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Gene: ENSG00000055732 |
Summary for MCOLN3 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000055732 | Gene symbol | MCOLN3 |
| Gene name | mucolipin TRP cation channel 3 | |
| HGNC | 13358 | |
| Entrez ID | 55283 | |
| Gene type | protein_coding | |
| Synonyms | MCOLN3|TRPML3|FLJ11006|TRP-ML3 | |
| UniProtAcc | Q8TDD5 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for MCOLN3 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MCOLN3 | 4.21e+02 | -1.17e+00 | 2.41e-01 | -4.85e+00 | 1.23e-06 | 6.15e-05 | SARC |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MCOLN3 | 9.79e+02 | 1.21e+00 | 3.61e-01 | 3.36e+00 | 7.76e-04 | 2.06e-03 | KICH |
| MCOLN3 | 4.43e+02 | 4.36e+00 | 1.02e+00 | 4.30e+00 | 1.72e-05 | 9.12e-05 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for MCOLN3 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for MCOLN3 |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| CHOL | cg12037450 | chr1:85047441 | CGI:chr1:85047826-85048872 | UTR,promoter,exon,gene body | 5.63e-01 | 4.25e-01 | 2.07e+00 | 3.85e-02 | 4.47e-02 | 1.38e-01 |
| CHOL | cg15129679 | chr1:85047632 | CGI:chr1:85047826-85048872 | promoter,gene body | 2.63e-01 | 1.35e-01 | 2.20e+00 | 2.80e-02 | 3.90e-02 | 1.28e-01 |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg12037450 | chr1:85047441 | CGI:chr1:85047826-85048872 | UTR,promoter,exon,gene body | 3.06e-01 | 1.70e-01 | 5.45e+00 | 5.05e-08 | 2.79e-07 | 1.36e-01 |
| KIRC | cg02345146 | chr1:85047274 | CGI:chr1:85047826-85048872 | promoter,gene body | 3.69e-01 | 2.26e-01 | 5.39e+00 | 7.03e-08 | 3.70e-07 | 1.43e-01 |
| KIRC | cg00893493 | chr1:85047508 | CGI:chr1:85047826-85048872 | UTR,promoter,exon,gene body | 3.79e-01 | 2.25e-01 | 5.27e+00 | 1.35e-07 | 6.43e-07 | 1.54e-01 |
| LUSC | cg12037450 | chr1:85047441 | CGI:chr1:85047826-85048872 | UTR,promoter,exon,gene body | 4.57e-01 | 3.50e-01 | 2.04e+00 | 4.09e-02 | 4.24e-02 | 1.08e-01 |
| LUSC | cg21147310 | chr1:85049025 | CGI:chr1:85047826-85048872 | promoter | 2.23e-01 | 3.33e-01 | -3.01e+00 | 2.61e-03 | 5.06e-03 | -1.09e-01 |
| COAD | cg12037450 | chr1:85047441 | CGI:chr1:85047826-85048872 | UTR,promoter,exon,gene body | 6.62e-01 | 5.60e-01 | 3.63e+00 | 2.86e-04 | 8.14e-04 | 1.02e-01 |
| BLCA | cg21147310 | chr1:85049025 | CGI:chr1:85047826-85048872 | promoter | 1.73e-01 | 3.63e-01 | -4.31e+00 | 1.64e-05 | 1.25e-04 | -1.90e-01 |
| KIRP | cg00893493 | chr1:85047508 | CGI:chr1:85047826-85048872 | UTR,promoter,exon,gene body | 3.57e-01 | 2.26e-01 | 3.45e+00 | 5.61e-04 | 1.12e-03 | 1.31e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| BRCA | cg15129679 | chr1:85047632 | CGI:chr1:85047826-85048872 | promoter,gene body | 4.38e-01 | 3.09e-01 | 5.91e+00 | 3.33e-09 | 7.75e-09 | 1.29e-01 |
| BRCA | cg21147310 | chr1:85049025 | CGI:chr1:85047826-85048872 | promoter | 2.36e-01 | 4.12e-01 | -1.23e+01 | 6.19e-35 | 1.80e-33 | -1.76e-01 |
| KIRC | cg21147310 | chr1:85049025 | CGI:chr1:85047826-85048872 | promoter | 2.37e-01 | 3.60e-01 | -3.25e+00 | 1.17e-03 | 4.87e-03 | -1.23e-01 |
| LUAD | cg21147310 | chr1:85049025 | CGI:chr1:85047826-85048872 | promoter | 2.25e-01 | 3.50e-01 | -3.74e+00 | 1.86e-04 | 1.16e-03 | -1.26e-01 |
| COAD | cg02345146 | chr1:85047274 | CGI:chr1:85047826-85048872 | promoter,gene body | 6.90e-01 | 5.51e-01 | 3.37e+00 | 7.45e-04 | 2.42e-03 | 1.40e-01 |
| COAD | cg00893493 | chr1:85047508 | CGI:chr1:85047826-85048872 | UTR,promoter,exon,gene body | 6.54e-01 | 5.43e-01 | 2.66e+00 | 7.79e-03 | 1.31e-02 | 1.11e-01 |
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Exon skipping events with PSI in TCGA for MCOLN3 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for MCOLN3 |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for MCOLN3 |
| TFs related to MCOLN3. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| ESCA | ZNF141 | MCOLN3 | 3.06e+00 | 6.60e-03 | 3.94e+00 | 9.81e-01 | Female-biased |
| ESCA | ZNF25 | MCOLN3 | 4.16e+00 | 9.85e-01 | 3.34e+00 | 5.53e-03 | Male-biased |
| ESCA | ZNF28 | MCOLN3 | 2.94e+00 | 4.16e-03 | 3.92e+00 | 9.83e-01 | Female-biased |
| ESCA | ZNF418 | MCOLN3 | 4.11e+00 | 9.90e-01 | 2.79e+00 | 3.14e-04 | Male-biased |
| ESCA | ZNF570 | MCOLN3 | 3.95e+00 | 9.81e-01 | 3.13e+00 | 5.49e-03 | Male-biased |
| ESCA | ZNF79 | MCOLN3 | 4.26e+00 | 9.90e-01 | 3.25e+00 | 1.89e-03 | Male-biased |
| ESCA | ZNF879 | MCOLN3 | 3.99e+00 | 9.86e-01 | 2.92e+00 | 1.33e-03 | Male-biased |
| THYM | SRY | MCOLN3 | 3.71e+00 | 6.99e-03 | 4.49e+00 | 9.85e-01 | Female-biased |
| THYM | ZNF580 | MCOLN3 | 3.56e+00 | 7.59e-03 | 4.32e+00 | 9.82e-01 | Female-biased |
| MCOLN3 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for MCOLN3 |
| RBPs related to ES in MCOLN3. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MCOLN3 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000055732 | NPTN-IT1,hsa-mir-132,MCOLN3 | Male-specific ceRNA | TCGA-KICH |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of MCOLN3 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
