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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: SLC9A3R2 (CAeditome ID:9351)

Gene summary for SLC9A3R2

check button Gene summary
Gene informationGene symbol

SLC9A3R2

Gene ID

9351

Gene nameSLC9A3 regulator 2
SynonymsE3KARP|NHE3RF2|NHERF-2|NHERF2|OCTS2|SIP-1|SIP1|TKA-1
Cytomap

16p13.3

Type of geneprotein-coding
DescriptionNa(+)/H(+) exchange regulatory cofactor NHE-RF2NHE3 kinase A regulatory protein E3KARPNHE3 regulatory factor 2SRY-interacting protein 1sodium/hydrogen exchanger 3 kinase A regulatory proteinsolute carrier family 9 (sodium/hydrogen exchanger), member
Modification date20210518
UniProtAcc

Q15599

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
SLC9A3R2

GO:0005886

Na(+)/H(+) exchange regulatory cofactor NHE-RF2

11786550


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RNA A-to-I events for SLC9A3R2

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000065054.12

check button RNA A-to-I editing events in Cancer.
CAediting_1079539(2030675, +), CAediting_1079540(2030684, +), CAediting_1079541(2030700, +), CAediting_1079542(2030719, +), CAediting_1079543(2030729, +), CAediting_1079544(2030739, +), CAediting_1079545(2030744, +), CAediting_1079546(2030762, +), CAediting_1079547(2030763, +), CAediting_1079548(2030764, +), CAediting_1079549(2030776, +), CAediting_1079550(2030779, +), CAediting_1079551(2030781, +), CAediting_1079552(2030782, +), CAediting_1079553(2030783, +), CAediting_1079554(2030788, +), CAediting_1079555(2030789, +), CAediting_1079556(2030790, +), CAediting_1079557(2030791, +), CAediting_1079558(2030794, +), CAediting_1079559(2030802, +), CAediting_1079560(2030812, +), CAediting_1079561(2030820, +), CAediting_1079562(2030826, +), CAediting_1079563(2030830, +), CAediting_1079564(2030843, +), CAediting_1079565(2030847, +), CAediting_1079566(2030861, +), CAediting_1079567(2030862, +), CAediting_1079568(2030886, +), CAediting_1079569(2030891, +), CAediting_1079570(2030906, +), CAediting_1079571(2031766, +), CAediting_1079572(2031772, +), CAediting_1079573(2031791, +), CAediting_1079574(2031792, +), CAediting_1079575(2031796, +), CAediting_1079576(2031818, +), CAediting_1079577(2031821, +), CAediting_1079578(2031831, +), CAediting_1079579(2031833, +), CAediting_1079580(2031849, +), CAediting_1079581(2031857, +), CAediting_1079582(2031875, +), CAediting_1079583(2031879, +), CAediting_1079584(2031889, +), CAediting_1079585(2031901, +), CAediting_1079586(2031921, +), CAediting_1079587(2031926, +), CAediting_1079588(2031954, +), CAediting_1079589(2031966, +), CAediting_1079590(2031968, +), CAediting_1079591(2032063, +), CAediting_1079592(2032094, +), CAediting_1079593(2032100, +), CAediting_1079594(2032119, +), CAediting_1079595(2032120, +), CAediting_1079596(2032137, +), CAediting_1079597(2032149, +), CAediting_1079598(2032159, +), CAediting_1079599(2032161, +), CAediting_1079600(2032169, +), CAediting_1079601(2032185, +), CAediting_1079602(2032203, +), CAediting_1079603(2032209, +), CAediting_1079604(2032254, +), CAediting_1079605(2032255, +), CAediting_1079606(2032272, +), CAediting_1079607(2032280, +), CAediting_1079608(2032294, +), CAediting_1079609(2032303, +), CAediting_1079610(2032911, +), CAediting_1079611(2036157, +), CAediting_1079612(2037785, +),

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RNA editing positional annotations for SLC9A3R2 using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_1079539chr16_2030675_+intronic
CAediting_1079540chr16_2030684_+intronic
CAediting_1079541chr16_2030700_+intronic
CAediting_1079542chr16_2030719_+intronic
CAediting_1079543chr16_2030729_+intronic
CAediting_1079544chr16_2030739_+intronic
CAediting_1079545chr16_2030744_+intronic
CAediting_1079546chr16_2030762_+intronic
CAediting_1079547chr16_2030763_+intronic
CAediting_1079548chr16_2030764_+intronic
CAediting_1079549chr16_2030776_+intronic
CAediting_1079550chr16_2030779_+intronic
CAediting_1079551chr16_2030781_+intronic
CAediting_1079552chr16_2030782_+intronic
CAediting_1079553chr16_2030783_+intronic
CAediting_1079554chr16_2030788_+intronic
CAediting_1079555chr16_2030789_+intronic
CAediting_1079556chr16_2030790_+intronic
CAediting_1079557chr16_2030791_+intronic
CAediting_1079558chr16_2030794_+intronic
CAediting_1079559chr16_2030802_+intronic
CAediting_1079560chr16_2030812_+intronic
CAediting_1079561chr16_2030820_+intronic
CAediting_1079562chr16_2030826_+intronic
CAediting_1079563chr16_2030830_+intronic
CAediting_1079564chr16_2030843_+intronic
CAediting_1079565chr16_2030847_+intronic
CAediting_1079566chr16_2030861_+intronic
CAediting_1079567chr16_2030862_+intronic
CAediting_1079568chr16_2030886_+intronic
CAediting_1079569chr16_2030891_+intronic
CAediting_1079570chr16_2030906_+intronic
CAediting_1079571chr16_2031766_+intronic
CAediting_1079572chr16_2031772_+intronic
CAediting_1079573chr16_2031791_+intronic
CAediting_1079574chr16_2031792_+intronic
CAediting_1079575chr16_2031796_+intronic
CAediting_1079576chr16_2031818_+intronic
CAediting_1079577chr16_2031821_+intronic
CAediting_1079578chr16_2031831_+intronic
CAediting_1079579chr16_2031833_+intronic
CAediting_1079580chr16_2031849_+intronic
CAediting_1079581chr16_2031857_+intronic
CAediting_1079582chr16_2031875_+intronic
CAediting_1079583chr16_2031879_+intronic
CAediting_1079584chr16_2031889_+intronic
CAediting_1079585chr16_2031901_+intronic
CAediting_1079586chr16_2031921_+intronic
CAediting_1079587chr16_2031926_+intronic
CAediting_1079588chr16_2031954_+intronic
CAediting_1079589chr16_2031966_+intronic
CAediting_1079590chr16_2031968_+intronic
CAediting_1079591chr16_2032063_+intronic
CAediting_1079592chr16_2032094_+intronic
CAediting_1079593chr16_2032100_+intronic
CAediting_1079594chr16_2032119_+intronic
CAediting_1079595chr16_2032120_+intronic
CAediting_1079596chr16_2032137_+intronic
CAediting_1079597chr16_2032149_+intronic
CAediting_1079598chr16_2032159_+intronic
CAediting_1079599chr16_2032161_+intronic
CAediting_1079600chr16_2032169_+intronic
CAediting_1079601chr16_2032185_+intronic
CAediting_1079602chr16_2032203_+intronic
CAediting_1079603chr16_2032209_+intronic
CAediting_1079604chr16_2032254_+intronic
CAediting_1079605chr16_2032255_+intronic
CAediting_1079606chr16_2032272_+intronic
CAediting_1079607chr16_2032280_+intronic
CAediting_1079608chr16_2032294_+intronic
CAediting_1079609chr16_2032303_+intronic
CAediting_1079610chr16_2032911_+ncRNA_exonic
CAediting_1079611chr16_2036157_+ncRNA_exonic
CAediting_1079612chr16_2037785_+exonic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_1079539chr16_2030675_+SINEAluAluSx
CAediting_1079540chr16_2030684_+SINEAluAluSx
CAediting_1079541chr16_2030700_+SINEAluAluSx
CAediting_1079542chr16_2030719_+SINEAluAluSx
CAediting_1079543chr16_2030729_+SINEAluAluSx
CAediting_1079544chr16_2030739_+SINEAluAluSx
CAediting_1079545chr16_2030744_+SINEAluAluSx
CAediting_1079546chr16_2030762_+SINEAluAluSx
CAediting_1079547chr16_2030763_+SINEAluAluSx
CAediting_1079548chr16_2030764_+SINEAluAluSx
CAediting_1079549chr16_2030776_+SINEAluAluSx
CAediting_1079550chr16_2030779_+SINEAluAluSx
CAediting_1079551chr16_2030781_+SINEAluAluSx
CAediting_1079552chr16_2030782_+SINEAluAluSx
CAediting_1079553chr16_2030783_+SINEAluAluSx
CAediting_1079554chr16_2030788_+SINEAluAluSx
CAediting_1079555chr16_2030789_+SINEAluAluSx
CAediting_1079556chr16_2030790_+SINEAluAluSx
CAediting_1079557chr16_2030791_+SINEAluAluSx
CAediting_1079558chr16_2030794_+SINEAluAluSx
CAediting_1079559chr16_2030802_+SINEAluAluSx
CAediting_1079560chr16_2030812_+SINEAluAluSx
CAediting_1079561chr16_2030820_+SINEAluAluSx
CAediting_1079562chr16_2030826_+SINEAluAluSx
CAediting_1079563chr16_2030830_+SINEAluAluSx
CAediting_1079564chr16_2030843_+SINEAluAluSx
CAediting_1079565chr16_2030847_+SINEAluAluSx
CAediting_1079566chr16_2030861_+SINEAluAluSx
CAediting_1079567chr16_2030862_+SINEAluAluSx
CAediting_1079568chr16_2030886_+SINEAluAluSx
CAediting_1079569chr16_2030891_+SINEAluAluSx
CAediting_1079570chr16_2030906_+SINEAluAluSx
CAediting_1079571chr16_2031766_+SINEAluAluSx
CAediting_1079572chr16_2031772_+SINEAluAluSx
CAediting_1079573chr16_2031791_+SINEAluAluSx
CAediting_1079574chr16_2031792_+SINEAluAluSx
CAediting_1079575chr16_2031796_+SINEAluAluSx
CAediting_1079576chr16_2031818_+SINEAluAluSx
CAediting_1079577chr16_2031821_+SINEAluAluSx
CAediting_1079578chr16_2031831_+SINEAluAluSx
CAediting_1079579chr16_2031833_+SINEAluAluSx
CAediting_1079580chr16_2031849_+SINEAluAluSx
CAediting_1079581chr16_2031857_+SINEAluAluSx
CAediting_1079582chr16_2031875_+SINEAluAluSx
CAediting_1079583chr16_2031879_+SINEAluAluSx
CAediting_1079584chr16_2031889_+SINEAluAluSx
CAediting_1079585chr16_2031901_+SINEAluAluSx
CAediting_1079586chr16_2031921_+SINEAluAluSx
CAediting_1079587chr16_2031926_+SINEAluAluSx
CAediting_1079588chr16_2031954_+SINEAluAluSx
CAediting_1079589chr16_2031966_+SINEAluAluSx
CAediting_1079590chr16_2031968_+SINEAluAluSx
CAediting_1079591chr16_2032063_+SINEAluAluSz
CAediting_1079592chr16_2032094_+SINEAluAluSz
CAediting_1079593chr16_2032100_+SINEAluAluSz
CAediting_1079594chr16_2032119_+SINEAluAluSz
CAediting_1079595chr16_2032120_+SINEAluAluSz
CAediting_1079596chr16_2032137_+SINEAluAluSz
CAediting_1079597chr16_2032149_+SINEAluAluSz
CAediting_1079598chr16_2032159_+SINEAluAluSz
CAediting_1079599chr16_2032161_+SINEAluAluSz
CAediting_1079600chr16_2032169_+SINEAluAluSz
CAediting_1079601chr16_2032185_+SINEAluAluSz
CAediting_1079602chr16_2032203_+SINEAluAluSz
CAediting_1079603chr16_2032209_+SINEAluAluSz
CAediting_1079604chr16_2032254_+SINEAluAluSz
CAediting_1079605chr16_2032255_+SINEAluAluSz
CAediting_1079606chr16_2032272_+SINEAluAluSz
CAediting_1079607chr16_2032280_+SINEAluAluSz
CAediting_1079608chr16_2032294_+SINEAluAluSz
CAediting_1079609chr16_2032303_+SINEAluAluSz

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RNA A-to-I editing events in the alternative splicing sites for SLC9A3R2

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000065054.12.SLC9A3R2.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000065054.12.SLC9A3R2.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for SLC9A3R2

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for SLC9A3R2

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for SLC9A3R2

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_980496chr14_31014685_-ENSG00000065054.12ENST00000424542hsa-miR-624-3p203868720386937mer-m820386732038694152-22.07
CAediting_980496chr14_31014685_-ENSG00000065054.12ENST00000424542hsa-miR-624-3p203889720389037mer-m820388842038904143-13.59
CAediting_1054808chr15_66496985_-ENSG00000065054.12ENST00000424542hsa-miR-4512203874420387518mer-1a20387292038751147-26.63
CAediting_1054808chr15_66496985_-ENSG00000065054.12ENST00000424542hsa-miR-4512203877920387857mer-m820387632038786151-28.23
CAediting_1368054chr19_46709310_-ENSG00000065054.12ENST00000424542hsa-miR-320e203836520383717mer-m820383552038372141-13.52
CAediting_580943chr7_100356700_+ENSG00000065054.12ENST00000424542hsa-miR-6840-3p203892020389267mer-m820389052038927147-32.33
CAediting_524911chr7_5495852_-ENSG00000065054.12ENST00000424542hsa-miR-589-3p203830220383087mer-m820382832038309152-21.59
CAediting_1368054chr19_46709310_-ENSG00000065054.12ENST00000432365hsa-miR-320e203836520383717mer-m820383552038372141-13.52
CAediting_524911chr7_5495852_-ENSG00000065054.12ENST00000432365hsa-miR-589-3p203830220383087mer-m820382832038309152-21.59
CAediting_1368054chr19_46709310_-ENSG00000065054.12ENST00000566198hsa-miR-320e203836520383717mer-m820383552038372141-13.52
CAediting_524911chr7_5495852_-ENSG00000065054.12ENST00000566198hsa-miR-589-3p203830220383087mer-m820382832038309152-21.59

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_1054808chr15_66496985_-ENSG00000065054.12ENST00000424542hsa-miR-4512203901120390177mer-m820389992039018146-20.01

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for SLC9A3R2

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for SLC9A3R2

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
BRCACAediting_1079539chr16_2030675_+0.01621280371015610.278654042510205....
BRCACAediting_1079574chr16_2031792_+4.22024232013253e-060.412417474914303....

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Relation with cancer stages for SLC9A3R2

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.

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Relation with survival for SLC9A3R2

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for SLC9A3R2

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SLC9A3R2

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource
SLC9A3R2C0020538Hypertensive disease1CTD_human