Home | SexAnnoDB: Genome wide sex and gender annotation database in cancer

About SexAnnoDB

Sex differences are a growing focus of cancer incidence and mortality studies. Recently, personalized approaches in cancer treatment have taken sex differences into account. However, there are no systematic and intensive analyses of different sex groups until now. Here we built SexAnnoDB(A comprehensive sex annotation database in cancer) to provide a resource and reference for intensive functional annotations of sex effects in cancer to facilitate the development of personalized precision medicine. In this database, we analyzed different levels of molecules, including molecules of genome, epigenome, transcriptome, and proteome of TCGA across 27 cancer types. For each molecule, we performed multiple systematic and bioinformatic analyses, including male-specific differential molecules, female-specific differential molecules, and sex-biased molecules. What's more, we analyzed transcript factor-gene regulation network, RNA binding protein-exon skipping regulation network, ceRNA of female and male groups, diverse variant information (Sex-biased Expression Quantitative Trait Loci (eQTL), Sex-biased Splicing Quantitative Trait Loci (sQTL)), and methylation information (Sex-biased Expression Quantitative Trait Methylation(eQTM), Sex-biased Splicing Quantitative Trait Methylation (sQTM)). SexAnnoDB is the first database that systematically and intensively annotates the sex effect across differential biomolecules in cancer, which will be a unique resource for cancer and drug research communities to develop personalized precision medicine plans for patients.