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Editing gene: CEP57 (CAeditome ID:9702)

Gene summary for CEP57

Gene summary

Gene information	Gene symbol	CEP57
	Gene ID	9702
	Gene name	centrosomal protein 57
	Synonyms	MVA2\|PIG8\|TSP57
	Cytomap	11q21
	Type of gene	protein-coding
	Description	centrosomal protein of 57 kDaFGF2-interacting proteincentrosomal protein 57kDaproliferation-inducing protein 8testis-specific protein 57translokin
	Modification date	20210518
	UniProtAcc	Q86XR8
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CEP57	GO:0005794	Centrosomal protein of 57 kDa	10942595
CEP57	GO:0005813	Centrosomal protein of 57 kDa	14654843
CEP57	GO:0005813	Centrosomal protein of 57 kDa	21399614
CEP57	GO:0005874	Centrosomal protein of 57 kDa	12717444

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RNA A-to-I events for CEP57

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000166037.9

RNA A-to-I editing events in Cancer.

CAediting_847040(95814194, +), CAediting_847041(95820471, +), CAediting_847042(95824119, +), CAediting_847043(95824131, +), CAediting_847044(95824161, +), CAediting_847045(95824166, +), CAediting_847046(95824190, +), CAediting_847047(95824203, +), CAediting_847048(95825787, +), CAediting_847049(95831071, +), CAediting_847050(95831076, +), CAediting_847051(95831094, +), CAediting_847052(95831180, +), CAediting_847053(95831193, +), CAediting_847054(95831226, +), CAediting_847055(95831236, +), CAediting_847056(95832599, +), CAediting_847057(95832635, +),

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RNA editing positional annotations for CEP57 using Annovar

Protein coding RNA editing(s).

CAeditome ID	Position	Variant type	ENST	NTchange	AAchange	SIFT_score	Polyphen2_HVAR_score	PROVEAN_pred
CAediting_847055	chr11_95831236_+	nonsynonymous SNV	ENST00000325486.8	c.A1405G	p.S469G	D	B	N
CAediting_847055	chr11_95831236_+	nonsynonymous SNV	ENST00000325542.8	c.A1483G	p.S495G	D	B	N
CAediting_847055	chr11_95831236_+	nonsynonymous SNV	ENST00000537677.4	c.A1402G	p.S468G	D	B	N
CAediting_847055	chr11_95831236_+	nonsynonymous SNV	ENST00000541150.4	c.A1456G	p.S486G	D	B	N

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_847040	chr11_95814194_+	ncRNA_intronic
CAediting_847041	chr11_95820471_+	intronic
CAediting_847042	chr11_95824119_+	intronic
CAediting_847043	chr11_95824131_+	intronic
CAediting_847044	chr11_95824161_+	intronic
CAediting_847045	chr11_95824166_+	intronic
CAediting_847046	chr11_95824190_+	intronic
CAediting_847047	chr11_95824203_+	intronic
CAediting_847048	chr11_95825787_+	ncRNA_exonic
CAediting_847049	chr11_95831071_+	exonic
CAediting_847050	chr11_95831076_+	exonic
CAediting_847051	chr11_95831094_+	exonic
CAediting_847052	chr11_95831180_+	exonic
CAediting_847053	chr11_95831193_+	exonic
CAediting_847054	chr11_95831226_+	exonic
CAediting_847055	chr11_95831236_+	exonic
CAediting_847056	chr11_95832599_+	UTR3
CAediting_847057	chr11_95832635_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_847040	chr11_95814194_+	SINE	Alu	AluSz6
CAediting_847041	chr11_95820471_+	SINE	Alu	AluSq
CAediting_847042	chr11_95824119_+	SINE	Alu	AluJo
CAediting_847043	chr11_95824131_+	SINE	Alu	AluJo
CAediting_847044	chr11_95824161_+	SINE	Alu	AluJo
CAediting_847045	chr11_95824166_+	SINE	Alu	AluJo
CAediting_847046	chr11_95824190_+	SINE	Alu	AluJo
CAediting_847047	chr11_95824203_+	SINE	Alu	AluJo
CAediting_847048	chr11_95825787_+	SINE	Alu	AluSx

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RNA A-to-I editing events in the alternative splicing sites for CEP57

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000166037.9.CEP57.

Correlation between RNA A-to-I editing and PSI for ENSG00000166037.9.CEP57.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CEP57

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CEP57

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CEP57

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_847050	chr11_95831076_+	ENSG00000166037.9	ENST00000539855	hsa-miR-6740-3p	95831074	95831080	7mer-m8	95831060	95831081	140.00	-8.84
CAediting_847050	chr11_95831076_+	ENSG00000166037.9	ENST00000540830	hsa-miR-6740-3p	95831074	95831080	7mer-m8	95831060	95831081	140.00	-8.84
CAediting_847052	chr11_95831180_+	ENSG00000166037.9	ENST00000539855	hsa-miR-4659a-3p	95831175	95831182	8mer-1a	95831161	95831182	141.00	-9.76
CAediting_847052	chr11_95831180_+	ENSG00000166037.9	ENST00000539855	hsa-miR-4659b-3p	95831175	95831182	8mer-1a	95831161	95831182	141.00	-10.61
CAediting_847052	chr11_95831180_+	ENSG00000166037.9	ENST00000539855	hsa-miR-942-5p	95831174	95831180	7mer-1a	95831158	95831180	143.00	-18.77
CAediting_847052	chr11_95831180_+	ENSG00000166037.9	ENST00000540830	hsa-miR-4659a-3p	95831175	95831182	8mer-1a	95831161	95831182	141.00	-9.76
CAediting_847052	chr11_95831180_+	ENSG00000166037.9	ENST00000540830	hsa-miR-4659b-3p	95831175	95831182	8mer-1a	95831161	95831182	141.00	-10.61
CAediting_847052	chr11_95831180_+	ENSG00000166037.9	ENST00000540830	hsa-miR-942-5p	95831174	95831180	7mer-1a	95831158	95831180	143.00	-18.77
CAediting_847053	chr11_95831193_+	ENSG00000166037.9	ENST00000539855	hsa-miR-7159-5p	95831190	95831197	8mer-1a	95831180	95831197	146.00	-12.47
CAediting_847053	chr11_95831193_+	ENSG00000166037.9	ENST00000540830	hsa-miR-7159-5p	95831190	95831197	8mer-1a	95831180	95831197	146.00	-12.47
CAediting_847055	chr11_95831236_+	ENSG00000166037.9	ENST00000539855	hsa-miR-324-3p	95831230	95831236	7mer-m8	95831215	95831237	140.00	-17.63
CAediting_847055	chr11_95831236_+	ENSG00000166037.9	ENST00000539855	hsa-miR-497-3p	95831233	95831239	7mer-m8	95831221	95831240	149.00	-17.45
CAediting_847055	chr11_95831236_+	ENSG00000166037.9	ENST00000539855	hsa-miR-6715a-3p	95831234	95831240	7mer-m8	95831221	95831241	142.00	-13.00
CAediting_847055	chr11_95831236_+	ENSG00000166037.9	ENST00000540830	hsa-miR-324-3p	95831230	95831236	7mer-m8	95831215	95831237	140.00	-17.63
CAediting_847055	chr11_95831236_+	ENSG00000166037.9	ENST00000540830	hsa-miR-497-3p	95831233	95831239	7mer-m8	95831221	95831240	149.00	-17.45
CAediting_847055	chr11_95831236_+	ENSG00000166037.9	ENST00000540830	hsa-miR-6715a-3p	95831234	95831240	7mer-m8	95831221	95831241	142.00	-13.00
CAediting_847056	chr11_95832599_+	ENSG00000166037.9	ENST00000325486	hsa-miR-12123	95832596	95832602	7mer-m8	95832578	95832603	153.00	-11.60
CAediting_847056	chr11_95832599_+	ENSG00000166037.9	ENST00000325486	hsa-miR-6074	95832597	95832604	8mer-1a	95832585	95832604	140.00	-7.90
CAediting_847056	chr11_95832599_+	ENSG00000166037.9	ENST00000325486	hsa-miR-664a-3p	95832596	95832602	7mer-1a	95832579	95832602	144.00	-17.13
CAediting_847056	chr11_95832599_+	ENSG00000166037.9	ENST00000325542	hsa-miR-12123	95832596	95832602	7mer-m8	95832578	95832603	153.00	-11.60
CAediting_847056	chr11_95832599_+	ENSG00000166037.9	ENST00000325542	hsa-miR-6074	95832597	95832604	8mer-1a	95832585	95832604	140.00	-7.90
CAediting_847056	chr11_95832599_+	ENSG00000166037.9	ENST00000325542	hsa-miR-664a-3p	95832596	95832602	7mer-1a	95832579	95832602	144.00	-17.13
CAediting_847056	chr11_95832599_+	ENSG00000166037.9	ENST00000541150	hsa-miR-12123	95832596	95832602	7mer-m8	95832578	95832603	153.00	-11.60
CAediting_847056	chr11_95832599_+	ENSG00000166037.9	ENST00000541150	hsa-miR-6074	95832597	95832604	8mer-1a	95832585	95832604	140.00	-7.90
CAediting_847056	chr11_95832599_+	ENSG00000166037.9	ENST00000541150	hsa-miR-664a-3p	95832596	95832602	7mer-1a	95832579	95832602	144.00	-17.13
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000325486	hsa-miR-208a-5p	95832630	95832636	7mer-m8	95832616	95832637	142.00	-13.04
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000325486	hsa-miR-208b-5p	95832630	95832636	7mer-m8	95832613	95832637	151.00	-11.15
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000325486	hsa-miR-28-5p	95832633	95832639	7mer-m8	95832619	95832640	142.00	-14.13
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000325486	hsa-miR-3139	95832633	95832639	7mer-m8	95832616	95832640	148.00	-17.16
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000325486	hsa-miR-708-5p	95832633	95832639	7mer-m8	95832620	95832640	166.00	-20.93
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000325542	hsa-miR-208a-5p	95832630	95832636	7mer-m8	95832616	95832637	142.00	-13.04
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000325542	hsa-miR-208b-5p	95832630	95832636	7mer-m8	95832613	95832637	151.00	-11.15
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000325542	hsa-miR-28-5p	95832633	95832639	7mer-m8	95832619	95832640	142.00	-14.13
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000325542	hsa-miR-3139	95832633	95832639	7mer-m8	95832616	95832640	148.00	-17.16
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000325542	hsa-miR-708-5p	95832633	95832639	7mer-m8	95832620	95832640	166.00	-20.93
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000541150	hsa-miR-208a-5p	95832630	95832636	7mer-m8	95832616	95832637	142.00	-13.04
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000541150	hsa-miR-208b-5p	95832630	95832636	7mer-m8	95832613	95832637	151.00	-11.15
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000541150	hsa-miR-28-5p	95832633	95832639	7mer-m8	95832619	95832640	142.00	-14.13
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000541150	hsa-miR-3139	95832633	95832639	7mer-m8	95832616	95832640	148.00	-17.16
CAediting_847057	chr11_95832635_+	ENSG00000166037.9	ENST00000541150	hsa-miR-708-5p	95832633	95832639	7mer-m8	95832620	95832640	166.00	-20.93
CAediting_847051	chr11_95831094_+	ENSG00000166037.9	ENST00000539855	hsa-miR-4768-5p	95831091	95831098	8mer-1a	95831077	95831098	154.00	-14.15
CAediting_847051	chr11_95831094_+	ENSG00000166037.9	ENST00000539855	hsa-miR-6515-3p	95831087	95831094	8mer-1a	95831075	95831094	152.00	-15.13
CAediting_847051	chr11_95831094_+	ENSG00000166037.9	ENST00000539855	hsa-miR-6833-3p	95831091	95831098	8mer-1a	95831078	95831098	152.00	-14.19
CAediting_847051	chr11_95831094_+	ENSG00000166037.9	ENST00000539855	hsa-miR-6873-3p	95831090	95831097	8mer-1a	95831076	95831097	144.00	-13.57
CAediting_847051	chr11_95831094_+	ENSG00000166037.9	ENST00000540830	hsa-miR-4768-5p	95831091	95831098	8mer-1a	95831077	95831098	154.00	-14.15
CAediting_847051	chr11_95831094_+	ENSG00000166037.9	ENST00000540830	hsa-miR-6515-3p	95831087	95831094	8mer-1a	95831075	95831094	152.00	-15.13
CAediting_847051	chr11_95831094_+	ENSG00000166037.9	ENST00000540830	hsa-miR-6833-3p	95831091	95831098	8mer-1a	95831078	95831098	152.00	-14.19
CAediting_847051	chr11_95831094_+	ENSG00000166037.9	ENST00000540830	hsa-miR-6873-3p	95831090	95831097	8mer-1a	95831076	95831097	144.00	-13.57
CAediting_847054	chr11_95831226_+	ENSG00000166037.9	ENST00000539855	hsa-miR-106a-3p	95831221	95831228	8mer-1a	95831207	95831228	142.00	-8.36
CAediting_847054	chr11_95831226_+	ENSG00000166037.9	ENST00000539855	hsa-miR-450b-5p	95831223	95831229	7mer-m8	95831210	95831230	158.00	-14.81
CAediting_847054	chr11_95831226_+	ENSG00000166037.9	ENST00000540830	hsa-miR-106a-3p	95831221	95831228	8mer-1a	95831207	95831228	142.00	-8.36
CAediting_847054	chr11_95831226_+	ENSG00000166037.9	ENST00000540830	hsa-miR-450b-5p	95831223	95831229	7mer-m8	95831210	95831230	158.00	-14.81

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_847055	chr11_95831236_+	ENSG00000166037.9	ENST00000539855	hsa-miR-606	95831232	95831238	7mer-m8	95831219	95831239	145	-12.21
CAediting_847055	chr11_95831236_+	ENSG00000166037.9	ENST00000540830	hsa-miR-606	95831232	95831238	7mer-m8	95831219	95831239	145	-12.21

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_77128	chr1_85133844_+	ENSG00000166037.9	ENST00000325486	hsa-miR-4423-3p	95831678	95831684	7mer-m8	95831665	95831685	145	-16.33
CAediting_524911	chr7_5495852_-	ENSG00000166037.9	ENST00000325486	hsa-miR-589-3p	95832581	95832587	7mer-m8	95832562	95832588	147	-25.36
CAediting_77128	chr1_85133844_+	ENSG00000166037.9	ENST00000325542	hsa-miR-4423-3p	95831678	95831684	7mer-m8	95831665	95831685	145	-16.33
CAediting_524911	chr7_5495852_-	ENSG00000166037.9	ENST00000325542	hsa-miR-589-3p	95832581	95832587	7mer-m8	95832562	95832588	147	-25.36
CAediting_1160181	chr17_7017644_-	ENSG00000166037.9	ENST00000538658	hsa-miR-195-3p	95822609	95822616	8mer-1a	95822595	95822616	145	-9.78
CAediting_442554	chr5_154685830_+	ENSG00000166037.9	ENST00000538658	hsa-miR-1303	95822997	95823003	7mer-m8	95822983	95823004	154	-19.14
CAediting_77128	chr1_85133844_+	ENSG00000166037.9	ENST00000541150	hsa-miR-4423-3p	95831678	95831684	7mer-m8	95831665	95831685	145	-16.33
CAediting_524911	chr7_5495852_-	ENSG00000166037.9	ENST00000541150	hsa-miR-589-3p	95832581	95832587	7mer-m8	95832562	95832588	147	-25.36
CAediting_468389	chr6_31355314_-	ENSG00000166037.9	ENST00000539855	hsa-miR-6891-5p	95827951	95827957	7mer-m8	95827940	95827958	158	-22.59
CAediting_468389	chr6_31355314_-	ENSG00000166037.9	ENST00000540830	hsa-miR-6891-5p	95827951	95827957	7mer-m8	95827940	95827958	158	-22.59

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_688080	chr9_63819626_+	ENSG00000166037.9	ENST00000325486	hsa-miR-4477b	95832439	95832445	7mer-m8	95832427	95832446	145	-9.15
CAediting_688081	chr9_63819627_+	ENSG00000166037.9	ENST00000325486	hsa-miR-4477b	95832439	95832445	7mer-m8	95832427	95832446	145	-9.15
CAediting_688080	chr9_63819626_+	ENSG00000166037.9	ENST00000325542	hsa-miR-4477b	95832439	95832445	7mer-m8	95832427	95832446	145	-9.15
CAediting_688081	chr9_63819627_+	ENSG00000166037.9	ENST00000325542	hsa-miR-4477b	95832439	95832445	7mer-m8	95832427	95832446	145	-9.15
CAediting_688080	chr9_63819626_+	ENSG00000166037.9	ENST00000541150	hsa-miR-4477b	95832439	95832445	7mer-m8	95832427	95832446	145	-9.15
CAediting_688081	chr9_63819627_+	ENSG00000166037.9	ENST00000541150	hsa-miR-4477b	95832439	95832445	7mer-m8	95832427	95832446	145	-9.15

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CEP57

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for CEP57

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for CEP57

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CEP57

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CEP57

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CEP57

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CEP57	C3279843	MOSAIC VARIEGATED ANEUPLOIDY SYNDROME 2	11	CLINGEN;GENOMICS_ENGLAND
CEP57	C1850343	Mosaic variegated aneuploidy syndrome 1	3	CTD_human;ORPHANET
CEP57	C2931286	Warburton Anyane Yeboa syndrome	2	ORPHANET
CEP57	C2931383	Chromosomal mosaicism due to mitotic instability	2	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene