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Center for Computational Systems Medicine
Soverview

Gene summary

Soverview

RNA A-to-I events

Soverview

Differntial gene expression between RNA A-to-I edited tumor samples versus normal samples

Soverview

Protein coding region RNA A-to-I editings

Soverview

The effects of the RNA editing to the miRNA binding sites

Soverview

The effects of the RNA editing to the stability of the RNA structures

Soverview

Relation with ADAR

Soverview

Relation with cancer stages

Soverview

Relation with survival state

Soverview

Related drugs with this gene

Soverview

Related diseases with this gene

Editing gene: HNRNPLL (CAeditome ID:92906)

Gene summary for HNRNPLL

check button Gene summary
Gene informationGene symbol

HNRNPLL

Gene ID

92906

Gene nameheterogeneous nuclear ribonucleoprotein L like
SynonymsHNRPLL|SRRF
Cytomap

2p22.1

Type of geneprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein L-likestromal RNA regulating factor
Modification date20210518
UniProtAcc

Q8WVV9

Context

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
HNRNPLL

GO:0003729

Heterogeneous nuclear ribonucleoprotein L-like

18669861

HNRNPLL

GO:0033120

Heterogeneous nuclear ribonucleoprotein L-like

18669861


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RNA A-to-I events for HNRNPLL

check buttonRNA A-to-I editing events across TCGA 33 cancers data sets based on Ensembl gene isoform structure.
all structure

check button RNA editing frequencies across 33 cancers of gene: ENSG00000143889.14
boxplot

check button RNA A-to-I editing events in Cancer.
CAediting_171495(38564394, -), CAediting_171496(38564428, -), CAediting_171497(38564432, -), CAediting_171498(38564435, -), CAediting_171499(38564440, -), CAediting_171500(38564496, -), CAediting_171501(38564498, -), CAediting_171502(38564520, -), CAediting_171503(38564574, -), CAediting_171504(38564600, -), CAediting_171505(38564612, -), CAediting_171506(38565488, -), CAediting_171507(38565517, -), CAediting_171508(38565646, -), CAediting_171509(38565695, -), CAediting_171510(38566110, -), CAediting_171511(38566112, -), CAediting_171512(38566125, -), CAediting_171513(38566139, -), CAediting_171514(38566163, -), CAediting_171515(38566176, -), CAediting_171516(38566185, -), CAediting_171517(38566188, -), CAediting_171518(38566256, -), CAediting_171519(38566268, -), CAediting_171520(38566285, -), CAediting_171521(38566299, -), CAediting_171522(38566305, -), CAediting_171523(38566306, -), CAediting_171524(38566321, -), CAediting_171525(38566324, -), CAediting_171526(38566335, -), CAediting_171527(38566365, -), CAediting_171528(38566733, -), CAediting_171529(38566772, -), CAediting_171530(38566804, -), CAediting_171531(38566812, -), CAediting_171532(38567111, -), CAediting_171533(38567137, -), CAediting_171534(38567166, -), CAediting_171535(38567169, -), CAediting_171536(38567171, -), CAediting_171537(38567176, -), CAediting_171538(38567180, -), CAediting_171539(38567187, -), CAediting_171540(38567199, -), CAediting_171541(38567200, -), CAediting_171542(38567208, -), CAediting_171543(38567209, -), CAediting_171544(38567214, -), CAediting_171545(38567218, -), CAediting_171546(38567231, -), CAediting_171547(38567241, -), CAediting_171548(38567251, -), CAediting_171549(38567266, -), CAediting_171550(38567267, -), CAediting_171551(38567293, -), CAediting_171552(38567298, -), CAediting_171553(38567309, -), CAediting_171554(38567310, -), CAediting_171555(38567319, -), CAediting_171556(38567320, -), CAediting_171557(38567329, -), CAediting_171558(38567332, -), CAediting_171559(38567343, -), CAediting_171560(38567348, -), CAediting_171561(38567388, -), CAediting_171562(38567389, -), CAediting_171563(38567397, -), CAediting_171564(38582475, -), CAediting_171565(38582478, -), CAediting_171566(38582486, -), CAediting_171567(38582489, -), CAediting_171568(38582490, -), CAediting_171569(38582491, -), CAediting_171570(38582494, -), CAediting_171571(38582505, -), CAediting_171572(38582538, -), CAediting_171573(38582591, -), CAediting_171574(38582685, -), CAediting_171575(38582820, -), CAediting_171576(38582874, -), CAediting_171577(38590961, -), CAediting_171578(38595082, -), CAediting_171579(38595268, -), CAediting_171580(38596537, -), CAediting_171581(38597788, -), CAediting_171582(38597799, -), CAediting_171583(38597816, -), CAediting_171584(38597820, -), CAediting_171585(38597826, -), CAediting_171586(38600482, -), CAediting_171587(38600484, -), CAediting_171588(38600638, -), CAediting_171589(38600738, -),

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RNA editing positional annotations for HNRNPLL using Annovar

check button Protein coding RNA editing(s).
CAeditome IDPositionVariant typeENSTNTchangeAAchangeSIFT_scorePolyphen2_HVAR_scorePROVEAN_pred

check button Gene structure information of RNA editing(s).
CAeditome IDPositionVariant type
CAediting_171495chr2_38564394_-intronic
CAediting_171496chr2_38564428_-intronic
CAediting_171497chr2_38564432_-intronic
CAediting_171498chr2_38564435_-intronic
CAediting_171499chr2_38564440_-intronic
CAediting_171500chr2_38564496_-intronic
CAediting_171501chr2_38564498_-intronic
CAediting_171502chr2_38564520_-intronic
CAediting_171503chr2_38564574_-intronic
CAediting_171504chr2_38564600_-intronic
CAediting_171505chr2_38564612_-intronic
CAediting_171506chr2_38565488_-intronic
CAediting_171507chr2_38565517_-intronic
CAediting_171508chr2_38565646_-intronic
CAediting_171509chr2_38565695_-intronic
CAediting_171510chr2_38566110_-intronic
CAediting_171511chr2_38566112_-intronic
CAediting_171512chr2_38566125_-intronic
CAediting_171513chr2_38566139_-intronic
CAediting_171514chr2_38566163_-intronic
CAediting_171515chr2_38566176_-intronic
CAediting_171516chr2_38566185_-intronic
CAediting_171517chr2_38566188_-intronic
CAediting_171518chr2_38566256_-intronic
CAediting_171519chr2_38566268_-intronic
CAediting_171520chr2_38566285_-intronic
CAediting_171521chr2_38566299_-intronic
CAediting_171522chr2_38566305_-intronic
CAediting_171523chr2_38566306_-intronic
CAediting_171524chr2_38566321_-intronic
CAediting_171525chr2_38566324_-intronic
CAediting_171526chr2_38566335_-intronic
CAediting_171527chr2_38566365_-intronic
CAediting_171528chr2_38566733_-intronic
CAediting_171529chr2_38566772_-intronic
CAediting_171530chr2_38566804_-intronic
CAediting_171531chr2_38566812_-intronic
CAediting_171532chr2_38567111_-intronic
CAediting_171533chr2_38567137_-intronic
CAediting_171534chr2_38567166_-intronic
CAediting_171535chr2_38567169_-intronic
CAediting_171536chr2_38567171_-intronic
CAediting_171537chr2_38567176_-intronic
CAediting_171538chr2_38567180_-intronic
CAediting_171539chr2_38567187_-intronic
CAediting_171540chr2_38567199_-intronic
CAediting_171541chr2_38567200_-intronic
CAediting_171542chr2_38567208_-intronic
CAediting_171543chr2_38567209_-intronic
CAediting_171544chr2_38567214_-intronic
CAediting_171545chr2_38567218_-intronic
CAediting_171546chr2_38567231_-intronic
CAediting_171547chr2_38567241_-intronic
CAediting_171548chr2_38567251_-intronic
CAediting_171549chr2_38567266_-intronic
CAediting_171550chr2_38567267_-intronic
CAediting_171551chr2_38567293_-intronic
CAediting_171552chr2_38567298_-intronic
CAediting_171553chr2_38567309_-intronic
CAediting_171554chr2_38567310_-intronic
CAediting_171555chr2_38567319_-intronic
CAediting_171556chr2_38567320_-intronic
CAediting_171557chr2_38567329_-intronic
CAediting_171558chr2_38567332_-intronic
CAediting_171559chr2_38567343_-intronic
CAediting_171560chr2_38567348_-intronic
CAediting_171561chr2_38567388_-intronic
CAediting_171562chr2_38567389_-intronic
CAediting_171563chr2_38567397_-intronic
CAediting_171564chr2_38582475_-ncRNA_intronic
CAediting_171565chr2_38582478_-ncRNA_intronic
CAediting_171566chr2_38582486_-ncRNA_intronic
CAediting_171567chr2_38582489_-ncRNA_intronic
CAediting_171568chr2_38582490_-ncRNA_intronic
CAediting_171569chr2_38582491_-ncRNA_intronic
CAediting_171570chr2_38582494_-ncRNA_intronic
CAediting_171571chr2_38582505_-ncRNA_intronic
CAediting_171572chr2_38582538_-ncRNA_intronic
CAediting_171573chr2_38582591_-ncRNA_intronic
CAediting_171574chr2_38582685_-ncRNA_intronic
CAediting_171575chr2_38582820_-ncRNA_intronic
CAediting_171576chr2_38582874_-ncRNA_intronic
CAediting_171577chr2_38590961_-intronic
CAediting_171578chr2_38595082_-ncRNA_intronic
CAediting_171579chr2_38595268_-ncRNA_intronic
CAediting_171580chr2_38596537_-ncRNA_intronic
CAediting_171581chr2_38597788_-ncRNA_intronic
CAediting_171582chr2_38597799_-ncRNA_intronic
CAediting_171583chr2_38597816_-ncRNA_intronic
CAediting_171584chr2_38597820_-ncRNA_intronic
CAediting_171585chr2_38597826_-ncRNA_intronic
CAediting_171586chr2_38600482_-ncRNA_intronic
CAediting_171587chr2_38600484_-ncRNA_intronic
CAediting_171588chr2_38600638_-ncRNA_intronic
CAediting_171589chr2_38600738_-ncRNA_intronic

check button Repat-regional RNA editing(s).
CAeditome IDPositionRepeat familyRepeat sub familyRepeat name
CAediting_171495chr2_38564394_-SINEAluAluSx
CAediting_171496chr2_38564428_-SINEAluAluSx
CAediting_171497chr2_38564432_-SINEAluAluSx
CAediting_171498chr2_38564435_-SINEAluAluSx
CAediting_171499chr2_38564440_-SINEAluAluSx
CAediting_171500chr2_38564496_-SINEAluAluSx
CAediting_171501chr2_38564498_-SINEAluAluSx
CAediting_171502chr2_38564520_-SINEAluAluSx
CAediting_171503chr2_38564574_-SINEAluAluSx
CAediting_171504chr2_38564600_-SINEAluAluSx
CAediting_171505chr2_38564612_-SINEAluAluSx
CAediting_171506chr2_38565488_-SINEAluAluJr
CAediting_171507chr2_38565517_-SINEAluAluJr
CAediting_171508chr2_38565646_-SINEAluAluJr
CAediting_171509chr2_38565695_-SINEAluAluJr
CAediting_171510chr2_38566110_-SINEAluAluSx1
CAediting_171511chr2_38566112_-SINEAluAluSx1
CAediting_171512chr2_38566125_-SINEAluAluSx1
CAediting_171513chr2_38566139_-SINEAluAluSx1
CAediting_171514chr2_38566163_-SINEAluAluSx1
CAediting_171515chr2_38566176_-SINEAluAluSx1
CAediting_171516chr2_38566185_-SINEAluAluSx1
CAediting_171517chr2_38566188_-SINEAluAluSx1
CAediting_171518chr2_38566256_-SINEAluAluSx1
CAediting_171519chr2_38566268_-SINEAluAluSx1
CAediting_171520chr2_38566285_-SINEAluAluSx1
CAediting_171521chr2_38566299_-SINEAluAluSx1
CAediting_171522chr2_38566305_-SINEAluAluSx1
CAediting_171523chr2_38566306_-SINEAluAluSx1
CAediting_171524chr2_38566321_-SINEAluAluSx1
CAediting_171525chr2_38566324_-SINEAluAluSx1
CAediting_171526chr2_38566335_-SINEAluAluSx1
CAediting_171527chr2_38566365_-SINEAluAluSx1
CAediting_171528chr2_38566733_-SINEAluFLAM_C
CAediting_171529chr2_38566772_-SINEAluFLAM_C
CAediting_171530chr2_38566804_-SINEAluFLAM_C
CAediting_171531chr2_38566812_-SINEAluFLAM_C
CAediting_171532chr2_38567111_-SINEAluAluSx
CAediting_171533chr2_38567137_-SINEAluAluSx
CAediting_171534chr2_38567166_-SINEAluAluSx
CAediting_171535chr2_38567169_-SINEAluAluSx
CAediting_171536chr2_38567171_-SINEAluAluSx
CAediting_171537chr2_38567176_-SINEAluAluSx
CAediting_171538chr2_38567180_-SINEAluAluSx
CAediting_171539chr2_38567187_-SINEAluAluSx
CAediting_171540chr2_38567199_-SINEAluAluSx
CAediting_171541chr2_38567200_-SINEAluAluSx
CAediting_171542chr2_38567208_-SINEAluAluSx
CAediting_171543chr2_38567209_-SINEAluAluSx
CAediting_171544chr2_38567214_-SINEAluAluSx
CAediting_171545chr2_38567218_-SINEAluAluSx
CAediting_171546chr2_38567231_-SINEAluAluSx
CAediting_171547chr2_38567241_-SINEAluAluSx
CAediting_171548chr2_38567251_-SINEAluAluSx
CAediting_171549chr2_38567266_-SINEAluAluSx
CAediting_171550chr2_38567267_-SINEAluAluSx
CAediting_171551chr2_38567293_-SINEAluAluSx
CAediting_171552chr2_38567298_-SINEAluAluSx
CAediting_171553chr2_38567309_-SINEAluAluSx
CAediting_171554chr2_38567310_-SINEAluAluSx
CAediting_171555chr2_38567319_-SINEAluAluSx
CAediting_171556chr2_38567320_-SINEAluAluSx
CAediting_171557chr2_38567329_-SINEAluAluSx
CAediting_171558chr2_38567332_-SINEAluAluSx
CAediting_171559chr2_38567343_-SINEAluAluSx
CAediting_171560chr2_38567348_-SINEAluAluSx
CAediting_171561chr2_38567388_-SINEAluAluSx
CAediting_171562chr2_38567389_-SINEAluAluSx
CAediting_171563chr2_38567397_-SINEAluAluSx
CAediting_171564chr2_38582475_-SINEAluAluSc
CAediting_171565chr2_38582478_-SINEAluAluSc
CAediting_171566chr2_38582486_-SINEAluAluSc
CAediting_171567chr2_38582489_-SINEAluAluSc
CAediting_171568chr2_38582490_-SINEAluAluSc
CAediting_171569chr2_38582491_-SINEAluAluSc
CAediting_171570chr2_38582494_-SINEAluAluSc
CAediting_171571chr2_38582505_-SINEAluAluSc
CAediting_171572chr2_38582538_-SINEAluAluSc
CAediting_171573chr2_38582591_-SINEAluAluSc
CAediting_171574chr2_38582685_-SINEAluAluSx1
CAediting_171575chr2_38582820_-SINEAluAluSx1
CAediting_171577chr2_38590961_-SINEAluAluJr
CAediting_171578chr2_38595082_-SINEAluAluSx3
CAediting_171579chr2_38595268_-SINEAluAluSx3
CAediting_171580chr2_38596537_-SINEAluAluSz
CAediting_171581chr2_38597788_-SINEAluAluSg7
CAediting_171582chr2_38597799_-SINEAluAluSg7
CAediting_171583chr2_38597816_-SINEAluAluSg7
CAediting_171584chr2_38597820_-SINEAluAluSg7
CAediting_171585chr2_38597826_-SINEAluAluSg7
CAediting_171586chr2_38600482_-SINEAluAluJb
CAediting_171587chr2_38600484_-SINEAluAluJb
CAediting_171588chr2_38600638_-SINEAluAluJb
CAediting_171589chr2_38600738_-SINEAluAluJb

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RNA A-to-I editing events in the alternative splicing sites for HNRNPLL

check button RNA A-to-I editing(s) in the alternative splicing sites.
AStypeCAeditomIDEditing positionAS positionAS directionExonic locationWildtype sequenceWildtype splicing strengthRNA edited sequenceRNA edited splicing strength
ESCAediting_171510chr2_38566110_-38566102:385661105SS3+0iAGGCGTGAG-23.07GGGCGTGAG-26.92
IRCAediting_171510chr2_38566110_-38566102:385661105SS3+0iAGGCGTGAG-23.07GGGCGTGAG-26.92
MEX_2CAediting_171510chr2_38566110_-38566102:385661105SS3+0iAGGCGTGAG-23.07GGGCGTGAG-26.92

check button Differential percent of spliced in (PSI) between RNA A-to-I edited and non-edited samples for ENSG00000143889.14.HNRNPLL.

check button Correlation between RNA A-to-I editing and PSI for ENSG00000143889.14.HNRNPLL.

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Differntial gene expression between RNA A-to-I edited versus non-edited samples for HNRNPLL

check button Differential gene expressions between RNA A-to-I edited and non-edited tumor samples.
* The grey color means N/A.
boxplot

check button Correlation between RNA A-to-I editing and gene expression.
boxplot

check button - Differentially expressed gene between RNA A-to-I edited samples versus non-edited samples.
* Click on the image to enlarge it in a new window.

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Protein coding region RNA A-to-I editings for HNRNPLL

check button- Lollipop plot for RNA A-to-I editings across protein structure.
* Click on the image to enlarge it in a new window.


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The effects of the RNA editing to the miRNA binding sites for HNRNPLL

**If you are searching a miRNA gene with RNA editing events in its seed regions, please see the search pages of miRNA targets to discover the effects of this RNA editing event to miRNA regulations. For more information, please check the files in the Download page.

check button RNA A-to-I editing in the 3'-UTR regions of mRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in the 3'-UTR regions of mRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA gained miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in lncRNA lost miRNA binding sites.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs lost binding to lncRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy

check button RNA A-to-I editing in miRNAs gained binding to the 3'-UTR region of mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000143889.14ENST00000409636hsa-miR-200b-3p38562751385627577mer-m83856275038562774141-12.16
CAediting_77128chr1_85133844_+ENSG00000143889.14ENST00000410076hsa-miR-4423-3p38581330385813367mer-m83858132938581349140-14.29
CAediting_442554chr5_154685830_+ENSG00000143889.14ENST00000410076hsa-miR-130338581647385816537mer-m83858164638581671149-20.87
CAediting_468389chr6_31355314_-ENSG00000143889.14ENST00000409636hsa-miR-6891-5p38562477385624837mer-m83856247638562496152-24.01

check button RNA A-to-I editing in miRNAs lost binding to the 3'-UTR mRNA.
CAeditom_IDPositionENSGENSTmiRNATargetscan startTargetscan endTargetscan scoreMiranda startMiranda endMiranda scoreMiranda energy
CAediting_393chr1_1167164_+ENSG00000143889.14ENST00000409636hsa-miR-200b-3p38563456385634616mer3856345538563475141-11.01
CAediting_524911chr7_5495852_-ENSG00000143889.14ENST00000409636hsa-miR-589-3p38564059385640657mer-m83856405838564081140-10.28
CAediting_1160181chr17_7017644_-ENSG00000143889.14ENST00000272249hsa-miR-195-3p38564009385640168mer-1a3856400938564031148-8.29

check button Differentially expressed gene-miRNA network

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The effects of the RNA editing to the stability of the RNA structures for HNRNPLL

check button - RNA A-to-I editing in mRNA.
* Click on the image to enlarge it in a new window.
ENSTENST typeRNA structure without RNA A-to-I editing.RNA structure with RNA A-to-I editing.

check button RNA A-to-I editing in RNA structures for Minimum free energy (MFE).
CAeditom_IDENSTEditing_PositionMFE_withoneAIMFE_withoutAIMFE_withmultipleAI

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Relation with ADAR for HNRNPLL

check button Correlation between ADAR gene expression and RNA editing frequency
CancerCAeditomIDpositionADAR1 (p-val)ADAR1 (coeff.)ADAR2 (p-val)ADAR2 (coeff.)ADAR3 (p-val)ADAR3 (coeff.)
STADCAediting_171515chr2_38566176_-..8.55749886163225e-050.485101352237318..
OVCAediting_171515chr2_38566176_-..0.01729448801709370.257629170142327..
LUADCAediting_171516chr2_38566185_-0.008284048915806070.313228278505714....
SKCMCAediting_171516chr2_38566185_-0.01588610293094580.29581348543743....
BRCACAediting_171517chr2_38566188_-0.008361600226389070.218993486337972....
LUSCCAediting_171517chr2_38566188_-0.001389114664516930.326772537860853....
OVCAediting_171517chr2_38566188_-0.008845921022294450.153482400469199....

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Relation with cancer stages for HNRNPLL

check button Correlation between Cancer stages and RNA editing frequency
CancerStage_typeCAeditomIDpositionP-valCoeff.
STADpathologic_stageCAediting_171517chr2_38566188_-0.0377732419200035-0.169233806059578

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Relation with survival for HNRNPLL

check button Correlation between RNA editing and survival
CancerCAeditomIDpositionKMpvalueCoxpvalueCoxHR

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RelatedDrugs for HNRNPLL

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.8 2021-01-03)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for HNRNPLL

check button Diseases associated with this gene.
(DisGeNet 7.0)
GeneDisease IDDisease name# pubmedsSource