|
||||||
|
 | |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
| |
|
Gene: ENSG00000136379 |
Summary for ABHD17C |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000136379 | Gene symbol | ABHD17C |
| Gene name | abhydrolase domain containing 17C, depalmitoylase | |
| HGNC | 26925 | |
| Entrez ID | 58489 | |
| Gene type | protein_coding | |
| Synonyms | ABHD17C| | |
| UniProtAcc | Q6PCB6 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for ABHD17C |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ABHD17C | 7.01e+02 | -1.49e+00 | 1.80e-01 | -8.30e+00 | 1.08e-16 | 1.56e-15 | KIRP |
| ABHD17C | 8.65e+02 | 1.97e+00 | 3.98e-01 | 4.95e+00 | 7.43e-07 | 5.48e-06 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| ABHD17C | 1.89e+03 | 1.36e+00 | 8.88e-02 | 1.53e+01 | 1.46e-52 | 1.61e-51 | BRCA |
Top |
Sex-biased somatic mutation for ABHD17C |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for ABHD17C |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for ABHD17C |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for ABHD17C |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for ABHD17C |
| TFs related to ABHD17C. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| BRCA | ZNF570 | ABHD17C | 4.01e+00 | 9.81e-01 | 2.30e+00 | 2.35e-03 | Male-biased |
| BRCA | ZNF79 | ABHD17C | 4.30e+00 | 9.88e-01 | 2.48e+00 | 1.69e-03 | Male-biased |
| BRCA | ZNF879 | ABHD17C | 4.28e+00 | 9.88e-01 | 2.36e+00 | 1.26e-03 | Male-biased |
| MESO | BARX1 | ABHD17C | 2.63e+00 | 5.11e-03 | 4.10e+00 | 9.82e-01 | Female-biased |
| MESO | HESX1 | ABHD17C | 2.93e+00 | 8.41e-03 | 4.25e+00 | 9.81e-01 | Female-biased |
| MESO | LHX9 | ABHD17C | 2.91e+00 | 7.46e-03 | 4.27e+00 | 9.82e-01 | Female-biased |
| MESO | MSX1 | ABHD17C | 2.35e+00 | 2.26e-03 | 4.04e+00 | 9.84e-01 | Female-biased |
| MESO | MSX2 | ABHD17C | 2.39e+00 | 2.38e-03 | 4.08e+00 | 9.84e-01 | Female-biased |
| MESO | NANOG | ABHD17C | 2.10e+00 | 1.80e-03 | 3.85e+00 | 9.80e-01 | Female-biased |
| MESO | SOX9 | ABHD17C | 2.19e+00 | 1.59e-03 | 3.98e+00 | 9.83e-01 | Female-biased |
| MESO | TBP | ABHD17C | 2.57e+00 | 5.36e-03 | 4.02e+00 | 9.80e-01 | Female-biased |
| MESO | ZKSCAN2 | ABHD17C | 2.19e+00 | 1.97e-03 | 3.92e+00 | 9.82e-01 | Female-biased |
| MESO | ZNF584 | ABHD17C | 2.08e+00 | 1.63e-03 | 3.86e+00 | 9.81e-01 | Female-biased |
| MESO | ZNF79 | ABHD17C | 1.18e+00 | 3.58e-05 | 3.92e+00 | 9.84e-01 | Female-biased |
| ABHD17C related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for ABHD17C |
| RBPs related to ES in ABHD17C. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ABHD17C related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000136379 | RORA-AS1,hsa-mir-202,ABHD17C | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000136379 | TEX41,hsa-mir-340,ABHD17C | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000136379 | LINC02798,hsa-mir-340,ABHD17C | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000136379 | AP005230.1,hsa-mir-340,ABHD17C | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000136379 | LINC00683,hsa-mir-340,ABHD17C | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000136379 | LINC01915,hsa-mir-340,ABHD17C | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000136379 | AC008771.1,hsa-mir-340,ABHD17C | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000136379 | TGFB2-AS1,hsa-mir-340,ABHD17C | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000136379 | ARHGEF26-AS1,hsa-mir-340,ABHD17C | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000136379 | MAP4K3-DT,hsa-mir-340,ABHD17C | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000136379 | AC025811.1,hsa-mir-340,ABHD17C | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000136379 | AC026124.2,hsa-mir-340,ABHD17C | Male-specific ceRNA | TCGA-KIRP |
| ENSG00000136379 | DHRS4-AS1,hsa-mir-340,ABHD17C | Male-specific ceRNA | TCGA-KIRP |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs66588428 | chr15:79810956:C:G | - | 0.170342165942759 | 0.0450336706391737 | SARC | Female-baised eQTL |
| rs12902848 | chr15:90686205:T:C | - | 0.0993411817335885 | 0.0351375120239577 | LIHC | Female-baised eQTL |
| rs12908656 | chr15:90687891:C:G | - | 0.0980355957267374 | 0.0411778475715117 | LIHC | Female-baised eQTL |
| rs10431841 | chr15:90690793:G:C | - | 0.0975432367071847 | 0.0464901672778156 | LIHC | Female-baised eQTL |
| rs34776072 | chr15:90684241:C:A | - | 0.0971256139547149 | 0.0492329470516179 | LIHC | Female-baised eQTL |
| rs12917203 | chr15:90685909:C:T | - | 0.0971256139547149 | 0.0492329470516179 | LIHC | Female-baised eQTL |
| rs8024713 | chr15:79914616:C:G | - | 0.0874155897913641 | 0.0370055241245349 | LUSC | Female-baised eQTL |
| rs62011189 | chr15:78997348:T:C | - | 0.111132425238226 | 0.0350514674837316 | LGG | Female-baised eQTL |
| rs7170392 | chr15:78999053:A:G | - | 0.111497519753859 | 0.0352542004193826 | LGG | Female-baised eQTL |
| rs4778767 | chr15:78996712:C:T | - | 0.108843484532254 | 0.0438742418351339 | LGG | Female-baised eQTL |
| rs4778768 | chr15:78996759:T:C | - | 0.108843484532254 | 0.0438742418351339 | LGG | Female-baised eQTL |
| rs62011190 | chr15:78997407:A:T | - | 0.108843484532254 | 0.0438742418351339 | LGG | Female-baised eQTL |
| rs62011191 | chr15:78997498:C:T | - | 0.108843484532254 | 0.0438742418351339 | LGG | Female-baised eQTL |
| rs62011192 | chr15:78997597:G:A | - | 0.108843484532254 | 0.0438742418351339 | LGG | Female-baised eQTL |
| rs55649475 | chr15:78997694:T:C | - | 0.108843484532254 | 0.0438742418351339 | LGG | Female-baised eQTL |
| rs34906037 | chr15:78998007:C:T | - | 0.108843484532254 | 0.0438742418351339 | LGG | Female-baised eQTL |
| rs4778771 | chr15:78998258:C:T | - | 0.108843484532254 | 0.0438742418351339 | LGG | Female-baised eQTL |
| rs11633802 | chr15:78998426:T:C | - | 0.108843484532254 | 0.0438742418351339 | LGG | Female-baised eQTL |
| rs4778772 | chr15:78998450:C:T | - | 0.108843484532254 | 0.0438742418351339 | LGG | Female-baised eQTL |
| rs4778773 | chr15:78998581:T:C | - | 0.109964468675631 | 0.0442722892119144 | LGG | Female-baised eQTL |
| rs28520896 | chr15:85516616:C:T | - | 0.0585371229093474 | 0.000921454832356064 | LUAD | Female-baised eQTL |
| rs3848183 | chr15:79630890:A:T | - | 0.0681643630889022 | 0.0128761783390638 | LUAD | Female-baised eQTL |
| rs56725751 | chr15:85501061:G:A | - | 0.0503195659988754 | 0.0155913708968678 | LUAD | Female-baised eQTL |
| rs73450329 | chr15:85502007:C:T | - | 0.0503195659988754 | 0.0155913708968678 | LUAD | Female-baised eQTL |
| rs57357668 | chr15:85504936:A:G | - | 0.0494102825838187 | 0.0184900998544884 | LUAD | Female-baised eQTL |
| rs60803479 | chr15:85498031:C:T | - | 0.0493625321417375 | 0.0187815359788757 | LUAD | Female-baised eQTL |
| rs28429464 | chr15:73427774:A:T | - | 0.0568179841497773 | 0.0238166380552867 | LUAD | Female-baised eQTL |
| rs11072419 | chr15:73428148:G:A | - | 0.0568179841497773 | 0.0238166380552867 | LUAD | Female-baised eQTL |
| rs12438333 | chr15:74775848:C:T | - | 0.0744879781323844 | 0.0252081256308661 | LUAD | Female-baised eQTL |
| rs12324755 | chr15:82013856:G:A | - | 0.0605465312981668 | 0.0272187076089429 | LUAD | Female-baised eQTL |
| rs7178054 | chr15:85440272:T:C | - | 0.0576469572468023 | 0.028327921983307 | LUAD | Female-baised eQTL |
| rs16971216 | chr15:79654414:A:T | - | 0.0684832005891593 | 0.0349814309316989 | LUAD | Female-baised eQTL |
| rs55857625 | chr15:85501207:G:A | - | 0.0507605350941407 | 0.0358613120972049 | LUAD | Female-baised eQTL |
| rs7173944 | chr15:85536226:T:C | - | 0.0458541827006743 | 0.0387071919511066 | LUAD | Female-baised eQTL |
| rs74024885 | chr15:85498149:C:A | - | 0.0495768957775026 | 0.0427977113428307 | LUAD | Female-baised eQTL |
| rs7170389 | chr15:73424131:A:T | - | 0.0458813528412052 | 0.0444496398921305 | LUAD | Female-baised eQTL |
| rs28672234 | chr15:73427045:A:G | - | 0.0458813528412052 | 0.0444496398921305 | LUAD | Female-baised eQTL |
| rs61092196 | chr15:78181150:G:T | - | 0.0430501476922148 | 0.0492900766253954 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs74251746 | chr15:90324349:C:T | - | 0.0794320244537549 | 0.00168783178748907 | BLCA | Male-baised eQTL |
| rs59363419 | chr15:90324539:G:A | - | 0.0793823331424758 | 0.00202813609322842 | BLCA | Male-baised eQTL |
| rs71405699 | chr15:90335408:T:C | - | 0.0748621815272988 | 0.0068108694846632 | BLCA | Male-baised eQTL |
| rs2601204 | chr15:90418286:G:A | - | 0.0725710526452725 | 0.0296316563322899 | BLCA | Male-baised eQTL |
| rs6496655 | chr15:90334508:A:C | - | 0.0594418094434256 | 0.0344815153722024 | BLCA | Male-baised eQTL |
| rs2589952 | chr15:90416353:T:C | - | 0.0707981027998453 | 0.0381533343896299 | BLCA | Male-baised eQTL |
| rs7168398 | chr15:81740834:C:T | - | -0.058798426034899 | 0.0447688439023971 | BLCA | Male-baised eQTL |
| rs2589969 | chr15:90364819:T:C | - | 0.062856665086887 | 0.0489079734941622 | BLCA | Male-baised eQTL |
| rs15939 | chr15:76949201:T:C | - | 0.168106361709891 | 0.00194655868964806 | LUAD | Male-baised eQTL |
| rs62028183 | chr15:76716538:G:A | - | 0.154398711506081 | 0.00252506390428636 | LUAD | Male-baised eQTL |
| rs56402836 | chr15:76789626:A:C | - | 0.151733420520272 | 0.00360596305082662 | LUAD | Male-baised eQTL |
| rs11634136 | chr15:76770698:A:G | - | 0.151233116789008 | 0.00381585749664297 | LUAD | Male-baised eQTL |
| rs62028181 | chr15:76713952:A:G | - | 0.148087598427616 | 0.00470462926183492 | LUAD | Male-baised eQTL |
| rs62028376 | chr15:76368353:G:T | - | 0.146523741148662 | 0.00568203302222564 | LUAD | Male-baised eQTL |
| rs117107946 | chr15:76425648:G:A | - | 0.145912006985604 | 0.00614091852847519 | LUAD | Male-baised eQTL |
| rs12593724 | chr15:80156134:T:C | - | -0.070252880747488 | 0.0451681411019072 | LUAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000136379 |
| CpG Site: cg13026773 | |
| Position to Gene: gene | |
| Male Effect: - | |
| Female Effect: -0.311624790029166 |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg13026773 | chr15:80694018 | gene | -0.311624790029166 | 6.57291869865263e-07 | -0.6522540877436143 | 4.066232046659438e-10 | KIRP |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
Top |
Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
Top |
Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
Top |
Related disease information of ABHD17C |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
