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Gene: ENSG00000124357 |
Summary for NAGK |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000124357 | Gene symbol | NAGK |
| Gene name | N-acetylglucosamine kinase | |
| HGNC | 17174 | |
| Entrez ID | 55577 | |
| Gene type | protein_coding | |
| Synonyms | NAGK|GNK | |
| UniProtAcc | Q9UJ70 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| ENSG00000124357 | NAGK | DB00141 | N-Acetylglucosamine | SmallMoleculeDrug |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for NAGK |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for NAGK |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for NAGK |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KICH | cg25568061 | chr2:71064823 | CGI:chr2:71068030-71068872 | promoter,gene body | 6.18e-01 | 5.10e-01 | 2.22e+00 | 2.62e-02 | 4.10e-02 | 1.08e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg25568061 | chr2:71064823 | CGI:chr2:71068030-71068872 | promoter,gene body | 5.47e-01 | 6.71e-01 | -4.42e+00 | 9.70e-06 | 2.64e-05 | -1.23e-01 |
| LUSC | cg25568061 | chr2:71064823 | CGI:chr2:71068030-71068872 | promoter,gene body | 3.60e-01 | 5.15e-01 | -3.23e+00 | 1.23e-03 | 2.99e-03 | -1.55e-01 |
| LIHC | cg25568061 | chr2:71064823 | CGI:chr2:71068030-71068872 | promoter,gene body | 4.32e-01 | 5.67e-01 | -4.35e+00 | 1.39e-05 | 3.65e-05 | -1.35e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| COAD | cg25568061 | chr2:71064823 | CGI:chr2:71068030-71068872 | promoter,gene body | 4.88e-01 | 6.01e-01 | -2.55e+00 | 1.08e-02 | 1.67e-02 | -1.13e-01 |
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Exon skipping events with PSI in TCGA for NAGK |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| BLCA | exon_skip_326384 | 7.18e-01 | 8.84e-01 | -2.86e+00 | 4.19e-03 | 1.29e-02 | -1.65e-01 |
| ESCA | exon_skip_326390 | 8.45e-01 | 9.79e-01 | -3.44e+00 | 5.92e-04 | 8.54e-03 | -1.34e-01 |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| THCA | exon_skip_326390 | 6.69e-01 | 7.74e-01 | -3.05e+00 | 2.29e-03 | 5.43e-03 | -1.05e-01 |
| LUSC | exon_skip_326384 | 7.50e-01 | 8.79e-01 | -2.58e+00 | 9.80e-03 | 1.68e-02 | -1.29e-01 |
| LUSC | exon_skip_326390 | 6.54e-01 | 8.11e-01 | -2.21e+00 | 2.71e-02 | 3.37e-02 | -1.57e-01 |
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RNA A-to-I editing events in TCGA for NAGK |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for NAGK |
| TFs related to NAGK. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| NAGK related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for NAGK |
| RBPs related to ES in NAGK. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ACC | SRSF2 | exon_skip_326362 | 9.15e+00 | 9.81e-01 | 8.78e+00 | 1.48e-02 | Male-biased |
| KICH | SRSF2 | exon_skip_326362 | 8.75e+00 | 5.40e-03 | 9.12e+00 | 9.91e-01 | Female-biased |
| HNSC | ESRP2 | exon_skip_326396 | 6.90e+00 | 9.82e-01 | 6.45e+00 | 3.45e-03 | Male-biased |
| NAGK related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs728476 | chr2:70145237:G:A | - | 0.112198040545782 | 0.0223429518667571 | KIRC | Female-baised eQTL |
| rs6714487 | chr2:70148183:C:T | - | 0.112198040545782 | 0.0223429518667571 | KIRC | Female-baised eQTL |
| rs12622572 | chr2:70151716:T:C | - | 0.112198040545782 | 0.0223429518667571 | KIRC | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs75511893 | chr2:61828002:T:C | - | -0.0787786396416648 | 0.00837639036132982 | COAD | Male-baised eQTL |
| rs2031022 | chr2:61830413:G:A | - | -0.0787786396416648 | 0.00837639036132982 | COAD | Male-baised eQTL |
| rs75321378 | chr2:61830833:G:A | - | -0.0787786396416648 | 0.00837639036132982 | COAD | Male-baised eQTL |
| rs6744777 | chr2:61818254:C:T | - | -0.0850068899742192 | 0.0114187862530685 | COAD | Male-baised eQTL |
| rs60822093 | chr2:61820072:A:G | - | -0.0850068899742192 | 0.0114187862530685 | COAD | Male-baised eQTL |
| rs10183056 | chr2:72485769:A:T | - | 0.075740968076961 | 0.0364193629876502 | COAD | Male-baised eQTL |
| rs656440 | chr2:72438206:T:C | - | 0.0782679284926028 | 0.0372619088740477 | COAD | Male-baised eQTL |
| rs658067 | chr2:72441174:A:C | - | 0.080262402545289 | 0.039805234070062 | COAD | Male-baised eQTL |
| rs631550 | chr2:72457195:A:G | - | 0.0752525791796972 | 0.040438886873135 | COAD | Male-baised eQTL |
| rs143118017 | chr2:72459598:A:G | - | 0.0752525791796972 | 0.040438886873135 | COAD | Male-baised eQTL |
| rs585653 | chr2:72470350:A:G | - | 0.0752525791796972 | 0.040438886873135 | COAD | Male-baised eQTL |
| rs6736305 | chr2:72474929:T:C | - | 0.0752525791796972 | 0.040438886873135 | COAD | Male-baised eQTL |
| rs684673 | chr2:72476604:T:G | - | 0.0752525791796972 | 0.040438886873135 | COAD | Male-baised eQTL |
| rs12476397 | chr2:72456449:A:G | - | 0.0752440327213958 | 0.0406049236041713 | COAD | Male-baised eQTL |
| rs656370 | chr2:72438256:G:C | - | 0.0778095572514715 | 0.0413814525888756 | COAD | Male-baised eQTL |
| rs647269 | chr2:72455827:G:C | - | 0.0778095572514715 | 0.0413814525888756 | COAD | Male-baised eQTL |
| rs674863 | chr2:72457637:G:A | - | 0.0778095572514715 | 0.0413814525888756 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of NAGK |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000124357 | NAGK | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| ENSG00000124357 | NAGK | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
| ENSG00000124357 | NAGK | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| ENSG00000124357 | NAGK | C0376358 | Malignant neoplasm of prostate | 1 | CTD_human |
