0166730751662227 | HNSC | Female-baised eQTL |
rs7541712 | chr1:91968038:C:T | - | 0.218967108404139 | 0.0166730751662227 | HNSC | Female-baised eQTL |
rs1156281 | chr1:91977138:A:C | - | 0.218967108404139 | 0.0166730751662227 | HNSC | Female-baised eQTL |
rs12045408 | chr1:91978642:A:G | - | 0.218947957905412 | 0.0264639739691271 | HNSC | Female-baised eQTL |
rs61779156 | chr1:91983727:C:T | - | 0.218947957905412 | 0.0264639739691271 | HNSC | Female-baised eQTL |
rs2799522 | chr1:91841419:C:G | - | 0.122537885034494 | 0.0237335160295521 | LGG | Female-baised eQTL |
rs3103333 | chr1:91836023:G:A | - | 0.12283957406076 | 0.026091576723742 | LGG | Female-baised eQTL |
rs1983170 | chr1:91520925:G:A | - | 0.10704447974551 | 0.0429670325174028 | BLCA | Female-baised eQTL |
rs13447527 | chr1:91517916:C:T | - | 0.105994399824753 | 0.0448234783739955 | BLCA | Female-baised eQTL |
rs530803 | chr1:91506817:T:G | - | -0.107093508262637 | 0.0448252264728843 | BLCA | Female-baised eQTL |
rs578155 | chr1:91510984:G:A | - | -0.107093508262637 | 0.0448252264728843 | BLCA | Female-baised eQTL |
rs483532 | chr1:91514890:A:G | - | -0.106252491977858 | 0.0480352340865452 | BLCA | Female-baised eQTL |
rs2044265 | chr1:88498831:T:G | - | 0.0601202667433955 | 0.0158765067730705 | LUAD | Female-baised eQTL |
rs72942437 | chr1:84832266:T:C | - | -0.072045212366021 | 0.033576227651725 | LUAD | Female-baised eQTL |
rs12130014 | chr1:84832131:G:C | - | 0.0517640672165898 | 0.0447591604443674 | LUAD | Female-baised eQTL |
rs1032185 | chr1:76158142:C:T | - | 0.0515415153551479 | 0.049399956942398 | LUAD | Female-baised eQTL |
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SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
rs10493767 | chr1:85483339:T:A | - | 0.109418933800948 | 0.00202083452406618 | LGG | Male-baised eQTL |
rs17127799 | chr1:85484375:T:C | - | 0.109418933800948 | 0.00202083452406618 | LGG | Male-baised eQTL |
rs4847369 | chr1:92793404:A:G | - | -0.0962707934541136 | 0.0291161766465069 | LGG | Male-baised eQTL |
rs4847218 | chr1:92793405:T:A | - | -0.0962707934541136 | 0.0291161766465069 | LGG | Male-baised eQTL |
rs1977224 | chr1:92802592:G:A | - | -0.0953884937275006 | 0.0313277187746494 | LGG | Male-baised eQTL |
rs61771337 | chr1:76144595:G:A | - | 0.0904888875745424 | 0.0392788681954709 | LGG | Male-baised eQTL |
rs7536227 | chr1:92796833:C:T | - | -0.0921631960438014 | 0.0433131911652012 | LGG | Male-baised eQTL |
rs149923993 | chr1:92796836:C:T | - | -0.0921631960438014 | 0.0433131911652012 | LGG | Male-baised eQTL |
rs7536228 | chr1:92796839:C:T | - | -0.0921631960438014 | 0.0433131911652012 | LGG | Male-baised eQTL |
rs11164818 | chr1:92800257:T:C | - | -0.091277596442469 | 0.0484074990443866 | LGG | Male-baised eQTL |
rs12029026 | chr1:92801281:T:C | - | -0.091277596442469 | 0.0484074990443866 | LGG | Male-baised eQTL |
rs6604024 | chr1:92790780:A:C | - | -0.0887720011470022 | 0.0494959965666727 | LGG | Male-baised eQTL |
rs11164812 | chr1:92791817:A:G | - | -0.0887720011470022 | 0.0494959965666727 | LGG | Male-baised eQTL |
rs11164813 | chr1:92792120:A:G | - | -0.0887720011470022 | 0.0494959965666727 | LGG | Male-baised eQTL |
rs4847370 | chr1:92793636:C:T | - | -0.0887720011470022 | 0.0494959965666727 | LGG | Male-baised eQTL |
rs684347 | chr1:88626496:C:T | - | 0.128594181318708 | 0.0451882871241748 | LUAD | Male-baised eQTL |
rs556966 | chr1:88627115:A:G | - | 0.128594181318708 | 0.0451882871241748 | LUAD | Male-baised eQTL |
rs9660834 | chr1:85932983:T:C | - | 0.105994690027915 | 0.00485696974708821 | COAD | Male-baised eQTL |
rs1768388 | chr1:81132679:A:G | - | 0.0646964009733707 | 0.00620142725051073 | COAD | Male-baised eQTL |
rs12098203 | chr1:81367926:A:G | - | 0.10322101996145 | 0.00724087305316692 | COAD | Male-baised eQTL |
rs1752220 | chr1:81131218:G:A | - | 0.0644861126278744 | 0.00807142906584252 | COAD | Male-baised eQTL |
rs17130580 | chr1:88698914:C:T | - | 0.134184643203887 | 0.00930148021527184 | COAD | Male-baised eQTL |
rs11163260 | chr1:81362746:G:A | - | 0.0997284115300336 | 0.0109863909231649 | COAD | Male-baised eQTL |
rs12120918 | chr1:85914741:C:T | - | 0.0916430679822344 | 0.0131429748647718 | COAD | Male-baised eQTL |
rs12136958 | chr1:85915967:G:A | - | 0.0916430679822344 | 0.0131429748647718 | COAD | Male-baised eQTL |
rs56301284 | chr1:85941335:C:G | - | 0.0909054786205341 | 0.014601362151436 | COAD | Male-baised eQTL |
rs17131660 | chr1:84395075:A:G | - | 0.104357604633284 | 0.017596363205561 | COAD | Male-baised eQTL |
rs404716 | chr1:91163098:G:A | - | -0.0648639498865 | 0.0197160959887481 | COAD | Male-baised eQTL |
rs17404261 | chr1:85968695:T:C | - | 0.0872901697282759 | 0.0200062352116392 | COAD | Male-baised eQTL |
rs2125723 | chr1:89566286:C:T | - | 0.0525991993291945 | 0.0264009556497894 | COAD | Male-baised eQTL |
rs12723903 | chr1:89571491:C:T | - | 0.0525991993291945 | 0.0264009556497894 | COAD | Male-baised eQTL |
rs12118443 | chr1:89573029:G:A | - | 0.0525991993291945 | 0.0264009556497894 | COAD | Male-baised eQTL |
rs12118464 | chr1:89573161:G:A | - | 0.0525991993291945 | 0.0264009556497894 | COAD | Male-baised eQTL |
rs12733491 | chr1:89573474:G:A | - | 0.0525991993291945 | 0.0264009556497894 | COAD | Male-baised eQTL |
rs10922667 | chr1:89573968:T:A | - | 0.0525991993291945 | 0.0264009556497894 | COAD | Male-baised eQTL |
rs12739453 | chr1:89574728:G:A | - | 0.0525991993291945 | 0.0264009556497894 | COAD | Male-baised eQTL |
rs12760395 | chr1:89574802:A:G | - | 0.0525991993291945 | 0.0264009556497894 | COAD | Male-baised eQTL |
rs1459637 | chr1:89575199:A:G | - | 0.0525991993291945 | 0.0264009556497894 | COAD | Male-baised eQTL |
rs61798917 | chr1:89040410:G:A | - | -0.059085504846162 | 0.0267114834384516 | COAD | Male-baised eQTL |
rs1752219 | chr1:81132221:C:T | - | 0.0577548366066648 | 0.0269206787196765 | COAD | Male-baised eQTL |
rs12410381 | chr1:89571135:T:C | - | 0.0517688266640286 | 0.0298352790112883 | COAD | Male-baised eQTL |
rs10922666 | chr1:89571143:G:C | - | 0.0517688266640286 | 0.0298352790112883 | COAD | Male-baised eQTL |
rs12411255 | chr1:89571188:G:A | - | 0.0517688266640286 | 0.0298352790112883 | COAD | Male-baised eQTL |
rs12410923 | chr1:89570227:G:A | - | 0.0517867100112755 | 0.0305456330170013 | COAD | Male-baised eQTL |
rs10922665 | chr1:89570949:G:C | - | 0.0517867100112755 | 0.0305456330170013 | COAD | Male-baised eQTL |
rs10518591 | chr1:78908894:C:T | - | 0.0730015371355881 | 0.0360837585408048 | COAD | Male-baised eQTL |
rs312395 | chr1:84509277:T:C | - | 0.0733327137579472 | 0.0371900790000874 | COAD | Male-baised eQTL |
rs17419571 | chr1:81338592:G:A | - | 0.0873344639168016 | 0.0431037780736957 | COAD | Male-baised eQTL |
rs1752211 | chr1:81126272:T:A | - | 0.0546930687377231 | 0.0435605264154618 | COAD | Male-baised eQTL |
rs12732722 | chr1:75642203:C:G | - | -0.0559307550835406 | 0.0455738851896961 | COAD | Male-baised eQTL |
rs10922668 | chr1:89577677:A:G | - | 0.050541508232536 | 0.0475482293300516 | COAD | Male-baised eQTL |
rs10922669 | chr1:89577681:A:G | - | 0.050541508232536 | 0.0475482293300516 | COAD | Male-baised eQTL |
rs138847036 | chr1:75825305:A:G | - | 0.0733002818504028 | 0.0477718187865926 | COAD | Male-baised eQTL |
rs4847319 | chr1:94630033:C:G | - | -0.055305486424637 | 0.0487733740689426 | COAD | Male-baised eQTL |
rs12125301 | chr1:89042818:G:A | - | -0.056198813887257 | 0.0490420341037928 | COAD | Male-baised eQTL |
rs12122780 | chr1:89043233:T:C | - | -0.056198813887257 | 0.0490420341037928 | COAD | Male-baised eQTL |
rs1074541 | chr1:89043816:A:G | - | -0.056198813887257 | 0.0490420341037928 | COAD | Male-baised eQTL |
rs7541867 | chr1:89047854:G:A | - | -0.056198813887257 | 0.0490420341037928 | COAD | Male-baised eQTL |
rs17106655 | chr1:81535601:G:A | - | 0.0803041883308955 | 0.0490427638666812 | COAD | Male-baised eQTL |
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SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
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eQTM | Description |
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CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
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CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
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CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
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sQTL | Description |
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ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
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ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
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ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
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sQTM | Description |
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EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
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EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
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EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of BCL10 |
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Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
ENSG00000142867 | BCL10 | C0024302 | Reticulosarcoma | 1 | CTD_human |
ENSG00000142867 | BCL10 | C0024304 | Lymphoma, Mixed-Cell | 1 | CTD_human |
ENSG00000142867 | BCL10 | C0024305 | Lymphoma, Non-Hodgkin | 1 | CTD_human |
ENSG00000142867 | BCL10 | C0024306 | Lymphoma, Undifferentiated | 1 | CTD_human |
ENSG00000142867 | BCL10 | C0079740 | High Grade Lymphoma (neoplasm) | 1 | CTD_human |
ENSG00000142867 | BCL10 | C0079741 | Lymphoma, Intermediate-Grade | 1 | CTD_human |
ENSG00000142867 | BCL10 | C0079747 | Low Grade Lymphoma (neoplasm) | 1 | CTD_human |
ENSG00000142867 | BCL10 | C0079757 | Diffuse Mixed-Cell Lymphoma | 1 | CTD_human |
ENSG00000142867 | BCL10 | C0079770 | Lymphoma, Small Noncleaved-Cell | 1 | CTD_human |
ENSG00000142867 | BCL10 | C0242647 | Mucosa-Associated Lymphoid Tissue Lymphoma | 1 | CTD_human |
ENSG00000142867 | BCL10 | C0345967 | Malignant mesothelioma | 1 | CTD_human |
ENSG00000142867 | BCL10 | C1336708 | Testicular Germ Cell Tumor | 1 | CTD_human |
ENSG00000142867 | BCL10 | C3714542 | Lymphoma, Diffuse | 1 | CTD_human |
ENSG00000142867 | BCL10 | C4015195 | IMMUNODEFICIENCY 37 | 1 | CTD_human |
ENSG00000142867 | BCL10 | C4721532 | Lymphoma, Non-Hodgkin, Familial | 1 | CTD_human |