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Gene: ENSG00000007944 |
Summary for MYLIP |
 Gene summary |
| Gene information | Ensembl ID | ENSG00000007944 | Gene symbol | MYLIP |
| Gene name | myosin regulatory light chain interacting protein | |
| HGNC | 21155 | |
| Entrez ID | 29116 | |
| Gene type | protein_coding | |
| Synonyms | MYLIP|MIR|IDOL | |
| UniProtAcc | Q8WY64 |
| Drugs associated with this gene(DrugBank). |
| Gene ID | Gene Symbol | Drug ID | Drug Name | Drug Type |
| Cancer therapeutic drugs associated with this gene(NCI). |
| Gene ID | Gene Name | Drug ID | Drug Name | Drug Type | Cancer |
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Structure and expression level for MYLIP |
| AS events and RNA A-to-I editing events of the gene in TCGA based on Genvode V22 structure. ∗For more information on exon skipping events please check the ExonskipDB database. ∗For more information on exon skipping events please check the CAeditome database. |
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| Landscape of gene expressions across multiple cancer types. |
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| Differentially expressed gene analysis between tumor male and tumor female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| Differentially expressed gene analysis between tumor male and normal male samples. |
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| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
| MYLIP | 5.72e+02 | 1.30e+00 | 3.82e-01 | 3.41e+00 | 6.58e-04 | 2.34e-03 | CHOL |
| Differentially expressed gene analysis between tumor female and normal female samples. |
| Coding Name | Base Mean | log2FoldChange | lfcSE | Stat | P value | P.adjust Value | Cancer Type |
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Sex-biased somatic mutation for MYLIP |
| ∗For more information on exon skipping events please check the ExonskipDB database. |
| Gene ID | Cancer Type | Hugo Symbol | Male | Female | pval | or | ci.up | ci.low | adjPval |
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DNA methylation with beta values for MYLIP |
| Landscape of DNA methylation across multiple cancer types. |
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| Differentially expressed CpG sites between male tumor and female tumor patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between male tumor and male normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
| Differentially expressed CpG sites between female tumor and female normal patients. |
| Cancer Type | CpG Site | Position | CpG Island | Position to Gene | ave1 | ave2 | wilcoxon.w | wilcoxon.p | padj | dBeta |
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Exon skipping events with PSI in TCGA for MYLIP |
| ∗Please access ExonSkipDB for exon skipping annotation. |
| Landscape of exon skipping events across multiple cancer types. |
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| Differentially expressed exon skipping events between male tumor and female tumor patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between male tumor and male normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
| Differentially expressed exon skipping events between female tumor and female normal patients. |
| Cancer Type | Exon Skipping | ave.female_T | ave.female_N | wilcoxon.w | wilcoxon.p | padj | dPSI |
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RNA A-to-I editing events in TCGA for MYLIP |
| ∗Please access CAeditome for RNA editing annotation. |
| Differentially expressed RNA editing events between male tumor and female tumor patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between male tumor and male normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Differentially expressed RNA editing events between female tumor and female normal patients. |
| Cancer Type | Transcript | Editing | ave.male_T | ave.female_T | wilcoxon.w | wilcoxon.p | p_adj | dFre |
| Protein coding RNA editing(s). |
| Editing Position | Variant Type | Gene Symbol | Transcript ID | NTchange | AAchange |
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Sex-biased TF-Gene network for MYLIP |
| TFs related to MYLIP. ∗The female-biased TF-gene edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased TF-gene edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
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| Cancer Type | TF | Target Gene | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| CHOL | ZFP28 | MYLIP | 3.87e+00 | 9.81e-01 | 2.70e+00 | 4.37e-03 | Male-biased |
| LGG | ZNF121 | MYLIP | 4.22e+00 | 9.81e-01 | 3.66e+00 | 6.14e-03 | Male-biased |
| LGG | ZNF443 | MYLIP | 4.25e+00 | 9.81e-01 | 3.73e+00 | 7.29e-03 | Male-biased |
| LGG | ZNF496 | MYLIP | 4.37e+00 | 9.84e-01 | 3.82e+00 | 6.43e-03 | Male-biased |
| PAAD | PRDM6 | MYLIP | 4.20e+00 | 9.85e-01 | 3.19e+00 | 4.15e-03 | Male-biased |
| PAAD | ZNF182 | MYLIP | 4.18e+00 | 9.83e-01 | 3.23e+00 | 5.34e-03 | Male-biased |
| PAAD | ZNF22 | MYLIP | 4.23e+00 | 9.86e-01 | 3.18e+00 | 3.29e-03 | Male-biased |
| PAAD | ZNF225 | MYLIP | 4.24e+00 | 9.84e-01 | 3.31e+00 | 6.07e-03 | Male-biased |
| PAAD | ZNF235 | MYLIP | 4.42e+00 | 9.90e-01 | 3.33e+00 | 2.64e-03 | Male-biased |
| PAAD | ZNF287 | MYLIP | 4.47e+00 | 9.90e-01 | 3.38e+00 | 2.67e-03 | Male-biased |
| PAAD | ZNF487 | MYLIP | 4.36e+00 | 9.89e-01 | 3.30e+00 | 3.01e-03 | Male-biased |
| PAAD | ZNF492 | MYLIP | 4.28e+00 | 9.84e-01 | 3.36e+00 | 6.26e-03 | Male-biased |
| PAAD | ZNF613 | MYLIP | 4.14e+00 | 9.82e-01 | 3.20e+00 | 5.71e-03 | Male-biased |
| PAAD | ZNF98 | MYLIP | 4.27e+00 | 9.83e-01 | 3.37e+00 | 7.11e-03 | Male-biased |
| READ | PRDM6 | MYLIP | 2.82e+00 | 7.04e-04 | 4.38e+00 | 9.90e-01 | Female-biased |
| READ | ZNF182 | MYLIP | 2.95e+00 | 1.24e-03 | 4.34e+00 | 9.89e-01 | Female-biased |
| READ | ZNF22 | MYLIP | 2.85e+00 | 7.55e-04 | 4.39e+00 | 9.90e-01 | Female-biased |
| READ | ZNF225 | MYLIP | 2.93e+00 | 9.22e-04 | 4.41e+00 | 9.91e-01 | Female-biased |
| READ | ZNF235 | MYLIP | 2.85e+00 | 3.85e-04 | 4.61e+00 | 9.94e-01 | Female-biased |
| READ | ZNF287 | MYLIP | 2.96e+00 | 5.84e-04 | 4.59e+00 | 9.93e-01 | Female-biased |
| READ | ZNF384 | MYLIP | 2.85e+00 | 2.14e-03 | 4.07e+00 | 9.83e-01 | Female-biased |
| READ | ZNF487 | MYLIP | 2.98e+00 | 9.04e-04 | 4.46e+00 | 9.91e-01 | Female-biased |
| READ | ZNF492 | MYLIP | 3.16e+00 | 1.71e-03 | 4.46e+00 | 9.91e-01 | Female-biased |
| READ | ZNF613 | MYLIP | 3.04e+00 | 2.24e-03 | 4.26e+00 | 9.87e-01 | Female-biased |
| READ | ZNF98 | MYLIP | 3.15e+00 | 1.59e-03 | 4.47e+00 | 9.91e-01 | Female-biased |
| MYLIP related gene. ∗Only the gene encode TF might with this result. ∗For more information please check Sex-biased TF-Coding gene network. |
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Sex-biased RBP-ES network for MYLIP |
| RBPs related to ES in MYLIP. ∗The female-biased RBP-ES edges were identified if Female_Edge_threshold>0.98 and Male_Edge_threshold<=0.98. ∗The male-biased RBP-ES edges were identified if Male_Edge_threshold>0.98 and Female_Edge_threshold<=0.98. |
| Cancer Type | RBP | Target ES | Male Edge Score | Male Edge Threshold | Female Edge Score | Female Edge Threshold | Type |
| MYLIP related ES. ∗Only the gene encode RBP might with this result. ∗For more information please check Sex-biased RBP-ES network in cancer. |
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Sex-biased CeRNA regulation of gene |
| Sex-biased CeRNA regulation of gene. |
| Gene ID | ceRNA(lncRNA-miRNA-mRNA) | Group | Cancer Type |
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Sex-biased eQTL regulation of gene |
| Sex-biased eQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| eQTL | Description |
| Male-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs74853654 | chr6:16217681:C:G | - | 0.221156749006419 | 0.00518024076278071 | HNSC | Female-baised eQTL |
| rs115337492 | chr6:16218870:G:A | - | 0.221156749006419 | 0.00518024076278071 | HNSC | Female-baised eQTL |
| rs146579968 | chr6:16218060:G:A | - | 0.220214607832109 | 0.00562634793408956 | HNSC | Female-baised eQTL |
| rs114243415 | chr6:16218174:C:T | - | 0.220214607832109 | 0.00562634793408956 | HNSC | Female-baised eQTL |
| rs149364711 | chr6:16216055:G:A | - | 0.221894924656139 | 0.00819533126191507 | HNSC | Female-baised eQTL |
| rs4716051 | chr6:16222499:T:C | - | 0.202700734974101 | 0.0172270679898116 | HNSC | Female-baised eQTL |
| rs12175878 | chr6:20615094:A:G | - | 0.0706596911158675 | 0.0342545417171508 | COAD | Female-baised eQTL |
| rs9350268 | chr6:20619772:A:G | - | 0.06967825655267 | 0.0369014979814057 | COAD | Female-baised eQTL |
| rs11966749 | chr6:20618958:G:T | - | 0.0689034316158724 | 0.0411923007546503 | COAD | Female-baised eQTL |
| rs2069015 | chr6:20620080:T:G | - | 0.0690157621433465 | 0.041442057411446 | COAD | Female-baised eQTL |
| rs9350267 | chr6:20613305:C:T | - | 0.0698013465274378 | 0.0429492261386045 | COAD | Female-baised eQTL |
| Female-specific eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Effect Score | FDR | Cancer Type | Biased Type |
| rs7765763 | chr6:24961653:A:T | - | 0.479328749786709 | 0.0487256815158942 | PCPG | Male-baised eQTL |
| rs1888931 | chr6:24966378:C:T | - | 0.479328749786709 | 0.0487256815158942 | PCPG | Male-baised eQTL |
| rs12665780 | chr6:25365516:C:G | - | 0.169632382713911 | 0.00803291822098433 | COAD | Male-baised eQTL |
| rs146357157 | chr6:10872191:C:G | - | 0.114620482696425 | 0.0214495061335571 | COAD | Male-baised eQTL |
| rs2328796 | chr6:23736858:C:T | - | 0.0739678867585462 | 0.0344879983964675 | COAD | Male-baised eQTL |
| rs10484370 | chr6:18578156:T:C | - | 0.10043765905954 | 0.0405262692584373 | COAD | Male-baised eQTL |
| rs2328793 | chr6:23736753:C:A | - | 0.0709509558072917 | 0.0450062341134248 | COAD | Male-baised eQTL |
| rs2328795 | chr6:23736849:T:C | - | 0.0709509558072917 | 0.0450062341134248 | COAD | Male-baised eQTL |
| Opposite sex-biased eQTL regulation. |
| SNP ID | SNP Info | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Sex-biased Gene in Cancer | Cancer Type |
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Sex-biased eQTM regulation of gene |
| Sex-biased eQTM regulation of gene (The figures only show the pairs with FDR<1e-5. For more information please check the below table). |
| eQTM | Description |
| Male-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Female-specific eQTM regulation. |
| CpG Site | CpG Postion | Position to Gene | Effect Score | FDR | Cor.r | Cor.Pvalue | Cancer Type |
| Opposite sex-biased eQTM regulation. |
| CpG Site | CpG Postion | CpG Island | Position to Gene | Male Effect | Male FDR | Female Effect | Female FDR | Male Cor | Male P-value | Female Cor | Female P-value | Sex-biased Coding Gene | Cancer Type |
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Sex-biased sQTL regulation of gene |
| Sex-biased sQTL regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTL | Description |
| Male-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_448047 | chr6:16143698:16143863 | In-frame | rs235149 | chr6:16490617:C:G | Distant downstream | -0.0515197933966105 | 0.0111378564825837 | STAD | Female-baised sQTL |
| exon_skip_448047 | chr6:16143698:16143863 | In-frame | rs9350009 | chr6:16543032:A:G | Distant downstream | -0.0509385593276754 | 0.0200564418387202 | STAD | Female-baised sQTL |
| Female-specific sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Effect Score | FDR | Cancer Type | Biased Type |
| exon_skip_448047 | chr6:16143698:16143863 | In-frame | rs10949343 | chr6:16101026:T:C | Distant upstream | -0.0241851334180022 | 0.00786369296312918 | LUAD | Male-baised sQTL |
| exon_skip_448047 | chr6:16143698:16143863 | In-frame | rs7766772 | chr6:16102508:A:C | Distant upstream | -0.0239741184114596 | 0.014328611284429 | LUAD | Male-baised sQTL |
| exon_skip_448047 | chr6:16143698:16143863 | In-frame | rs7745965 | chr6:16102511:G:A | Distant upstream | -0.0239741184114596 | 0.014328611284429 | LUAD | Male-baised sQTL |
| exon_skip_448047 | chr6:16143698:16143863 | In-frame | rs12192575 | chr6:16102071:C:T | Distant upstream | -0.0229876396370917 | 0.0234213320003568 | LUAD | Male-baised sQTL |
| exon_skip_448047 | chr6:16143698:16143863 | In-frame | rs7749877 | chr6:16102571:G:A | Distant upstream | -0.0227131492040345 | 0.0278030732461697 | LUAD | Male-baised sQTL |
| Opposite sex-biased sQTL regulation. |
| ES ID | Skipped Exon | ORF Anno | SNP ID | SNP Info | SNP Position to ES | Male Effect | Male FDR | Female Effect | Female FDR | Cancer Type |
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Sex-biased sQTM regulation of gene |
| Sex-biased sQTM regulation of gene (The figures only show the pairs with FDR <1e-5. For more information please check the below table). |
| sQTM | Description |
| Male-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Female-specific sQTM regulation. |
| EX ID | Skipped Exon | CPG Site | CPG Position | Position to EX Events | Effect Score | FDR | Cor.r | Cor.Pvalue | ORF_anno | Cancer Type |
| Opposite sex-biased sQTM regulation. |
| EX ID | EX Info | Skipped Exon | CPG Site | CPG Position | CPG Island | Position to EX Events | Male Effect | Male FDR | Female Effect | Female FDR | Male Correlation | Male P-value | Female Correlation | Female P-value | ORF_anno | Cancer Type |
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Related disease information of MYLIP |
| Diseases associated with this gene (DisGeNET). |
| Gene ID | Gene Symbol | Disease ID | Disease Name | Number of PMID | Source |
| ENSG00000007944 | MYLIP | C0014175 | Endometriosis | 1 | CTD_human |
| ENSG00000007944 | MYLIP | C0269102 | Endometrioma | 1 | CTD_human |
