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![]() | Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples |
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![]() | The effects of the RNA editing to the stability of the RNA structures |
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Editing gene: KMT2B (CAeditome ID:9757) |
Gene summary for KMT2B |
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Gene information | Gene symbol | KMT2B | Gene ID | 9757 |
Gene name | lysine methyltransferase 2B | |
Synonyms | CXXC10|DYT28|HRX2|MLL1B|MLL2|MLL4|TRX2|WBP-7|WBP7 | |
Cytomap | 19q13.12 | |
Type of gene | protein-coding | |
Description | histone-lysine N-methyltransferase 2BWW domain binding protein 7histone-lysine N-methyltransferase MLL4lysine (K)-specific methyltransferase 2Bmixed lineage leukemia gene homolog 2myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosoph | |
Modification date | 20210531 | |
UniProtAcc | Q9UMN6 | |
Context |
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Gene | GO ID | GO term | PubMed ID |
KMT2B | GO:0008270 | Histone-lysine N-methyltransferase 2B | 29276034 |
KMT2B | GO:0042800 | Histone-lysine N-methyltransferase 2B | 17500065 |
KMT2B | GO:0045322 | Histone-lysine N-methyltransferase 2B | 29276034 |
KMT2B | GO:0044648 | Histone-lysine N-methyltransferase 2B | 25561738 |
KMT2B | GO:0097692 | Histone-lysine N-methyltransferase 2B | 25561738 |
KMT2B | GO:0005634 | Histone-lysine N-methyltransferase 2B | 17500065 |
KMT2B | GO:0035097 | Histone-lysine N-methyltransferase 2B | 17500065 |
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RNA A-to-I events for KMT2B |
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CAediting_1338870(35720497, +), CAediting_1338871(35722207, +), CAediting_1338872(35724367, +), CAediting_1338873(35724371, +), CAediting_1338874(35735486, +), |
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RNA editing positional annotations for KMT2B using Annovar |
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CAeditome ID | Position | Variant type | ENST | NTchange | AAchange | SIFT_score | Polyphen2_HVAR_score | PROVEAN_pred |
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CAeditome ID | Position | Variant type |
CAediting_1338870 | chr19_35720497_+ | exonic |
CAediting_1338871 | chr19_35722207_+ | intronic |
CAediting_1338872 | chr19_35724367_+ | intronic |
CAediting_1338873 | chr19_35724371_+ | intronic |
CAediting_1338874 | chr19_35735486_+ | ncRNA_exonic |
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CAeditome ID | Position | Repeat family | Repeat sub family | Repeat name |
CAediting_1338871 | chr19_35722207_+ | SINE | Alu | AluSx4 |
CAediting_1338872 | chr19_35724367_+ | SINE | Alu | AluJo |
CAediting_1338873 | chr19_35724371_+ | SINE | Alu | AluJo |
CAediting_1338874 | chr19_35735486_+ | LINE | L2 | L2 |
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RNA A-to-I editing events in the alternative splicing sites for KMT2B |
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AStype | CAeditomID | Editing position | AS position | AS direction | Exonic location | Wildtype sequence | Wildtype splicing strength | RNA edited sequence | RNA edited splicing strength |
IR | CAediting_1338872 | chr19_35724367_+ | 35724364:35724386 | 3SS | 0+17i | GGCACGCATCTGTGGTCTCAGCT | -13.28 | GGCGCGCATCTGTGGTCTCAGCT | -12.3 |
IR | CAediting_1338873 | chr19_35724371_+ | 35724364:35724386 | 3SS | 0+13i | GGCACGCATCTGTGGTCTCAGCT | -13.28 | GGCACGCGTCTGTGGTCTCAGCT | -12.79 |
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Differntial gene expression between RNA A-to-I edited versus non-edited samples for KMT2B |
![]() * The grey color means N/A. |
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Protein coding region RNA A-to-I editings for KMT2B |
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The effects of the RNA editing to the miRNA binding sites for KMT2B |
**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page. |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
CAediting_86358 | chr1_109598906_+ | ENSG00000272333.4 | ENST00000420124 | hsa-miR-197-5p | 35738711 | 35738717 | 7mer-m8 | 35738694 | 35738718 | 158 | -27.48 |
CAediting_1524209 | chrX_134546392_- | ENSG00000272333.4 | ENST00000420124 | hsa-miR-503-5p | 35738593 | 35738598 | 6mer | 35738586 | 35738608 | 148 | -22.17 |
CAediting_1524209 | chrX_134546392_- | ENSG00000272333.4 | ENST00000420124 | hsa-miR-503-5p | 35738601 | 35738608 | 8mer-1a | 35738586 | 35738608 | 148 | -22.17 |
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CAeditom_ID | Position | ENSG | ENST | miRNA | Targetscan start | Targetscan end | Targetscan score | Miranda start | Miranda end | Miranda score | Miranda energy |
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The effects of the RNA editing to the stability of the RNA structures for KMT2B |
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ENST | ENST type | RNA structure without RNA A-to-I editing. | RNA structure with RNA A-to-I editing. |
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CAeditom_ID | ENST | Editing_Position | MFE_withoneAI | MFE_withoutAI | MFE_withmultipleAI |
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Relation with ADAR for KMT2B |
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Cancer | CAeditomID | position | ADAR1 (p-val) | ADAR1 (coeff.) | ADAR2 (p-val) | ADAR2 (coeff.) | ADAR3 (p-val) | ADAR3 (coeff.) |
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Relation with cancer stages for KMT2B |
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Cancer | Stage_type | CAeditomID | position | P-val | Coeff. |
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Relation with survival for KMT2B |
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Cancer | CAeditomID | position | KMpvalue | Coxpvalue | CoxHR |
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RelatedDrugs for KMT2B |
![]() (DrugBank Version 5.1.8 2021-01-03) |
Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KMT2B |
![]() (DisGeNet 7.0) |
Gene | Disease ID | Disease name | # pubmeds | Source |
KMT2B | C4310633 | DYSTONIA 28, CHILDHOOD-ONSET | 3 | GENOMICS_ENGLAND;UNIPROT |
KMT2B | C0013421 | Dystonia | 1 | CTD_human |
KMT2B | C0393588 | Dystonia, Paroxysmal | 1 | CTD_human |
KMT2B | C0393610 | Dystonia, Diurnal | 1 | CTD_human |
KMT2B | C0751093 | Dystonia, Limb | 1 | CTD_human |
KMT2B | C2239176 | Liver carcinoma | 1 | CTD_human |