CAeditome Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: PMPCB (CAeditome ID:9512)

Gene summary for PMPCB

check button Gene summary
Gene informationGene symbol

PMPCB

Gene ID

9512

Gene namepeptidase, mitochondrial processing subunit beta
SynonymsBeta-MPP|MAS1|MPP11|MPPB|MPPP52|P-52
Cytomap

7q22.1

Type of geneprotein-coding
Descriptionmitochondrial-processing peptidase subunit betamitochondrial processing peptidase beta subunitpeptidase (mitochondrial processing) betapeptidase, mitochondrial processing beta subunit
Modification date20210518
UniProtAcc

O75439

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
PMPCB

GO:0004222

Mitochondrial-processing peptidase subunit beta

22354088

PMPCB

GO:0006627

Mitochondrial-processing peptidase subunit beta

22354088

PMPCB

GO:0005739

Mitochondrial-processing peptidase subunit beta

0000052

PMPCB

GO:0005739

Mitochondrial-processing peptidase subunit beta

22354088


Top

RNA A-to-I events for PMPCB

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000105819.12

check button RNA A-to-I editing events in Cancer.
CAediting_589546(103302769, +), CAediting_589547(103302802, +), CAediting_589548(103302807, +), CAediting_589549(103304809, +), CAediting_589550(103304838, +), CAediting_589551(103304898, +), CAediting_589552(103306419, +), CAediting_589553(103306436, +), CAediting_589554(103306482, +), CAediting_589555(103306512, +), CAediting_589556(103306522, +), CAediting_589557(103306524, +), CAediting_589558(103306528, +), CAediting_589559(103306540, +), CAediting_589560(103306556, +), CAediting_589561(103306562, +), CAediting_589562(103306565, +), CAediting_589563(103306614, +), CAediting_589564(103306637, +), CAediting_589565(103306659, +), CAediting_589566(103306779, +), CAediting_589567(103306825, +), CAediting_589568(103306830, +), CAediting_589569(103306849, +), CAediting_589570(103306855, +), CAediting_589571(103306856, +), CAediting_589572(103306859, +), CAediting_589573(103306885, +), CAediting_589574(103306898, +), CAediting_589575(103306920, +), CAediting_589576(103306924, +), CAediting_589577(103306925, +), CAediting_589578(103306939, +), CAediting_589579(103306942, +), CAediting_589580(103306948, +), CAediting_589581(103306968, +), CAediting_589582(103307006, +), CAediting_589583(103307020, +), CAediting_589584(103307021, +), CAediting_589585(103307129, +), CAediting_589586(103308501, +), CAediting_589587(103310407, +), CAediting_589588(103310921, +), CAediting_589589(103311311, +), CAediting_589590(103312134, +), CAediting_589591(103312155, +), CAediting_589592(103312181, +), CAediting_589593(103312182, +), CAediting_589594(103312360, +), CAediting_589595(103312378, +), CAediting_589596(103312383, +), CAediting_589597(103312396, +), CAediting_589598(103312397, +),

Top

RNA editing positional annotations for PMPCB using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred
CAediting_589593chr7_103312182_+nonsynonymous SNVENST00000428154.4c.A1456Gp.I486VDBN

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_589546chr7_103302769_+ncRNA_intronic
CAediting_589547chr7_103302802_+ncRNA_intronic
CAediting_589548chr7_103302807_+ncRNA_intronic
CAediting_589549chr7_103304809_+ncRNA_intronic
CAediting_589550chr7_103304838_+ncRNA_intronic
CAediting_589551chr7_103304898_+ncRNA_intronic
CAediting_589552chr7_103306419_+ncRNA_intronic
CAediting_589553chr7_103306436_+ncRNA_intronic
CAediting_589554chr7_103306482_+ncRNA_intronic
CAediting_589555chr7_103306512_+ncRNA_intronic
CAediting_589556chr7_103306522_+ncRNA_intronic
CAediting_589557chr7_103306524_+ncRNA_intronic
CAediting_589558chr7_103306528_+ncRNA_intronic
CAediting_589559chr7_103306540_+ncRNA_intronic
CAediting_589560chr7_103306556_+ncRNA_intronic
CAediting_589561chr7_103306562_+ncRNA_intronic
CAediting_589562chr7_103306565_+ncRNA_intronic
CAediting_589563chr7_103306614_+ncRNA_intronic
CAediting_589564chr7_103306637_+ncRNA_intronic
CAediting_589565chr7_103306659_+ncRNA_intronic
CAediting_589566chr7_103306779_+ncRNA_intronic
CAediting_589567chr7_103306825_+ncRNA_intronic
CAediting_589568chr7_103306830_+ncRNA_intronic
CAediting_589569chr7_103306849_+ncRNA_intronic
CAediting_589570chr7_103306855_+ncRNA_intronic
CAediting_589571chr7_103306856_+ncRNA_intronic
CAediting_589572chr7_103306859_+ncRNA_intronic
CAediting_589573chr7_103306885_+ncRNA_intronic
CAediting_589574chr7_103306898_+ncRNA_intronic
CAediting_589575chr7_103306920_+ncRNA_intronic
CAediting_589576chr7_103306924_+ncRNA_intronic
CAediting_589577chr7_103306925_+ncRNA_intronic
CAediting_589578chr7_103306939_+ncRNA_intronic
CAediting_589579chr7_103306942_+ncRNA_intronic
CAediting_589580chr7_103306948_+ncRNA_intronic
CAediting_589581chr7_103306968_+ncRNA_intronic
CAediting_589582chr7_103307006_+ncRNA_intronic
CAediting_589583chr7_103307020_+ncRNA_intronic
CAediting_589584chr7_103307021_+ncRNA_intronic
CAediting_589585chr7_103307129_+ncRNA_intronic
CAediting_589586chr7_103308501_+ncRNA_intronic
CAediting_589587chr7_103310407_+exonic
CAediting_589588chr7_103310921_+ncRNA_exonic
CAediting_589589chr7_103311311_+ncRNA_exonic
CAediting_589590chr7_103312134_+exonic
CAediting_589591chr7_103312155_+exonic
CAediting_589592chr7_103312181_+exonic
CAediting_589593chr7_103312182_+exonic
CAediting_589594chr7_103312360_+UTR3
CAediting_589595chr7_103312378_+UTR3
CAediting_589596chr7_103312383_+UTR3
CAediting_589597chr7_103312396_+UTR3
CAediting_589598chr7_103312397_+UTR3

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_589546chr7_103302769_+SINEAluFLAM_A
CAediting_589547chr7_103302802_+SINEAluFLAM_A
CAediting_589548chr7_103302807_+SINEAluFLAM_A
CAediting_589549chr7_103304809_+SINEAluAluSx3
CAediting_589550chr7_103304838_+SINEAluAluSx3
CAediting_589551chr7_103304898_+SINEAluAluSx3
CAediting_589552chr7_103306419_+SINEAluAluSp
CAediting_589553chr7_103306436_+SINEAluAluSp
CAediting_589554chr7_103306482_+SINEAluAluSp
CAediting_589555chr7_103306512_+SINEAluAluSp
CAediting_589556chr7_103306522_+SINEAluAluSp
CAediting_589557chr7_103306524_+SINEAluAluSp
CAediting_589558chr7_103306528_+SINEAluAluSp
CAediting_589559chr7_103306540_+SINEAluAluSp
CAediting_589560chr7_103306556_+SINEAluAluSp
CAediting_589561chr7_103306562_+SINEAluAluSp
CAediting_589562chr7_103306565_+SINEAluAluSp
CAediting_589563chr7_103306614_+SINEAluAluSp
CAediting_589564chr7_103306637_+SINEAluAluSp
CAediting_589565chr7_103306659_+SINEAluAluSp
CAediting_589566chr7_103306779_+SINEAluAluSx1
CAediting_589567chr7_103306825_+SINEAluAluSx1
CAediting_589568chr7_103306830_+SINEAluAluSx1
CAediting_589569chr7_103306849_+SINEAluAluSx1
CAediting_589570chr7_103306855_+SINEAluAluSx1
CAediting_589571chr7_103306856_+SINEAluAluSx1
CAediting_589572chr7_103306859_+SINEAluAluSx1
CAediting_589573chr7_103306885_+SINEAluAluSx1
CAediting_589574chr7_103306898_+SINEAluAluSx1
CAediting_589575chr7_103306920_+SINEAluAluSx1
CAediting_589576chr7_103306924_+SINEAluAluSx1
CAediting_589577chr7_103306925_+SINEAluAluSx1
CAediting_589578chr7_103306939_+SINEAluAluSx1
CAediting_589579chr7_103306942_+SINEAluAluSx1
CAediting_589580chr7_103306948_+SINEAluAluSx1
CAediting_589581chr7_103306968_+SINEAluAluSx1
CAediting_589582chr7_103307006_+SINEAluAluSx1
CAediting_589583chr7_103307020_+SINEAluAluSx1
CAediting_589584chr7_103307021_+SINEAluAluSx1
CAediting_589585chr7_103307129_+SINEAluAluJo
CAediting_589586chr7_103308501_+SINEAluAluSz
CAediting_589588chr7_103310921_+SINEAluAluSx1

Top

RNA A-to-I editing events in the alternative splicing sites for PMPCB

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
IRCAediting_589590chr7_103312134_+103312129:1033121375SS0+3iTTGGTAAGC8.72TTGGTGAGC7.43
IRCAediting_589590chr7_103312134_+103312133:1033121415SS2+0iTAAGCCTGG-17.91TGAGCCTGG-21.14

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000105819.12.PMPCB.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000105819.12.PMPCB.

Top

Differntial gene expression between RNA A-to-I edited versus non-edited samples for PMPCB

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.

check button Correlation between RNA A-to-I editing and gene expression.

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

Top

Protein coding region RNA A-to-I editings for PMPCB

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.
all structure


Top

The effects of the RNA editing to the miRNA binding sites for PMPCB

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_589595chr7_103312378_+ENSG00000105819.12ENST00000428154hsa-miR-3681-3p1033123721033123776mer103312357103312378145.00-11.13
CAediting_589595chr7_103312378_+ENSG00000105819.12ENST00000428154hsa-miR-425-5p1033123751033123828mer-1a103312360103312382143.00-9.84
CAediting_589597chr7_103312396_+ENSG00000105819.12ENST00000428154hsa-miR-335-3p1033123931033123997mer-m8103312379103312400148.00-8.92
CAediting_589596chr7_103312383_+ENSG00000105819.12ENST00000428154hsa-miR-44221033123801033123867mer-m8103312367103312387157.00-9.70

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_589594chr7_103312360_+ENSG00000105819.12ENST00000428154hsa-miR-3606-3p1033123561033123627mer-m8103312343103312363141-3.96
CAediting_589594chr7_103312360_+ENSG00000105819.12ENST00000428154hsa-miR-513a-3p1033123561033123627mer-m8103312341103312363140-11.09
CAediting_589594chr7_103312360_+ENSG00000105819.12ENST00000428154hsa-miR-513a-3p1033123561033123627mer-m8103312341103312363140-11.09
CAediting_589594chr7_103312360_+ENSG00000105819.12ENST00000428154hsa-miR-513c-3p1033123561033123627mer-m8103312341103312363140-7.35
CAediting_589596chr7_103312383_+ENSG00000105819.12ENST00000428154hsa-miR-548l1033123801033123867mer-m8103312365103312387155-10.95
CAediting_589594chr7_103312360_+ENSG00000105819.12ENST00000443722hsa-miR-3606-3p1033123561033123627mer-m8103312343103312363141-3.96
CAediting_589594chr7_103312360_+ENSG00000105819.12ENST00000443722hsa-miR-513a-3p1033123561033123627mer-m8103312341103312363140-11.09
CAediting_589594chr7_103312360_+ENSG00000105819.12ENST00000443722hsa-miR-513a-3p1033123561033123627mer-m8103312341103312363140-11.09
CAediting_589594chr7_103312360_+ENSG00000105819.12ENST00000443722hsa-miR-513c-3p1033123561033123627mer-m8103312341103312363140-7.35

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1368054chr19_46709310_-ENSG00000105819.12ENST00000456433hsa-miR-320e1033103341033103418mer-1a103310324103310341148-19.64
CAediting_1368054chr19_46709310_-ENSG00000105819.12ENST00000443722hsa-miR-320e1033076721033076787mer-m8103307661103307679142-15.19
CAediting_1368054chr19_46709310_-ENSG00000105819.12ENST00000443722hsa-miR-320e1033103341033103418mer-1a103310324103310341148-19.64
CAediting_1399425chr20_1392958_-ENSG00000105819.12ENST00000444457hsa-miR-6869-5p1032986101032986178mer-1a103298596103298617153-18.86
CAediting_1229415chr17_67471547_+ENSG00000105819.12ENST00000444457hsa-miR-548aa1032995181032995247mer-m8103299503103299525147-11.53
CAediting_1368054chr19_46709310_-ENSG00000105819.12ENST00000444457hsa-miR-320e1033076721033076787mer-m8103307661103307679142-15.19
CAediting_1368054chr19_46709310_-ENSG00000105819.12ENST00000444457hsa-miR-320e1033103341033103418mer-1a103310324103310341148-19.64
CAediting_604450chr7_133034877_-ENSG00000105819.12ENST00000444457hsa-miR-36541033121101033121167mer-m8103312099103312117140-14.88
CAediting_1368054chr19_46709310_-ENSG00000105819.12ENST00000453466hsa-miR-320e1033076721033076787mer-m8103307661103307679142-15.19
CAediting_1368054chr19_46709310_-ENSG00000105819.12ENST00000453466hsa-miR-320e1033103341033103418mer-1a103310324103310341148-19.64
CAediting_604450chr7_133034877_-ENSG00000105819.12ENST00000453466hsa-miR-36541033121101033121167mer-m8103312099103312117140-14.88

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button Differentially expressed gene-miRNA network

Top

The effects of the RNA editing to the stability of the RNA structures for PMPCB

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.
ENST00000249269.7protein_codingSoverviewSoverview
ENST00000428154.4protein_codingSoverviewSoverview
ENST00000443722.4nonsense_mediated_decaySoverviewSoverview
ENST00000444457.4nonsense_mediated_decaySoverviewSoverview
ENST00000453466.1nonsense_mediated_decaySoverviewSoverview
ENST00000456433.4nonsense_mediated_decaySoverviewSoverview
ENST00000469560.1retained_intronSoverviewSoverview

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI
CAediting_589587ENST00000249269.7chr7_103310407_+-647.50-645.30-651.80
CAediting_589594ENST00000249269.7chr7_103312360_+-648.20-645.30-651.80
CAediting_589595ENST00000249269.7chr7_103312378_+-645.80-645.30-651.80
CAediting_589596ENST00000249269.7chr7_103312383_+-645.70-645.30-651.80
CAediting_589597ENST00000249269.7chr7_103312396_+-645.30-645.30-651.80
CAediting_589598ENST00000249269.7chr7_103312397_+-646.50-645.30-651.80
CAediting_589587ENST00000428154.4chr7_103310407_+-463.60-461.70-479.10
CAediting_589590ENST00000428154.4chr7_103312134_+-466.00-461.70-479.10
CAediting_589591ENST00000428154.4chr7_103312155_+-461.80-461.70-479.10
CAediting_589592ENST00000428154.4chr7_103312181_+-463.00-461.70-479.10
CAediting_589593ENST00000428154.4chr7_103312182_+-462.80-461.70-479.10
CAediting_589594ENST00000428154.4chr7_103312360_+-465.40-461.70-479.10
CAediting_589595ENST00000428154.4chr7_103312378_+-464.30-461.70-479.10
CAediting_589596ENST00000428154.4chr7_103312383_+-461.80-461.70-479.10
CAediting_589597ENST00000428154.4chr7_103312396_+-462.50-461.70-479.10
CAediting_589598ENST00000428154.4chr7_103312397_+-463.10-461.70-479.10
CAediting_589587ENST00000443722.4chr7_103310407_+-367.40-365.70-368.80
CAediting_589594ENST00000443722.4chr7_103312360_+-367.10-365.70-368.80
CAediting_589587ENST00000444457.4chr7_103310407_+-729.00-727.70-729.00
CAediting_589587ENST00000453466.1chr7_103310407_+-431.10-428.10-431.10
CAediting_589587ENST00000456433.4chr7_103310407_+-267.60-264.90-267.60
CAediting_589588ENST00000469560.1chr7_103310921_+-387.40-388.10-394.60
CAediting_589589ENST00000469560.1chr7_103311311_+-388.20-388.10-394.60
CAediting_589590ENST00000469560.1chr7_103312134_+-388.60-388.10-394.60
CAediting_589591ENST00000469560.1chr7_103312155_+-388.40-388.10-394.60
CAediting_589592ENST00000469560.1chr7_103312181_+-389.40-388.10-394.60
CAediting_589593ENST00000469560.1chr7_103312182_+-388.10-388.10-394.60

Top

Relation with ADAR for PMPCB

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

Top

Relation with cancer stages for PMPCB

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

Top

Relation with survival for PMPCB

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

Top

RelatedDrugs for PMPCB

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PMPCB

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
PMPCBC4693741MULTIPLE MITOCHONDRIAL DYSFUNCTIONS SYNDROME 61GENOMICS_ENGLAND;UNIPROT