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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: EPSTI1 (CAeditome ID:94240)

Gene summary for EPSTI1

check button Gene summary
Gene informationGene symbol

EPSTI1

Gene ID

94240

Gene nameepithelial stromal interaction 1
SynonymsBRESI1
Cytomap

13q14.11

Type of geneprotein-coding
Descriptionepithelial-stromal interaction protein 1epithelial stromal interaction 1 (breast)
Modification date20210518
UniProtAcc

Q96J88

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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RNA A-to-I events for EPSTI1

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000133106.13

check button RNA A-to-I editing events in Cancer.
CAediting_960778(42890292, -), CAediting_960779(42890367, -), CAediting_960780(42890370, -), CAediting_960781(42890394, -), CAediting_960782(42890430, -), CAediting_960783(42890436, -), CAediting_960784(42890462, -), CAediting_960785(42890493, -), CAediting_960786(42890503, -), CAediting_960787(42890609, -), CAediting_960788(42903507, -), CAediting_960789(42908301, -), CAediting_960790(42910335, -), CAediting_960791(42910390, -), CAediting_960792(42910399, -), CAediting_960793(42910400, -), CAediting_960794(42910410, -), CAediting_960795(42938061, -), CAediting_960796(42938081, -), CAediting_960797(42938082, -), CAediting_960798(42938083, -), CAediting_960799(42938256, -), CAediting_960800(42938257, -), CAediting_960801(42940712, -), CAediting_960802(42941576, -), CAediting_960803(42941589, -), CAediting_960804(42948574, -), CAediting_960805(42948575, -), CAediting_960806(42948597, -), CAediting_960807(42951002, -), CAediting_960808(42974217, -), CAediting_960809(42988476, -), CAediting_960810(42988565, -), CAediting_960811(42988568, -), CAediting_960812(42988574, -), CAediting_960813(42988601, -), CAediting_960814(42988607, -), CAediting_960815(42988609, -), CAediting_960816(42988612, -), CAediting_960817(42988619, -), CAediting_960818(42988648, -), CAediting_960819(42988649, -), CAediting_960820(42988671, -), CAediting_960821(42988674, -), CAediting_960822(42988679, -), CAediting_960823(42988690, -), CAediting_960824(42988723, -), CAediting_960825(42988727, -), CAediting_960826(42988729, -), CAediting_960827(42988898, -), CAediting_960828(42988917, -), CAediting_960829(42988936, -), CAediting_960830(42988938, -), CAediting_960831(42988953, -), CAediting_960832(42988958, -), CAediting_960833(42988976, -), CAediting_960834(42988984, -), CAediting_960835(42988989, -), CAediting_960836(42989006, -), CAediting_960837(42989016, -), CAediting_960838(42989024, -), CAediting_960839(42989033, -), CAediting_960840(42989034, -), CAediting_960841(42989035, -), CAediting_960842(42989112, -), CAediting_960843(42989116, -), CAediting_960844(42989134, -), CAediting_960845(42989651, -), CAediting_960846(42989722, -), CAediting_960847(42989732, -), CAediting_960848(42989758, -), CAediting_960849(42989798, -), CAediting_960850(42989822, -), CAediting_960851(42989865, -), CAediting_960852(42989866, -), CAediting_960853(42989874, -), CAediting_960854(42991414, -), CAediting_960855(42991424, -), CAediting_960856(42991451, -), CAediting_960857(42991478, -), CAediting_960858(42991479, -), CAediting_960859(42991488, -), CAediting_960860(42991489, -), CAediting_960861(42991498, -), CAediting_960862(42991502, -),

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RNA editing positional annotations for EPSTI1 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_960778chr13_42890292_-ncRNA_intronic
CAediting_960779chr13_42890367_-ncRNA_intronic
CAediting_960780chr13_42890370_-ncRNA_intronic
CAediting_960781chr13_42890394_-ncRNA_intronic
CAediting_960782chr13_42890430_-ncRNA_intronic
CAediting_960783chr13_42890436_-ncRNA_intronic
CAediting_960784chr13_42890462_-ncRNA_intronic
CAediting_960785chr13_42890493_-ncRNA_intronic
CAediting_960786chr13_42890503_-ncRNA_intronic
CAediting_960787chr13_42890609_-ncRNA_intronic
CAediting_960788chr13_42903507_-ncRNA_intronic
CAediting_960789chr13_42908301_-ncRNA_intronic
CAediting_960790chr13_42910335_-ncRNA_intronic
CAediting_960791chr13_42910390_-ncRNA_intronic
CAediting_960792chr13_42910399_-ncRNA_intronic
CAediting_960793chr13_42910400_-ncRNA_intronic
CAediting_960794chr13_42910410_-ncRNA_intronic
CAediting_960795chr13_42938061_-ncRNA_intronic
CAediting_960796chr13_42938081_-ncRNA_intronic
CAediting_960797chr13_42938082_-ncRNA_intronic
CAediting_960798chr13_42938083_-ncRNA_intronic
CAediting_960799chr13_42938256_-ncRNA_intronic
CAediting_960800chr13_42938257_-ncRNA_intronic
CAediting_960801chr13_42940712_-ncRNA_intronic
CAediting_960802chr13_42941576_-ncRNA_intronic
CAediting_960803chr13_42941589_-ncRNA_intronic
CAediting_960804chr13_42948574_-ncRNA_intronic
CAediting_960805chr13_42948575_-ncRNA_intronic
CAediting_960806chr13_42948597_-ncRNA_intronic
CAediting_960807chr13_42951002_-ncRNA_intronic
CAediting_960808chr13_42974217_-ncRNA_intronic
CAediting_960809chr13_42988476_-ncRNA_intronic
CAediting_960810chr13_42988565_-ncRNA_intronic
CAediting_960811chr13_42988568_-ncRNA_intronic
CAediting_960812chr13_42988574_-ncRNA_intronic
CAediting_960813chr13_42988601_-ncRNA_intronic
CAediting_960814chr13_42988607_-ncRNA_intronic
CAediting_960815chr13_42988609_-ncRNA_intronic
CAediting_960816chr13_42988612_-ncRNA_intronic
CAediting_960817chr13_42988619_-ncRNA_intronic
CAediting_960818chr13_42988648_-ncRNA_intronic
CAediting_960819chr13_42988649_-ncRNA_intronic
CAediting_960820chr13_42988671_-ncRNA_intronic
CAediting_960821chr13_42988674_-ncRNA_intronic
CAediting_960822chr13_42988679_-ncRNA_intronic
CAediting_960823chr13_42988690_-ncRNA_intronic
CAediting_960824chr13_42988723_-ncRNA_intronic
CAediting_960825chr13_42988727_-ncRNA_intronic
CAediting_960826chr13_42988729_-ncRNA_intronic
CAediting_960827chr13_42988898_-ncRNA_intronic
CAediting_960828chr13_42988917_-ncRNA_intronic
CAediting_960829chr13_42988936_-ncRNA_intronic
CAediting_960830chr13_42988938_-ncRNA_intronic
CAediting_960831chr13_42988953_-ncRNA_intronic
CAediting_960832chr13_42988958_-ncRNA_intronic
CAediting_960833chr13_42988976_-ncRNA_intronic
CAediting_960834chr13_42988984_-ncRNA_intronic
CAediting_960835chr13_42988989_-ncRNA_intronic
CAediting_960836chr13_42989006_-ncRNA_intronic
CAediting_960837chr13_42989016_-ncRNA_intronic
CAediting_960838chr13_42989024_-ncRNA_intronic
CAediting_960839chr13_42989033_-ncRNA_intronic
CAediting_960840chr13_42989034_-ncRNA_intronic
CAediting_960841chr13_42989035_-ncRNA_intronic
CAediting_960842chr13_42989112_-ncRNA_intronic
CAediting_960843chr13_42989116_-ncRNA_intronic
CAediting_960844chr13_42989134_-ncRNA_intronic
CAediting_960845chr13_42989651_-ncRNA_intronic
CAediting_960846chr13_42989722_-ncRNA_intronic
CAediting_960847chr13_42989732_-ncRNA_intronic
CAediting_960848chr13_42989758_-ncRNA_intronic
CAediting_960849chr13_42989798_-ncRNA_intronic
CAediting_960850chr13_42989822_-ncRNA_intronic
CAediting_960851chr13_42989865_-ncRNA_intronic
CAediting_960852chr13_42989866_-ncRNA_intronic
CAediting_960853chr13_42989874_-ncRNA_intronic
CAediting_960854chr13_42991414_-ncRNA_intronic
CAediting_960855chr13_42991424_-ncRNA_intronic
CAediting_960856chr13_42991451_-ncRNA_intronic
CAediting_960857chr13_42991478_-ncRNA_intronic
CAediting_960858chr13_42991479_-ncRNA_intronic
CAediting_960859chr13_42991488_-ncRNA_intronic
CAediting_960860chr13_42991489_-ncRNA_intronic
CAediting_960861chr13_42991498_-ncRNA_intronic
CAediting_960862chr13_42991502_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_960778chr13_42890292_-SINEAluAluY
CAediting_960779chr13_42890367_-SINEAluAluY
CAediting_960780chr13_42890370_-SINEAluAluY
CAediting_960781chr13_42890394_-SINEAluAluY
CAediting_960782chr13_42890430_-SINEAluAluY
CAediting_960783chr13_42890436_-SINEAluAluY
CAediting_960784chr13_42890462_-SINEAluAluY
CAediting_960785chr13_42890493_-SINEAluAluY
CAediting_960786chr13_42890503_-SINEAluAluY
CAediting_960788chr13_42903507_-LINEL1L1PA11
CAediting_960789chr13_42908301_-SINEAluAluSz6
CAediting_960790chr13_42910335_-SINEAluAluSq2
CAediting_960791chr13_42910390_-SINEAluAluSq2
CAediting_960792chr13_42910399_-SINEAluAluSq2
CAediting_960793chr13_42910400_-SINEAluAluSq2
CAediting_960794chr13_42910410_-SINEAluAluSq2
CAediting_960795chr13_42938061_-LINEL2L2
CAediting_960796chr13_42938081_-LINEL2L2
CAediting_960797chr13_42938082_-LINEL2L2
CAediting_960798chr13_42938083_-LINEL2L2
CAediting_960799chr13_42938256_-DNATcMar-TiggerTigger1
CAediting_960800chr13_42938257_-DNATcMar-TiggerTigger1
CAediting_960801chr13_42940712_-SINEAluAluJo
CAediting_960802chr13_42941576_-SINEAluAluJb
CAediting_960803chr13_42941589_-SINEAluAluJb
CAediting_960804chr13_42948574_-SINEAluAluJr
CAediting_960805chr13_42948575_-SINEAluAluJr
CAediting_960806chr13_42948597_-SINEAluAluJr
CAediting_960807chr13_42951002_-SINEAluAluSz
CAediting_960808chr13_42974217_-SINEAluAluSz
CAediting_960809chr13_42988476_-SINEAluAluSx4
CAediting_960810chr13_42988565_-SINEAluAluSx4
CAediting_960811chr13_42988568_-SINEAluAluSx4
CAediting_960812chr13_42988574_-SINEAluAluSx4
CAediting_960813chr13_42988601_-SINEAluAluSx4
CAediting_960814chr13_42988607_-SINEAluAluSx4
CAediting_960815chr13_42988609_-SINEAluAluSx4
CAediting_960816chr13_42988612_-SINEAluAluSx4
CAediting_960817chr13_42988619_-SINEAluAluSx4
CAediting_960818chr13_42988648_-SINEAluAluSx4
CAediting_960819chr13_42988649_-SINEAluAluSx4
CAediting_960820chr13_42988671_-SINEAluAluSx4
CAediting_960821chr13_42988674_-SINEAluAluSx4
CAediting_960822chr13_42988679_-SINEAluAluSx4
CAediting_960823chr13_42988690_-SINEAluAluSx4
CAediting_960824chr13_42988723_-SINEAluAluSx4
CAediting_960825chr13_42988727_-SINEAluAluSx4
CAediting_960826chr13_42988729_-SINEAluAluSx4
CAediting_960827chr13_42988898_-SINEAluAluJr4
CAediting_960828chr13_42988917_-SINEAluAluJr4
CAediting_960829chr13_42988936_-SINEAluAluJr4
CAediting_960830chr13_42988938_-SINEAluAluJr4
CAediting_960831chr13_42988953_-SINEAluAluJr4
CAediting_960832chr13_42988958_-SINEAluAluJr4
CAediting_960833chr13_42988976_-SINEAluAluJr4
CAediting_960834chr13_42988984_-SINEAluAluJr4
CAediting_960835chr13_42988989_-SINEAluAluJr4
CAediting_960836chr13_42989006_-SINEAluAluJr4
CAediting_960837chr13_42989016_-SINEAluAluJr4
CAediting_960838chr13_42989024_-SINEAluAluJr4
CAediting_960839chr13_42989033_-Simple_repeatSimple_repeat(T)n
CAediting_960840chr13_42989034_-Simple_repeatSimple_repeat(T)n
CAediting_960841chr13_42989035_-Simple_repeatSimple_repeat(T)n
CAediting_960842chr13_42989112_-SINEAluAluJr4
CAediting_960843chr13_42989116_-SINEAluAluJr4
CAediting_960844chr13_42989134_-SINEAluAluJr4
CAediting_960845chr13_42989651_-SINEAluAluY
CAediting_960846chr13_42989722_-SINEAluAluY
CAediting_960847chr13_42989732_-SINEAluAluY
CAediting_960848chr13_42989758_-SINEAluAluY
CAediting_960849chr13_42989798_-SINEAluAluY
CAediting_960850chr13_42989822_-SINEAluAluY
CAediting_960851chr13_42989865_-SINEAluAluY
CAediting_960852chr13_42989866_-SINEAluAluY
CAediting_960853chr13_42989874_-SINEAluAluY
CAediting_960854chr13_42991414_-SINEAluAluSx
CAediting_960855chr13_42991424_-SINEAluAluSx
CAediting_960856chr13_42991451_-SINEAluAluSx
CAediting_960857chr13_42991478_-SINEAluAluSx
CAediting_960858chr13_42991479_-SINEAluAluSx
CAediting_960859chr13_42991488_-SINEAluAluSx
CAediting_960860chr13_42991489_-SINEAluAluSx
CAediting_960861chr13_42991498_-SINEAluAluSx
CAediting_960862chr13_42991502_-SINEAluAluSx

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RNA A-to-I editing events in the alternative splicing sites for EPSTI1

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000133106.13.EPSTI1.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000133106.13.EPSTI1.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for EPSTI1

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for EPSTI1

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for EPSTI1

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000133106.13ENST00000313640hsa-miR-200b-3p42887447428874548mer-1a4288744742887468160-17.6
CAediting_393chr1_1167164_+ENSG00000133106.13ENST00000313624hsa-miR-200b-3p42887447428874548mer-1a4288744742887468160-17.6
CAediting_1229413chr17_67471544_+ENSG00000133106.13ENST00000313640hsa-miR-548aa42887218428872247mer-m84288721742887239151-11.14
CAediting_1229414chr17_67471546_+ENSG00000133106.13ENST00000313640hsa-miR-548aa42887851428878577mer-m84288785042887874150-10.86
CAediting_1229415chr17_67471547_+ENSG00000133106.13ENST00000313640hsa-miR-548aa42887668428876747mer-m84288766742887689147-12.55
CAediting_117844chr1_162342605_+ENSG00000133106.13ENST00000313640hsa-miR-556-3p42886443428864497mer-m84288644242886461145-9.41
CAediting_524911chr7_5495852_-ENSG00000133106.13ENST00000313640hsa-miR-589-3p42887704428877107mer-m84288770342887726150-14.66
CAediting_1229413chr17_67471544_+ENSG00000133106.13ENST00000313624hsa-miR-548aa42887218428872247mer-m84288721742887239151-11.14
CAediting_1229414chr17_67471546_+ENSG00000133106.13ENST00000313624hsa-miR-548aa42887851428878577mer-m84288785042887874150-10.86
CAediting_1229415chr17_67471547_+ENSG00000133106.13ENST00000313624hsa-miR-548aa42887668428876747mer-m84288766742887689147-12.55
CAediting_117844chr1_162342605_+ENSG00000133106.13ENST00000313624hsa-miR-556-3p42886443428864497mer-m84288644242886461145-9.41
CAediting_524911chr7_5495852_-ENSG00000133106.13ENST00000313624hsa-miR-589-3p42887704428877107mer-m84288770342887726150-14.66
CAediting_77128chr1_85133844_+ENSG00000133106.13ENST00000538562hsa-miR-4423-3p42969103429691086mer4296910242969122150-18.39
CAediting_468389chr6_31355314_-ENSG00000133106.13ENST00000313640hsa-miR-6891-5p42887209428872146mer4288720842887226144-21.91
CAediting_468389chr6_31355314_-ENSG00000133106.13ENST00000313624hsa-miR-6891-5p42887209428872146mer4288720842887226144-21.91

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_86358chr1_109598906_+ENSG00000133106.13ENST00000313640hsa-miR-197-5p42886837428868426mer4288683642886858144-33.55
CAediting_228905chr2_188297554_+ENSG00000133106.13ENST00000313640hsa-miR-561-3p42886450428864578mer-1a4288645042886471140-3.62
CAediting_86358chr1_109598906_+ENSG00000133106.13ENST00000313624hsa-miR-197-5p42886837428868426mer4288683642886858144-33.55
CAediting_228905chr2_188297554_+ENSG00000133106.13ENST00000313624hsa-miR-561-3p42886450428864578mer-1a4288645042886471140-3.62

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for EPSTI1

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for EPSTI1

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)

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Relation with cancer stages for EPSTI1

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for EPSTI1

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR
STADCAediting_960840chr13_42989034_-0.003010718435166650.04642387.8185

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RelatedDrugs for EPSTI1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for EPSTI1

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource