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Editing gene: TATDN2 (CAeditome ID:9797)

Gene summary for TATDN2

Gene summary

Gene information	Gene symbol	TATDN2
	Gene ID	9797
	Gene name	TatD DNase domain containing 2
	Synonyms	-
	Cytomap	3p25.3
	Type of gene	protein-coding
	Description	putative deoxyribonuclease TATDN2
	Modification date	20210525
	UniProtAcc	Q93075
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for TATDN2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000157014.9

RNA A-to-I editing events in Cancer.

CAediting_257030(10256335, +), CAediting_257031(10257429, +), CAediting_257032(10257454, +), CAediting_257033(10257455, +), CAediting_257034(10257467, +), CAediting_257035(10257470, +), CAediting_257036(10257482, +), CAediting_257037(10257508, +), CAediting_257038(10257509, +), CAediting_257039(10257535, +), CAediting_257040(10257586, +), CAediting_257041(10258045, +), CAediting_257042(10260282, +), CAediting_257043(10265515, +), CAediting_257044(10265535, +), CAediting_257045(10265588, +), CAediting_257046(10265608, +), CAediting_257047(10271734, +), CAediting_257048(10271737, +), CAediting_257049(10271943, +), CAediting_257050(10272205, +), CAediting_257051(10272959, +), CAediting_257052(10275492, +), CAediting_257053(10275671, +), CAediting_257054(10275734, +), CAediting_257055(10276647, +),

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RNA editing positional annotations for TATDN2 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_257042	chr3_10260282_+	nonsynonymous SNV	ENST00000287652.7	c.A560G	p.Y187C	D	D	D
CAediting_257042	chr3_10260282_+	nonsynonymous SNV	ENST00000448281.5	c.A560G	p.Y187C	D	D	D

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_257030	chr3_10256335_+	intronic
CAediting_257031	chr3_10257429_+	intronic
CAediting_257032	chr3_10257454_+	intronic
CAediting_257033	chr3_10257455_+	intronic
CAediting_257034	chr3_10257467_+	intronic
CAediting_257035	chr3_10257470_+	intronic
CAediting_257036	chr3_10257482_+	intronic
CAediting_257037	chr3_10257508_+	intronic
CAediting_257038	chr3_10257509_+	intronic
CAediting_257039	chr3_10257535_+	intronic
CAediting_257040	chr3_10257586_+	intronic
CAediting_257041	chr3_10258045_+	intronic
CAediting_257042	chr3_10260282_+	exonic
CAediting_257043	chr3_10265515_+	intronic
CAediting_257044	chr3_10265535_+	intronic
CAediting_257045	chr3_10265588_+	intronic
CAediting_257046	chr3_10265608_+	intronic
CAediting_257047	chr3_10271734_+	intronic
CAediting_257048	chr3_10271737_+	intronic
CAediting_257049	chr3_10271943_+	intronic
CAediting_257050	chr3_10272205_+	intronic
CAediting_257051	chr3_10272959_+	intronic
CAediting_257052	chr3_10275492_+	intronic
CAediting_257053	chr3_10275671_+	intronic
CAediting_257054	chr3_10275734_+	intronic
CAediting_257055	chr3_10276647_+	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_257030	chr3_10256335_+	SINE	Alu	AluJb
CAediting_257031	chr3_10257429_+	SINE	Alu	AluSx
CAediting_257032	chr3_10257454_+	SINE	Alu	AluSx
CAediting_257033	chr3_10257455_+	SINE	Alu	AluSx
CAediting_257034	chr3_10257467_+	SINE	Alu	AluSx
CAediting_257035	chr3_10257470_+	SINE	Alu	AluSx
CAediting_257036	chr3_10257482_+	SINE	Alu	AluSx
CAediting_257037	chr3_10257508_+	SINE	Alu	AluSx
CAediting_257038	chr3_10257509_+	SINE	Alu	AluSx
CAediting_257039	chr3_10257535_+	SINE	Alu	AluSx
CAediting_257040	chr3_10257586_+	SINE	Alu	AluSx
CAediting_257041	chr3_10258045_+	SINE	Alu	AluY
CAediting_257043	chr3_10265515_+	SINE	Alu	AluY
CAediting_257044	chr3_10265535_+	SINE	Alu	AluY
CAediting_257045	chr3_10265588_+	SINE	Alu	AluY
CAediting_257046	chr3_10265608_+	SINE	Alu	AluY
CAediting_257047	chr3_10271734_+	SINE	Alu	AluSz
CAediting_257048	chr3_10271737_+	SINE	Alu	AluSz
CAediting_257049	chr3_10271943_+	SINE	Alu	AluSz
CAediting_257050	chr3_10272205_+	SINE	Alu	AluJb
CAediting_257051	chr3_10272959_+	SINE	Alu	AluJb
CAediting_257052	chr3_10275492_+	SINE	Alu	AluSz
CAediting_257053	chr3_10275671_+	SINE	Alu	AluSz
CAediting_257054	chr3_10275734_+	SINE	Alu	AluSz
CAediting_257055	chr3_10276647_+	SINE	Alu	AluSg

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RNA A-to-I editing events in the alternative splicing sites for TATDN2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000157014.9.TATDN2.

Correlation between RNA A-to-I editing and PSI for ENSG00000157014.9.TATDN2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for TATDN2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for TATDN2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for TATDN2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_748296	chr10_51299626_+	ENSG00000157014.9	ENST00000287652	hsa-miR-605-3p	10279945	10279952	8mer-1a	10279930	10279952	154	-18.03
CAediting_980496	chr14_31014685_-	ENSG00000157014.9	ENST00000287652	hsa-miR-624-3p	10280921	10280926	6mer	10280905	10280927	146	-28.2
CAediting_748296	chr10_51299626_+	ENSG00000157014.9	ENST00000448281	hsa-miR-605-3p	10279945	10279952	8mer-1a	10279930	10279952	154	-18.03
CAediting_980496	chr14_31014685_-	ENSG00000157014.9	ENST00000448281	hsa-miR-624-3p	10280921	10280926	6mer	10280905	10280927	146	-28.2
CAediting_1229414	chr17_67471546_+	ENSG00000157014.9	ENST00000287652	hsa-miR-548aa	10280525	10280531	7mer-m8	10280508	10280532	150	-14.95
CAediting_1229415	chr17_67471547_+	ENSG00000157014.9	ENST00000287652	hsa-miR-548aa	10280268	10280274	7mer-m8	10280251	10280275	140	-13.72
CAediting_1351755	chr19_40282625_-	ENSG00000157014.9	ENST00000287652	hsa-miR-641	10279263	10279269	7mer-1a	10279245	10279269	149	-26.54
CAediting_442554	chr5_154685830_+	ENSG00000157014.9	ENST00000287652	hsa-miR-1303	10280960	10280966	7mer-m8	10280946	10280967	145	-17.89
CAediting_524911	chr7_5495852_-	ENSG00000157014.9	ENST00000287652	hsa-miR-589-3p	10280361	10280366	6mer	10280349	10280372	145	-16.25
CAediting_524911	chr7_5495852_-	ENSG00000157014.9	ENST00000287652	hsa-miR-589-3p	10280365	10280371	7mer-m8	10280349	10280372	145	-16.25
CAediting_1229414	chr17_67471546_+	ENSG00000157014.9	ENST00000448281	hsa-miR-548aa	10280525	10280531	7mer-m8	10280508	10280532	150	-14.95
CAediting_1229415	chr17_67471547_+	ENSG00000157014.9	ENST00000448281	hsa-miR-548aa	10280268	10280274	7mer-m8	10280251	10280275	140	-13.72
CAediting_1351755	chr19_40282625_-	ENSG00000157014.9	ENST00000448281	hsa-miR-641	10279263	10279269	7mer-1a	10279245	10279269	149	-26.54
CAediting_442554	chr5_154685830_+	ENSG00000157014.9	ENST00000448281	hsa-miR-1303	10280960	10280966	7mer-m8	10280946	10280967	145	-17.89
CAediting_524911	chr7_5495852_-	ENSG00000157014.9	ENST00000448281	hsa-miR-589-3p	10280361	10280366	6mer	10280349	10280372	145	-16.25
CAediting_524911	chr7_5495852_-	ENSG00000157014.9	ENST00000448281	hsa-miR-589-3p	10280365	10280371	7mer-m8	10280349	10280372	145	-16.25
CAediting_468389	chr6_31355314_-	ENSG00000157014.9	ENST00000287652	hsa-miR-6891-5p	10280868	10280873	6mer	10280856	10280874	140	-17.5
CAediting_468389	chr6_31355314_-	ENSG00000157014.9	ENST00000287652	hsa-miR-6891-5p	10279706	10279712	7mer-m8	10279695	10279713	149	-23.56
CAediting_468389	chr6_31355314_-	ENSG00000157014.9	ENST00000287652	hsa-miR-6891-5p	10279933	10279940	8mer-1a	10279922	10279940	147	-21.21
CAediting_468389	chr6_31355314_-	ENSG00000157014.9	ENST00000448281	hsa-miR-6891-5p	10280868	10280873	6mer	10280856	10280874	140	-17.5
CAediting_468389	chr6_31355314_-	ENSG00000157014.9	ENST00000448281	hsa-miR-6891-5p	10279706	10279712	7mer-m8	10279695	10279713	149	-23.56
CAediting_468389	chr6_31355314_-	ENSG00000157014.9	ENST00000448281	hsa-miR-6891-5p	10279933	10279940	8mer-1a	10279922	10279940	147	-21.21

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_846604	chr11_93733708_-	ENSG00000157014.9	ENST00000287652	hsa-miR-1304-3p	10280488	10280494	7mer-m8	10280474	10280495	151	-19.51
CAediting_1368054	chr19_46709310_-	ENSG00000157014.9	ENST00000287652	hsa-miR-320e	10281108	10281113	6mer	10281097	10281114	148	-15.42
CAediting_228905	chr2_188297554_+	ENSG00000157014.9	ENST00000287652	hsa-miR-561-3p	10279637	10279643	7mer-m8	10279623	10279644	140	-10.28
CAediting_524911	chr7_5495852_-	ENSG00000157014.9	ENST00000287652	hsa-miR-589-3p	10279747	10279753	7mer-m8	10279732	10279754	152	-16.55
CAediting_980496	chr14_31014685_-	ENSG00000157014.9	ENST00000287652	hsa-miR-624-3p	10280385	10280391	7mer-1a	10280371	10280391	143	-15.08
CAediting_468389	chr6_31355314_-	ENSG00000157014.9	ENST00000287652	hsa-miR-6891-5p	10280036	10280042	7mer-m8	10280025	10280043	140	-16.31
CAediting_846604	chr11_93733708_-	ENSG00000157014.9	ENST00000448281	hsa-miR-1304-3p	10280488	10280494	7mer-m8	10280474	10280495	151	-19.51
CAediting_1368054	chr19_46709310_-	ENSG00000157014.9	ENST00000448281	hsa-miR-320e	10281108	10281113	6mer	10281097	10281114	148	-15.42
CAediting_228905	chr2_188297554_+	ENSG00000157014.9	ENST00000448281	hsa-miR-561-3p	10279637	10279643	7mer-m8	10279623	10279644	140	-10.28
CAediting_524911	chr7_5495852_-	ENSG00000157014.9	ENST00000448281	hsa-miR-589-3p	10279747	10279753	7mer-m8	10279732	10279754	152	-16.55
CAediting_980496	chr14_31014685_-	ENSG00000157014.9	ENST00000448281	hsa-miR-624-3p	10280385	10280391	7mer-1a	10280371	10280391	143	-15.08
CAediting_468389	chr6_31355314_-	ENSG00000157014.9	ENST00000448281	hsa-miR-6891-5p	10280036	10280042	7mer-m8	10280025	10280043	140	-16.31

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for TATDN2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000287652.7	protein_coding
ENST00000448281.5	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_257042	ENST00000287652.7	chr3_10260282_+	-2068.90	-2067.80	-2068.90
CAediting_257042	ENST00000448281.5	chr3_10260282_+	-1627.60	-1626.10	-1627.60

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Relation with ADAR for TATDN2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for TATDN2

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for TATDN2

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for TATDN2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for TATDN2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene