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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: CD40 (CAeditome ID:958)

Gene summary for CD40

check button Gene summary
Gene informationGene symbol

CD40

Gene ID

958

Gene nameCD40 molecule
SynonymsBp50|CDW40|TNFRSF5|p50
Cytomap

20q13.12

Type of geneprotein-coding
Descriptiontumor necrosis factor receptor superfamily member 5B cell surface antigen CD40B cell-associated moleculeCD40 molecule, TNF receptor superfamily member 5CD40L receptor
Modification date20210518
UniProtAcc

P25942

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
CD40

GO:0023035

Tumor necrosis factor receptor superfamily member 5

31331973

CD40

GO:2000353

Tumor necrosis factor receptor superfamily member 5

12885753


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RNA A-to-I events for CD40

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000101017.12
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_1431840(46124021, +), CAediting_1431841(46124043, +), CAediting_1431842(46124044, +), CAediting_1431843(46124083, +), CAediting_1431844(46124088, +), CAediting_1431845(46124097, +), CAediting_1431846(46124102, +), CAediting_1431847(46124112, +), CAediting_1431848(46124120, +), CAediting_1431849(46124133, +), CAediting_1431850(46124136, +), CAediting_1431851(46124137, +), CAediting_1431852(46124142, +), CAediting_1431853(46124145, +), CAediting_1431854(46124146, +), CAediting_1431855(46124147, +), CAediting_1431856(46124148, +), CAediting_1431857(46124149, +), CAediting_1431858(46124153, +), CAediting_1431859(46124179, +), CAediting_1431860(46124180, +), CAediting_1431861(46124185, +), CAediting_1431862(46124220, +), CAediting_1431863(46124221, +), CAediting_1431864(46124228, +), CAediting_1431865(46124245, +), CAediting_1431866(46124250, +), CAediting_1431867(46124254, +), CAediting_1431868(46124279, +), CAediting_1431869(46124280, +), CAediting_1431870(46124282, +), CAediting_1431871(46124284, +), CAediting_1431872(46124966, +), CAediting_1431873(46124974, +), CAediting_1431874(46124978, +), CAediting_1431875(46125028, +), CAediting_1431876(46125029, +), CAediting_1431877(46125041, +), CAediting_1431878(46125128, +), CAediting_1431879(46125282, +), CAediting_1431880(46125284, +), CAediting_1431881(46125290, +), CAediting_1431882(46125291, +), CAediting_1431883(46125299, +), CAediting_1431884(46125321, +), CAediting_1431885(46125329, +), CAediting_1431886(46125334, +), CAediting_1431887(46125335, +), CAediting_1431888(46125357, +), CAediting_1431889(46125358, +), CAediting_1431890(46125365, +), CAediting_1431891(46125366, +), CAediting_1431892(46125367, +), CAediting_1431893(46125368, +), CAediting_1431894(46125379, +), CAediting_1431895(46125382, +), CAediting_1431896(46125383, +), CAediting_1431897(46125384, +), CAediting_1431898(46125388, +), CAediting_1431899(46125394, +), CAediting_1431900(46125397, +), CAediting_1431901(46125423, +), CAediting_1431902(46125429, +), CAediting_1431903(46125437, +), CAediting_1431904(46125446, +), CAediting_1431905(46125456, +), CAediting_1431906(46125465, +), CAediting_1431907(46125485, +), CAediting_1431908(46125489, +), CAediting_1431909(46125494, +), CAediting_1431910(46125496, +), CAediting_1431911(46125528, +), CAediting_1431912(46125529, +), CAediting_1431913(46125534, +), CAediting_1431914(46125535, +), CAediting_1431915(46125550, +), CAediting_1431916(46125556, +), CAediting_1431917(46125560, +), CAediting_1431918(46125562, +), CAediting_1431919(46127613, +),

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RNA editing positional annotations for CD40 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1431840chr20_46124021_+ncRNA_intronic
CAediting_1431841chr20_46124043_+ncRNA_intronic
CAediting_1431842chr20_46124044_+ncRNA_intronic
CAediting_1431843chr20_46124083_+ncRNA_intronic
CAediting_1431844chr20_46124088_+ncRNA_intronic
CAediting_1431845chr20_46124097_+ncRNA_intronic
CAediting_1431846chr20_46124102_+ncRNA_intronic
CAediting_1431847chr20_46124112_+ncRNA_intronic
CAediting_1431848chr20_46124120_+ncRNA_intronic
CAediting_1431849chr20_46124133_+ncRNA_intronic
CAediting_1431850chr20_46124136_+ncRNA_intronic
CAediting_1431851chr20_46124137_+ncRNA_intronic
CAediting_1431852chr20_46124142_+ncRNA_intronic
CAediting_1431853chr20_46124145_+ncRNA_intronic
CAediting_1431854chr20_46124146_+ncRNA_intronic
CAediting_1431855chr20_46124147_+ncRNA_intronic
CAediting_1431856chr20_46124148_+ncRNA_intronic
CAediting_1431857chr20_46124149_+ncRNA_intronic
CAediting_1431858chr20_46124153_+ncRNA_intronic
CAediting_1431859chr20_46124179_+ncRNA_intronic
CAediting_1431860chr20_46124180_+ncRNA_intronic
CAediting_1431861chr20_46124185_+ncRNA_intronic
CAediting_1431862chr20_46124220_+ncRNA_intronic
CAediting_1431863chr20_46124221_+ncRNA_intronic
CAediting_1431864chr20_46124228_+ncRNA_intronic
CAediting_1431865chr20_46124245_+ncRNA_intronic
CAediting_1431866chr20_46124250_+ncRNA_intronic
CAediting_1431867chr20_46124254_+ncRNA_intronic
CAediting_1431868chr20_46124279_+ncRNA_intronic
CAediting_1431869chr20_46124280_+ncRNA_intronic
CAediting_1431870chr20_46124282_+ncRNA_intronic
CAediting_1431871chr20_46124284_+ncRNA_intronic
CAediting_1431872chr20_46124966_+ncRNA_intronic
CAediting_1431873chr20_46124974_+ncRNA_intronic
CAediting_1431874chr20_46124978_+ncRNA_intronic
CAediting_1431875chr20_46125028_+ncRNA_intronic
CAediting_1431876chr20_46125029_+ncRNA_intronic
CAediting_1431877chr20_46125041_+ncRNA_intronic
CAediting_1431878chr20_46125128_+ncRNA_intronic
CAediting_1431879chr20_46125282_+ncRNA_intronic
CAediting_1431880chr20_46125284_+ncRNA_intronic
CAediting_1431881chr20_46125290_+ncRNA_intronic
CAediting_1431882chr20_46125291_+ncRNA_intronic
CAediting_1431883chr20_46125299_+ncRNA_intronic
CAediting_1431884chr20_46125321_+ncRNA_intronic
CAediting_1431885chr20_46125329_+ncRNA_intronic
CAediting_1431886chr20_46125334_+ncRNA_intronic
CAediting_1431887chr20_46125335_+ncRNA_intronic
CAediting_1431888chr20_46125357_+ncRNA_intronic
CAediting_1431889chr20_46125358_+ncRNA_intronic
CAediting_1431890chr20_46125365_+ncRNA_intronic
CAediting_1431891chr20_46125366_+ncRNA_intronic
CAediting_1431892chr20_46125367_+ncRNA_intronic
CAediting_1431893chr20_46125368_+ncRNA_intronic
CAediting_1431894chr20_46125379_+ncRNA_intronic
CAediting_1431895chr20_46125382_+ncRNA_intronic
CAediting_1431896chr20_46125383_+ncRNA_intronic
CAediting_1431897chr20_46125384_+ncRNA_intronic
CAediting_1431898chr20_46125388_+ncRNA_intronic
CAediting_1431899chr20_46125394_+ncRNA_intronic
CAediting_1431900chr20_46125397_+ncRNA_intronic
CAediting_1431901chr20_46125423_+ncRNA_intronic
CAediting_1431902chr20_46125429_+ncRNA_intronic
CAediting_1431903chr20_46125437_+ncRNA_intronic
CAediting_1431904chr20_46125446_+ncRNA_intronic
CAediting_1431905chr20_46125456_+ncRNA_intronic
CAediting_1431906chr20_46125465_+ncRNA_intronic
CAediting_1431907chr20_46125485_+ncRNA_intronic
CAediting_1431908chr20_46125489_+ncRNA_intronic
CAediting_1431909chr20_46125494_+ncRNA_intronic
CAediting_1431910chr20_46125496_+ncRNA_intronic
CAediting_1431911chr20_46125528_+ncRNA_intronic
CAediting_1431912chr20_46125529_+ncRNA_intronic
CAediting_1431913chr20_46125534_+ncRNA_intronic
CAediting_1431914chr20_46125535_+ncRNA_intronic
CAediting_1431915chr20_46125550_+ncRNA_intronic
CAediting_1431916chr20_46125556_+ncRNA_intronic
CAediting_1431917chr20_46125560_+ncRNA_intronic
CAediting_1431918chr20_46125562_+ncRNA_intronic
CAediting_1431919chr20_46127613_+ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1431840chr20_46124021_+SINEAluAluSx1
CAediting_1431841chr20_46124043_+SINEAluAluSx1
CAediting_1431842chr20_46124044_+SINEAluAluSx1
CAediting_1431843chr20_46124083_+SINEAluAluSx1
CAediting_1431844chr20_46124088_+SINEAluAluSx1
CAediting_1431845chr20_46124097_+SINEAluAluSx1
CAediting_1431846chr20_46124102_+SINEAluAluSx1
CAediting_1431847chr20_46124112_+SINEAluAluSx1
CAediting_1431848chr20_46124120_+SINEAluAluSx1
CAediting_1431849chr20_46124133_+SINEAluAluSx1
CAediting_1431850chr20_46124136_+SINEAluAluSx1
CAediting_1431851chr20_46124137_+SINEAluAluSx1
CAediting_1431852chr20_46124142_+SINEAluAluSx1
CAediting_1431853chr20_46124145_+SINEAluAluSx1
CAediting_1431854chr20_46124146_+SINEAluAluSx1
CAediting_1431855chr20_46124147_+SINEAluAluSx1
CAediting_1431856chr20_46124148_+SINEAluAluSx1
CAediting_1431857chr20_46124149_+SINEAluAluSx1
CAediting_1431858chr20_46124153_+SINEAluAluSx1
CAediting_1431859chr20_46124179_+SINEAluAluSx1
CAediting_1431860chr20_46124180_+SINEAluAluSx1
CAediting_1431861chr20_46124185_+SINEAluAluSx1
CAediting_1431862chr20_46124220_+SINEAluAluSx1
CAediting_1431863chr20_46124221_+SINEAluAluSx1
CAediting_1431864chr20_46124228_+SINEAluAluSx1
CAediting_1431865chr20_46124245_+SINEAluAluSx1
CAediting_1431866chr20_46124250_+SINEAluAluSx1
CAediting_1431867chr20_46124254_+SINEAluAluSx1
CAediting_1431868chr20_46124279_+SINEAluAluSx1
CAediting_1431869chr20_46124280_+SINEAluAluSx1
CAediting_1431870chr20_46124282_+SINEAluAluSx1
CAediting_1431871chr20_46124284_+SINEAluAluSx1
CAediting_1431872chr20_46124966_+SINEAluAluY
CAediting_1431873chr20_46124974_+SINEAluAluY
CAediting_1431874chr20_46124978_+SINEAluAluY
CAediting_1431875chr20_46125028_+SINEAluAluY
CAediting_1431876chr20_46125029_+SINEAluAluY
CAediting_1431877chr20_46125041_+SINEAluAluY
CAediting_1431878chr20_46125128_+SINEMIRMIRc
CAediting_1431879chr20_46125282_+SINEAluAluSc
CAediting_1431880chr20_46125284_+SINEAluAluSc
CAediting_1431881chr20_46125290_+SINEAluAluSc
CAediting_1431882chr20_46125291_+SINEAluAluSc
CAediting_1431883chr20_46125299_+SINEAluAluSc
CAediting_1431884chr20_46125321_+SINEAluAluSc
CAediting_1431885chr20_46125329_+SINEAluAluSc
CAediting_1431886chr20_46125334_+SINEAluAluSc
CAediting_1431887chr20_46125335_+SINEAluAluSc
CAediting_1431888chr20_46125357_+SINEAluAluSc
CAediting_1431889chr20_46125358_+SINEAluAluSc
CAediting_1431890chr20_46125365_+SINEAluAluSc
CAediting_1431891chr20_46125366_+SINEAluAluSc
CAediting_1431892chr20_46125367_+SINEAluAluSc
CAediting_1431893chr20_46125368_+SINEAluAluSc
CAediting_1431894chr20_46125379_+SINEAluAluSc
CAediting_1431895chr20_46125382_+SINEAluAluSc
CAediting_1431896chr20_46125383_+SINEAluAluSc
CAediting_1431897chr20_46125384_+SINEAluAluSc
CAediting_1431898chr20_46125388_+SINEAluAluSc
CAediting_1431899chr20_46125394_+SINEAluAluSc
CAediting_1431900chr20_46125397_+SINEAluAluSc
CAediting_1431901chr20_46125423_+SINEAluAluSc
CAediting_1431902chr20_46125429_+SINEAluAluSc
CAediting_1431903chr20_46125437_+SINEAluAluSc
CAediting_1431904chr20_46125446_+SINEAluAluSc
CAediting_1431905chr20_46125456_+SINEAluAluSc
CAediting_1431906chr20_46125465_+SINEAluAluSc
CAediting_1431907chr20_46125485_+SINEAluAluSc
CAediting_1431908chr20_46125489_+SINEAluAluSc
CAediting_1431909chr20_46125494_+SINEAluAluSc
CAediting_1431910chr20_46125496_+SINEAluAluSc
CAediting_1431911chr20_46125528_+SINEAluAluSc
CAediting_1431912chr20_46125529_+SINEAluAluSc
CAediting_1431913chr20_46125534_+SINEAluAluSc
CAediting_1431914chr20_46125535_+SINEAluAluSc
CAediting_1431915chr20_46125550_+SINEAluAluSc
CAediting_1431916chr20_46125556_+SINEAluAluSc
CAediting_1431917chr20_46125560_+SINEAluAluSc
CAediting_1431918chr20_46125562_+SINEAluAluSc
CAediting_1431919chr20_46127613_+DNAhAT-Tip100MER96B

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RNA A-to-I editing events in the alternative splicing sites for CD40

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_1431848chr20_46124120_+46124114:461241225SS0+4iATGGTAAAA4.79ATGGTAGAA1.05

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000101017.12.CD40.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000101017.12.CD40.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CD40

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.
KIRC.CAediting_1431880.ENSG00000101017.CD40.png
Soverview

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Protein coding region RNA A-to-I editings for CD40

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for CD40

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000101017.12ENST00000620709hsa-miR-200b-3p46129425461294317mer-m84612941046129432152-17.07
CAediting_393chr1_1167164_+ENSG00000101017.12ENST00000372276hsa-miR-200b-3p46129425461294317mer-m84612941046129432152-17.07
CAediting_1229414chr17_67471546_+ENSG00000101017.12ENST00000620709hsa-miR-548aa46128212461282187mer-m84612819546128219146-17.19
CAediting_77128chr1_85133844_+ENSG00000101017.12ENST00000620709hsa-miR-4423-3p46129360461293667mer-m84612934746129367164-22.7
CAediting_1229415chr17_67471547_+ENSG00000101017.12ENST00000372276hsa-miR-548aa46129766461297727mer-m84612975046129773165-17.68
CAediting_77128chr1_85133844_+ENSG00000101017.12ENST00000372276hsa-miR-4423-3p46129360461293667mer-m84612934746129367164-22.7
CAediting_1229414chr17_67471546_+ENSG00000101017.12ENST00000466205hsa-miR-548aa46128212461282187mer-m84612819546128219146-17.19

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CD40

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for CD40

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for CD40

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for CD40

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
OVCAediting_1431840chr20_46124021_+0.005569496252292640.044063917.2107

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RelatedDrugs for CD40

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CD40

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
CD40C0003873Rheumatoid Arthritis3CTD_human
CD40C1720957Hyper-IgM Immunodeficiency Syndrome, Type 33CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
CD40C0026691Mucocutaneous Lymph Node Syndrome2CTD_human
CD40C0006142Malignant neoplasm of breast1CTD_human
CD40C0020456Hyperglycemia1CTD_human
CD40C0020459Hyperinsulinism1CTD_human
CD40C0021655Insulin Resistance1CTD_human
CD40C0026769Multiple Sclerosis1CTD_human
CD40C0028754Obesity1CTD_human
CD40C0038220Status Epilepticus1CTD_human
CD40C0270823Petit mal status1CTD_human
CD40C0311335Grand Mal Status Epilepticus1CTD_human
CD40C0393734Complex Partial Status Epilepticus1CTD_human
CD40C0678222Breast Carcinoma1CTD_human
CD40C0751324Multiple Sclerosis, Acute Fulminating1CTD_human
CD40C0751522Status Epilepticus, Subclinical1CTD_human
CD40C0751523Non-Convulsive Status Epilepticus1CTD_human
CD40C0751524Simple Partial Status Epilepticus1CTD_human
CD40C0920563Insulin Sensitivity1CTD_human
CD40C1257931Mammary Neoplasms, Human1CTD_human
CD40C1257963Endogenous Hyperinsulinism1CTD_human
CD40C1257964Exogenous Hyperinsulinism1CTD_human
CD40C1257965Compensatory Hyperinsulinemia1CTD_human
CD40C1458155Mammary Neoplasms1CTD_human
CD40C1855520Hyperglycemia, Postprandial1CTD_human
CD40C4704874Mammary Carcinoma, Human1CTD_human