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Editing gene: CEP41 (CAeditome ID:95681)

Gene summary for CEP41

Gene summary

Gene information	Gene symbol	CEP41
	Gene ID	95681
	Gene name	centrosomal protein 41
	Synonyms	JBTS15\|TSGA14
	Cytomap	7q32.2
	Type of gene	protein-coding
	Description	centrosomal protein of 41 kDacentrosomal protein 41 kDacentrosomal protein 41kDatestis specific protein A14testis specific, 14testis-specific gene A14 protein
	Modification date	20210518
	UniProtAcc	Q9BYV8
	Context

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CEP41	GO:0005813	Centrosomal protein of 41 kDa	14654843
CEP41	GO:0005813	Centrosomal protein of 41 kDa	21399614
CEP41	GO:0005814	Centrosomal protein of 41 kDa	22246503
CEP41	GO:0005929	Centrosomal protein of 41 kDa	22246503
CEP41	GO:0036064	Centrosomal protein of 41 kDa	22246503

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RNA A-to-I events for CEP41

RNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.

RNA editing frequencies across 33 cancers of gene: ENSG00000106477.17

RNA A-to-I editing events in Cancer.

CAediting_603048(130397336, -), CAediting_603049(130413106, -),

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RNA editing positional annotations for CEP41 using Annovar

Protein coding RNA editing(s).

CAeditome ID

Position

Variant type

ENST

NTchange

AAchange

SIFT_score

Polyphen2_HVAR_score

PROVEAN_pred

Gene structure information of RNA editing(s).

CAeditome ID	Position	Variant type
CAediting_603048	chr7_130397336_-	UTR3
CAediting_603049	chr7_130413106_-	ncRNA_intronic

Repat-regional RNA editing(s).

CAeditome ID	Position	Repeat family	Repeat sub family	Repeat name
CAediting_603049	chr7_130413106_-	SINE	Alu	AluSx1

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RNA A-to-I editing events in the alternative splicing sites for CEP41

RNA A-to-I editing(s) in the alternative splicing sites.

AStype

CAeditomID

Editing position

AS position

AS direction

Exonic location

Wildtype sequence

Wildtype splicing strength

RNA edited sequence

RNA edited splicing strength

Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000106477.17.CEP41.

Correlation between RNA A-to-I editing and PSI for ENSG00000106477.17.CEP41.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for CEP41

Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

Correlation between RNA A-to-I editing and gene expression.

- Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for CEP41

- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.

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The effects of the RNA editing to the miRNA binding sites for CEP41

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_603048	chr7_130397336_-	ENSG00000106477.17	ENST00000223208	hsa-miR-330-3p	130397336	130397342	7mer-m8	130397335	130397356	143.00	-13.81
CAediting_603048	chr7_130397336_-	ENSG00000106477.17	ENST00000541543	hsa-miR-330-3p	130397336	130397342	7mer-m8	130397335	130397356	143.00	-13.81

RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA gained miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in lncRNA lost miRNA binding sites.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs lost binding to lncRNA.

CAeditom_ID

Position

ENSG

ENST

miRNA

Targetscan start

Targetscan end

Targetscan score

Miranda start

Miranda end

Miranda score

Miranda energy

RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_980496	chr14_31014685_-	ENSG00000106477.17	ENST00000223208	hsa-miR-624-3p	130394790	130394796	7mer-m8	130394789	130394808	153	-20.23
CAediting_980496	chr14_31014685_-	ENSG00000106477.17	ENST00000223208	hsa-miR-624-3p	130394543	130394549	7mer-m8	130394542	130394562	159	-20.17
CAediting_393	chr1_1167164_+	ENSG00000106477.17	ENST00000223208	hsa-miR-200b-3p	130397799	130397806	8mer-1a	130397799	130397820	149	-12.63
CAediting_980496	chr14_31014685_-	ENSG00000106477.17	ENST00000541543	hsa-miR-624-3p	130394790	130394796	7mer-m8	130394789	130394808	153	-20.23
CAediting_980496	chr14_31014685_-	ENSG00000106477.17	ENST00000541543	hsa-miR-624-3p	130394543	130394549	7mer-m8	130394542	130394562	159	-20.17
CAediting_393	chr1_1167164_+	ENSG00000106477.17	ENST00000541543	hsa-miR-200b-3p	130397799	130397806	8mer-1a	130397799	130397820	149	-12.63
CAediting_1229414	chr17_67471546_+	ENSG00000106477.17	ENST00000223208	hsa-miR-548aa	130396932	130396938	7mer-m8	130396931	130396953	163	-14.99
CAediting_1229415	chr17_67471547_+	ENSG00000106477.17	ENST00000223208	hsa-miR-548aa	130397147	130397153	7mer-m8	130397146	130397169	160	-10.18
CAediting_1160181	chr17_7017644_-	ENSG00000106477.17	ENST00000223208	hsa-miR-195-3p	130395231	130395237	7mer-m8	130395230	130395249	153	-13.26
CAediting_1306323	chr19_13836462_-	ENSG00000106477.17	ENST00000223208	hsa-miR-27a-3p	130394117	130394124	8mer-1a	130394117	130394137	151	-16.76
CAediting_228905	chr2_188297554_+	ENSG00000106477.17	ENST00000223208	hsa-miR-561-3p	130397722	130397727	6mer	130397721	130397742	146	-20.92
CAediting_414656	chr5_72878640_+	ENSG00000106477.17	ENST00000223208	hsa-miR-4804-3p	130397297	130397303	7mer-m8	130397296	130397316	143	-11.03
CAediting_604450	chr7_133034877_-	ENSG00000106477.17	ENST00000223208	hsa-miR-3654	130398558	130398564	7mer-m8	130398557	130398575	140	-14.79
CAediting_524911	chr7_5495852_-	ENSG00000106477.17	ENST00000223208	hsa-miR-589-3p	130397152	130397158	7mer-m8	130397151	130397174	143	-15.26
CAediting_524911	chr7_5495852_-	ENSG00000106477.17	ENST00000223208	hsa-miR-589-3p	130393992	130393998	7mer-m8	130393991	130394016	167	-26.77
CAediting_1229414	chr17_67471546_+	ENSG00000106477.17	ENST00000541543	hsa-miR-548aa	130396932	130396938	7mer-m8	130396931	130396953	163	-14.99
CAediting_1229415	chr17_67471547_+	ENSG00000106477.17	ENST00000541543	hsa-miR-548aa	130397147	130397153	7mer-m8	130397146	130397169	160	-10.18
CAediting_1160181	chr17_7017644_-	ENSG00000106477.17	ENST00000541543	hsa-miR-195-3p	130395231	130395237	7mer-m8	130395230	130395249	153	-13.26
CAediting_1306323	chr19_13836462_-	ENSG00000106477.17	ENST00000541543	hsa-miR-27a-3p	130394117	130394124	8mer-1a	130394117	130394137	151	-16.76
CAediting_228905	chr2_188297554_+	ENSG00000106477.17	ENST00000541543	hsa-miR-561-3p	130397722	130397727	6mer	130397721	130397742	146	-20.92
CAediting_414656	chr5_72878640_+	ENSG00000106477.17	ENST00000541543	hsa-miR-4804-3p	130397297	130397303	7mer-m8	130397296	130397316	143	-11.03
CAediting_604450	chr7_133034877_-	ENSG00000106477.17	ENST00000541543	hsa-miR-3654	130398558	130398564	7mer-m8	130398557	130398575	140	-14.79
CAediting_524911	chr7_5495852_-	ENSG00000106477.17	ENST00000541543	hsa-miR-589-3p	130397152	130397158	7mer-m8	130397151	130397174	143	-15.26
CAediting_524911	chr7_5495852_-	ENSG00000106477.17	ENST00000541543	hsa-miR-589-3p	130393992	130393998	7mer-m8	130393991	130394016	167	-26.77
CAediting_1229414	chr17_67471546_+	ENSG00000106477.17	ENST00000489512	hsa-miR-548aa	130420433	130420439	7mer-m8	130420432	130420456	150	-16.25
CAediting_1229415	chr17_67471547_+	ENSG00000106477.17	ENST00000489512	hsa-miR-548aa	130419924	130419930	7mer-m8	130419923	130419950	157	-12.79
CAediting_77128	chr1_85133844_+	ENSG00000106477.17	ENST00000489512	hsa-miR-4423-3p	130419942	130419948	7mer-m8	130419941	130419962	150	-17.13
CAediting_468389	chr6_31355314_-	ENSG00000106477.17	ENST00000489512	hsa-miR-6891-5p	130420087	130420094	8mer-1a	130420087	130420106	152	-22.94

RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.

CAeditom_ID	Position	ENSG	ENST	miRNA	Targetscan start	Targetscan end	Targetscan score	Miranda start	Miranda end	Miranda score	Miranda energy
CAediting_442554	chr5_154685830_+	ENSG00000106477.17	ENST00000223208	hsa-miR-1303	130395685	130395691	7mer-m8	130395684	130395708	144	-12.01
CAediting_393	chr1_1167164_+	ENSG00000106477.17	ENST00000223208	hsa-miR-200b-3p	130397493	130397499	7mer-m8	130397492	130397511	147	-11.21
CAediting_393	chr1_1167164_+	ENSG00000106477.17	ENST00000223208	hsa-miR-200b-3p	130397915	130397922	8mer-1a	130397915	130397936	140	-9.83
CAediting_1306323	chr19_13836462_-	ENSG00000106477.17	ENST00000223208	hsa-miR-27a-3p	130397854	130397860	7mer-m8	130397853	130397870	141	-12.11
CAediting_1368054	chr19_46709310_-	ENSG00000106477.17	ENST00000223208	hsa-miR-320e	130397619	130397625	7mer-m8	130397618	130397634	146	-13.22
CAediting_1368054	chr19_46709310_-	ENSG00000106477.17	ENST00000223208	hsa-miR-320e	130397094	130397099	6mer	130397093	130397111	143	-18
CAediting_1368054	chr19_46709310_-	ENSG00000106477.17	ENST00000223208	hsa-miR-320e	130398556	130398562	7mer-m8	130398555	130398572	143	-13.24
CAediting_1368054	chr19_46709310_-	ENSG00000106477.17	ENST00000223208	hsa-miR-320e	130398066	130398072	7mer-m8	130398065	130398082	146	-16.38
CAediting_1368054	chr19_46709310_-	ENSG00000106477.17	ENST00000223208	hsa-miR-320e	130398012	130398018	7mer-m8	130398011	130398029	143	-12.53
CAediting_1229414	chr17_67471546_+	ENSG00000106477.17	ENST00000223208	hsa-miR-548aa	130395607	130395613	7mer-m8	130395606	130395633	144	-10.59
CAediting_1229415	chr17_67471547_+	ENSG00000106477.17	ENST00000223208	hsa-miR-548aa	130395607	130395613	7mer-m8	130395606	130395633	144	-10.59
CAediting_228905	chr2_188297554_+	ENSG00000106477.17	ENST00000223208	hsa-miR-561-3p	130394049	130394055	7mer-m8	130394048	130394073	149	-10.6
CAediting_228905	chr2_188297554_+	ENSG00000106477.17	ENST00000223208	hsa-miR-561-3p	130393851	130393857	7mer-m8	130393850	130393871	154	-5.34
CAediting_748296	chr10_51299626_+	ENSG00000106477.17	ENST00000223208	hsa-miR-605-3p	130394264	130394271	8mer-1a	130394264	130394288	154	-17.89
CAediting_1351755	chr19_40282625_-	ENSG00000106477.17	ENST00000223208	hsa-miR-641	130394846	130394852	7mer-m8	130394845	130394869	153	-13.42
CAediting_468389	chr6_31355314_-	ENSG00000106477.17	ENST00000223208	hsa-miR-6891-5p	130396924	130396930	7mer-m8	130396923	130396942	150	-20.15
CAediting_442554	chr5_154685830_+	ENSG00000106477.17	ENST00000541543	hsa-miR-1303	130395685	130395691	7mer-m8	130395684	130395708	144	-12.01
CAediting_393	chr1_1167164_+	ENSG00000106477.17	ENST00000541543	hsa-miR-200b-3p	130397493	130397499	7mer-m8	130397492	130397511	147	-11.21
CAediting_393	chr1_1167164_+	ENSG00000106477.17	ENST00000541543	hsa-miR-200b-3p	130397915	130397922	8mer-1a	130397915	130397936	140	-9.83
CAediting_1306323	chr19_13836462_-	ENSG00000106477.17	ENST00000541543	hsa-miR-27a-3p	130397854	130397860	7mer-m8	130397853	130397870	141	-12.11
CAediting_1368054	chr19_46709310_-	ENSG00000106477.17	ENST00000541543	hsa-miR-320e	130397619	130397625	7mer-m8	130397618	130397634	146	-13.22
CAediting_1368054	chr19_46709310_-	ENSG00000106477.17	ENST00000541543	hsa-miR-320e	130397094	130397099	6mer	130397093	130397111	143	-18
CAediting_1368054	chr19_46709310_-	ENSG00000106477.17	ENST00000541543	hsa-miR-320e	130398556	130398562	7mer-m8	130398555	130398572	143	-13.24
CAediting_1368054	chr19_46709310_-	ENSG00000106477.17	ENST00000541543	hsa-miR-320e	130398066	130398072	7mer-m8	130398065	130398082	146	-16.38
CAediting_1368054	chr19_46709310_-	ENSG00000106477.17	ENST00000541543	hsa-miR-320e	130398012	130398018	7mer-m8	130398011	130398029	143	-12.53
CAediting_1229414	chr17_67471546_+	ENSG00000106477.17	ENST00000541543	hsa-miR-548aa	130395607	130395613	7mer-m8	130395606	130395633	144	-10.59
CAediting_1229415	chr17_67471547_+	ENSG00000106477.17	ENST00000541543	hsa-miR-548aa	130395607	130395613	7mer-m8	130395606	130395633	144	-10.59
CAediting_228905	chr2_188297554_+	ENSG00000106477.17	ENST00000541543	hsa-miR-561-3p	130394049	130394055	7mer-m8	130394048	130394073	149	-10.6
CAediting_228905	chr2_188297554_+	ENSG00000106477.17	ENST00000541543	hsa-miR-561-3p	130393851	130393857	7mer-m8	130393850	130393871	154	-5.34
CAediting_748296	chr10_51299626_+	ENSG00000106477.17	ENST00000541543	hsa-miR-605-3p	130394264	130394271	8mer-1a	130394264	130394288	154	-17.89
CAediting_1351755	chr19_40282625_-	ENSG00000106477.17	ENST00000541543	hsa-miR-641	130394846	130394852	7mer-m8	130394845	130394869	153	-13.42
CAediting_468389	chr6_31355314_-	ENSG00000106477.17	ENST00000541543	hsa-miR-6891-5p	130396924	130396930	7mer-m8	130396923	130396942	150	-20.15
CAediting_1160181	chr17_7017644_-	ENSG00000106477.17	ENST00000489512	hsa-miR-195-3p	130421339	130421346	8mer-1a	130421339	130421358	144	-11.55
CAediting_468389	chr6_31355314_-	ENSG00000106477.17	ENST00000489512	hsa-miR-6891-5p	130419147	130419152	6mer	130419146	130419164	153	-24.87

Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for CEP41

- RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.

ENST	ENST type	RNA structure without RNA A-to-I editing.	RNA structure with RNA A-to-I editing.
ENST00000223208.8	protein_coding
ENST00000541543.4	protein_coding

RNA A-to-I editing in RNA structures for Minimum free energy (MFE).

CAeditom_ID	ENST	Editing_Position	MFE_withoneAI	MFE_withoutAI	MFE_withmultipleAI
CAediting_603048	ENST00000223208.8	chr7_130397336_-	-1895.91	-1889.31	-1895.91
CAediting_603048	ENST00000541543.4	chr7_130397336_-	-1797.17	-1790.57	-1797.17

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Relation with ADAR for CEP41

Correlation between ADAR gene expression and RNA editing frequency

Cancer	CAeditomID	position	ADAR1 (p-val)	ADAR1 (coeff.)	ADAR2 (p-val)	ADAR2 (coeff.)	ADAR3 (p-val)	ADAR3 (coeff.)
BRCA	CAediting_603048	chr7_130397336_-	0.0138877268575398	0.284884115052223	.	.	.	.

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Relation with cancer stages for CEP41

Correlation between Cancer stages and RNA editing frequency

Cancer

Stage_type

CAeditomID

position

P-val

Coeff.

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Relation with survival for CEP41

Correlation between RNA editing and survival

Cancer

CAeditomID

position

KMpvalue

Coxpvalue

CoxHR

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RelatedDrugs for CEP41

Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CEP41

Diseases associated with this gene.
(DisGeNet 7.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CEP41	C0431399	Familial aplasia of the vermis	1	GENOMICS_ENGLAND;ORPHANET
CEP41	C1510586	Autism Spectrum Disorders	1	CTD_human
CEP41	C3280897	JOUBERT SYNDROME 15	1	GENOMICS_ENGLAND
CEP41	C4274118	Joubert syndrome with ocular defect	1	ORPHANET
CEP41	C4551568	Joubert syndrome 1	1	ORPHANET

	Gene summary
	RNA A-to-I events
	Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples
	Protein coding region RNA A-to-I editings
	The effects of the RNA editing to the miRNA binding sites
	The effects of the RNA editing to the stability of the RNA structures
	Relation with ADAR
	Relation with cancer stages
	Relation with survival state
	Related drugs with this gene
	Related diseases with this gene