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Editing gene: SAFB2 (CAeditome ID:9667)

Gene summary for SAFB2

Gene summary

Gene information	Gene symbol	SAFB2
	Gene ID	9667
	Gene name	scaffold attachment factor B2
	Synonyms	-
	Cytomap	19p13.3
	Type of gene	protein-coding
	Description	scaffold attachment factor B2
	Modification date	20210518
	UniProtAcc	Q14151
	Context	- 22817742(SAFB1- and SAFB2-mediated transcriptional repression: relevance to cancer)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
SAFB2	GO:0005654	Scaffold attachment factor B2	0000052
SAFB2	GO:0016604	Scaffold attachment factor B2	0000052
SAFB2	GO:0043231	Scaffold attachment factor B2	0000052

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RNA A-to-I events for SAFB2

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000130254.10

RNA A-to-I editing events in Cancer.

CAediting_1279597(5591339, -), CAediting_1279598(5591375, -), CAediting_1279599(5591376, -), CAediting_1279600(5591417, -), CAediting_1279601(5594744, -), CAediting_1279602(5594790, -), CAediting_1279603(5594933, -), CAediting_1279604(5594987, -), CAediting_1279605(5595057, -), CAediting_1279606(5595068, -), CAediting_1279607(5595138, -), CAediting_1279608(5595815, -), CAediting_1279609(5595864, -), CAediting_1279610(5596008, -), CAediting_1279611(5596019, -), CAediting_1279612(5596100, -), CAediting_1279613(5596106, -), CAediting_1279614(5596115, -), CAediting_1279615(5596135, -), CAediting_1279616(5596139, -), CAediting_1279617(5596141, -), CAediting_1279618(5596151, -), CAediting_1279619(5596155, -), CAediting_1279620(5596180, -), CAediting_1279621(5596227, -), CAediting_1279622(5596241, -), CAediting_1279623(5596261, -), CAediting_1279624(5596389, -), CAediting_1279625(5596391, -), CAediting_1279626(5596392, -), CAediting_1279627(5596396, -), CAediting_1279628(5596411, -), CAediting_1279629(5596460, -), CAediting_1279630(5596469, -), CAediting_1279631(5596473, -), CAediting_1279632(5596505, -), CAediting_1279633(5596509, -), CAediting_1279634(5596512, -), CAediting_1279635(5596513, -), CAediting_1279636(5596518, -), CAediting_1279637(5596520, -), CAediting_1279638(5596521, -), CAediting_1279639(5596522, -), CAediting_1279640(5596523, -), CAediting_1279641(5596526, -), CAediting_1279642(5596537, -), CAediting_1279643(5596550, -), CAediting_1279644(5596560, -), CAediting_1279645(5596562, -), CAediting_1279646(5596568, -), CAediting_1279647(5596586, -), CAediting_1279648(5596589, -), CAediting_1279649(5596592, -), CAediting_1279650(5596615, -), CAediting_1279651(5596616, -), CAediting_1279652(5596622, -), CAediting_1279653(5596624, -), CAediting_1279654(5596655, -), CAediting_1279655(5596656, -), CAediting_1279656(5604386, -), CAediting_1279657(5605361, -), CAediting_1279658(5605377, -), CAediting_1279659(5608784, -), CAediting_1279660(5608793, -), CAediting_1279661(5608856, -), CAediting_1279662(5609371, -), CAediting_1279663(5609389, -), CAediting_1279664(5609424, -), CAediting_1279665(5609432, -), CAediting_1279666(5609442, -), CAediting_1279667(5609468, -), CAediting_1279668(5609472, -), CAediting_1279669(5609479, -), CAediting_1279670(5609481, -), CAediting_1279671(5609482, -), CAediting_1279672(5609483, -), CAediting_1279673(5609497, -), CAediting_1279674(5609535, -), CAediting_1279675(5609536, -), CAediting_1279676(5609541, -), CAediting_1279677(5615255, -), CAediting_1279678(5615268, -), CAediting_1279679(5615269, -), CAediting_1279680(5615273, -), CAediting_1279681(5616744, -), CAediting_1279682(5616776, -), CAediting_1279683(5616790, -), CAediting_1279684(5616808, -), CAediting_1279685(5616922, -),

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RNA editing positional annotations for SAFB2 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_1279597	chr19_5591339_-	ncRNA_exonic
CAediting_1279598	chr19_5591375_-	ncRNA_exonic
CAediting_1279599	chr19_5591376_-	ncRNA_exonic
CAediting_1279600	chr19_5591417_-	ncRNA_exonic
CAediting_1279601	chr19_5594744_-	intronic
CAediting_1279602	chr19_5594790_-	intronic
CAediting_1279603	chr19_5594933_-	intronic
CAediting_1279604	chr19_5594987_-	intronic
CAediting_1279605	chr19_5595057_-	intronic
CAediting_1279606	chr19_5595068_-	intronic
CAediting_1279607	chr19_5595138_-	intronic
CAediting_1279608	chr19_5595815_-	intronic
CAediting_1279609	chr19_5595864_-	intronic
CAediting_1279610	chr19_5596008_-	intronic
CAediting_1279611	chr19_5596019_-	intronic
CAediting_1279612	chr19_5596100_-	intronic
CAediting_1279613	chr19_5596106_-	intronic
CAediting_1279614	chr19_5596115_-	intronic
CAediting_1279615	chr19_5596135_-	intronic
CAediting_1279616	chr19_5596139_-	intronic
CAediting_1279617	chr19_5596141_-	intronic
CAediting_1279618	chr19_5596151_-	intronic
CAediting_1279619	chr19_5596155_-	intronic
CAediting_1279620	chr19_5596180_-	intronic
CAediting_1279621	chr19_5596227_-	intronic
CAediting_1279622	chr19_5596241_-	intronic
CAediting_1279623	chr19_5596261_-	intronic
CAediting_1279624	chr19_5596389_-	intronic
CAediting_1279625	chr19_5596391_-	intronic
CAediting_1279626	chr19_5596392_-	intronic
CAediting_1279627	chr19_5596396_-	intronic
CAediting_1279628	chr19_5596411_-	intronic
CAediting_1279629	chr19_5596460_-	intronic
CAediting_1279630	chr19_5596469_-	intronic
CAediting_1279631	chr19_5596473_-	intronic
CAediting_1279632	chr19_5596505_-	intronic
CAediting_1279633	chr19_5596509_-	intronic
CAediting_1279634	chr19_5596512_-	intronic
CAediting_1279635	chr19_5596513_-	intronic
CAediting_1279636	chr19_5596518_-	intronic
CAediting_1279637	chr19_5596520_-	intronic
CAediting_1279638	chr19_5596521_-	intronic
CAediting_1279639	chr19_5596522_-	intronic
CAediting_1279640	chr19_5596523_-	intronic
CAediting_1279641	chr19_5596526_-	intronic
CAediting_1279642	chr19_5596537_-	intronic
CAediting_1279643	chr19_5596550_-	intronic
CAediting_1279644	chr19_5596560_-	intronic
CAediting_1279645	chr19_5596562_-	intronic
CAediting_1279646	chr19_5596568_-	intronic
CAediting_1279647	chr19_5596586_-	intronic
CAediting_1279648	chr19_5596589_-	intronic
CAediting_1279649	chr19_5596592_-	intronic
CAediting_1279650	chr19_5596615_-	intronic
CAediting_1279651	chr19_5596616_-	intronic
CAediting_1279652	chr19_5596622_-	intronic
CAediting_1279653	chr19_5596624_-	intronic
CAediting_1279654	chr19_5596655_-	intronic
CAediting_1279655	chr19_5596656_-	intronic
CAediting_1279656	chr19_5604386_-	ncRNA_intronic
CAediting_1279657	chr19_5605361_-	ncRNA_intronic
CAediting_1279658	chr19_5605377_-	ncRNA_intronic
CAediting_1279659	chr19_5608784_-	ncRNA_intronic
CAediting_1279660	chr19_5608793_-	ncRNA_intronic
CAediting_1279661	chr19_5608856_-	ncRNA_intronic
CAediting_1279662	chr19_5609371_-	ncRNA_intronic
CAediting_1279663	chr19_5609389_-	ncRNA_intronic
CAediting_1279664	chr19_5609424_-	ncRNA_intronic
CAediting_1279665	chr19_5609432_-	ncRNA_intronic
CAediting_1279666	chr19_5609442_-	ncRNA_intronic
CAediting_1279667	chr19_5609468_-	ncRNA_intronic
CAediting_1279668	chr19_5609472_-	ncRNA_intronic
CAediting_1279669	chr19_5609479_-	ncRNA_intronic
CAediting_1279670	chr19_5609481_-	ncRNA_intronic
CAediting_1279671	chr19_5609482_-	ncRNA_intronic
CAediting_1279672	chr19_5609483_-	ncRNA_intronic
CAediting_1279673	chr19_5609497_-	ncRNA_intronic
CAediting_1279674	chr19_5609535_-	ncRNA_intronic
CAediting_1279675	chr19_5609536_-	ncRNA_intronic
CAediting_1279676	chr19_5609541_-	ncRNA_intronic
CAediting_1279677	chr19_5615255_-	intronic
CAediting_1279678	chr19_5615268_-	intronic
CAediting_1279679	chr19_5615269_-	intronic
CAediting_1279680	chr19_5615273_-	intronic
CAediting_1279681	chr19_5616744_-	intronic
CAediting_1279682	chr19_5616776_-	intronic
CAediting_1279683	chr19_5616790_-	intronic
CAediting_1279684	chr19_5616808_-	intronic
CAediting_1279685	chr19_5616922_-	intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_1279597	chr19_5591339_-	SINE	Alu	AluSx3
CAediting_1279598	chr19_5591375_-	SINE	Alu	AluSx3
CAediting_1279599	chr19_5591376_-	SINE	Alu	AluSx3
CAediting_1279600	chr19_5591417_-	SINE	Alu	AluSx3
CAediting_1279601	chr19_5594744_-	SINE	Alu	AluJo
CAediting_1279602	chr19_5594790_-	SINE	Alu	AluJo
CAediting_1279603	chr19_5594933_-	SINE	Alu	AluJr
CAediting_1279604	chr19_5594987_-	SINE	Alu	AluJr
CAediting_1279605	chr19_5595057_-	SINE	Alu	AluJr
CAediting_1279606	chr19_5595068_-	SINE	Alu	AluJr
CAediting_1279607	chr19_5595138_-	SINE	Alu	AluJr
CAediting_1279610	chr19_5596008_-	SINE	Alu	AluSg
CAediting_1279611	chr19_5596019_-	SINE	Alu	AluSg
CAediting_1279612	chr19_5596100_-	SINE	Alu	AluSg
CAediting_1279613	chr19_5596106_-	SINE	Alu	AluSg
CAediting_1279614	chr19_5596115_-	SINE	Alu	AluSg
CAediting_1279615	chr19_5596135_-	SINE	Alu	AluSg
CAediting_1279616	chr19_5596139_-	SINE	Alu	AluSg
CAediting_1279617	chr19_5596141_-	SINE	Alu	AluSg
CAediting_1279618	chr19_5596151_-	SINE	Alu	AluSg
CAediting_1279619	chr19_5596155_-	SINE	Alu	AluSg
CAediting_1279620	chr19_5596180_-	SINE	Alu	AluSg
CAediting_1279621	chr19_5596227_-	SINE	Alu	AluSg
CAediting_1279622	chr19_5596241_-	SINE	Alu	AluSg
CAediting_1279623	chr19_5596261_-	SINE	Alu	AluSg
CAediting_1279624	chr19_5596389_-	SINE	Alu	AluJb
CAediting_1279625	chr19_5596391_-	SINE	Alu	AluJb
CAediting_1279626	chr19_5596392_-	SINE	Alu	AluJb
CAediting_1279627	chr19_5596396_-	SINE	Alu	AluJb
CAediting_1279628	chr19_5596411_-	SINE	Alu	AluJb
CAediting_1279629	chr19_5596460_-	SINE	Alu	AluJb
CAediting_1279630	chr19_5596469_-	SINE	Alu	AluJb
CAediting_1279631	chr19_5596473_-	SINE	Alu	AluJb
CAediting_1279632	chr19_5596505_-	SINE	Alu	AluJb
CAediting_1279633	chr19_5596509_-	SINE	Alu	AluJb
CAediting_1279634	chr19_5596512_-	SINE	Alu	AluJb
CAediting_1279635	chr19_5596513_-	SINE	Alu	AluJb
CAediting_1279636	chr19_5596518_-	SINE	Alu	AluJb
CAediting_1279637	chr19_5596520_-	SINE	Alu	AluJb
CAediting_1279638	chr19_5596521_-	SINE	Alu	AluJb
CAediting_1279639	chr19_5596522_-	SINE	Alu	AluJb
CAediting_1279640	chr19_5596523_-	SINE	Alu	AluJb
CAediting_1279641	chr19_5596526_-	SINE	Alu	AluJb
CAediting_1279642	chr19_5596537_-	SINE	Alu	AluJb
CAediting_1279643	chr19_5596550_-	SINE	Alu	AluJb
CAediting_1279644	chr19_5596560_-	SINE	Alu	AluJb
CAediting_1279645	chr19_5596562_-	SINE	Alu	AluJb
CAediting_1279646	chr19_5596568_-	SINE	Alu	AluJb
CAediting_1279647	chr19_5596586_-	SINE	Alu	AluJb
CAediting_1279648	chr19_5596589_-	SINE	Alu	AluJb
CAediting_1279649	chr19_5596592_-	SINE	Alu	AluJb
CAediting_1279650	chr19_5596615_-	SINE	Alu	AluJb
CAediting_1279651	chr19_5596616_-	SINE	Alu	AluJb
CAediting_1279652	chr19_5596622_-	SINE	Alu	AluJb
CAediting_1279653	chr19_5596624_-	SINE	Alu	AluJb
CAediting_1279656	chr19_5604386_-	SINE	Alu	AluJb
CAediting_1279657	chr19_5605361_-	SINE	Alu	AluSx1
CAediting_1279658	chr19_5605377_-	SINE	Alu	AluSx1
CAediting_1279659	chr19_5608784_-	SINE	Alu	AluSx1
CAediting_1279660	chr19_5608793_-	SINE	Alu	AluSx1
CAediting_1279661	chr19_5608856_-	SINE	Alu	AluSx1
CAediting_1279662	chr19_5609371_-	SINE	Alu	AluSx
CAediting_1279663	chr19_5609389_-	SINE	Alu	AluSx
CAediting_1279664	chr19_5609424_-	SINE	Alu	AluSx
CAediting_1279665	chr19_5609432_-	SINE	Alu	AluSx
CAediting_1279666	chr19_5609442_-	SINE	Alu	AluSx
CAediting_1279667	chr19_5609468_-	SINE	Alu	AluSx
CAediting_1279668	chr19_5609472_-	SINE	Alu	AluSx
CAediting_1279669	chr19_5609479_-	SINE	Alu	AluSx
CAediting_1279670	chr19_5609481_-	SINE	Alu	AluSx
CAediting_1279671	chr19_5609482_-	SINE	Alu	AluSx
CAediting_1279672	chr19_5609483_-	SINE	Alu	AluSx
CAediting_1279673	chr19_5609497_-	SINE	Alu	AluSx
CAediting_1279674	chr19_5609535_-	SINE	Alu	AluSx
CAediting_1279675	chr19_5609536_-	SINE	Alu	AluSx
CAediting_1279676	chr19_5609541_-	SINE	Alu	AluSx
CAediting_1279677	chr19_5615255_-	SINE	Alu	AluSx3
CAediting_1279678	chr19_5615268_-	SINE	Alu	AluSx3
CAediting_1279679	chr19_5615269_-	SINE	Alu	AluSx3
CAediting_1279680	chr19_5615273_-	SINE	Alu	AluSx3
CAediting_1279681	chr19_5616744_-	SINE	Alu	AluSx4
CAediting_1279682	chr19_5616776_-	SINE	Alu	AluSx4
CAediting_1279683	chr19_5616790_-	SINE	Alu	AluSx4
CAediting_1279684	chr19_5616808_-	SINE	Alu	AluSx4
CAediting_1279685	chr19_5616922_-	SINE	Alu	AluSx4

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RNA A-to-I editing events in the alternative splicing sites for SAFB2

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000130254.10.SAFB2.

Correlation between RNA A-to-I editing and PSI for ENSG00000130254.10.SAFB2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SAFB2

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

GBM.CAediting_1279611.ENSG00000130254.SAFB2.png
Soverview

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Protein coding region RNA A-to-I editings for SAFB2

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for SAFB2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_396018	chr5_1062918_-	ENSG00000130254.10	ENST00000591123	hsa-miR-4635	5610018	5610024	7mer-1a	5610018	5610039	141	-19.61
CAediting_1160181	chr17_7017644_-	ENSG00000130254.10	ENST00000591120	hsa-miR-195-3p	5611942	5611947	6mer	5611941	5611962	146	-25.14

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SAFB2

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for SAFB2

Correlation between ADAR gene expression and RNA editing frequency

Cancer

CAeditomID

position

ADAR1 (p-val)

ADAR1 (coeff.)

ADAR2 (p-val)

ADAR2 (coeff.)

ADAR3 (p-val)

ADAR3 (coeff.)

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Relation with cancer stages for SAFB2

Correlation between Cancer stages and RNA editing frequency

Cancer	Stage_type	CAeditomID	position	P-val	Coeff.
KIRC	pathologic_stage	CAediting_1279609	chr19_5595864_-	0.00810534739917793	0.336029359495524

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Relation with survival for SAFB2

Correlation between RNA editing and survival

Cancer	CAeditomID	position	KMpvalue	Coxpvalue	CoxHR
LAML	CAediting_1279641	chr19_5596526_-	0.044257922267063	0.0247482	15.3751

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RelatedDrugs for SAFB2

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SAFB2

Diseases associated with this gene.
(DisGeNet 7.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene