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Editing gene: ARHGAP25 (CAeditome ID:9938)

Gene summary for ARHGAP25

Gene summary

Gene information	Gene symbol	ARHGAP25
	Gene ID	9938
	Gene name	Rho GTPase activating protein 25
	Synonyms	HEL-S-308\|KAIA0053
	Cytomap	2p13.3
	Type of gene	protein-coding
	Description	rho GTPase-activating protein 25epididymis secretory protein Li 308epididymis secretory sperm binding proteinrho-type GTPase-activating protein 25
	Modification date	20210518
	UniProtAcc	P42331
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
ARHGAP25	GO:0001891	Rho GTPase-activating protein 25	26465210

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RNA A-to-I events for ARHGAP25

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000163219.10

RNA A-to-I editing events in Cancer.

CAediting_189177(68738700, +), CAediting_189178(68746861, +), CAediting_189179(68746929, +), CAediting_189180(68746983, +), CAediting_189181(68747345, +), CAediting_189182(68747350, +), CAediting_189183(68747374, +), CAediting_189184(68747377, +), CAediting_189185(68747384, +), CAediting_189186(68747394, +), CAediting_189187(68750423, +), CAediting_189188(68750452, +), CAediting_189189(68754032, +), CAediting_189190(68754042, +), CAediting_189191(68754110, +), CAediting_189192(68783562, +), CAediting_189193(68786008, +), CAediting_189194(68786037, +), CAediting_189195(68786042, +), CAediting_189196(68786043, +), CAediting_189197(68786045, +), CAediting_189198(68786051, +), CAediting_189199(68786052, +), CAediting_189200(68786058, +), CAediting_189201(68786063, +), CAediting_189202(68786068, +), CAediting_189203(68786080, +), CAediting_189204(68786081, +), CAediting_189205(68786086, +), CAediting_189206(68786530, +), CAediting_189207(68786599, +), CAediting_189208(68786604, +), CAediting_189209(68786632, +), CAediting_189210(68786634, +), CAediting_189211(68786635, +), CAediting_189212(68786636, +), CAediting_189213(68786637, +), CAediting_189214(68786655, +), CAediting_189215(68786656, +), CAediting_189216(68786658, +), CAediting_189217(68786672, +), CAediting_189218(68786677, +), CAediting_189219(68786692, +), CAediting_189220(68786694, +), CAediting_189221(68786695, +), CAediting_189222(68786700, +), CAediting_189223(68786712, +), CAediting_189224(68786715, +), CAediting_189225(68786716, +), CAediting_189226(68786720, +), CAediting_189227(68786727, +), CAediting_189228(68786731, +), CAediting_189229(68786737, +), CAediting_189230(68786747, +), CAediting_189231(68802154, +), CAediting_189232(68802155, +), CAediting_189233(68802184, +), CAediting_189234(68802189, +), CAediting_189235(68802230, +), CAediting_189236(68802287, +), CAediting_189237(68802297, +), CAediting_189238(68802304, +), CAediting_189239(68802343, +), CAediting_189240(68813621, +), CAediting_189241(68813623, +), CAediting_189242(68813641, +), CAediting_189243(68813650, +), CAediting_189244(68813655, +), CAediting_189245(68813660, +), CAediting_189246(68813662, +), CAediting_189247(68813673, +), CAediting_189248(68813675, +), CAediting_189249(68813683, +), CAediting_189250(68813702, +), CAediting_189251(68813708, +), CAediting_189252(68813720, +), CAediting_189253(68813737, +), CAediting_189254(68813750, +), CAediting_189255(68813775, +), CAediting_189256(68813776, +), CAediting_189257(68813782, +), CAediting_189258(68813815, +), CAediting_189259(68813819, +), CAediting_189260(68813823, +), CAediting_189261(68813830, +), CAediting_189262(68813837, +), CAediting_189263(68813840, +), CAediting_189264(68813891, +), CAediting_189265(68815616, +), CAediting_189266(68815637, +), CAediting_189267(68815658, +), CAediting_189268(68815661, +), CAediting_189269(68815670, +), CAediting_189270(68815672, +), CAediting_189271(68815702, +), CAediting_189272(68815725, +), CAediting_189273(68815740, +), CAediting_189274(68815776, +), CAediting_189275(68815778, +), CAediting_189276(68815784, +), CAediting_189277(68815847, +), CAediting_189278(68815880, +), CAediting_189279(68815907, +), CAediting_189280(68815908, +),

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RNA editing positional annotations for ARHGAP25 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_189177	chr2_68738700_+	ncRNA_intronic
CAediting_189178	chr2_68746861_+	ncRNA_intronic
CAediting_189179	chr2_68746929_+	ncRNA_intronic
CAediting_189180	chr2_68746983_+	ncRNA_intronic
CAediting_189181	chr2_68747345_+	ncRNA_intronic
CAediting_189182	chr2_68747350_+	ncRNA_intronic
CAediting_189183	chr2_68747374_+	ncRNA_intronic
CAediting_189184	chr2_68747377_+	ncRNA_intronic
CAediting_189185	chr2_68747384_+	ncRNA_intronic
CAediting_189186	chr2_68747394_+	ncRNA_intronic
CAediting_189187	chr2_68750423_+	ncRNA_intronic
CAediting_189188	chr2_68750452_+	ncRNA_intronic
CAediting_189189	chr2_68754032_+	ncRNA_intronic
CAediting_189190	chr2_68754042_+	ncRNA_intronic
CAediting_189191	chr2_68754110_+	ncRNA_intronic
CAediting_189192	chr2_68783562_+	ncRNA_intronic
CAediting_189193	chr2_68786008_+	ncRNA_intronic
CAediting_189194	chr2_68786037_+	ncRNA_intronic
CAediting_189195	chr2_68786042_+	ncRNA_intronic
CAediting_189196	chr2_68786043_+	ncRNA_intronic
CAediting_189197	chr2_68786045_+	ncRNA_intronic
CAediting_189198	chr2_68786051_+	ncRNA_intronic
CAediting_189199	chr2_68786052_+	ncRNA_intronic
CAediting_189200	chr2_68786058_+	ncRNA_intronic
CAediting_189201	chr2_68786063_+	ncRNA_intronic
CAediting_189202	chr2_68786068_+	ncRNA_intronic
CAediting_189203	chr2_68786080_+	ncRNA_intronic
CAediting_189204	chr2_68786081_+	ncRNA_intronic
CAediting_189205	chr2_68786086_+	ncRNA_intronic
CAediting_189206	chr2_68786530_+	ncRNA_intronic
CAediting_189207	chr2_68786599_+	ncRNA_intronic
CAediting_189208	chr2_68786604_+	ncRNA_intronic
CAediting_189209	chr2_68786632_+	ncRNA_intronic
CAediting_189210	chr2_68786634_+	ncRNA_intronic
CAediting_189211	chr2_68786635_+	ncRNA_intronic
CAediting_189212	chr2_68786636_+	ncRNA_intronic
CAediting_189213	chr2_68786637_+	ncRNA_intronic
CAediting_189214	chr2_68786655_+	ncRNA_intronic
CAediting_189215	chr2_68786656_+	ncRNA_intronic
CAediting_189216	chr2_68786658_+	ncRNA_intronic
CAediting_189217	chr2_68786672_+	ncRNA_intronic
CAediting_189218	chr2_68786677_+	ncRNA_intronic
CAediting_189219	chr2_68786692_+	ncRNA_intronic
CAediting_189220	chr2_68786694_+	ncRNA_intronic
CAediting_189221	chr2_68786695_+	ncRNA_intronic
CAediting_189222	chr2_68786700_+	ncRNA_intronic
CAediting_189223	chr2_68786712_+	ncRNA_intronic
CAediting_189224	chr2_68786715_+	ncRNA_intronic
CAediting_189225	chr2_68786716_+	ncRNA_intronic
CAediting_189226	chr2_68786720_+	ncRNA_intronic
CAediting_189227	chr2_68786727_+	ncRNA_intronic
CAediting_189228	chr2_68786731_+	ncRNA_intronic
CAediting_189229	chr2_68786737_+	ncRNA_intronic
CAediting_189230	chr2_68786747_+	ncRNA_intronic
CAediting_189231	chr2_68802154_+	ncRNA_intronic
CAediting_189232	chr2_68802155_+	ncRNA_intronic
CAediting_189233	chr2_68802184_+	ncRNA_intronic
CAediting_189234	chr2_68802189_+	ncRNA_intronic
CAediting_189235	chr2_68802230_+	ncRNA_intronic
CAediting_189236	chr2_68802287_+	ncRNA_intronic
CAediting_189237	chr2_68802297_+	ncRNA_intronic
CAediting_189238	chr2_68802304_+	ncRNA_intronic
CAediting_189239	chr2_68802343_+	ncRNA_intronic
CAediting_189240	chr2_68813621_+	intronic
CAediting_189241	chr2_68813623_+	intronic
CAediting_189242	chr2_68813641_+	intronic
CAediting_189243	chr2_68813650_+	intronic
CAediting_189244	chr2_68813655_+	intronic
CAediting_189245	chr2_68813660_+	intronic
CAediting_189246	chr2_68813662_+	intronic
CAediting_189247	chr2_68813673_+	intronic
CAediting_189248	chr2_68813675_+	intronic
CAediting_189249	chr2_68813683_+	intronic
CAediting_189250	chr2_68813702_+	intronic
CAediting_189251	chr2_68813708_+	intronic
CAediting_189252	chr2_68813720_+	intronic
CAediting_189253	chr2_68813737_+	intronic
CAediting_189254	chr2_68813750_+	intronic
CAediting_189255	chr2_68813775_+	intronic
CAediting_189256	chr2_68813776_+	intronic
CAediting_189257	chr2_68813782_+	intronic
CAediting_189258	chr2_68813815_+	intronic
CAediting_189259	chr2_68813819_+	intronic
CAediting_189260	chr2_68813823_+	intronic
CAediting_189261	chr2_68813830_+	intronic
CAediting_189262	chr2_68813837_+	intronic
CAediting_189263	chr2_68813840_+	intronic
CAediting_189264	chr2_68813891_+	intronic
CAediting_189265	chr2_68815616_+	intronic
CAediting_189266	chr2_68815637_+	intronic
CAediting_189267	chr2_68815658_+	intronic
CAediting_189268	chr2_68815661_+	intronic
CAediting_189269	chr2_68815670_+	intronic
CAediting_189270	chr2_68815672_+	intronic
CAediting_189271	chr2_68815702_+	intronic
CAediting_189272	chr2_68815725_+	intronic
CAediting_189273	chr2_68815740_+	intronic
CAediting_189274	chr2_68815776_+	intronic
CAediting_189275	chr2_68815778_+	intronic
CAediting_189276	chr2_68815784_+	intronic
CAediting_189277	chr2_68815847_+	intronic
CAediting_189278	chr2_68815880_+	intronic
CAediting_189279	chr2_68815907_+	intronic
CAediting_189280	chr2_68815908_+	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_189177	chr2_68738700_+	SINE	Alu	AluSx3
CAediting_189178	chr2_68746861_+	SINE	Alu	AluSp
CAediting_189179	chr2_68746929_+	SINE	Alu	AluSp
CAediting_189180	chr2_68746983_+	SINE	Alu	AluSp
CAediting_189181	chr2_68747345_+	DNA	hAT-Tip100	MER45A
CAediting_189182	chr2_68747350_+	DNA	hAT-Tip100	MER45A
CAediting_189183	chr2_68747374_+	DNA	hAT-Tip100	MER45A
CAediting_189184	chr2_68747377_+	DNA	hAT-Tip100	MER45A
CAediting_189185	chr2_68747384_+	DNA	hAT-Tip100	MER45A
CAediting_189186	chr2_68747394_+	DNA	hAT-Tip100	MER45A
CAediting_189187	chr2_68750423_+	SINE	Alu	AluSq2
CAediting_189188	chr2_68750452_+	SINE	Alu	AluSq2
CAediting_189189	chr2_68754032_+	SINE	Alu	AluYj4
CAediting_189190	chr2_68754042_+	SINE	Alu	AluYj4
CAediting_189191	chr2_68754110_+	SINE	Alu	AluYj4
CAediting_189192	chr2_68783562_+	SINE	Alu	AluSx
CAediting_189231	chr2_68802154_+	SINE	Alu	AluSc8
CAediting_189232	chr2_68802155_+	SINE	Alu	AluSc8
CAediting_189233	chr2_68802184_+	SINE	Alu	AluSc8
CAediting_189234	chr2_68802189_+	SINE	Alu	AluSc8
CAediting_189235	chr2_68802230_+	SINE	Alu	AluSc8
CAediting_189236	chr2_68802287_+	SINE	Alu	AluSc8
CAediting_189237	chr2_68802297_+	SINE	Alu	AluSc8
CAediting_189238	chr2_68802304_+	SINE	Alu	AluSc8
CAediting_189239	chr2_68802343_+	SINE	Alu	AluSc8
CAediting_189249	chr2_68813683_+	LINE	RTE-BovB	MamRTE1
CAediting_189250	chr2_68813702_+	LINE	RTE-BovB	MamRTE1
CAediting_189251	chr2_68813708_+	LINE	RTE-BovB	MamRTE1
CAediting_189252	chr2_68813720_+	LINE	RTE-BovB	MamRTE1
CAediting_189253	chr2_68813737_+	LINE	RTE-BovB	MamRTE1
CAediting_189265	chr2_68815616_+	SINE	Alu	AluSq4

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RNA A-to-I editing events in the alternative splicing sites for ARHGAP25

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000163219.10.ARHGAP25.

Correlation between RNA A-to-I editing and PSI for ENSG00000163219.10.ARHGAP25.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for ARHGAP25

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for ARHGAP25

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for ARHGAP25

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000163219.10	ENST00000473986	hsa-miR-624-3p	68787945	68787951	7mer-m8	68787933	68787952	144	-17.1
CAediting_117844	chr1_162342605_+	ENSG00000163219.10	ENST00000409202	hsa-miR-556-3p	68826494	68826500	7mer-m8	68826482	68826501	143	-8.56
CAediting_442554	chr5_154685830_+	ENSG00000163219.10	ENST00000409202	hsa-miR-1303	68826726	68826732	7mer-m8	68826715	68826733	150	-16.83
CAediting_524911	chr7_5495852_-	ENSG00000163219.10	ENST00000488795	hsa-miR-589-3p	68813381	68813387	7mer-m8	68813366	68813388	145	-19.1
CAediting_1054808	chr15_66496985_-	ENSG00000163219.10	ENST00000488795	hsa-miR-4512	68816367	68816373	7mer-m8	68816350	68816374	149	-22.54
CAediting_117844	chr1_162342605_+	ENSG00000163219.10	ENST00000409030	hsa-miR-556-3p	68826494	68826500	7mer-m8	68826482	68826501	143	-8.56
CAediting_442554	chr5_154685830_+	ENSG00000163219.10	ENST00000409030	hsa-miR-1303	68826726	68826732	7mer-m8	68826715	68826733	150	-16.83
CAediting_117844	chr1_162342605_+	ENSG00000163219.10	ENST00000409220	hsa-miR-556-3p	68826494	68826500	7mer-m8	68826482	68826501	143	-8.56
CAediting_442554	chr5_154685830_+	ENSG00000163219.10	ENST00000409220	hsa-miR-1303	68826726	68826732	7mer-m8	68826715	68826733	150	-16.83
CAediting_1368054	chr19_46709310_-	ENSG00000163219.10	ENST00000473986	hsa-miR-320e	68787887	68787893	7mer-m8	68787876	68787894	151	-20.44
CAediting_77128	chr1_85133844_+	ENSG00000163219.10	ENST00000473986	hsa-miR-4423-3p	68807334	68807340	7mer-m8	68807321	68807341	152	-18.81
CAediting_524911	chr7_5495852_-	ENSG00000163219.10	ENST00000473986	hsa-miR-589-3p	68813381	68813387	7mer-m8	68813366	68813388	145	-19.1
CAediting_1229413	chr17_67471544_+	ENSG00000163219.10	ENST00000497079	hsa-miR-548aa	68819698	68819704	7mer-m8	68819683	68819705	152	-11.25
CAediting_1160181	chr17_7017644_-	ENSG00000163219.10	ENST00000497079	hsa-miR-195-3p	68819638	68819644	7mer-m8	68819624	68819645	149	-13
CAediting_117844	chr1_162342605_+	ENSG00000163219.10	ENST00000497259	hsa-miR-556-3p	68826494	68826500	7mer-m8	68826482	68826501	143	-8.56
CAediting_442554	chr5_154685830_+	ENSG00000163219.10	ENST00000497259	hsa-miR-1303	68826726	68826732	7mer-m8	68826715	68826733	150	-16.83
CAediting_117844	chr1_162342605_+	ENSG00000163219.10	ENST00000479844	hsa-miR-556-3p	68826494	68826500	7mer-m8	68826482	68826501	143	-8.56
CAediting_442554	chr5_154685830_+	ENSG00000163219.10	ENST00000479844	hsa-miR-1303	68826726	68826732	7mer-m8	68826715	68826733	150	-16.83

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for ARHGAP25

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for ARHGAP25

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for ARHGAP25

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for ARHGAP25

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
LAML	CAediting_189245	chr2_68813660_+	0.0487967278527172	0.00752027	0.00358122

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RelatedDrugs for ARHGAP25

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for ARHGAP25

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene