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Gene: ENSG00000018408 |
Summary for WWTR1 |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000018408 | Gene symbol | WWTR1 |
| Gene name | WW domain containing transcription regulator 1 | |
| HGNC | 24042 | |
| Entrez ID | 25937 | |
| Gene type | protein_coding | |
| Synonyms | WWTR1|TAZ|DKFZp586I1419 | |
| UniProtAcc | Q9GZV5 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
Top |
Structure and expression level for WWTR1 |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
 |
| Landscape of gene expressions across multiple cancer types. |
 |
| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| WWTR1 | 1.03e+03 | -1.40e+00 | 2.63e-01 | -5.32e+00 | 1.03e-07 | 4.45e-07 | COAD |
| WWTR1 | 6.47e+03 | 1.71e+00 | 5.11e-01 | 3.34e+00 | 8.36e-04 | 2.90e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
 |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| WWTR1 | 4.39e+03 | -1.09e+00 | 1.15e-01 | -9.46e+00 | 3.22e-21 | 4.33e-20 | LUAD |
| WWTR1 | 6.03e+03 | -1.31e+00 | 1.91e-01 | -6.83e+00 | 8.31e-12 | 6.74e-11 | KICH |
| WWTR1 | 1.09e+03 | -2.30e+00 | 3.96e-01 | -5.80e+00 | 6.53e-09 | 1.10e-07 | READ |
Top |
Sex-biased somatic mutation for WWTR1 |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
Top |
DNA methylation with beta values for WWTR1 |
| Landscape of DNA methylation across multiple cancer types. |
 |
| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| KIRC | cg08928408 | chr3:149736319 | CGI:chr3:149752122-149752601 | promoter,gene body | 3.52e-01 | 2.06e-01 | 5.25e+00 | 1.55e-07 | 7.26e-07 | 1.46e-01 |
| LUSC | cg08928408 | chr3:149736319 | CGI:chr3:149752122-149752601 | promoter,gene body | 2.78e-01 | 5.39e-01 | -3.50e+00 | 4.66e-04 | 1.59e-03 | -2.62e-01 |
| KIRP | cg08928408 | chr3:149736319 | CGI:chr3:149752122-149752601 | promoter,gene body | 1.97e-01 | 3.00e-01 | -2.94e+00 | 3.33e-03 | 5.04e-03 | -1.04e-01 |
| CHOL | cg08928408 | chr3:149736319 | CGI:chr3:149752122-149752601 | promoter,gene body | 3.40e-01 | 5.91e-01 | -2.73e+00 | 6.38e-03 | 1.82e-02 | -2.51e-01 |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
Top |
Exon skipping events with PSI in TCGA for WWTR1 |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
 |
| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
Top |
RNA A-to-I editing events in TCGA for WWTR1 |
| ∗Please access CAeditome for RNA editing annotation. |
| Landscape of RNA editing events across multiple cancer types. |
 |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| LUAD | WWTR1-009 | chr3_149651926_- | 8.29e-01 | 6.08e-01 | 2.03e+00 | 4.24e-02 | 4.77e-02 | 2.21e-01 |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| ESCA | WWTR1-009 | chr3_149651926_- | 7.37e-01 | 4.34e-01 | 3.00e+00 | 2.73e-03 | 1.16e-02 | 3.03e-01 |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
Top |
Sex-biased TF-Gene network for WWTR1 |
| TFs related to WWTR1. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
 |
| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| DLBC | ZNF418 | WWTR1 | 2.49e+00 | 1.30e-03 | 3.94e+00 | 9.82e-01 | Female-biased |
| SARC | ZNF418 | WWTR1 | 4.52e+00 | 9.83e-01 | 3.96e+00 | 9.78e-03 | Male-biased |
| WWTR1 related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
Top |
Sex-biased RBP-ES network for WWTR1 |
| RBPs related to ES in WWTR1. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| WWTR1 related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
Top |
Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
| ENSG00000018408 | AP002957.1,hsa-mir-1224,WWTR1 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000018408 | LINC01537,hsa-mir-1224,WWTR1 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000018408 | AC103740.2,hsa-mir-1224,WWTR1 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000018408 | LINC02783,hsa-mir-1224,WWTR1 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000018408 | BX088651.4,hsa-mir-1224,WWTR1 | Female-specific ceRNA | TCGA-KICH |
| ENSG00000018408 | LOXL1-AS1,hsa-mir-1224,WWTR1 | Female-specific ceRNA | TCGA-KICH |
Top |
Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs79909433 | chr3:139616164:C:T | - | 0.150880670666027 | 0.0258991666542389 | LIHC | Female-baised eQTL |
| rs78293134 | chr3:151926868:T:C | - | 0.211177158537724 | 0.00140172220736054 | BLCA | Female-baised eQTL |
| rs183457137 | chr3:151927490:T:C | - | 0.211177158537724 | 0.00140172220736054 | BLCA | Female-baised eQTL |
| rs76741543 | chr3:151927839:A:C | - | 0.211177158537724 | 0.00140172220736054 | BLCA | Female-baised eQTL |
| rs192870349 | chr3:151928923:C:T | - | 0.211177158537724 | 0.00140172220736054 | BLCA | Female-baised eQTL |
| rs115974762 | chr3:151888193:T:C | - | 0.209837047079862 | 0.00160612661824644 | BLCA | Female-baised eQTL |
| rs2166262 | chr3:151884991:G:A | - | 0.207745824430534 | 0.00197679978144822 | BLCA | Female-baised eQTL |
| rs116163270 | chr3:151885404:C:G | - | 0.207745824430534 | 0.00197679978144822 | BLCA | Female-baised eQTL |
| rs114721814 | chr3:151885608:C:A | - | 0.207745824430534 | 0.00197679978144822 | BLCA | Female-baised eQTL |
| rs77756460 | chr3:151895615:C:T | - | 0.207745824430534 | 0.00197679978144822 | BLCA | Female-baised eQTL |
| rs142765295 | chr3:151897286:G:A | - | 0.207745824430534 | 0.00197679978144822 | BLCA | Female-baised eQTL |
| rs74724813 | chr3:151864693:G:A | - | 0.207335691897981 | 0.0020969922077315 | BLCA | Female-baised eQTL |
| rs79174723 | chr3:151865646:T:C | - | 0.207335691897981 | 0.0020969922077315 | BLCA | Female-baised eQTL |
| rs77143965 | chr3:151869437:G:A | - | 0.207335691897981 | 0.0020969922077315 | BLCA | Female-baised eQTL |
| rs79906316 | chr3:151872327:T:C | - | 0.207335691897981 | 0.0020969922077315 | BLCA | Female-baised eQTL |
| rs78598704 | chr3:151875205:C:T | - | 0.207335691897981 | 0.0020969922077315 | BLCA | Female-baised eQTL |
| rs79020368 | chr3:151875605:G:C | - | 0.207335691897981 | 0.0020969922077315 | BLCA | Female-baised eQTL |
| rs115417483 | chr3:151894947:T:A | - | 0.177642101216248 | 0.00510641409123077 | BLCA | Female-baised eQTL |
| rs76052074 | chr3:151904858:G:T | - | 0.18587471253937 | 0.00796403805502508 | BLCA | Female-baised eQTL |
| rs77258517 | chr3:151906510:C:G | - | 0.18587471253937 | 0.00796403805502508 | BLCA | Female-baised eQTL |
| rs78802848 | chr3:151916372:T:C | - | 0.18587471253937 | 0.00796403805502508 | BLCA | Female-baised eQTL |
| rs74519689 | chr3:151921932:T:C | - | 0.18587471253937 | 0.00796403805502508 | BLCA | Female-baised eQTL |
| rs79241971 | chr3:151923733:T:C | - | 0.18587471253937 | 0.00796403805502508 | BLCA | Female-baised eQTL |
| rs115625616 | chr3:151923870:C:T | - | 0.18587471253937 | 0.00796403805502508 | BLCA | Female-baised eQTL |
| rs77255233 | chr3:151924669:A:C | - | 0.18587471253937 | 0.00796403805502508 | BLCA | Female-baised eQTL |
| rs2120978 | chr3:151884902:C:A | - | 0.160102712336812 | 0.0168098270831823 | BLCA | Female-baised eQTL |
| rs115396082 | chr3:151885663:T:G | - | 0.160102712336812 | 0.0168098270831823 | BLCA | Female-baised eQTL |
| rs115858749 | chr3:151885755:C:T | - | 0.160102712336812 | 0.0168098270831823 | BLCA | Female-baised eQTL |
| rs80108055 | chr3:151885839:G:A | - | 0.160102712336812 | 0.0168098270831823 | BLCA | Female-baised eQTL |
| rs75481802 | chr3:151902953:G:C | - | 0.163787741116468 | 0.0312153175772602 | BLCA | Female-baised eQTL |
| rs78229422 | chr3:151899382:T:C | - | 0.153041089908518 | 0.0316791163438051 | BLCA | Female-baised eQTL |
| rs77888260 | chr3:151846070:C:G | - | 0.155730531968081 | 0.0376498710602447 | BLCA | Female-baised eQTL |
| rs139201603 | chr3:151848944:T:G | - | 0.155730531968081 | 0.0376498710602447 | BLCA | Female-baised eQTL |
| rs9830973 | chr3:145870516:G:A | - | 0.11674993925166 | 0.00760594572682889 | LUAD | Female-baised eQTL |
| rs9845726 | chr3:145878850:C:T | - | 0.11674993925166 | 0.00760594572682889 | LUAD | Female-baised eQTL |
| rs9877333 | chr3:145877506:A:G | - | 0.113203663392607 | 0.00996727759602103 | LUAD | Female-baised eQTL |
| rs2084507 | chr3:159361753:A:G | - | 0.0496307746614653 | 0.0184402488870402 | LUAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7430565 | chr3:158389391:G:A | - | 0.0486909573792787 | 0.029792474044044 | LUSC | Male-baised eQTL |
| rs9877909 | chr3:158426475:C:T | - | 0.0481999610168445 | 0.0323247269210368 | LUSC | Male-baised eQTL |
| rs827184 | chr3:158339261:C:T | - | -0.0476741601390783 | 0.0387925134099558 | LUSC | Male-baised eQTL |
| rs827134 | chr3:158351408:C:G | - | -0.0476741601390783 | 0.0387925134099558 | LUSC | Male-baised eQTL |
| rs827106 | chr3:158360274:T:C | - | -0.0476741601390783 | 0.0387925134099558 | LUSC | Male-baised eQTL |
| rs77879537 | chr3:158431276:T:G | - | 0.0472695546218557 | 0.0411154354893739 | LUSC | Male-baised eQTL |
| rs28820925 | chr3:158394147:T:C | - | 0.0473811902232 | 0.0415639509770631 | LUSC | Male-baised eQTL |
| rs6774461 | chr3:158375012:G:T | - | 0.0475037087670499 | 0.0416821677434502 | LUSC | Male-baised eQTL |
| rs4561872 | chr3:158438968:T:C | - | 0.0471850958522956 | 0.0422310557585374 | LUSC | Male-baised eQTL |
| rs1526190 | chr3:158372383:T:C | - | 0.0473560993784249 | 0.0424231025342737 | LUSC | Male-baised eQTL |
| rs6780061 | chr3:157651664:G:C | - | 0.0922467671767574 | 0.0209952673852589 | KIRC | Male-baised eQTL |
| rs67785207 | chr3:143737996:T:C | - | 0.0699974371795066 | 0.0499061814801293 | BLCA | Male-baised eQTL |
| rs56300470 | chr3:145793772:G:A | - | 0.0788443247728981 | 0.0227805535043039 | LUAD | Male-baised eQTL |
| rs7635462 | chr3:145793320:A:G | - | 0.0786324610477632 | 0.023463715189341 | LUAD | Male-baised eQTL |
| rs112779766 | chr3:145794280:G:A | - | 0.0786324610477632 | 0.023463715189341 | LUAD | Male-baised eQTL |
| rs73018645 | chr3:145791601:G:A | - | 0.0767381388786773 | 0.028763510444933 | LUAD | Male-baised eQTL |
| rs76868901 | chr3:145795657:C:T | - | 0.0755825139695044 | 0.0344112036321751 | LUAD | Male-baised eQTL |
| rs73016786 | chr3:145791041:C:G | - | 0.0754627182168085 | 0.0350509438928185 | LUAD | Male-baised eQTL |
| rs73018671 | chr3:145796263:T:G | - | 0.0752299641308868 | 0.0365070323323931 | LUAD | Male-baised eQTL |
| rs73018674 | chr3:145796577:T:C | - | 0.0751547226216085 | 0.0372089602367379 | LUAD | Male-baised eQTL |
| rs73018676 | chr3:145796644:C:T | - | 0.0751547226216085 | 0.0372089602367379 | LUAD | Male-baised eQTL |
| rs73018678 | chr3:145796695:G:C | - | 0.0751547226216085 | 0.0372089602367379 | LUAD | Male-baised eQTL |
| rs7637554 | chr3:145797244:T:G | - | 0.0751547226216085 | 0.0372089602367379 | LUAD | Male-baised eQTL |
| rs59250152 | chr3:149471582:C:T | - | 0.143774866400035 | 2.91499917858948e-05 | COAD | Male-baised eQTL |
| rs72615625 | chr3:149476382:G:C | - | 0.143774866400035 | 2.91499917858948e-05 | COAD | Male-baised eQTL |
| rs72615626 | chr3:149477494:C:G | - | 0.143774866400035 | 2.91499917858948e-05 | COAD | Male-baised eQTL |
| rs4234367 | chr3:149491230:G:A | - | 0.119669859854241 | 0.000104752971869289 | COAD | Male-baised eQTL |
| rs72615628 | chr3:149492469:A:G | - | 0.119455460360077 | 0.000110924620874465 | COAD | Male-baised eQTL |
| rs4591452 | chr3:149490932:C:T | - | 0.119013035338025 | 0.000123388258734699 | COAD | Male-baised eQTL |
| rs60388273 | chr3:149496756:G:A | - | 0.129639524249089 | 0.000155255277372646 | COAD | Male-baised eQTL |
| rs6774054 | chr3:149493912:G:A | - | 0.127567490225523 | 0.000185096416668548 | COAD | Male-baised eQTL |
| rs4681180 | chr3:149497613:C:T | - | 0.122615737217284 | 0.000202105801026856 | COAD | Male-baised eQTL |
| rs67695770 | chr3:149495366:C:T | - | 0.125228634324738 | 0.000280590548914738 | COAD | Male-baised eQTL |
| rs72615629 | chr3:149496661:G:A | - | 0.125228634324738 | 0.000280590548914738 | COAD | Male-baised eQTL |
| rs12636498 | chr3:149507490:G:A | - | 0.141552875759225 | 0.000288540394147768 | COAD | Male-baised eQTL |
| rs66711088 | chr3:149494978:G:A | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs67976172 | chr3:149495114:A:C | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs67483870 | chr3:149495142:G:A | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs67354369 | chr3:149495208:G:T | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs4681178 | chr3:149495487:G:A | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs4681179 | chr3:149495550:T:G | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs4234368 | chr3:149495682:G:A | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs4234369 | chr3:149495801:C:T | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs4234370 | chr3:149495898:A:G | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs4681517 | chr3:149496022:A:G | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs4681518 | chr3:149496160:G:A | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs67662617 | chr3:149496236:G:T | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs4681519 | chr3:149496255:G:A | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs66886315 | chr3:149496275:C:T | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs67617174 | chr3:149496350:T:C | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs73152650 | chr3:149496396:G:A | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs73152651 | chr3:149496397:G:T | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs67142611 | chr3:149496484:A:G | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs67952339 | chr3:149496497:A:G | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs67269375 | chr3:149496517:C:G | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs55965250 | chr3:149496627:A:G | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs57072461 | chr3:149496701:C:G | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs66903714 | chr3:149497269:A:T | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs67012762 | chr3:149497483:A:G | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs67283005 | chr3:149497567:T:A | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs76571716 | chr3:149497894:T:C | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs58165326 | chr3:149498031:C:T | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs57941249 | chr3:149498169:C:A | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs9799030 | chr3:149498842:C:T | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs9799336 | chr3:149498974:A:G | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs9799220 | chr3:149499071:T:A | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs66806920 | chr3:149499122:T:C | - | 0.122827642421267 | 0.000368022362168511 | COAD | Male-baised eQTL |
| rs2566339 | chr3:158591086:T:C | - | -0.0815806237281001 | 0.000694274072857085 | COAD | Male-baised eQTL |
| rs10513275 | chr3:145965447:C:T | - | 0.0898764369200339 | 0.00101145737430646 | COAD | Male-baised eQTL |
| rs9831050 | chr3:145965822:C:T | - | 0.0898764369200339 | 0.00101145737430646 | COAD | Male-baised eQTL |
| rs12233446 | chr3:143792288:C:T | - | 0.090737819550179 | 0.00148444644214774 | COAD | Male-baised eQTL |
| rs2121775 | chr3:143793310:A:G | - | 0.0952733973102638 | 0.00150167930504476 | COAD | Male-baised eQTL |
| rs7618372 | chr3:149453041:G:A | - | 0.0989770867067775 | 0.00166181364853216 | COAD | Male-baised eQTL |
| rs9840245 | chr3:145972915:C:T | - | 0.0802524072394954 | 0.0020670043417396 | COAD | Male-baised eQTL |
| rs1985503 | chr3:143792118:A:T | - | 0.0917879324263595 | 0.00244194988751001 | COAD | Male-baised eQTL |
| rs7628962 | chr3:145903904:A:C | - | 0.0919565911883771 | 0.00302885771133521 | COAD | Male-baised eQTL |
| rs11718136 | chr3:143797057:A:T | - | 0.0887035920678945 | 0.00334976259185829 | COAD | Male-baised eQTL |
| rs7642357 | chr3:142945436:G:T | - | -0.0623511245221403 | 0.0036995800443007 | COAD | Male-baised eQTL |
| rs7651211 | chr3:145903691:G:A | - | 0.0906728234373613 | 0.00377195898465568 | COAD | Male-baised eQTL |
| rs34906476 | chr3:145902410:G:A | - | 0.0717601419943417 | 0.00428799825262776 | COAD | Male-baised eQTL |
| rs13086070 | chr3:145944666:T:C | - | 0.0919231915299068 | 0.00432739056087744 | COAD | Male-baised eQTL |
| rs4589932 | chr3:143802788:G:A | - | 0.0868102381662265 | 0.00450720723169276 | COAD | Male-baised eQTL |
| rs11921871 | chr3:145943647:G:T | - | 0.0917844991030499 | 0.00466828732813679 | COAD | Male-baised eQTL |
| rs12629663 | chr3:145914955:A:G | - | 0.0920380166110754 | 0.00486094825555203 | COAD | Male-baised eQTL |
| rs71300355 | chr3:145936720:T:C | - | 0.0926640012518117 | 0.00504842591210512 | COAD | Male-baised eQTL |
| rs11706302 | chr3:143795395:A:G | - | 0.0856841029209843 | 0.0051671517240784 | COAD | Male-baised eQTL |
| rs116708439 | chr3:143798095:A:C | - | 0.0851341743604641 | 0.0053450199927162 | COAD | Male-baised eQTL |
| rs16857603 | chr3:145938001:C:A | - | 0.0911514034698255 | 0.00546899175825858 | COAD | Male-baised eQTL |
| rs11720499 | chr3:143799312:A:G | - | 0.0853190719349333 | 0.00555844243967542 | COAD | Male-baised eQTL |
| rs7611414 | chr3:145981415:T:C | - | 0.0801777910289379 | 0.00562838805979851 | COAD | Male-baised eQTL |
| rs113408231 | chr3:143797740:C:A | - | 0.0849960517547242 | 0.00572862050422651 | COAD | Male-baised eQTL |
| rs71300356 | chr3:145936808:T:A | - | 0.0909973525109883 | 0.00580264447630894 | COAD | Male-baised eQTL |
| rs9836919 | chr3:145987612:C:T | - | 0.0795965099543917 | 0.00595842122287818 | COAD | Male-baised eQTL |
| rs13094663 | chr3:145912883:A:G | - | 0.0874141303231488 | 0.00644229807487673 | COAD | Male-baised eQTL |
| rs13085714 | chr3:145914419:T:C | - | 0.0856685295519668 | 0.00772575618023838 | COAD | Male-baised eQTL |
| rs11712438 | chr3:140789683:C:G | - | 0.065555470839664 | 0.00788594395414908 | COAD | Male-baised eQTL |
| rs12632142 | chr3:145896882:T:C | - | 0.0726646006707321 | 0.00807521301895008 | COAD | Male-baised eQTL |
| rs9790074 | chr3:145897058:T:A | - | 0.0726646006707321 | 0.00807521301895008 | COAD | Male-baised eQTL |
| rs9856416 | chr3:145987221:T:G | - | 0.0789020020436626 | 0.00815799576592938 | COAD | Male-baised eQTL |
| rs77715164 | chr3:149567304:T:C | gene | 0.112595785668662 | 0.00821305751930548 | COAD | Male-baised eQTL |
| rs11718620 | chr3:145923905:G:T | - | 0.0864507524557228 | 0.00842726015829006 | COAD | Male-baised eQTL |
| rs4465920 | chr3:140773165:C:T | - | 0.0638104395793086 | 0.00853064529831544 | COAD | Male-baised eQTL |
| rs6800578 | chr3:143793895:C:T | - | 0.0808966846385003 | 0.0103701723084783 | COAD | Male-baised eQTL |
| rs12488991 | chr3:145935433:C:A | - | 0.0844126700042668 | 0.0105473672115779 | COAD | Male-baised eQTL |
| rs13099386 | chr3:145878301:A:G | - | 0.0717119871492413 | 0.0111335186112173 | COAD | Male-baised eQTL |
| rs1553406 | chr3:145926636:C:G | - | 0.0840384767938269 | 0.0112570368253117 | COAD | Male-baised eQTL |
| rs12639425 | chr3:145927155:T:C | - | 0.0840384767938269 | 0.0112570368253117 | COAD | Male-baised eQTL |
| rs11711716 | chr3:140785470:C:G | - | 0.0641578041572266 | 0.0113839685752581 | COAD | Male-baised eQTL |
| rs7649697 | chr3:140787222:C:G | - | 0.0641578041572266 | 0.0113839685752581 | COAD | Male-baised eQTL |
| rs13097670 | chr3:145918098:C:G | - | 0.0839192215597075 | 0.0115768137985265 | COAD | Male-baised eQTL |
| rs12633788 | chr3:145918214:C:A | - | 0.0839192215597075 | 0.0115768137985265 | COAD | Male-baised eQTL |
| rs200105848 | chr3:145920709:A:C | - | 0.0839192215597075 | 0.0115768137985265 | COAD | Male-baised eQTL |
| rs67671123 | chr3:145924142:C:G | - | 0.0839192215597075 | 0.0115768137985265 | COAD | Male-baised eQTL |
| rs34787415 | chr3:145924376:T:C | - | 0.0839192215597075 | 0.0115768137985265 | COAD | Male-baised eQTL |
| rs36025939 | chr3:145925030:C:A | - | 0.0839192215597075 | 0.0115768137985265 | COAD | Male-baised eQTL |
| rs13062906 | chr3:145944440:A:C | - | 0.0783945043024519 | 0.0121184718940931 | COAD | Male-baised eQTL |
| rs62272614 | chr3:145983922:G:A | - | 0.0770451213062141 | 0.0123126047500578 | COAD | Male-baised eQTL |
| rs62271985 | chr3:149440374:T:A | - | 0.0832883456340413 | 0.0124997433983453 | COAD | Male-baised eQTL |
| rs6802982 | chr3:140775808:C:G | - | 0.0634618780143743 | 0.0127002814435239 | COAD | Male-baised eQTL |
| rs7633606 | chr3:145893221:C:G | - | 0.0703346592038819 | 0.0129584503790513 | COAD | Male-baised eQTL |
| rs13061647 | chr3:145882705:T:C | - | 0.0706969046540606 | 0.0130563070152113 | COAD | Male-baised eQTL |
| rs6774823 | chr3:149444834:T:G | - | 0.0827985511307825 | 0.0134461177159744 | COAD | Male-baised eQTL |
| rs7630171 | chr3:145870774:A:T | - | 0.0698036918397802 | 0.0138585915679026 | COAD | Male-baised eQTL |
| rs9289708 | chr3:145969518:A:C | - | 0.0666318854893257 | 0.013896341366741 | COAD | Male-baised eQTL |
| rs7632807 | chr3:140766601:C:T | - | 0.0624815376219729 | 0.0140494421372896 | COAD | Male-baised eQTL |
| rs708482 | chr3:145463083:C:T | - | 0.0889595507206797 | 0.0142994505436747 | COAD | Male-baised eQTL |
| rs693344 | chr3:145464849:A:G | - | 0.0889595507206797 | 0.0142994505436747 | COAD | Male-baised eQTL |
| rs1666491 | chr3:145467153:A:G | - | 0.0889595507206797 | 0.0142994505436747 | COAD | Male-baised eQTL |
| rs9811465 | chr3:145986930:C:T | - | 0.0872956757075712 | 0.014446732281486 | COAD | Male-baised eQTL |
| rs1398776 | chr3:145935840:C:A | - | 0.081858654552612 | 0.0145989690498554 | COAD | Male-baised eQTL |
| rs11719451 | chr3:145894114:C:T | - | 0.0694468360402643 | 0.0151014125275408 | COAD | Male-baised eQTL |
| rs58714532 | chr3:140789627:C:G | - | 0.0622604492518593 | 0.0153031110462034 | COAD | Male-baised eQTL |
| rs11717493 | chr3:140790013:T:A | - | 0.0622604492518593 | 0.0153031110462034 | COAD | Male-baised eQTL |
| rs345021 | chr3:145471599:A:T | - | 0.089122488009071 | 0.0153992272181702 | COAD | Male-baised eQTL |
| rs345022 | chr3:145472964:C:T | - | 0.089122488009071 | 0.0153992272181702 | COAD | Male-baised eQTL |
| rs237664 | chr3:145473945:C:T | - | 0.089122488009071 | 0.0153992272181702 | COAD | Male-baised eQTL |
| rs345024 | chr3:145474709:A:C | - | 0.089122488009071 | 0.0153992272181702 | COAD | Male-baised eQTL |
| rs1085549 | chr3:145480741:C:T | - | 0.0889169909873539 | 0.0159352002234521 | COAD | Male-baised eQTL |
| rs506011 | chr3:145481946:T:C | - | 0.0889169909873539 | 0.0159352002234521 | COAD | Male-baised eQTL |
| rs168270 | chr3:145486952:T:C | - | 0.0889169909873539 | 0.0159352002234521 | COAD | Male-baised eQTL |
| rs345016 | chr3:145468135:A:C | - | 0.0882351313386964 | 0.0166116140433492 | COAD | Male-baised eQTL |
| rs4331654 | chr3:140772925:A:G | - | 0.0614982321567574 | 0.0171127640175911 | COAD | Male-baised eQTL |
| rs7644487 | chr3:140766457:T:G | - | 0.0610139983064521 | 0.017470222243966 | COAD | Male-baised eQTL |
| rs1840677 | chr3:157532111:C:T | - | 0.0762771148581874 | 0.0178541103721979 | COAD | Male-baised eQTL |
| rs12639093 | chr3:157532485:T:C | - | 0.0762771148581874 | 0.0178541103721979 | COAD | Male-baised eQTL |
| rs9811819 | chr3:140794047:T:C | - | 0.0620865570920063 | 0.018633279332005 | COAD | Male-baised eQTL |
| rs6440455 | chr3:146746826:C:G | - | 0.0585873906751579 | 0.0188701820476556 | COAD | Male-baised eQTL |
| rs76207072 | chr3:143439725:C:T | - | 0.0797016410719487 | 0.0190644870151654 | COAD | Male-baised eQTL |
| rs6766981 | chr3:149441156:G:A | - | 0.0780322390276025 | 0.0190919597388914 | COAD | Male-baised eQTL |
| rs1381464 | chr3:158806802:G:A | - | 0.0732497548343762 | 0.022065753495609 | COAD | Male-baised eQTL |
| rs16858488 | chr3:146552544:G:A | - | 0.0884190524171965 | 0.0228272451586394 | COAD | Male-baised eQTL |
| rs11714711 | chr3:145902568:A:G | - | 0.0623727607994431 | 0.0232861688198359 | COAD | Male-baised eQTL |
| rs11711135 | chr3:145902580:T:C | - | 0.0623727607994431 | 0.0232861688198359 | COAD | Male-baised eQTL |
| rs11711136 | chr3:145902583:T:G | - | 0.0623727607994431 | 0.0232861688198359 | COAD | Male-baised eQTL |
| rs1522331 | chr3:145865774:C:A | - | 0.0694762576371315 | 0.0239212156465466 | COAD | Male-baised eQTL |
| rs7632490 | chr3:140766100:G:A | - | 0.0585818152410133 | 0.0251463088081994 | COAD | Male-baised eQTL |
| rs2036469 | chr3:145900638:G:A | - | 0.0618495972703279 | 0.0251983647259667 | COAD | Male-baised eQTL |
| rs6440405 | chr3:145939140:A:G | - | 0.0759428117315393 | 0.0252230903596812 | COAD | Male-baised eQTL |
| rs1403066 | chr3:145939652:G:C | - | 0.0759428117315393 | 0.0252230903596812 | COAD | Male-baised eQTL |
| rs1024079 | chr3:145940703:A:G | - | 0.0759428117315393 | 0.0252230903596812 | COAD | Male-baised eQTL |
| rs2864430 | chr3:145938569:A:G | - | 0.0762963429587659 | 0.0253462434106208 | COAD | Male-baised eQTL |
| rs7634405 | chr3:140771885:C:T | - | 0.0591964465960856 | 0.0257008317119603 | COAD | Male-baised eQTL |
| rs12491155 | chr3:145895438:A:T | - | 0.0616189292381865 | 0.0259452582821534 | COAD | Male-baised eQTL |
| rs3914311 | chr3:145898320:A:G | - | 0.0616189292381865 | 0.0259452582821534 | COAD | Male-baised eQTL |
| rs3914310 | chr3:145898494:T:A | - | 0.0616189292381865 | 0.0259452582821534 | COAD | Male-baised eQTL |
| rs4318523 | chr3:145899075:A:G | - | 0.0616189292381865 | 0.0259452582821534 | COAD | Male-baised eQTL |
| rs67122199 | chr3:145901298:T:G | - | 0.0616189292381865 | 0.0259452582821534 | COAD | Male-baised eQTL |
| rs62270819 | chr3:145901408:A:G | - | 0.0616189292381865 | 0.0259452582821534 | COAD | Male-baised eQTL |
| rs34309398 | chr3:145902396:T:C | - | 0.0616189292381865 | 0.0259452582821534 | COAD | Male-baised eQTL |
| rs1472665 | chr3:145902978:T:C | - | 0.0616189292381865 | 0.0259452582821534 | COAD | Male-baised eQTL |
| rs13073973 | chr3:145891579:C:G | - | 0.062319153614609 | 0.0268173886438771 | COAD | Male-baised eQTL |
| rs1355789 | chr3:145891645:C:A | - | 0.062319153614609 | 0.0268173886438771 | COAD | Male-baised eQTL |
| rs10935589 | chr3:145896244:C:T | - | 0.0613526927049478 | 0.0273263869757435 | COAD | Male-baised eQTL |
| rs72987149 | chr3:140789383:A:G | - | 0.0578439420534375 | 0.0279591668867449 | COAD | Male-baised eQTL |
| rs7639879 | chr3:140791153:A:G | - | 0.0578439420534375 | 0.0279591668867449 | COAD | Male-baised eQTL |
| rs7616609 | chr3:140786696:T:A | - | 0.05769425078652 | 0.0286200508687959 | COAD | Male-baised eQTL |
| rs796819 | chr3:145494472:G:A | - | -0.0828161666859651 | 0.0290415617068841 | COAD | Male-baised eQTL |
| rs6778901 | chr3:140776091:A:G | - | 0.0571573465611257 | 0.0306833908433043 | COAD | Male-baised eQTL |
| rs1967207 | chr3:145903119:G:A | - | 0.0613325273183172 | 0.0308403158053076 | COAD | Male-baised eQTL |
| rs4680466 | chr3:158782909:C:T | - | 0.0686404042650044 | 0.031097058159381 | COAD | Male-baised eQTL |
| rs13091194 | chr3:145866535:A:G | - | 0.0667096423552981 | 0.0315516100901703 | COAD | Male-baised eQTL |
| rs1381462 | chr3:158801174:T:C | - | 0.0679765561264315 | 0.0332261478130009 | COAD | Male-baised eQTL |
| rs9845912 | chr3:140767531:C:T | - | 0.0562107902420744 | 0.0337017335988607 | COAD | Male-baised eQTL |
| rs9855702 | chr3:157522627:T:C | - | 0.0724401903911093 | 0.0341539990916846 | COAD | Male-baised eQTL |
| rs1355788 | chr3:145893687:A:G | - | 0.0595986902316473 | 0.0370962230010596 | COAD | Male-baised eQTL |
| rs9864041 | chr3:157568400:C:T | - | 0.070303261311381 | 0.0376853340049661 | COAD | Male-baised eQTL |
| rs1993904 | chr3:141284512:C:G | - | -0.0633944600757424 | 0.0385383450429852 | COAD | Male-baised eQTL |
| rs4422276 | chr3:140788132:G:C | - | 0.0557286963351465 | 0.0385901324863329 | COAD | Male-baised eQTL |
| rs345015 | chr3:145467315:G:A | - | 0.079249952493267 | 0.039361535885118 | COAD | Male-baised eQTL |
| rs1513423 | chr3:145901677:C:T | - | 0.0595225759534845 | 0.0408984463006683 | COAD | Male-baised eQTL |
| rs9857480 | chr3:158753969:C:T | - | 0.0637606360333442 | 0.0417423234774176 | COAD | Male-baised eQTL |
| rs9849629 | chr3:158757363:C:T | - | 0.0637606360333442 | 0.0417423234774176 | COAD | Male-baised eQTL |
| rs9833054 | chr3:157564382:A:G | - | 0.0720324016365361 | 0.0428240197787669 | COAD | Male-baised eQTL |
| rs11928144 | chr3:157565459:C:T | - | 0.0720324016365361 | 0.0428240197787669 | COAD | Male-baised eQTL |
| rs61794722 | chr3:159522636:G:A | - | 0.0769044277811277 | 0.0428316514054086 | COAD | Male-baised eQTL |
| rs149925147 | chr3:159510964:G:A | - | 0.0763852130001408 | 0.0451765203117977 | COAD | Male-baised eQTL |
| rs3755746 | chr3:158770844:C:G | - | 0.0643316690400512 | 0.0464100746660834 | COAD | Male-baised eQTL |
| rs7620380 | chr3:158746280:G:C | - | 0.0618312765224027 | 0.0474746336071331 | COAD | Male-baised eQTL |
| rs9990118 | chr3:157592886:G:A | - | 0.0672446691200615 | 0.0478512728525763 | COAD | Male-baised eQTL |
| rs7429899 | chr3:158754585:C:T | - | 0.0624780035833367 | 0.0492670143309112 | COAD | Male-baised eQTL |
| rs9861289 | chr3:158760007:C:A | - | 0.0624780035833367 | 0.0492670143309112 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
Top |
Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
 | Gene ID: ENSG00000018408 |
| CpG Site: cg06728055 | |
| Position to Gene: gene | |
| Male Effect: -0.071758901154798 | |
| Female Effect: - | |
 | Gene ID: ENSG00000018408 |
| CpG Site: cg04215287 | |
| Position to Gene: gene | |
| Male Effect: -0.232251024888465 | |
| Female Effect: - | |
 | Gene ID: ENSG00000018408 |
| CpG Site: cg16430963 | |
| Position to Gene: gene | |
| Male Effect: -0.316198499251109 | |
| Female Effect: - | |
 | Gene ID: ENSG00000018408 |
| CpG Site: cg06694299 | |
| Position to Gene: gene | |
| Male Effect: -0.282013055453059 | |
| Female Effect: - |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| cg06728055 | chr3:149576499 | gene | -0.071758901154798 | 6.23662721012269e-06 | -0.337897386488745 | 9.309300734135724e-07 | KIRP |
| cg04215287 | chr3:149593075 | gene | -0.232251024888465 | 7.55483762514322e-11 | -0.45813733102411824 | 3.5261802322624586e-13 | LIHC |
| cg16430963 | chr3:149647359 | gene | -0.316198499251109 | 7.98288544507495e-13 | -0.44545782915915877 | 1.221929367220709e-15 | SKCM |
| cg06694299 | chr3:149536234 | gene | -0.282013055453059 | 2.67519168836731e-06 | -0.3362361878087088 | 7.45291488375691e-09 | SKCM |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of WWTR1 |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000018408 | WWTR1 | C0026846 | Muscular Atrophy | 1 | CTD_human |
| ENSG00000018408 | WWTR1 | C0206655 | Alveolar rhabdomyosarcoma | 1 | CTD_human |
| ENSG00000018408 | WWTR1 | C0270948 | Neurogenic Muscular Atrophy | 1 | CTD_human |
