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Editing gene: GDA (CAeditome ID:9615)

Gene summary for GDA

Gene summary

Gene information	Gene symbol	GDA
	Gene ID	9615
	Gene name	guanine deaminase
	Synonyms	CYPIN\|GAH\|GUANASE\|NEDASIN
	Cytomap	9q21.13
	Type of gene	protein-coding
	Description	guanine deaminasecytoplasmic PSD95 interactorguanine aminaseguanine aminohydrolasep51-nedasin
	Modification date	20210518
	UniProtAcc	Q9Y2T3
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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RNA A-to-I events for GDA

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000119125.15

RNA A-to-I editing events in Cancer.

CAediting_689760(72156716, +), CAediting_689761(72158338, +), CAediting_689762(72159263, +), CAediting_689763(72159273, +), CAediting_689764(72159274, +), CAediting_689765(72159283, +), CAediting_689766(72159287, +), CAediting_689767(72160044, +), CAediting_689768(72160045, +), CAediting_689769(72160050, +), CAediting_689770(72160237, +), CAediting_689771(72161000, +), CAediting_689772(72161001, +), CAediting_689773(72161032, +), CAediting_689774(72163754, +), CAediting_689775(72168165, +), CAediting_689776(72168263, +), CAediting_689777(72189298, +), CAediting_689778(72189308, +), CAediting_689779(72189310, +), CAediting_689780(72189322, +), CAediting_689781(72189425, +), CAediting_689782(72189440, +), CAediting_689783(72189585, +), CAediting_689784(72189612, +), CAediting_689785(72203861, +), CAediting_689786(72203872, +), CAediting_689787(72203878, +), CAediting_689788(72203916, +), CAediting_689789(72203917, +), CAediting_689790(72203934, +), CAediting_689791(72203942, +), CAediting_689792(72203946, +), CAediting_689793(72203951, +), CAediting_689794(72203982, +), CAediting_689795(72204014, +), CAediting_689796(72204856, +), CAediting_689797(72204857, +), CAediting_689798(72204862, +), CAediting_689799(72204878, +), CAediting_689800(72204898, +), CAediting_689801(72204902, +), CAediting_689802(72204926, +), CAediting_689803(72204934, +), CAediting_689804(72204947, +), CAediting_689805(72204959, +), CAediting_689806(72204991, +), CAediting_689807(72204992, +), CAediting_689808(72204997, +), CAediting_689809(72205001, +), CAediting_689810(72205005, +), CAediting_689811(72205008, +), CAediting_689812(72205014, +), CAediting_689813(72205032, +), CAediting_689814(72205060, +), CAediting_689815(72205061, +), CAediting_689816(72205063, +), CAediting_689817(72205066, +), CAediting_689818(72205071, +), CAediting_689819(72205074, +), CAediting_689820(72205093, +), CAediting_689821(72206523, +), CAediting_689822(72207859, +), CAediting_689823(72207981, +), CAediting_689824(72217983, +), CAediting_689825(72219998, +), CAediting_689826(72220000, +), CAediting_689827(72220001, +), CAediting_689828(72220003, +), CAediting_689829(72220039, +), CAediting_689830(72220049, +), CAediting_689831(72220053, +), CAediting_689832(72220099, +), CAediting_689833(72235532, +), CAediting_689834(72235535, +), CAediting_689835(72235536, +), CAediting_689836(72236909, +), CAediting_689837(72243912, +), CAediting_689838(72257033, +), CAediting_689839(72257036, +), CAediting_689840(72257043, +), CAediting_689841(72257055, +),

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RNA editing positional annotations for GDA using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_689760	chr9_72156716_+	intronic
CAediting_689761	chr9_72158338_+	intronic
CAediting_689762	chr9_72159263_+	intronic
CAediting_689763	chr9_72159273_+	intronic
CAediting_689764	chr9_72159274_+	intronic
CAediting_689765	chr9_72159283_+	intronic
CAediting_689766	chr9_72159287_+	intronic
CAediting_689767	chr9_72160044_+	intronic
CAediting_689768	chr9_72160045_+	intronic
CAediting_689769	chr9_72160050_+	intronic
CAediting_689770	chr9_72160237_+	intronic
CAediting_689771	chr9_72161000_+	intronic
CAediting_689772	chr9_72161001_+	intronic
CAediting_689773	chr9_72161032_+	intronic
CAediting_689774	chr9_72163754_+	intronic
CAediting_689775	chr9_72168165_+	intronic
CAediting_689776	chr9_72168263_+	intronic
CAediting_689777	chr9_72189298_+	intronic
CAediting_689778	chr9_72189308_+	intronic
CAediting_689779	chr9_72189310_+	intronic
CAediting_689780	chr9_72189322_+	intronic
CAediting_689781	chr9_72189425_+	intronic
CAediting_689782	chr9_72189440_+	intronic
CAediting_689783	chr9_72189585_+	intronic
CAediting_689784	chr9_72189612_+	intronic
CAediting_689785	chr9_72203861_+	ncRNA_intronic
CAediting_689786	chr9_72203872_+	ncRNA_intronic
CAediting_689787	chr9_72203878_+	ncRNA_intronic
CAediting_689788	chr9_72203916_+	ncRNA_intronic
CAediting_689789	chr9_72203917_+	ncRNA_intronic
CAediting_689790	chr9_72203934_+	ncRNA_intronic
CAediting_689791	chr9_72203942_+	ncRNA_intronic
CAediting_689792	chr9_72203946_+	ncRNA_intronic
CAediting_689793	chr9_72203951_+	ncRNA_intronic
CAediting_689794	chr9_72203982_+	ncRNA_intronic
CAediting_689795	chr9_72204014_+	ncRNA_intronic
CAediting_689796	chr9_72204856_+	ncRNA_intronic
CAediting_689797	chr9_72204857_+	ncRNA_intronic
CAediting_689798	chr9_72204862_+	ncRNA_intronic
CAediting_689799	chr9_72204878_+	ncRNA_intronic
CAediting_689800	chr9_72204898_+	ncRNA_intronic
CAediting_689801	chr9_72204902_+	ncRNA_intronic
CAediting_689802	chr9_72204926_+	ncRNA_intronic
CAediting_689803	chr9_72204934_+	ncRNA_intronic
CAediting_689804	chr9_72204947_+	ncRNA_intronic
CAediting_689805	chr9_72204959_+	ncRNA_intronic
CAediting_689806	chr9_72204991_+	ncRNA_intronic
CAediting_689807	chr9_72204992_+	ncRNA_intronic
CAediting_689808	chr9_72204997_+	ncRNA_intronic
CAediting_689809	chr9_72205001_+	ncRNA_intronic
CAediting_689810	chr9_72205005_+	ncRNA_intronic
CAediting_689811	chr9_72205008_+	ncRNA_intronic
CAediting_689812	chr9_72205014_+	ncRNA_intronic
CAediting_689813	chr9_72205032_+	ncRNA_intronic
CAediting_689814	chr9_72205060_+	ncRNA_intronic
CAediting_689815	chr9_72205061_+	ncRNA_intronic
CAediting_689816	chr9_72205063_+	ncRNA_intronic
CAediting_689817	chr9_72205066_+	ncRNA_intronic
CAediting_689818	chr9_72205071_+	ncRNA_intronic
CAediting_689819	chr9_72205074_+	ncRNA_intronic
CAediting_689820	chr9_72205093_+	ncRNA_intronic
CAediting_689821	chr9_72206523_+	ncRNA_intronic
CAediting_689822	chr9_72207859_+	ncRNA_intronic
CAediting_689823	chr9_72207981_+	ncRNA_intronic
CAediting_689824	chr9_72217983_+	ncRNA_intronic
CAediting_689825	chr9_72219998_+	ncRNA_intronic
CAediting_689826	chr9_72220000_+	ncRNA_intronic
CAediting_689827	chr9_72220001_+	ncRNA_intronic
CAediting_689828	chr9_72220003_+	ncRNA_intronic
CAediting_689829	chr9_72220039_+	ncRNA_intronic
CAediting_689830	chr9_72220049_+	ncRNA_intronic
CAediting_689831	chr9_72220053_+	ncRNA_intronic
CAediting_689832	chr9_72220099_+	ncRNA_intronic
CAediting_689833	chr9_72235532_+	intronic
CAediting_689834	chr9_72235535_+	intronic
CAediting_689835	chr9_72235536_+	intronic
CAediting_689836	chr9_72236909_+	intronic
CAediting_689837	chr9_72243912_+	intronic
CAediting_689838	chr9_72257033_+	UTR3
CAediting_689839	chr9_72257036_+	UTR3
CAediting_689840	chr9_72257043_+	UTR3
CAediting_689841	chr9_72257055_+	UTR3

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_689761	chr9_72158338_+	SINE	Alu	AluSc8
CAediting_689762	chr9_72159263_+	SINE	Alu	AluSg
CAediting_689763	chr9_72159273_+	SINE	Alu	AluSg
CAediting_689764	chr9_72159274_+	SINE	Alu	AluSg
CAediting_689765	chr9_72159283_+	SINE	Alu	AluSg
CAediting_689766	chr9_72159287_+	SINE	Alu	AluSg
CAediting_689767	chr9_72160044_+	SINE	Alu	AluY
CAediting_689768	chr9_72160045_+	SINE	Alu	AluY
CAediting_689769	chr9_72160050_+	SINE	Alu	AluY
CAediting_689770	chr9_72160237_+	SINE	Alu	AluY
CAediting_689771	chr9_72161000_+	SINE	Alu	AluSx1
CAediting_689772	chr9_72161001_+	SINE	Alu	AluSx1
CAediting_689773	chr9_72161032_+	SINE	Alu	AluSx1
CAediting_689774	chr9_72163754_+	SINE	Alu	AluY
CAediting_689775	chr9_72168165_+	SINE	Alu	AluJo
CAediting_689776	chr9_72168263_+	SINE	Alu	AluJo
CAediting_689777	chr9_72189298_+	SINE	Alu	AluJb
CAediting_689778	chr9_72189308_+	SINE	Alu	AluJb
CAediting_689779	chr9_72189310_+	SINE	Alu	AluJb
CAediting_689780	chr9_72189322_+	SINE	Alu	AluJb
CAediting_689781	chr9_72189425_+	SINE	Alu	AluJb
CAediting_689782	chr9_72189440_+	SINE	Alu	AluJb
CAediting_689783	chr9_72189585_+	SINE	Alu	AluJb
CAediting_689784	chr9_72189612_+	SINE	Alu	AluJb
CAediting_689785	chr9_72203861_+	SINE	Alu	AluSg4
CAediting_689786	chr9_72203872_+	SINE	Alu	AluSg4
CAediting_689787	chr9_72203878_+	SINE	Alu	AluSg4
CAediting_689788	chr9_72203916_+	SINE	Alu	AluSg4
CAediting_689789	chr9_72203917_+	SINE	Alu	AluSg4
CAediting_689790	chr9_72203934_+	SINE	Alu	AluSg4
CAediting_689791	chr9_72203942_+	SINE	Alu	AluSg4
CAediting_689792	chr9_72203946_+	SINE	Alu	AluSg4
CAediting_689793	chr9_72203951_+	SINE	Alu	AluSg4
CAediting_689794	chr9_72203982_+	SINE	Alu	AluSg4
CAediting_689795	chr9_72204014_+	SINE	Alu	AluSg4
CAediting_689796	chr9_72204856_+	SINE	Alu	AluSz6
CAediting_689797	chr9_72204857_+	SINE	Alu	AluSz6
CAediting_689798	chr9_72204862_+	SINE	Alu	AluSz6
CAediting_689799	chr9_72204878_+	SINE	Alu	AluSz6
CAediting_689800	chr9_72204898_+	SINE	Alu	AluSz6
CAediting_689801	chr9_72204902_+	SINE	Alu	AluSz6
CAediting_689802	chr9_72204926_+	SINE	Alu	AluSz6
CAediting_689803	chr9_72204934_+	SINE	Alu	AluSz6
CAediting_689804	chr9_72204947_+	SINE	Alu	AluSz6
CAediting_689805	chr9_72204959_+	SINE	Alu	AluSz6
CAediting_689806	chr9_72204991_+	SINE	Alu	AluSz6
CAediting_689807	chr9_72204992_+	SINE	Alu	AluSz6
CAediting_689808	chr9_72204997_+	SINE	Alu	AluSz6
CAediting_689809	chr9_72205001_+	SINE	Alu	AluSz6
CAediting_689810	chr9_72205005_+	SINE	Alu	AluSz6
CAediting_689811	chr9_72205008_+	SINE	Alu	AluSz6
CAediting_689812	chr9_72205014_+	SINE	Alu	AluSz6
CAediting_689813	chr9_72205032_+	SINE	Alu	AluSz6
CAediting_689814	chr9_72205060_+	SINE	Alu	AluSz6
CAediting_689815	chr9_72205061_+	SINE	Alu	AluSz6
CAediting_689816	chr9_72205063_+	SINE	Alu	AluSz6
CAediting_689817	chr9_72205066_+	SINE	Alu	AluSz6
CAediting_689818	chr9_72205071_+	SINE	Alu	AluSz6
CAediting_689819	chr9_72205074_+	SINE	Alu	AluSz6
CAediting_689820	chr9_72205093_+	SINE	Alu	AluSz6
CAediting_689821	chr9_72206523_+	SINE	Alu	AluSx1
CAediting_689822	chr9_72207859_+	SINE	Alu	AluJr
CAediting_689823	chr9_72207981_+	SINE	Alu	AluJr
CAediting_689824	chr9_72217983_+	SINE	Alu	AluSx1
CAediting_689825	chr9_72219998_+	LINE	L1	L1MA9
CAediting_689826	chr9_72220000_+	LINE	L1	L1MA9
CAediting_689827	chr9_72220001_+	LINE	L1	L1MA9
CAediting_689828	chr9_72220003_+	LINE	L1	L1MA9
CAediting_689829	chr9_72220039_+	LINE	L1	L1MA9
CAediting_689830	chr9_72220049_+	LINE	L1	L1MA9
CAediting_689831	chr9_72220053_+	LINE	L1	L1MA9
CAediting_689832	chr9_72220099_+	LINE	L1	L1MA9
CAediting_689833	chr9_72235532_+	SINE	Alu	AluSx
CAediting_689834	chr9_72235535_+	SINE	Alu	AluSx
CAediting_689835	chr9_72235536_+	SINE	Alu	AluSx
CAediting_689836	chr9_72236909_+	SINE	Alu	AluSx
CAediting_689837	chr9_72243912_+	SINE	Alu	AluY
CAediting_689838	chr9_72257033_+	SINE	Alu	AluJb
CAediting_689839	chr9_72257036_+	SINE	Alu	AluJb
CAediting_689840	chr9_72257043_+	SINE	Alu	AluJb
CAediting_689841	chr9_72257055_+	SINE	Alu	AluJb

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RNA A-to-I editing events in the alternative splicing sites for GDA

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000119125.15.GDA.

Correlation between RNA A-to-I editing and PSI for ENSG00000119125.15.GDA.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for GDA

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

STAD.CAediting_689810.ENSG00000119125.GDA.png
Soverview

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Protein coding region RNA A-to-I editings for GDA

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for GDA

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_689839	chr9_72257036_+	ENSG00000119125.15	ENST00000489618	hsa-miR-5687	72257034	72257041	8mer-1a	72257021	72257041	149.00	-16.99
CAediting_689841	chr9_72257055_+	ENSG00000119125.15	ENST00000489618	hsa-miR-106a-3p	72257051	72257056	6mer	72257036	72257057	141.00	-21.13

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_689841	chr9_72257055_+	ENSG00000119125.15	ENST00000489618	hsa-miR-3686	72257052	72257058	7mer-m8	72257038	72257059	140	-9.49
CAediting_689838	chr9_72257033_+	ENSG00000119125.15	ENST00000489618	hsa-miR-4728-3p	72257030	72257036	7mer-m8	72257013	72257037	140	-9.23
CAediting_689839	chr9_72257036_+	ENSG00000119125.15	ENST00000489618	hsa-miR-4728-3p	72257030	72257036	7mer-m8	72257013	72257037	140	-9.23
CAediting_689838	chr9_72257033_+	ENSG00000119125.15	ENST00000489618	hsa-miR-7160-5p	72257028	72257035	8mer-1a	72257015	72257035	150	-21.24
CAediting_689838	chr9_72257033_+	ENSG00000119125.15	ENST00000489618	hsa-miR-7162-3p	72257027	72257033	7mer-m8	72257016	72257034	152	-18.37

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000119125.15	ENST00000545168	hsa-miR-624-3p	72249406	72249412	7mer-m8	72249393	72249413	153	-16.54
CAediting_688081	chr9_63819627_+	ENSG00000119125.15	ENST00000545168	hsa-miR-4477b	72249918	72249924	7mer-m8	72249904	72249925	142	-12.17
CAediting_688081	chr9_63819627_+	ENSG00000119125.15	ENST00000545168	hsa-miR-4477b	72251013	72251019	7mer-m8	72250999	72251020	149	-13.25
CAediting_980496	chr14_31014685_-	ENSG00000119125.15	ENST00000358399	hsa-miR-624-3p	72249406	72249412	7mer-m8	72249393	72249413	153	-16.54
CAediting_688081	chr9_63819627_+	ENSG00000119125.15	ENST00000358399	hsa-miR-4477b	72249918	72249924	7mer-m8	72249904	72249925	142	-12.17
CAediting_688081	chr9_63819627_+	ENSG00000119125.15	ENST00000358399	hsa-miR-4477b	72251013	72251019	7mer-m8	72250999	72251020	149	-13.25
CAediting_393	chr1_1167164_+	ENSG00000119125.15	ENST00000489618	hsa-miR-200b-3p	72257031	72257037	7mer-m8	72257017	72257038	145	-11.82
CAediting_1160181	chr17_7017644_-	ENSG00000119125.15	ENST00000545168	hsa-miR-195-3p	72251754	72251760	7mer-m8	72251739	72251761	153	-15.8
CAediting_86358	chr1_109598906_+	ENSG00000119125.15	ENST00000545168	hsa-miR-197-5p	72249292	72249299	8mer-1a	72249277	72249299	169	-29.36
CAediting_77128	chr1_85133844_+	ENSG00000119125.15	ENST00000545168	hsa-miR-4423-3p	72248398	72248404	7mer-m8	72248382	72248405	144	-12.59
CAediting_228905	chr2_188297554_+	ENSG00000119125.15	ENST00000545168	hsa-miR-561-3p	72251140	72251146	7mer-m8	72251126	72251147	143	-6.54
CAediting_228905	chr2_188297554_+	ENSG00000119125.15	ENST00000545168	hsa-miR-561-3p	72251196	72251202	7mer-m8	72251182	72251203	149	-8.66
CAediting_442554	chr5_154685830_+	ENSG00000119125.15	ENST00000545168	hsa-miR-1303	72250549	72250555	7mer-m8	72250535	72250556	140	-11.61
CAediting_1160181	chr17_7017644_-	ENSG00000119125.15	ENST00000358399	hsa-miR-195-3p	72251754	72251760	7mer-m8	72251739	72251761	153	-15.8
CAediting_86358	chr1_109598906_+	ENSG00000119125.15	ENST00000358399	hsa-miR-197-5p	72249292	72249299	8mer-1a	72249277	72249299	169	-29.36
CAediting_77128	chr1_85133844_+	ENSG00000119125.15	ENST00000358399	hsa-miR-4423-3p	72248398	72248404	7mer-m8	72248382	72248405	144	-12.59
CAediting_228905	chr2_188297554_+	ENSG00000119125.15	ENST00000358399	hsa-miR-561-3p	72251140	72251146	7mer-m8	72251126	72251147	143	-6.54
CAediting_228905	chr2_188297554_+	ENSG00000119125.15	ENST00000358399	hsa-miR-561-3p	72251196	72251202	7mer-m8	72251182	72251203	149	-8.66
CAediting_442554	chr5_154685830_+	ENSG00000119125.15	ENST00000358399	hsa-miR-1303	72250549	72250555	7mer-m8	72250535	72250556	140	-11.61
CAediting_77128	chr1_85133844_+	ENSG00000119125.15	ENST00000475764	hsa-miR-4423-3p	72248398	72248404	7mer-m8	72248382	72248405	144	-12.59
CAediting_77128	chr1_85133844_+	ENSG00000119125.15	ENST00000489618	hsa-miR-4423-3p	72248398	72248404	7mer-m8	72248382	72248405	144	-12.59
CAediting_1399425	chr20_1392958_-	ENSG00000119125.15	ENST00000489618	hsa-miR-6869-5p	72257162	72257168	7mer-m8	72257149	72257169	146	-20.39
CAediting_396018	chr5_1062918_-	ENSG00000119125.15	ENST00000489618	hsa-miR-4635	72257011	72257016	6mer	72256997	72257017	142	-17.83
CAediting_468389	chr6_31355314_-	ENSG00000119125.15	ENST00000545168	hsa-miR-6891-5p	72250772	72250779	8mer-1a	72250761	72250779	152	-22.88
CAediting_468389	chr6_31355314_-	ENSG00000119125.15	ENST00000358399	hsa-miR-6891-5p	72250772	72250779	8mer-1a	72250761	72250779	152	-22.88
CAediting_1524209	chrX_134546392_-	ENSG00000119125.15	ENST00000376986	hsa-miR-503-5p	72253523	72253528	6mer	72253506	72253529	143	-22.12
CAediting_468389	chr6_31355314_-	ENSG00000119125.15	ENST00000475764	hsa-miR-6891-5p	72250772	72250779	8mer-1a	72250761	72250779	152	-22.88
CAediting_468389	chr6_31355314_-	ENSG00000119125.15	ENST00000489618	hsa-miR-6891-5p	72250772	72250779	8mer-1a	72250761	72250779	152	-22.88

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_573001	chr7_92204086_-	ENSG00000119125.15	ENST00000545168	hsa-miR-1285-5p	72250019	72250026	8mer-1a	72250006	72250026	140	-9.13
CAediting_573001	chr7_92204086_-	ENSG00000119125.15	ENST00000545168	hsa-miR-1285-5p	72251293	72251299	7mer-m8	72251280	72251300	146	-15.94
CAediting_573001	chr7_92204086_-	ENSG00000119125.15	ENST00000545168	hsa-miR-1285-5p	72249141	72249147	7mer-m8	72249127	72249148	144	-12.59
CAediting_1160181	chr17_7017644_-	ENSG00000119125.15	ENST00000545168	hsa-miR-195-3p	72249385	72249391	7mer-m8	72249372	72249392	141	-6.77
CAediting_393	chr1_1167164_+	ENSG00000119125.15	ENST00000545168	hsa-miR-200b-3p	72248473	72248479	7mer-m8	72248457	72248480	141	-10.07
CAediting_1306324	chr19_13836464_-	ENSG00000119125.15	ENST00000545168	hsa-miR-27a-3p	72251116	72251122	7mer-m8	72251104	72251123	151	-14.65
CAediting_1306323	chr19_13836462_-	ENSG00000119125.15	ENST00000545168	hsa-miR-27a-3p	72251116	72251122	7mer-m8	72251104	72251123	151	-14.65
CAediting_688081	chr9_63819627_+	ENSG00000119125.15	ENST00000545168	hsa-miR-4477b	72250797	72250803	7mer-m8	72250784	72250804	150	-10.98
CAediting_688080	chr9_63819626_+	ENSG00000119125.15	ENST00000545168	hsa-miR-4477b	72250797	72250803	7mer-m8	72250784	72250804	150	-10.98
CAediting_1229414	chr17_67471546_+	ENSG00000119125.15	ENST00000545168	hsa-miR-548aa	72251600	72251606	7mer-m8	72251582	72251607	148	-10.77
CAediting_1229415	chr17_67471547_+	ENSG00000119125.15	ENST00000545168	hsa-miR-548aa	72251600	72251606	7mer-m8	72251582	72251607	148	-10.77
CAediting_228905	chr2_188297554_+	ENSG00000119125.15	ENST00000545168	hsa-miR-561-3p	72249797	72249804	8mer-1a	72249783	72249804	140	-4.9
CAediting_980496	chr14_31014685_-	ENSG00000119125.15	ENST00000545168	hsa-miR-624-3p	72248892	72248898	7mer-m8	72248876	72248899	145	-18.67
CAediting_573001	chr7_92204086_-	ENSG00000119125.15	ENST00000358399	hsa-miR-1285-5p	72250019	72250026	8mer-1a	72250006	72250026	140	-9.13
CAediting_573001	chr7_92204086_-	ENSG00000119125.15	ENST00000358399	hsa-miR-1285-5p	72251293	72251299	7mer-m8	72251280	72251300	146	-15.94
CAediting_573001	chr7_92204086_-	ENSG00000119125.15	ENST00000358399	hsa-miR-1285-5p	72249141	72249147	7mer-m8	72249127	72249148	144	-12.59
CAediting_1160181	chr17_7017644_-	ENSG00000119125.15	ENST00000358399	hsa-miR-195-3p	72249385	72249391	7mer-m8	72249372	72249392	141	-6.77
CAediting_393	chr1_1167164_+	ENSG00000119125.15	ENST00000358399	hsa-miR-200b-3p	72248473	72248479	7mer-m8	72248457	72248480	141	-10.07
CAediting_1306324	chr19_13836464_-	ENSG00000119125.15	ENST00000358399	hsa-miR-27a-3p	72251116	72251122	7mer-m8	72251104	72251123	151	-14.65
CAediting_1306323	chr19_13836462_-	ENSG00000119125.15	ENST00000358399	hsa-miR-27a-3p	72251116	72251122	7mer-m8	72251104	72251123	151	-14.65
CAediting_688081	chr9_63819627_+	ENSG00000119125.15	ENST00000358399	hsa-miR-4477b	72250797	72250803	7mer-m8	72250784	72250804	150	-10.98
CAediting_688080	chr9_63819626_+	ENSG00000119125.15	ENST00000358399	hsa-miR-4477b	72250797	72250803	7mer-m8	72250784	72250804	150	-10.98
CAediting_1229414	chr17_67471546_+	ENSG00000119125.15	ENST00000358399	hsa-miR-548aa	72251600	72251606	7mer-m8	72251582	72251607	148	-10.77
CAediting_1229415	chr17_67471547_+	ENSG00000119125.15	ENST00000358399	hsa-miR-548aa	72251600	72251606	7mer-m8	72251582	72251607	148	-10.77
CAediting_228905	chr2_188297554_+	ENSG00000119125.15	ENST00000358399	hsa-miR-561-3p	72249797	72249804	8mer-1a	72249783	72249804	140	-4.9
CAediting_980496	chr14_31014685_-	ENSG00000119125.15	ENST00000358399	hsa-miR-624-3p	72248892	72248898	7mer-m8	72248876	72248899	145	-18.67
CAediting_688080	chr9_63819626_+	ENSG00000119125.15	ENST00000475764	hsa-miR-4477b	72250797	72250803	7mer-m8	72250784	72250804	150	-10.98
CAediting_688080	chr9_63819626_+	ENSG00000119125.15	ENST00000489618	hsa-miR-4477b	72250797	72250803	7mer-m8	72250784	72250804	150	-10.98

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for GDA

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST

ENST type

RNA structure without RNA A-to-I editing.

RNA structure with RNA A-to-I editing.

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID

ENST

Editing_Position

MFE_withoneAI

MFE_withoutAI

MFE_withmultipleAI

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Relation with ADAR for GDA

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
STAD	CAediting_689814	chr9_72205060_+	0.0114160963237432	0.332827649106162	.	.	.	.
STAD	CAediting_689819	chr9_72205074_+	0.0276028867616575	0.30267035348187	.	.	.	.

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Relation with cancer stages for GDA

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for GDA

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for GDA

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for GDA

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
GDA	C0007097	Carcinoma	1	CTD_human
GDA	C0019193	Hepatitis, Toxic	1	CTD_human
GDA	C0024667	Animal Mammary Neoplasms	1	CTD_human
GDA	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
GDA	C0205696	Anaplastic carcinoma	1	CTD_human
GDA	C0205697	Carcinoma, Spindle-Cell	1	CTD_human
GDA	C0205698	Undifferentiated carcinoma	1	CTD_human
GDA	C0205699	Carcinomatosis	1	CTD_human
GDA	C0860207	Drug-Induced Liver Disease	1	CTD_human
GDA	C1257925	Mammary Carcinoma, Animal	1	CTD_human
GDA	C1262760	Hepatitis, Drug-Induced	1	CTD_human
GDA	C3658290	Drug-Induced Acute Liver Injury	1	CTD_human
GDA	C4277682	Chemical and Drug Induced Liver Injury	1	CTD_human
GDA	C4279912	Chemically-Induced Liver Toxicity	1	CTD_human

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene